Theoretical study of Escherichia Coli peptide deformylase inhibition by several drugs

In Silico Biology

Volumn 6, Issue 5, 2006, Pages 459-466

  Chikhi, Abdelouahab ^a   Bensegueni, Abderrahmane ^a   Boulahrouf, Abderrahmane ^a   Bencharif, Mustapha ^a  

^a Universite Mentouri Constantine   (Algeria)

Author keywords

Affinity; Antibacterial agents; Antibiotic resistance; Binding energy; Cobalt metalloenzyme; Deformylation; Docking software; Enzyme inhibitor complex; FlexX program; Hydrogen bonds; Interactions; Modeling; Peptide deformylase; Protein maturation; Substitution; Target; Theoretical method

Indexed keywords

ACTINONIN; AMIDE; AMINE; METHYL GROUP; N (1 TERT BUTYL 2 DIMETHYLAMINO 2 OXOETHYL) 2 (N FORMYL N HYDROXYAMINOMETHYL)HEXANAMIDE; PEPTIDE DEFORMYLASE; PEPTIDE DEFORMYLASE INHIBITOR; PHENYL GROUP; PROPANE; RO 66 0376; RO 66 1467; RO 66 6976;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; COMPUTER PROGRAM; COMPUTER SIMULATION; DRUG DESIGN; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ESCHERICHIA COLI; HYDROGEN BOND; LIGAND BINDING; MOLECULAR STABILITY; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; THEORETICAL MODEL;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; CATALYTIC DOMAIN; COMPUTER SIMULATION; COMPUTER-AIDED DESIGN; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; LIGANDS; MODELS, MOLECULAR; THERMODYNAMICS;

EID: 33845248414     PISSN: 13866338     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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