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Volumn 59, Issue 5, 2006, Pages 1122-1130

Lactate, not glucose, up-regulates mitochondrial oxygen consumption both in sham and lateral fluid percussed rat brains

Author keywords

Brain injury; Glucose; Lactate; Oxygen; Oxygen consumption

Indexed keywords

BICARBONATE; CARBON DIOXIDE; GLUCOSE; LACTIC ACID; OXYGEN;

EID: 33845216277     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/01.NEU.0000245581.00908.AF     Document Type: Article
Times cited : (30)

References (70)
  • 1
    • 0033254491 scopus 로고    scopus 로고
    • Glucose and lactate metabolism after severe human head injury: Influence of excitatory neurotransmitters and injury type
    • Alessandri B, Doppenberg E, Bullock R, Woodward J, Choi S, Koura S, Young HF: Glucose and lactate metabolism after severe human head injury: Influence of excitatory neurotransmitters and injury type. Acta Neurochir Suppl 75:21-24, 1999.
    • (1999) Acta Neurochir Suppl , vol.75 , pp. 21-24
    • Alessandri, B.1    Doppenberg, E.2    Bullock, R.3    Woodward, J.4    Choi, S.5    Koura, S.6    Young, H.F.7
  • 2
    • 0036329446 scopus 로고    scopus 로고
    • Cyclosporin A improves brain tissue oxygen consumption and learning/memory performance after lateral fluid percussion injury rats
    • Alessandri B, Rice AC, Levasseur J, DeFord M, Hamm RJ, Bullock MR: Cyclosporin A improves brain tissue oxygen consumption and learning/memory performance after lateral fluid percussion injury rats. J Neurotrauma 19:829-841, 2002.
    • (2002) J Neurotrauma , vol.19 , pp. 829-841
    • Alessandri, B.1    Rice, A.C.2    Levasseur, J.3    DeFord, M.4    Hamm, R.J.5    Bullock, M.R.6
  • 3
    • 0026738714 scopus 로고
    • Functional compartmentalization of energy production in neural tissue
    • Andersen B, Marmarou A: Functional compartmentalization of energy production in neural tissue. Brain Res 585:190-195, 1992.
    • (1992) Brain Res , vol.585 , pp. 190-195
    • Andersen, B.1    Marmarou, A.2
  • 4
    • 28044442099 scopus 로고    scopus 로고
    • Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation
    • Aubert A, Costalat R, Magistretti PJ, Pellerin L: Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation. PNAS 102:16448-16453, 2005.
    • (2005) PNAS , vol.102 , pp. 16448-16453
    • Aubert, A.1    Costalat, R.2    Magistretti, P.J.3    Pellerin, L.4
  • 5
    • 0036429377 scopus 로고    scopus 로고
    • Amodel of the coupling between brain electrical activity, metabolism, and hemodynamics: Application to the interpretation of functional neuroimaging
    • Aubert A, Costalat R: Amodel of the coupling between brain electrical activity, metabolism, and hemodynamics: Application to the interpretation of functional neuroimaging. Neuroimage 17:1162-1181, 2002.
    • (2002) Neuroimage , vol.17 , pp. 1162-1181
    • Aubert, A.1    Costalat, R.2
  • 6
    • 27544470356 scopus 로고    scopus 로고
    • Interaction between astrocytes and neurons studied using a mathematical model of compartmentalized energy metabolism
    • Aubert A, Costalat R: Interaction between astrocytes and neurons studied using a mathematical model of compartmentalized energy metabolism. J Cereb Blood Flow Metab 25:1476-1490, 2005.
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 1476-1490
    • Aubert, A.1    Costalat, R.2
  • 8
    • 0029990892 scopus 로고    scopus 로고
    • Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain
    • Bittar PG, Charnay Y, Pellerin L, Bouras C, Magistretti PJ: Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain. J Cereb Blood Flow Metab 16:1079-1089, 1996.
    • (1996) J Cereb Blood Flow Metab , vol.16 , pp. 1079-1089
    • Bittar, P.G.1    Charnay, Y.2    Pellerin, L.3    Bouras, C.4    Magistretti, P.J.5
  • 9
    • 0033994101 scopus 로고    scopus 로고
    • Lactate/glucose dynamics after rat fluid percussion brain injury
    • Chen, T, Qian YZ, Di X, Rice A, Zhu JP, Bullock R: Lactate/glucose dynamics after rat fluid percussion brain injury. J Neurotrauma 17:135-142, 2000.
    • (2000) J Neurotrauma , vol.17 , pp. 135-142
    • Chen, T.1    Qian, Y.Z.2    Di, X.3    Rice, A.4    Zhu, J.P.5    Bullock, R.6
  • 10
    • 0034575201 scopus 로고    scopus 로고
    • Evidence for lactate uptake after rat fluid percussion brain injury
    • Chen T, Qian YZ, Di X, Zhu JP, Bullock R: Evidence for lactate uptake after rat fluid percussion brain injury. Acta Neurochir Suppl 76:359-364, 2000.
    • (2000) Acta Neurochir Suppl , vol.76 , pp. 359-364
    • Chen, T.1    Qian, Y.Z.2    Di, X.3    Zhu, J.P.4    Bullock, R.5
  • 11
    • 0031798027 scopus 로고    scopus 로고
    • Effect of glucose administration on contusion volume after moderate cortical impact injury in rats
    • Cherian L, Goodman JC, Robertson CS: Effect of glucose administration on contusion volume after moderate cortical impact injury in rats. J Neurotrauma 15:1059-1066, 1998.
    • (1998) J Neurotrauma , vol.15 , pp. 1059-1066
    • Cherian, L.1    Goodman, J.C.2    Robertson, C.S.3
  • 12
    • 4143088238 scopus 로고    scopus 로고
    • Effects of hyperbaric oxygen therapy on cerebral oxygenation and mitochondrial function following moderate lateral fluid-percussion injury in rats
    • Daugherty WP, Levasseur JE, Sun D, Rockswold GL, Bullock MR: Effects of hyperbaric oxygen therapy on cerebral oxygenation and mitochondrial function following moderate lateral fluid-percussion injury in rats. J Neurosurg 101:499-504, 2004.
    • (2004) J Neurosurg , vol.101 , pp. 499-504
    • Daugherty, W.P.1    Levasseur, J.E.2    Sun, D.3    Rockswold, G.L.4    Bullock, M.R.5
  • 13
    • 4143148852 scopus 로고    scopus 로고
    • Hyperoxia treatment improves cerebral aerobic metabolism as measured by tissue ATP early after lateral fluid percussion brain injury
    • Daugherty WP, Harvey H, Levasseur JE, Dong S, Fraykor M, Abd-Elfattah A, Bullock MR: Hyperoxia treatment improves cerebral aerobic metabolism as measured by tissue ATP early after lateral fluid percussion brain injury. J Neurotrauma 20:1162, 2003.
    • (2003) J Neurotrauma , vol.20 , pp. 1162
    • Daugherty, W.P.1    Harvey, H.2    Levasseur, J.E.3    Dong, S.4    Fraykor, M.5    Abd-Elfattah, A.6    Bullock, M.R.7
  • 14
    • 0032101792 scopus 로고    scopus 로고
    • Correlations between brain tissue oxygen tension, carbon dioxide tension, pH, and cerebral blood flow-a better way of monitoring the severely injured brain?
    • Doppenberg EM, Zauner A, Bullock R, Ward JD, Fatouros PP, Young HF: Correlations between brain tissue oxygen tension, carbon dioxide tension, pH, and cerebral blood flow-a better way of monitoring the severely injured brain? Surg Neurol 49:650-654, 1998.
    • (1998) Surg Neurol , vol.49 , pp. 650-654
    • Doppenberg, E.M.1    Zauner, A.2    Bullock, R.3    Ward, J.D.4    Fatouros, P.P.5    Young, H.F.6
  • 15
    • 0032910812 scopus 로고    scopus 로고
    • Reducing hemoglobin oxygen affinitydoes not increase hydroxyl radicals after acute subdural hematoma in the rat
    • Doppenberg EM, Rice MR, Alessandri, B, Qian Y, Di X, Bullock R: Reducing hemoglobin oxygen affinitydoes not increase hydroxyl radicals after acute subdural hematoma in the rat. J Neurotrauma 16:123-133, 1999.
    • (1999) J Neurotrauma , vol.16 , pp. 123-133
    • Doppenberg, E.M.1    Rice, M.R.2    Alessandri, B.3    Qian, Y.4    Di, X.5    Bullock, R.6
  • 16
    • 0027512740 scopus 로고
    • Physiological stimulation increases nonoxidative glucose metabolism in the brain of the freely moving rat
    • Fellows LK, Boutelle MG, Fillenz M: Physiological stimulation increases nonoxidative glucose metabolism in the brain of the freely moving rat. J Neurochem 60:1258-1263, 1993.
    • (1993) J Neurochem , vol.60 , pp. 1258-1263
    • Fellows, L.K.1    Boutelle, M.G.2    Fillenz, M.3
  • 17
    • 0001697241 scopus 로고
    • The significance of the ratio of lactic acid to pyruvic acid in blood after exercise
    • Friedmann T, Barborka C: The significance of the ratio of lactic acid to pyruvic acid in blood after exercise. J Biol Chem 141:993-994, 1941.
    • (1941) J Biol Chem , vol.141 , pp. 993-994
    • Friedmann, T.1    Barborka, C.2
  • 18
    • 0028189686 scopus 로고
    • Focal microvascular occlusion after acute subdural haematoma in the rat: A mechanism for ischaemic damage and brain swelling?
    • Fujisawa H, Maxwell WL, Graham DI, Reasdale GM, Bullock R: Focal microvascular occlusion after acute subdural haematoma in the rat: A mechanism for ischaemic damage and brain swelling? Acta Neurochir Suppl (Wien) 60:193-196, 1994.
    • (1994) Acta Neurochir Suppl (Wien) , vol.60 , pp. 193-196
    • Fujisawa, H.1    Maxwell, W.L.2    Graham, D.I.3    Reasdale, G.M.4    Bullock, R.5
  • 21
    • 0032879143 scopus 로고    scopus 로고
    • Extracellular lactate and glucose alterations in the brain after head injury measured by microdialysis
    • Goodman JC, Valadka AB, Gopinath SP, Uzura M, Robertson CS: Extracellular lactate and glucose alterations in the brain after head injury measured by microdialysis. Crit Care Med 27:1965-1973, 1999.
    • (1999) Crit Care Med , vol.27 , pp. 1965-1973
    • Goodman, J.C.1    Valadka, A.B.2    Gopinath, S.P.3    Uzura, M.4    Robertson, C.S.5
  • 22
    • 0001235483 scopus 로고
    • Lactate metabolism
    • Haljamae H: Lactate metabolism. Intens Care World 4:118-121, 1987.
    • (1987) Intens Care World , vol.4 , pp. 118-121
    • Haljamae, H.1
  • 23
  • 24
    • 0034778032 scopus 로고    scopus 로고
    • Traumatic brain injury-induced changes in gene expression and functional activity of mitochondria cytochrome C oxidase
    • Harris LK, Black RT, Golden KM, Reeves TM, Povlishock JT, Phillips LL: Traumatic brain injury-induced changes in gene expression and functional activity of mitochondria cytochrome C oxidase. J Neurotrauma 18:993-1009, 2001.
    • (2001) J Neurotrauma , vol.18 , pp. 993-1009
    • Harris, L.K.1    Black, R.T.2    Golden, K.M.3    Reeves, T.M.4    Povlishock, J.T.5    Phillips, L.L.6
  • 26
    • 33845214257 scopus 로고    scopus 로고
    • Determination of the optimum lactate dose combined with oxygen therapy and its effect on cognitive deficits in rats after moderate traumatic brain injury
    • Holloway R, Harvey HB, Levasseur JE, Rice AC, Hamm RJ, Bullock MR: Determination of the optimum lactate dose combined with oxygen therapy and its effect on cognitive deficits in rats after moderate traumatic brain injury. J Neurotrauma 20:1127, 2003.
    • (2003) J Neurotrauma , vol.20 , pp. 1127
    • Holloway, R.1    Harvey, H.B.2    Levasseur, J.E.3    Rice, A.C.4    Hamm, R.J.5    Bullock, M.R.6
  • 28
    • 0030931102 scopus 로고    scopus 로고
    • A temporary local energy pool coupled to neuronal activity: Fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor
    • Hu Y, Wilson GS: A temporary local energy pool coupled to neuronal activity: Fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor. J Neurochem 69:1484-1490, 1997.
    • (1997) J Neurochem , vol.69 , pp. 1484-1490
    • Hu, Y.1    Wilson, G.S.2
  • 29
    • 1542316374 scopus 로고    scopus 로고
    • Effect of mild hypothermia on brain dialysate lactate after fluid percussion brain injury in rodents
    • Jiang JY, Liang YM, Luo QZ, Zhu C: Effect of mild hypothermia on brain dialysate lactate after fluid percussion brain injury in rodents. Neurosurgery 54:713-718, 2004.
    • (2004) Neurosurgery , vol.54 , pp. 713-718
    • Jiang, J.Y.1    Liang, Y.M.2    Luo, Q.Z.3    Zhu, C.4
  • 30
    • 0025616746 scopus 로고
    • Early cellular swelling in experimental traumatic brain injury: Aphenomenon mediated by excitatory amino acids
    • Katayama Y, Becker DP, Tamura, T, Ikezaki K: Early cellular swelling in experimental traumatic brain injury: Aphenomenon mediated by excitatory amino acids. Acta Neurochir Suppl (Wien) 51:271-273, 1990.
    • (1990) Acta Neurochir Suppl (Wien) , vol.51 , pp. 271-273
    • Katayama, Y.1    Becker, D.P.2    Tamura, T.3    Ikezaki, K.4
  • 31
    • 0025242563 scopus 로고
    • Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury
    • Katayama Y, Becker DP, Tamura T, Hovda DA: Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J Neurosurg 73:889-900, 1990.
    • (1990) J Neurosurg , vol.73 , pp. 889-900
    • Katayama, Y.1    Becker, D.P.2    Tamura, T.3    Hovda, D.A.4
  • 32
    • 0028879714 scopus 로고
    • Role of excitatory amino acid-mediated ionic fluxes in traumatic brain injury
    • Katayama Y, Maeda T, Koshinaga M, Kawamata T, Tsubokawa T: Role of excitatory amino acid-mediated ionic fluxes in traumatic brain injury. Brain Pathol 5:427-435, 1995.
    • (1995) Brain Pathol , vol.5 , pp. 427-435
    • Katayama, Y.1    Maeda, T.2    Koshinaga, M.3    Kawamata, T.4    Tsubokawa, T.5
  • 33
    • 0025012269 scopus 로고
    • Lactography as an approach to monitor glucose metabolism on-line in brain and muscle
    • Korf J, de Boer J: Lactography as an approach to monitor glucose metabolism on-line in brain and muscle. Int J Biochem 22:1371-1378, 1990.
    • (1990) Int J Biochem , vol.22 , pp. 1371-1378
    • Korf, J.1    De Boer, J.2
  • 34
    • 0024263595 scopus 로고
    • In vivo identification and quantitative evaluation of carrier-mediated transport of lactate at the cellular level in the striatum of conscious, freely moving rats
    • Kuhr WG, van den Berg CJ, Korf J: In vivo identification and quantitative evaluation of carrier-mediated transport of lactate at the cellular level in the striatum of conscious, freely moving rats. J Cereb Blood Flow Metab 8:848-856, 1988.
    • (1988) J Cereb Blood Flow Metab , vol.8 , pp. 848-856
    • Kuhr, W.G.1    Van Den Berg, C.J.2    Korf, J.3
  • 35
    • 0028906312 scopus 로고
    • Lactate metabolism and its effect on glucose metabolism in an excised neural tissue
    • Larabee MG: Lactate metabolism and its effect on glucose metabolism in an excised neural tissue. J Neurochem 64:1734-1741, 1995.
    • (1995) J Neurochem , vol.64 , pp. 1734-1741
    • Larabee, M.G.1
  • 36
    • 0029661937 scopus 로고    scopus 로고
    • Partitioning of CO2 production between glucose and lactate in excised sympathetic ganglia, with implications for brain
    • Larabee MG: Partitioning of CO2 production between glucose and lactate in excised sympathetic ganglia, with implications for brain. J Neurochem 67:1726-1734, 1996.
    • (1996) J Neurochem , vol.67 , pp. 1726-1734
    • Larabee, M.G.1
  • 37
    • 4944239339 scopus 로고    scopus 로고
    • Modeling cerebral arteriovenous lactate kinetics after intravenous lactate infusion in the rat
    • Leegsma-Vogt G, van der Werf S, Venema K, Korf J: Modeling cerebral arteriovenous lactate kinetics after intravenous lactate infusion in the rat. J Cereb Blood Flow Metab 24:1071-1080, 2004.
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 1071-1080
    • Leegsma-Vogt, G.1    Van Der Werf, S.2    Venema, K.3    Korf, J.4
  • 38
    • 0022052811 scopus 로고
    • Reduction in cerebral arterial oxygen consumption by arachidonate
    • Levasseur JE, Kontos HA, Ellis EF: Reduction in cerebral arterial oxygen consumption by arachidonate. Am J Physiol 248:H534-H539, 1985.
    • (1985) Am J Physiol , vol.248
    • Levasseur, J.E.1    Kontos, H.A.2    Ellis, E.F.3
  • 39
    • 0033980639 scopus 로고    scopus 로고
    • Fluid percussion injury transiently increases then decreases brain oxygen consumption in the rat
    • Levasseur JE, Alessandri B, Reinert M, Bullock R, Kontos HA: Fluid percussion injury transiently increases then decreases brain oxygen consumption in the rat. J Neurotrauma 17:101-112, 2000.
    • (2000) J Neurotrauma , vol.17 , pp. 101-112
    • Levasseur, J.E.1    Alessandri, B.2    Reinert, M.3    Bullock, R.4    Kontos, H.A.5
  • 42
    • 0011818097 scopus 로고
    • On the theory of the Cartesian diver micro respirometer
    • Linderstrom-Lang K: On the theory of the Cartesian diver micro respirometer. CR Trav Lab Carlsberg Ser Physiol 24:333-398, 1943.
    • (1943) CR Trav Lab Carlsberg Ser Physiol , vol.24 , pp. 333-398
    • Linderstrom-Lang, K.1
  • 43
    • 0027763898 scopus 로고
    • Neurotransmitters regulate energy metabolism in astrocytes: Implications for the metabolic trafficking between neural cells
    • Magistretti PJ, Sorg O, Yu N, Martin JL, Pellerin L: Neurotransmitters regulate energy metabolism in astrocytes: Implications for the metabolic trafficking between neural cells. Dev Neurosci 15:306-312, 1993.
    • (1993) Dev Neurosci , vol.15 , pp. 306-312
    • Magistretti, P.J.1    Sorg, O.2    Yu, N.3    Martin, J.L.4    Pellerin, L.5
  • 46
    • 0001472408 scopus 로고
    • Glucose level, metabolism, and response to electrical impulses in cerebral tissues from man and laboratory animals
    • McIlwain H: Glucose level, metabolism, and response to electrical impulses in cerebral tissues from man and laboratory animals. Biochem J 55:618-624, 1953.
    • (1953) Biochem J , vol.55 , pp. 618-624
    • McIlwain, H.1
  • 47
    • 0032698420 scopus 로고    scopus 로고
    • Increased inspired oxygen concentration as a factor in improved brain tissue oxygenation and tissue lactate levels after severe human head injury
    • Menzel M, Doppenberg EM, Zauner A, Soukup J, Reinert MM, Bullock R: Increased inspired oxygen concentration as a factor in improved brain tissue oxygenation and tissue lactate levels after severe human head injury. J Neurosurg 91:1-10, 1999.
    • (1999) J Neurosurg , vol.91 , pp. 1-10
    • Menzel, M.1    Doppenberg, E.M.2    Zauner, A.3    Soukup, J.4    Reinert, M.M.5    Bullock, R.6
  • 48
    • 0032887962 scopus 로고    scopus 로고
    • Cerebral oxygenation in patients after severe head injury: Monitoring and effects of arterial hyperoxia on cerebral blood flow, metabolism and intracranial pressure
    • Menzel M, Doppenberg EM, Zauner A, Soukup J, Reinert MM, Clausen T, Brockenbrough PB, Bullock R: Cerebral oxygenation in patients after severe head injury: Monitoring and effects of arterial hyperoxia on cerebral blood flow, metabolism and intracranial pressure. J Neurosurg Anesthesiol 11:240-251, 1999.
    • (1999) J Neurosurg Anesthesiol , vol.11 , pp. 240-251
    • Menzel, M.1    Doppenberg, E.M.2    Zauner, A.3    Soukup, J.4    Reinert, M.M.5    Clausen, T.6    Brockenbrough, P.B.7    Bullock, R.8
  • 49
    • 0028080101 scopus 로고
    • Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization
    • Pellerin L, Magistretti P: Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci USA 91:10625-10629, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10625-10629
    • Pellerin, L.1    Magistretti, P.2
  • 51
    • 0034434015 scopus 로고    scopus 로고
    • High level of extracellular potassium and its correlates after severe head injury: Relationship to high intracranial pressure
    • Reinert M, Khaldi A, Zauner A, Doppenberg E, Choi S, Bullock R: High level of extracellular potassium and its correlates after severe head injury: Relationship to high intracranial pressure. J Neurosurg 93:800-807, 2000.
    • (2000) J Neurosurg , vol.93 , pp. 800-807
    • Reinert, M.1    Khaldi, A.2    Zauner, A.3    Doppenberg, E.4    Choi, S.5    Bullock, R.6
  • 52
    • 0036717774 scopus 로고    scopus 로고
    • Influence of inspired oxygen on glucose-lactate dynamics after subdural hematoma in the rat
    • Reinert M, Alessandri B, Seiler R, Bullock R: Influence of inspired oxygen on glucose-lactate dynamics after subdural hematoma in the rat. Neurol Res 24:601-606, 2002.
    • (2002) Neurol Res , vol.24 , pp. 601-606
    • Reinert, M.1    Alessandri, B.2    Seiler, R.3    Bullock, R.4
  • 53
    • 3242758983 scopus 로고    scopus 로고
    • Influence of oxygen therapy on glucose-lactate metabolism after diffuse brain injury
    • Reinert M, Schaller B, Widmer HR, Seiler R, Bullock R: Influence of oxygen therapy on glucose-lactate metabolism after diffuse brain injury. J Neurosurg 101:323-329, 2004.
    • (2004) J Neurosurg , vol.101 , pp. 323-329
    • Reinert, M.1    Schaller, B.2    Widmer, H.R.3    Seiler, R.4    Bullock, R.5
  • 55
    • 10244227953 scopus 로고    scopus 로고
    • Mitochondrial dysfunction contributes to cell death following brain injury in adult and immature animals
    • Robertson CL: Mitochondrial dysfunction contributes to cell death following brain injury in adult and immature animals. J Bioenerg Biomembr 36:363-368, 2004.
    • (2004) J Bioenerg Biomembr , vol.36 , pp. 363-368
    • Robertson, C.L.1
  • 57
    • 0023890868 scopus 로고
    • Lactate-supported synaptic function in the rat hippocampal slice preparation
    • Schurr A, West CA, Rigor BM: Lactate-supported synaptic function in the rat hippocampal slice preparation. Science 240:1326-1328, 1988.
    • (1988) Science , vol.240 , pp. 1326-1328
    • Schurr, A.1    West, C.A.2    Rigor, B.M.3
  • 58
    • 0032929864 scopus 로고    scopus 로고
    • An increase in lactate output by brain tissue serves to meet the energy needs of glutamate-activated neurons
    • Schurr A, Miller JJ, Payne RS, Rigor BM: An increase in lactate output by brain tissue serves to meet the energy needs of glutamate-activated neurons. J Neurosci 19:34-39, 1999.
    • (1999) J Neurosci , vol.19 , pp. 34-39
    • Schurr, A.1    Miller, J.J.2    Payne, R.S.3    Rigor, B.M.4
  • 59
    • 0035937484 scopus 로고    scopus 로고
    • Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia
    • Schurr A, Payne RS, Miller JJ, Tseng MT, Rigor BM: Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia. Brain Res 895:268-272, 2001.
    • (2001) Brain Res , vol.895 , pp. 268-272
    • Schurr, A.1    Payne, R.S.2    Miller, J.J.3    Tseng, M.T.4    Rigor, B.M.5
  • 60
    • 33845200565 scopus 로고    scopus 로고
    • Effects of exogenous lactate on glutamate release and lesion volume following controlled cortical contusion in rats
    • Schwandt ES, Alessandri B, Nagata M, Kempski O: Effects of exogenous lactate on glutamate release and lesion volume following controlled cortical contusion in rats. J Neurotrauma 20:1096, 2003.
    • (2003) J Neurotrauma , vol.20 , pp. 1096
    • Schwandt, E.S.1    Alessandri, B.2    Nagata, M.3    Kempski, O.4
  • 61
    • 0019842691 scopus 로고
    • Cell damage in the brain: A speculative synthesis
    • Siesjö BK: Cell damage in the brain: a speculative synthesis. J Cereb Blood Flow Metab 1:155-185, 1981.
    • (1981) J Cereb Blood Flow Metab , vol.1 , pp. 155-185
    • Siesjö, B.K.1
  • 62
    • 4644324464 scopus 로고    scopus 로고
    • The protective effect of cyclosporine A upon N-acetyl-aspartate and mitochondrial dysfunction following experimental diffuse traumatic brain injury
    • Signoretti S, Marmarou A, Tavazzi B, Dunbar J, Amorini AM, Lazzarino G, Vagnozzi R: The protective effect of cyclosporine A upon N-acetyl-aspartate and mitochondrial dysfunction following experimental diffuse traumatic brain injury. J Neurotrauma 21:1154-1167, 2004.
    • (2004) J Neurotrauma , vol.21 , pp. 1154-1167
    • Signoretti, S.1    Marmarou, A.2    Tavazzi, B.3    Dunbar, J.4    Amorini, A.M.5    Lazzarino, G.6    Vagnozzi, R.7
  • 63
    • 0034782504 scopus 로고    scopus 로고
    • N-Acetylaspartate reduction as a measure of injury severity and mitochondrial dysfunction following diffuse traumatic brain injury
    • Signoretti S, Marmarou A, Tavazzi B, Lazzarino G, Beaumont A, Vagnozzi R: N-Acetylaspartate reduction as a measure of injury severity and mitochondrial dysfunction following diffuse traumatic brain injury. J Neurotrauma 18:977-991, 2001.
    • (2001) J Neurotrauma , vol.18 , pp. 977-991
    • Signoretti, S.1    Marmarou, A.2    Tavazzi, B.3    Lazzarino, G.4    Beaumont, A.5    Vagnozzi, R.6
  • 64
    • 0029927343 scopus 로고    scopus 로고
    • Metabolic coupling between glia and neurons
    • Tscaopoulos M, Magistretti P: Metabolic coupling between glia and neurons. J Neurosci 16:877-885, 1996.
    • (1996) J Neurosci , vol.16 , pp. 877-885
    • Tscaopoulos, M.1    Magistretti, P.2
  • 65
    • 4143109120 scopus 로고    scopus 로고
    • Normobaric hyperoxia-induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: A prospective historical cohort-matched study
    • Tolias CM, Reinert M, Seiler R, Gilman C, Scharf A, Bullock MR: Normobaric hyperoxia-induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: A prospective historical cohort-matched study. J Neurosurg 101:435-444, 2004.
    • (2004) J Neurosurg , vol.101 , pp. 435-444
    • Tolias, C.M.1    Reinert, M.2    Seiler, R.3    Gilman, C.4    Scharf, A.5    Bullock, M.R.6
  • 67
    • 0030971953 scopus 로고    scopus 로고
    • Ultrastructural study of brain microvessels in patients with traumatic cerebral contusions
    • Vaz R, Sarmento A, Borges N, Cruz C, Azevedo I: Ultrastructural study of brain microvessels in patients with traumatic cerebral contusions. Acta Neurochir (Wien) 139:215-220, 1997.
    • (1997) Acta Neurochir (Wien) , vol.139 , pp. 215-220
    • Vaz, R.1    Sarmento, A.2    Borges, N.3    Cruz, C.4    Azevedo, I.5
  • 68
    • 0027933397 scopus 로고
    • Bioenergetic analysis of oxidative metabolism following traumatic brain injury
    • Vink R, Golding E, Headrick J: Bioenergetic analysis of oxidative metabolism following traumatic brain injury. J Neurotrauma 11:265-274, 1994.
    • (1994) J Neurotrauma , vol.11 , pp. 265-274
    • Vink, R.1    Golding, E.2    Headrick, J.3
  • 69
    • 0030915477 scopus 로고    scopus 로고
    • Mitochondrial dysfunction after experimental and human brain injury and its possible reversal with a selective N-type calcium channel antagonist (SNX-111)
    • Verweij BH, Muizelaar JP, Vinas FC, Peterson PL, Xiong Y, Lee CP: Mitochondrial dysfunction after experimental and human brain injury and its possible reversal with a selective N-type calcium channel antagonist (SNX-111). Neurol Res 19:334-339, 1997.
    • (1997) Neurol Res , vol.19 , pp. 334-339
    • Verweij, B.H.1    Muizelaar, J.P.2    Vinas, F.C.3    Peterson, P.L.4    Xiong, Y.5    Lee, C.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.