Critical role of methionine-722 in the stimulation of human brain G-proteins and neurotoxicity induced by London familial Alzheimer's disease (FAD) mutated V717G-APP714-723

Neuroscience

Volumn 144, Issue 2, 2007, Pages 571-578

  Reis, K ^a   Zharkovsky, A ^b   Bogdanovic, N ^c   Karelson, E ^a,b   Land, T ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b UNIVERSITY OF TARTU   (Estonia)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

antioxidants; G proteins; methionine 722 oxidation; neurotoxicity; V717G APP714 723 fragment

Indexed keywords

AMYLOID PRECURSOR PROTEIN; DEFEROXAMINE; ESTRADIOL; GLUTATHIONE; GUANINE NUCLEOTIDE BINDING PROTEIN; MELATONIN; METHIONINE; MUTANT PROTEIN; PEPTIDE DERIVATIVE; PERTUSSIS TOXIN;

ADULT; AGED; ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN MEMBRANE; CELL VIABILITY; CEREBELLUM CORTEX; CONTROLLED STUDY; FAMILIAL DISEASE; FEMALE; GRANULAR CELL; HUMAN; HUMAN TISSUE; MALE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; TEMPORAL CORTEX;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; CELLS, CULTURED; DEFEROXAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; FEMALE; GLUTATHIONE; GLYCINE; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; MALE; MELATONIN; METHIONINE; MIDDLE AGED; PEPTIDES; PROTEIN BINDING; RATS; TEMPORAL LOBE; VALINE;

EID: 33845207273     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2006.10.007     Document Type: Article

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