From disease genes to cellular pathways: A progress report

Novartis Foundation Symposium

Volumn 255, Issue , 2003, Pages 147-160

  Yu, J ^a,b   Mears, A J ^a   Yoshida, S ^a   Farjo, R ^a   Carter, T A ^c   Ghosh, D ^b   Hero, A ^b   Barlow, C ^c   Swaroop, A ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33751573446     PISSN: 15282511     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (34)

1. Bennett J, Zeng Y, Bajwa R, Klatt L, Li Y, Maguire AM 1998 Adenovirus-mediated delivery of rhodopsin-promoted bcl-2 results in a delay in photoreceptor cell death in the rd/rd mouse. Gene Ther 5:1156-1164
2. Bessant DA, Payne AM, Mitton KP, et al 1999 A mutation in NRL is associated with autosomal dominant retinitis pigmentosa. Nat Genet 21:355-356
3. Bessant DA, Payne AM, Plant C, Bird AC, Swaroop A, Bhattacharya SS 2000 NRL S50T mutation and the importance of 'founder effects' in inherited retinal dystrophies. Eur J Hum Genet 8:783-787
4. Bessant DA, Ali RR, Bhattacharya SS 2001 Molecular genetics and prospects for therapy of the inherited retinal dystrophies. Curr Opin Genet Dev 11:307-316
5. Chen S, Wang QL, Nie Z et al 1997 Crx, a novel Otxl-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron 19:1017-1030
6. Cheng L, Chaidhawangul S, Wong-Staal F et al 2002 Human immunodeficiency virus type 2 (HIV-2) vector-mediated in vivo gene transfer into adult rabbit retina. Curr Eye Res 24:196-201
7. DeAngelis MM, Grimsby JL, Sandberg MA, Berson EL, Dryja TP 2002 Novel mutations in the NRL gene and associated clinical findings in patients with dominant retinitis pigmentosa. Arch Ophthalmol 120:369-375
8. Farjo Q, Jackson AU, Xu J et al 1993 Molecular characterization of the murine neural retina leucine zipper gene, Nrl. Genomics 18:216-222
9. Farjo R, Yu J, Othman MI et al 2002 Mouse eye gene microarrays for investigating ocular development and disease. Vision Res 42:463-470
10. Hammerle H, Kobuch K, Kohler K, Nisch W, Sachs H, Stelzle M 2002 Biostability of microphotodiode arrays for subretinal implantation. Biomaterials 23:797-804
11. Klein R, Wang Q, Klein BE, Moss SE, Meuer SM 1995 The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity. Invest Ophthalmol Vis Sci 36:182-191
12. Kumar R, Chen S, Scheurer D et al 1996 The bZIP transcription factor Nrl stimulates rhodopsin promoter activity in primary retinal cell cultures. J Biol Chem 271:29612-29618
13. LaVail MM, Yasumura D, Matthes MT et al 1998 Protection of mouse photoreceptors by-survival factors in retinal degenerations. Invest Ophthalmol Vis Sci 39:592-602
14. Lerner LE, Gribanova YE, Ji M, Knox BE, Farber DB 2001 Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of multiple response elements. J Biol Chem 276:34999-35007
15. Liang FQ, Dejneka NS, Cohen DR et al 2001 AAV-mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse. Mol Ther 3:241-248
16. Livesey FJ, Furukawa T, Steffen MA, Church GM, Cepko CL 2000 Microarray analysis of the transcriptional network controlled by the photoreceptor homeobox gene Crx. Curr Biol 10:301-310
17. Livesey R 2002 Have microarrays failed to deliver for developmental biology? Genome Biol 3:COMMENT2009
18. Martinez-Gimeno M, Maseras M, Baiget M et al 2001 Mutations P51U and G122E in retinal transcription factor NRL associated with autosomal dominant and sporadic retinitis pigmentosa. Hum Mutat 17:520
19. Mears AJ, Kondo M, Swain PK et al 2001 Nrl is required for rod photoreceptor development. Nat Genet 29:447-452
20. Mitton KP, Swain PK, Chen S, Xu S, Zack DJ, Swaroop A 2000 The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation. J Biol Chem 275:29794-29799
21. Otani A, Kinder K, Ewalt K, Otero FJ, Schimmel P, Friedlander M 2002 Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis. Nat Med 8:1004-1010
22. Radner W, Sadda SR, Humayun MS, Suzuki S, de Juan E Jr 2002 Increased spontaneous retinal ganglion cell activity in rd mice after neural retinal transplantation. Invest Ophthalmol Vis Sci 43:3053-3058
23. Rehemtulla A, Warwar R, Kumar R, Ji X, Zack DJ, Swaroop A 1996 The basic motif-leucine zipper transcription factor Nrl can positively regulate rhodopsin gene expression. Proc Natl Acad Sci USA 93:191-195
24. Saleem RA, Walter MA 2002 The complexities of ocular genetics. Clin Genet 61:79-88
25. Semkova I, Kreppel F, Welsandt G et al 2002 Autologous transplantation of genetically modified iris pigment epithelial cells: a promising concept for the treatment of age-related macular degeneration and other disorders of the eye. Proc Natl Acad Sci USA 99:13090-13095
26. Swain PK, Hicks D, Mears AJ et al 2001 Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptors. J Biol Chem 276:36824-36830
27. Swaroop A, Zack DJ 2002 Transcriptome analysis of the retina. Genome Biol 3:REVIEWS1022
28. Swaroop A, Xu JZ, Pawar H, Jackson A, Skolnick C, Agarwal N 1992 A conserved retina-specific gene encodes a basic motif/leucine zipper domain. Proc Natl Acad Sci USA 89:266-270
29. Tao W, Wen R, Goddard MB et al 2002 Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest Ophthalmol Vis Sci 43:3292-3298
30. Travis GH 1998 Mechanisms of cell death in the inherited retinal degenerations. Am J Hum Genet 62:503-508
31. Yoshida S, Yashar BM, Hiriyanna S, Swaroop A 2002 Microarray analysis of gene expression in the aging human retina. Invest Ophthalmol Vis Sci 43:2554-2560
32. Yu J, Othman MI, Farjo R et al 2002 Evaluation and optimization of procedures for target labeling and hybridization of cDNA microarrays. Mol Vis 8:130-137
33. Yu J, Farjo R, MacNee SP, Baehr W, Stambolian DE, Swaroop A 2003 Annotation and analysis of 10,000 expressed squence tags from developing mouse eye and adult retina. Genome Biol 4:R65 (open access full text at http:\\www.genomebiology.com/2003/4/10/R65)
34. Zrenner E, Gekeler F, Gabel VP et al 2001 Subretinal microphotodiode array as replacement for degenerated photoreceptors? (German) Ophthalmologe 98:357-363