Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function

Journal of Leukocyte Biology

Volumn 80, Issue 3, 2006, Pages 621-629

  Wrenger, Sabine ^a   Faust, Jürgen ^b   Friedrich, Daniel ^c   Hoffmann, Torsten ^c   Hartig, Roland ^a   Lendeckel, Uwe ^a   Kähne, Thilo ^a   Thielitz, Anja ^a   Neubert, Klaus ^b   Reinhold, Dirk ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c PROBIODRUG AG   (Germany)

Author keywords

Cell adhesion; Counter current elutriation; Cytokine production; DP IV inhibitor

Indexed keywords

ATTRACTIN; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; INTERLEUKIN 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL ADHESION; CELL FUNCTION; CELL STIMULATION; CELL VIABILITY; COUNTERCURRENT SYSTEM; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; T LYMPHOCYTE ACTIVATION;

ADENOSINE DEAMINASE; ANTIGENS, CD26; ENZYME ACTIVATION; GENE EXPRESSION PROFILING; GLYCOPROTEINS; HUMANS; LEUKOCYTES, MONONUCLEAR; LYSINE; MEMBRANE PROTEINS; MONOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 33751546187     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1105678     Document Type: Article

References (34)

1. Hopsu-Havu, V. K., Glenner, G. G. (1966) A new dipeptide naphthylamidase hydrolyzing glycyl-prolyl-β-naphthylamide. Histochemie 7, 197-201.
2. Oravecz, T., Pall, M., Roderiquez, G., Gorrell, M. D., Ditto, M., Nguyen, N. Y., Boykins, R., Unsworth, E., Norcross, M. A. (1997) Regulation of the receptor specificity and function of the chemokine RANTES (regulated on activation, normal T cell expressed and secreted) by dipeptidyl peptidase IV (CD26)-mediated cleavage. J. Exp. Med. 186, 1865-1872.
3. Proost, P., De Meester, I., Schols, D., Struyf, S., Lambeir, A. M., Wuyts, A., Opdenakker, G., De Clercq, E., Scharpe, S., Van Damme, J. (1998) Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection. J. Biol. Chem. 273, 7222-7227.
4. Shioda, T., Kato, H., Ohnishi, Y., Tashiro, K., Ikegawa, M., Nakayama, E. E., Hu, H., Kato, A., Sakai, Y., Liu, H., Honjo, T., Nomoto, A., Iwamoto, A., Morimoto, C., Nagai, Y. (1998) Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1α (SDF-1α) and SDF-1β are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage. Proc. Natl. Acad. Sci. USA 95, 6331-6336.
5. Reinhold, D., Kähne, T., Steinbrecher, A., Wrenger, S., Neubert, K., Ansorge, S., Brocke, S. (2002) The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity. Biol. Chem. 383, 1133-1138.
6. Sedo, A., Malik, R. (2001) Dipeptidyl peptidase IV-like molecules: homologous proteins or homologous activities? Biochim. Biophys. Acta 1550, 107-116.
7. Duke-Cohan, J. S., Gu, J., McLaughlin, D. F., Xu, Y., Freeman, G. J., Schlossman, S. F. (1998) Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions. Proc. Natl. Acad. Sci. USA 95, 11336-11341.
8. Korom, S., De Meester, I., Schmidbauer, G., Pratschke, J., Brendel, M. D., Durinx, C., Schwemmle, K., Haemers, A., Scharpe, S., Kupiec-Weglinski, J. W. (1999) Specific inhibition of CD26/DPP IV enzymatic activity in allograft recipients: effects on humoral immunity. Transplant. Proc. 31, 778.
9. Korom, S., De Meester, I., Stadlbauer, T. H., Chandraker, A., Schaub, M., Sayegh, M. H., Belyaev, A., Haemers, A., Scharpe, S., Kupiec-Weglinski, J. W. (1997) Inhibition of CD26/dipeptidyl peptidase IV activity in vivo prolongs cardiac allograft survival in rat recipients. Transplantation 63, 1495-1500.
10. Tanaka, S., Murakami, T., Horikawa, H., Sugiura, M., Kawashima, K., Sugita, T. (1997) Suppression of arthritis by the inhibitors of dipeptidyl peptidase IV. Int. J. Immunopharmacol. 19, 15-24.
11. Tanaka, S., Murakami, T., Nonaka, N., Ohnuki, T., Yamada, M., Sugita, T. (1998) Anti-arthritic effects of the novel dipeptidyl peptidase IV inhibitors TMC-2A and TSL-225. Immunopharmacology 40, 21-26.
12. Ben-Nun, A., Wekerle, H., Cohen, I. R. (1981) Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein. Nature 292, 60-61.
13. Ben-Nun, A., Wekerle, H., Cohen, I. R. (1981) The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol. 11, 195-199.
14. Reinhold, D., Hemmer, B., Gran, B., Born, I., Faust, J., Neubert, K., McFarland, H. F., Martin, R., Ansorge, S. (1998) Inhibitors of dipeptidyl peptidase IV/CD26 suppress activation of human MBP-specific CD4+ T cell clones. J. Neuroimmunol. 87, 203-209.
15. Steinbrecher, A., Reinhold, D., Quigley, L., Gado, A., Tresser, N., Izikson, L., Born, I., Faust, J., Neubert, K., Martin, R., Ansorge, S., Brocke, S. (2001) Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-β 1 secretion in vivo. J. Immunol. 166, 2041-2048.
16. Bauvois, B., Sanceau, J., Wietzerbin, J. (1992) Human U937 cell surface peptidase activities: characterization and degradative effect on tumor necrosis factor-α. Eur. J. Immunol. 22, 923-930.
17. Laman, J. D., Visser, L., Maassen, C. B., de Groot, C. J., de Jong, L. A., 't Hart, B. A., van Meurs, M., Schellekens, M. M. (2001) Novel monoclonal antibodies against proteolipid protein peptide 139-151 demonstrate demyelination and myelin uptake by macrophages in MS and marmoset EAE lesions. J. Neuroimmunol. 119, 124-130.
18. Reinhold, D., Bank, U., Bühling, F., Neubert, K., Mattern, T., Ulmer, A. J., Flad, H. D., Ansorge, S. (1993) Dipeptidyl peptidase IV (CD26) on human lymphocytes. Synthetic inhibitors of and antibodies against dipeptidyl peptidase IV suppress the proliferation of pokeweed mitogen-stimulated peripheral blood mononuclear cells, and IL-2 and IL-6 production. Immunobiology 188, 403-414.
19. Wahl, S. M., Katona, I. M., Stadler, B. M., Wilder, R. L., Helsel, W. E., Wahl, L. M. (1984) Isolation of human mononuclear cell subsets by counterflow centrifugal elutriation (CCE). II. Functional properties of B-lymphocyte-, T-lymphocyte-, and monocyte-enriched fractions. Cell. Immunol. 85, 384-395.
20. Boyum, A. (1968) Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand. J. Clin. Lab. Invest. Suppl. 97, 77-89.
21. Schön, E., Demuth, H. U., Barth, A., Ansorge, S. (1984) Dipeptidyl peptidase IV of human lymphocytes. Evidence for specific hydrolysis of glycylproline p-nitroanilide in T-lymphocytes. Biochem. J. 223, 255-258.
22. Schön, E., Born, I., Demuth, H. U., Faust, J., Neubert, K., Steinmetzer, T., Barth, A., Ansorge, S. (1991) Dipeptidyl peptidase IV in the immune system. Effects of specific enzyme inhibitors on activity of dipeptidyl peptidase IV and proliferation of human lymphocytes. Biol. Chem. Hoppe Seyler 372, 305-311.
23. Friedrich, D., Kuhn-Wache, K., Hoffmann, T., Demuth, H. U. (2003) Isolation and characterization of attractin-2. Adv. Exp. Med. Biol. 524, 109-113.
24. Baer, J. W., Gerhartz, B., Hoffmann, T., Rosche, F., Demuth, H. U. (2003) Characterization of human DP IV produced by a Pichia pastoris expression system. Adv. Exp. Med. Biol. 524, 103-108.
25. Reinhold, D., Wrenger, S., Bank, U., Bühling, F., Hoffmann, T., Neubert, K., Kraft, M., Frank, R., Ansorge, S. (1996) CD26 mediates the action of HIV-1 Tat protein on DNA synthesis and cytokine production in U937 cells. Immunobiology 195, 119-128.
26. Scanlan, M. J., Raj, B. K., Calvo, B., Garin Chesa, P., Sanz Moncasi, M. P., Healey, J. H., Old, L. J., Rettig, W. J. (1994) Molecular cloning of fibroblast activation protein α, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. Proc. Natl. Acad. Sci. USA 91, 5657-5661.
27. Duke-Cohan, J. S., Morimoto, C., Rocker, J. A., Schlossman, S. F. (1996) Serum high molecular weight dipeptidyl peptidase IV (CD26) is similar to a novel antigen DPPT-L released from activated T cells. J. Immunol. 156, 1714-1721.
28. Duke-Cohan, J. S., Morimoto, C., Rocker, J. A., Schlossman, S. F. (1995) A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26). J. Biol. Chem. 270, 14107-14114.
29. Demuth, H. U., McIntosh, C. H., Pederson, R. A. (2005) Type 2 diabetes-therapy with dipeptidyl peptidase IV inhibitors. Biochim. Biophys. Acta 1751, 33-44.
30. Evans, R. (1975) Macrophage-mediated cytotoxicity: its possible role in rheumatoid arthritis. Ann. N. Y. Acad. Sci. 256, 275-287.
31. Gorrell, M. D., Wickson, J., McCaughan, G. W. (1991) Expression of the rat CD26 antigen (dipeptidyl peptidase IV) on subpopulations of rat lymphocytes. Cell. Immunol. 134, 205-215.
32. Bühling, F., Junker, U., Reinhold, D., Neubert, K., Jäger, L., Ansorge, S. (1995) Functional role of CD26 on human B lymphocytes. Immunol. Lett. 45, 47-51.
33. Gliddon, D. R., Howard, C. J. (2002) CD26 is expressed on a restricted subpopulation of dendritic cells in vivo. Eur. J. Immunol. 32, 1472-1481.
34. Juillerat-Jeanneret, L., Aubert, J. D., Leuenberger, P. (1997) Peptidases in human bronchoalveolar lining fluid, macrophages, and epithelial cells: dipeptidyl (amino)peptidase IV, aminopeptidase N, and dipeptidyl (carboxy) peptidase (angiotensin-converting enzyme). J. Lab. Clin. Med. 130, 603-614.