CD26 mediates the action of HIV-1 tat protein on DNA synthesis and cytokine production in U937 cells

Immunobiology

Volumn 195, Issue 1, 1996, Pages 119-128

  Reinhold, Dirk ^a   Wrenger, Sabine ^a   Bank, Ute ^a   Buhling, Frank ^a   Hoffmann, Torsten ^a   Neubert, Klaus ^b   Kraft, Margot ^c   Frank, Rainer ^c   Ansorge, Siegfried ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOGENIC SUBSTRATE; CYTOKINE; DIPEPTIDYL PEPTIDASE IV; DNA; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; TRANSACTIVATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROLYSIS; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; T LYMPHOCYTE ACTIVATION;

EID: 0030020731     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0171-2985(96)80010-6     Document Type: Article

References (24)

1. ANSORGE, S., E. SCHON, and D. KUNZ. 1991. Membrane-bound peptidases of lymphocytes: Functional implications. Biomed. Biochem. Acta 50: 799.
2. BÜHLING, F., U. JUNKER, D. REINTHOLD, K. NECBERT, L. JÄGER, and S. ANSORGE. 1995. Functional role of CD26 on human B lymphocytes. Immunol. Lett. 45: 47.
3. BUHLING, F., D. KUNZ, D. REINHOLD, A. J. ULMER, M. ERNST, H.-D. FLAD, and S. ANSORGE. 1994. Expression and functional role of dipeptidyl peptidase IV on human natural killer cells. Nat. Immun. 13: 270.
4. DANG, N. H., Y. TORIMOTO, K. DEUSCH, S. F. SCHLOSSMAN, and C. MORIMOTO. 1990. Comitogenic effect of solid-phase immobilized anti-1F7 on human CD4 T cell activation via CD3 and CD2 pathways. J. Immunol. 144: 4092.
5. DANG, N. H., Y. TORIMOTO, K. SHIMAMURA, T. TANAKA, J. F. DALEY, S. F. SCHLOSSMAN, and C. MORIMOTO. 1991. 1F7 (CD26): A marker of thymic maturation involved in the differential regulation of the CD3 and CD2 pathways of human thymocyte activation. J. Immunol. 147: 2825.
6. DANG, N. H., Y. TORIMOTO, K. SUGITA, J. F. DALEY, P. SHOW, C. PORADO, S. F. SCHLOSSMAN, and C. MORIMOTO. 1990. Cell surface modulation of CD26 by anti-1F7 monoclonal antibody. Analysis of surface expression and human T cell activation. J. Immunol. 145: 3963.
7. FLEISCHER, B. 1994. CD26: a surface protease involved in T-cell activation. J. Immunol. 15: 180.
8. FLENTKE, G. R., E. MUNOZ, B. T. HUBER, A. G. PLAUT, C. A. KETTNER, and W. W. BACHOVCHIN. 1991. Inhibition of dipeptidyl aminopeptidase IV (DP-IV) by XaaboroPro dipeptides and use of these inhibitors to examine the role of DP-IV in T-cell function. Proc. Natl. Acad. Sci. USA 88: 1556.
9. GUTHEIL, W. G., M. SUBRAMANYAM, G. R. FLENTKE, D. G. SANFORD, E. MUNOZ, B. T. HUBER, and W. W. BACHOVCHIN. 1994. Human immunodeficiency virus 1 Tat binds to dipeptidyl aminopeptidase IV (CD26); A possible mechanism for Tat s immunosuppressive activity. Proc. Natl. Acad. Sci. USA 91: 6594.
10. HOFFMANN, T., J. FAUST, K. NEUBERT, and S. ANSORGE. 1993. Dipeptidyl peptidase IV (CD26) and aminopeptidase N (CD13) catalyzed hydrolysis of cytokines and peptides with N-terminal cytokine sequences. FEBS Lett. 336: 61.
11. HOFFMANN, T., D. REINHOLD, T. KAHNE, J. FAUST, K. NEUBERT, R. FRANK, and S. ANSORGE. 1995. Inhibition of dipeptidyl peptidase IV by anti-DP IV antibodies and non-substrate X-X-Pro-oligopeptides ascertained by capillary electrophoresis. J. Chromatography, in press.
12. MEYAARD, L., S. A. OTTO, H. SCHUITEMAKER, and F. MIEDEMA. 1992. Effects of HIV-1 Tat protein on human T cell proliferation. Eur. J. Immunol. 22: 2729.
13. NEUBERT, R., H. HELGE, and D. NEUBERT. 1995. Thalidomide and the immune system. 4. Down-regulation of the CD26 receptor, probably involved in the binding of HIV components to T cells in primates. Life Sci. 56: 407.
14. REINHOLD, D., U. BANK, F. BÜHLING, T. KAHNE, D. KUNZ, J. FAUST, K. NEUBERT, and S. ANSORGE. 1994. Inhibitors of Dipeptidyl peptidase IV (DP IV, CD26) specifically suppress proliferation and modulate cytokine production of strongly CD26 expressing U937 cells. Immunobiology 192: 121.
15. REINHOLD, D., U. BANK, F. BUHLING, K. NEUBERT, T. MATTERN, A. J. ULMER, H.-D. FLAD, and S. ANSORGE. 1993. Dipeptidyl peptidase IV (CD26) on human lymphocytes. Synthetic inhibitors of and antibodies against Dipeptidyl peptidase IV suppress the proliferation of pokeweed mitogen-stimulated peripheral blood mononuclear cells and IL-2 and IL-6 production. Immunobiol. 188: 403.
16. SCHON, E., I. BORN, H.-U. DEMUTH, J. FAUST, K. NEUBERT, T. STEINMEIZER, A. BARTH, and S. ANSORGE. 1991. Dipeptidyl peptidase IV in the immune system. Effects of specific enzyme inhibitors on activity of dipeptidyl peptidase IV and proliferation of human lymphocytes. Biol. Chem. Hoppe Seyler 372: 305.
17. SCHON, E., H.-U. DEMUTH, E. EICHMANN, H.-J. HORST, I.-J. KORNER, J. KOPP, T. MATTERN, K. NEUBERT, F. NOLL, and J. A. ULMER et al. 1989. Dipeptidyl peptidase IV in human T lymphocytes impaired induction of interleukin 2 and gamma interferon due to specific inhibition of dipeptidyl peptidase IV. Scand. J. Immunol. 29: 127.
18. SCHÖN, E., U. H. DEMUTH, A. BARTH, and S. ANSORGF. 1984. Dipeptidyl peptidase IV of human lymphocytes. Evidence for specific hydrolysis of glycylprolin in T-lymphocytes. Biochem. J. 223: 255.
19. SCHON, E., S. JAHN, S. T. KILSSIG, H.-U. DEMUTH, K. NLUBERT, A. BARTH, R. VON BAEHR, and S. ANSORGE. 1987. The role of dipeptidyl peptidase IV in human T lymphocyte activation. Inhibitors and antibodies against dipeptidyl peptidase IV suppress lymphocyte proliferation and immunoglobulin synthesis in vitro. Eur. J. Immunol. 17: 1821.
20. SUBRAMANYAM, M., W. G. GUTHEIL, W. W. BACHOVCHIN, and B. T. HUBER. 1993. Mechanism of HIV-1 Tat induced inhibition of antigen-specific T cell responsiveness. J. Immunol. 150: 2544.
21. TANAKA, T., J. KAMEOKA, A. YARON, F. S. SCHLOSSMAN, and C. MORIMOTO. 1993. The costimulatory activity of the CD26 antigen requires dipeptidyl peptidase IV enzymatic activity. Proc. Natl. Acad. Sci. USA 90: 4586.
22. TORIMOTO, Y., N. H. DANG, T. TANAKA, C. PRADO, S. F. SCHLOSSMAN, and C. MORIMOTO. 1992. Biochemical characterization of CD26 (dipeptidyl peptidase IV): Functional comparison of distinct epitopes recognized by various anti-CD26 monoclonal antibodies. Mol. Immunol. 29: 183.
23. TORIMOTO, Y., N. H. DANG, E. VIVIER, T. TANAKA, S. F. SCHLOSSMAN, and C. MORIMOTO. 1991. Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes. J. Immunol. 147: 2514.
24. WRIGHT, C. M., B. K. FELBER, H. PASKALIS, and G. N. PAVLAKIS. 1986. Expression and characterization of the trans-activator of HTLV-III/LAV virus. Science 234: 988.