A selective and convenient ruthenium mediated method for the synthesis of mixed acetals and orthoesters

Tetrahedron Letters

Volumn 48, Issue 1, 2007, Pages 137-140

  Krompiec, Stanisław ^a   Penczek, Robert ^a   Kuźnik, Nikodem ^b   Małecki, Jan Grzegorz ^a   Matlengiewicz, Marek ^a  

^a UNIVERSITY OF SILESIA   (Poland)

^b SILESIAN UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Addition; Mixed acetals; O Allyl compounds; Orthoesters; Ruthenium complexes

Indexed keywords

ACETAL DERIVATIVE; ACROLEIN DERIVATIVE; ALCOHOL DERIVATIVE; ALLYL COMPOUND; ESTER DERIVATIVE; ETHER DERIVATIVE; HYDROXYL GROUP; PHENOL DERIVATIVE; RUTHENIUM; RUTHENIUM DERIVATIVE;

ARTICLE; ASYMMETRIC SYNTHESIS; DRUG INDUSTRY; MOLECULAR INTERACTION; ORGANIC CHEMISTRY; PROCESS DEVELOPMENT; SYNTHESIS;

EID: 33751439555     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.10.138     Document Type: Article

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21. 3 (if applicable) in a glass screw-capped ampoule, purged with argon, and tightly capped were vigorously stirred and heated in an oil bath for a given period of time. Molar ratios of the reaction mixture components and the temperature are shown in the Tables and Schemes. Acetals and orthoesters were separated by distillation. When ROH was a phenol, the excess was removed, before distillation, by extraction with 1 M NaOH.
22. Ph[1]). GC-MS (EI, 40 eV), m/e (int (%)): 208 (<1), 135 (48), 115 (54), 114 (58), 94 (80), 77 (26), 59 (100), 57 (68).
23. 2O-), 112.4 (C). GC-MS (EI, 40 eV), m/e (int (%)): 187 (<1), 159 (4), 115 (100), 103 (42), 75 (22), 57 (64).