Ruthenium(III) chloride-catalyzed chemoselective synthesis of acetals from aldehydes

Tetrahedron Letters

Volumn 45, Issue 44, 2004, Pages 8141-8144

  De, Surya K ^a   Gibbs, Richard A ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAL DERIVATIVE; ALDEHYDE; KETONE; RUTHENIUM DERIVATIVE;

ACETALIZATION; ARTICLE; CATALYSIS; SYNTHESIS;

EID: 4744370320     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.09.060     Document Type: Article

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18. 3 (5 mol %, anhydrous available from Aldrich) in dry alcohol (10 mL) was refluxed for the specified time (Table 1). After completion of reaction (TLC monitoring), the reaction mixture was concentrated in vacuo. The residue was chromatographed over silica gel (10% ethyl acetate in hexane) to afford the pure product in good to excellent yields
19. 1H NMR of crude mixture
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23. 1H NMR analysis of crude mixture
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