Mutations in the palm region of a plus-strand RNA virus polymerase result in attenuated phenotype

Journal of General Virology

Volumn 87, Issue 12, 2006, Pages 3631-3636

  Gallei, Andreas ^a   Widauer, Simone ^a   Thiel, Jürgen Heinz ^a   Becher, Paul ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LIVE VACCINE; RNA DIRECTED RNA POLYMERASE; VIRUS PROTEIN; VIRUS RNA; VIRUS VACCINE;

ANIMAL CELL; ARTICLE; BOVINE DIARRHEA VIRUS; CELL CULTURE; CODON; CONTROLLED STUDY; GENE DELETION; GENE DUPLICATION; GENE MUTATION; IN VITRO STUDY; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RNA STRUCTURE; RNA SYNTHESIS; VIRUS ATTENUATION; VIRUS REPLICATION; VIRUS VECTOR;

ANIMALS; CATTLE; CELL LINE; DIARRHEA VIRUSES, BOVINE VIRAL; MUTATION; PLAQUE ASSAY; RECOMBINATION, GENETIC; RNA REPLICASE; RNA, VIRAL; SEQUENCE DELETION; STATISTICS; VIRAL PROTEINS; VIRULENCE; VIRUS REPLICATION;

BOVINE VIRAL DIARRHEA VIRUS 1; RNA VIRUSES;

EID: 33751420297     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.81809-0     Document Type: Article

References (27)

1. Ago, H., Adachi, T., Yoshida, A., Yamamoto, M., Habuka, N., Yatsunami, K. & Mlyano, M. (1999). Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure 7, 1417-1426.
2. Baroth, M., Orlich, M., Thiel, H.-J. & Becher, P. (2000). Insertion of cellular NEDD8 coding sequences in a pestivirus. Virology 278, 456-466.
3. Becher, P., Orlich, M. & Thiel, H.-J. (2000). Mutations in the 5′ nontranslated region of bovine viral diarrhea virus result in altered growth characteristics. J Virol 74, 7884-7894.
4. Becher, P., Orlich, M. & Thiel, H.-J. (2001). RNA recombination between persisting pestivirus and a vaccine strain: generation of cytopathogenic virus and induction of lethal disease. J Virol 75, 6256-6264.
5. Bressanelli, S., Tomei, L., Roussel, A., Incitti, I., Vitale, R. L., Mathieu, M., De Francesco, R. & Rey, F. A. (1999). Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Proc Natl Acad Sci U S A 96, 13034-13039.
6. Butcher, S. J., Grimes, J. M., Makeyev, E. V., Bamford, D. H. & Stuart, D. I. (2001). A mechanism for initiating RNA-dependent RNA polymerization. Nature 410, 235-240.
7. Choi, K. H., Groarke, J. M., Young, D. C., Kuhn, R. J., Smith, J. L., Pevear, D. C. & Rossmann, M. G. (2004). The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation. Proc Natl Acad Sci U S A 101, 4425-4430.
8. Choi, K. H., Gallei, A., Becher, P. & Rossmann, M. G. (2006). The structure of bovine viral diarrhea virus RNA-dependent RNA polymerase and its amino-terminal domain. Structure 14, 1107-1113.
9. Gallei, A., Pankraz, A., Thiel, H.-J. & Becher, P. (2004). RNA recombination in the absence of viral replication. J Virol 78, 6271-6281.
10. Gallei, A., Orlich, M., Thiel, H.-J. & Becher, P. (2005a). Noncytopathogenic pestivirus strains generated by nonhomologous RNA recombination: alterations in the NS4A/NS4B coding region. J Virol 79, 14261-14270.
11. Gallei, A., Rümenapf, T., Thiel, H.-J. & Becher, P. (2005b). Characterization of helper virus-independent cytopathogenic classical swine fever virus generated by an in vivo RNA recombination system. J Virol 79, 2440-2448.
12. Gallo, R. C. (1971). Reverse transcriptase, the DNA polymerase of oncogenic RNA viruses. Nature 234, 194-198.
13. Hansen, J. L., Long, A. M. & Schultz, S. C. (1997). Structure of the RNA-dependent RNA polymerase of poliovirus. Structure 5, 1109-1122.
14. Haruna, I., Nozu, K., Ohtaka, Y. & Spiegelman, S. (1963). An RNA "replicase" induced by and selective for a viral RNA: isolation and properties. Proc Natl Acad Sci U S A 50, 905-911.
15. Jaeger, J., Restle, T. & Steitz, T. A. (1998). The structure of HIV-1 reverse transcriptase complexed with an RNA pseudoknot inhibitor. EMBO J 17, 4535-4542.
16. Koonin, E. V. (1991). The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses. J Gen Virol 72, 2197-2206.
17. Kuhn, R. J., Griffin, D. E., Zhang, H., Niesters, H. G. M. & Strauss, J. H. (1992). Attenuation of Sindbis virus neurovirulence by using defined mutations in nontranslated regions of the genome RNA. J Virol 66, 7121-7127.
18. Lackner, T., Müller, A., König, M., Thiel, H.-J. & Tautz, N. (2005). Persistence of bovine viral diarrhea virus is determined by a cellular cofactor of a viral autoprotease. J Virol 79, 9746-9755.
19. Lesburg, C. A., Cable, M. B., Ferrari, E., Hong, Z., Mannarino, A. F. & Weber, P. C. (1999). Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat Struct Biol 6, 937-943.
20. Lindenbach, B. D. & Rice, C. M. (2001). Flaviviridae: the viruses and their replication. In Fields Virology, 4th edn, pp. 991-1041. Edited by D. M. Knipe & P. M. Howley. Philadelphia, PA: Lippincott Williams & Wilkins.
21. Makoschey, B., Becher, P., Janssen, M. G. J., Orlich, M., Thiel, H.-J. & Lütticken, D. (2004). Bovine viral diarrhea virus with deletions in the 5′-nontranslated region: reduction of replication in calves and induction of protective immunity. Vaccine 22, 3285-3294.
22. Mandi, C. W., Holzmann, H., Meixner, T., Rauscher, S., Stadler, P. F., Allison, S. L. & Heinz, F. X. (1998). Spontaneous and engineered deletions in the 3′ noncoding region of tick-borne encephalitis virus: construction of highly attenuated mutants of a flavivirus. J Virol 72, 2132-2140.
23. Men, R., Bray, M., Clark D., Chanock, C. M. & Lai, C.-J. (1996). Dengue type 4 virus mutants containing deletions in the 3′ noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeys. J Virol 70, 3930-3937.
24. Ng., Cherney, M. M., Löpez Vázquez, A., Machín, A., Martín Alonso, J. M., Parra, F. & James, M. N. G. (2002). Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase. J Biol Chem 277, 1381-1387.
25. Tao, Y., Farsetta, D. L., Nibert, M. L. & Harrison, S. C. (2002). RNA synthesis in a cage - structural studies of reovirus polymerase λ3. Cell 111, 733-745.
26. Tautz, N., Meyers, G., Stark R., Dubovi, E. J. & Thiel, H.-J. (1996). Cytopathogenicity of a pestivirus correlates with a 27-nucleotide insertion. J Virol 70, 7851-7858.
27. Thiel, H.-J., Plagemann, P. G. W. & Moennig, V. (1996). Pesti-viruses. In Fields Virology, 3rd edn, pp. 1059-1073. Edited by B. N. Fields, D. M. Knipe & P. M. Howley. Philadelphia, PA: Lippincott-Raven.