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Volumn 72, Issue 3, 1998, Pages 2132-2140

Spontaneous and engineered deletions in the 3' noncoding region of tick- borne encephalitis virus: Construction of highly attenuated mutants of a flavivirus

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; GENE DELETION; GENETIC STABILITY; INFECTION PREVENTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TICK BORNE ENCEPHALITIS FLAVIVIRUS; VIROGENESIS; VIRUS MUTANT; VIRUS VIRULENCE;

EID: 0031887847     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.3.2132-2140.1998     Document Type: Article
Times cited : (173)

References (37)
  • 1
    • 0029149642 scopus 로고
    • BHK cell proteins that bind to the 3′ stem-loop structure of the West Nile virus genome RNA
    • Blackwell, J. L., and M. A. Brinton. 1995. BHK cell proteins that bind to the 3′ stem-loop structure of the West Nile virus genome RNA. J. Virol. 69: 5650-5658.
    • (1995) J. Virol. , vol.69 , pp. 5650-5658
    • Blackwell, J.L.1    Brinton, M.A.2
  • 2
    • 0028930544 scopus 로고
    • Growth-restricted dengue virus mutants containing deletions in the 5′ noncoding region of the RNA genome
    • Cahour, A., A. Pletnev, M. Vazeille-Falcoz, L. Rosen, and C.-J. Lai. 1995. Growth-restricted dengue virus mutants containing deletions in the 5′ noncoding region of the RNA genome. Virology 207:68-76.
    • (1995) Virology , vol.207 , pp. 68-76
    • Cahour, A.1    Pletnev, A.2    Vazeille-Falcoz, M.3    Rosen, L.4    Lai, C.-J.5
  • 3
  • 4
    • 0031001919 scopus 로고    scopus 로고
    • RNA-protein interactions: Involvement of NS3, NS5, and 3′ noncoding regions of Japanese encephalitis virus genomic RNA
    • Chen, C.-J., M.-D. Kuo, L.-J. Chien, S.-L. Hsu, Y.-M. Wang, and J.-H. Lin. 1997. RNA-protein interactions: involvement of NS3, NS5, and 3′ noncoding regions of Japanese encephalitis virus genomic RNA. J. Virol. 71:3466-3473.
    • (1997) J. Virol. , vol.71 , pp. 3466-3473
    • Chen, C.-J.1    Kuo, M.-D.2    Chien, L.-J.3    Hsu, S.-L.4    Wang, Y.-M.5    Lin, J.-H.6
  • 6
    • 0024593180 scopus 로고
    • Epitope model of tick-borne encephalitis virus envelope glycoprotein E: Analysis of structural properties, role of carbohydrate side chain, and conformational changes occurring at acidic pH
    • Guirakhoo, F., F. X. Heinz, and C. Kunz. 1989. Epitope model of tick-borne encephalitis virus envelope glycoprotein E: analysis of structural properties, role of carbohydrate side chain, and conformational changes occurring at acidic pH. Virology 169:90-99.
    • (1989) Virology , vol.169 , pp. 90-99
    • Guirakhoo, F.1    Heinz, F.X.2    Kunz, C.3
  • 7
    • 0023645817 scopus 로고
    • Conserved elements in the 3′ untranslated region of flavivirus RNAs and potential cyclization sequences
    • Hahn, C. S., Y. S. Hahn, C. M. Rice, E. Lee, L. Dalgarno, E. G. Strauss, and J. H. Strauss. 1987. Conserved elements in the 3′ untranslated region of flavivirus RNAs and potential cyclization sequences. J. Mol. Biol. 198:33-41.
    • (1987) J. Mol. Biol. , vol.198 , pp. 33-41
    • Hahn, C.S.1    Hahn, Y.S.2    Rice, C.M.3    Lee, E.4    Dalgarno, L.5    Strauss, E.G.6    Strauss, J.H.7
  • 8
    • 0020535267 scopus 로고
    • A topological and functional model of epitopes on the structural glycoprotein of tick-borne encephalitis virus defined by monoclonal antibodies
    • Heinz, F. X., R. Berger, W. Tuma, and C. Kunz. 1983. A topological and functional model of epitopes on the structural glycoprotein of tick-borne encephalitis virus defined by monoclonal antibodies. Virology 126:525-537.
    • (1983) Virology , vol.126 , pp. 525-537
    • Heinz, F.X.1    Berger, R.2    Tuma, W.3    Kunz, C.4
  • 11
    • 0029140422 scopus 로고
    • Tick-borne encephalitis virus envelope protein E-specific monoclonal antibodies for the study of low pH-induced conformational changes and immature virions
    • Holzmann, H., K. Stiasny, H. York, F. Dorner, C. Kunz, and F. X. Heinz. 1995. Tick-borne encephalitis virus envelope protein E-specific monoclonal antibodies for the study of low pH-induced conformational changes and immature virions. Arch. Virol. 140:213-222.
    • (1995) Arch. Virol. , vol.140 , pp. 213-222
    • Holzmann, H.1    Stiasny, K.2    York, H.3    Dorner, F.4    Kunz, C.5    Heinz, F.X.6
  • 12
    • 0031014304 scopus 로고    scopus 로고
    • Characterization of monoclonal antibody-escape mutants of tick-borne encephalitis virus with reduced neuroinvasiveness in mice
    • Holzmann, H., K. Stiasny, M. Ecker, C. Kunz, and F. X. Heinz. 1997. Characterization of monoclonal antibody-escape mutants of tick-borne encephalitis virus with reduced neuroinvasiveness in mice. J. Gen. Virol. 78: 31-37.
    • (1997) J. Gen. Virol. , vol.78 , pp. 31-37
    • Holzmann, H.1    Stiasny, K.2    Ecker, M.3    Kunz, C.4    Heinz, F.X.5
  • 13
    • 0029938477 scopus 로고    scopus 로고
    • Identification of a highly conserved sequence element at the 3′ terminus of hepatitis C virus genome RNA
    • Kolykhalov, A. A. S. M. Feinstone, and C. M. Rice. 1996. Identification of a highly conserved sequence element at the 3′ terminus of hepatitis C virus genome RNA. J. Virol. 70:3363-3371.
    • (1996) J. Virol. , vol.70 , pp. 3363-3371
    • Kolykhalov, A.A.1    Feinstone, S.M.2    Rice, C.M.3
  • 14
    • 0031014022 scopus 로고    scopus 로고
    • Subgenomic replicons of the flavivirus Kunjin: Construction and applications
    • Khromykh, A. A., and E. G. Westaway. 1997. Subgenomic replicons of the flavivirus Kunjin: construction and applications. J. Virol. 71:1497-1505.
    • (1997) J. Virol. , vol.71 , pp. 1497-1505
    • Khromykh, A.A.1    Westaway, E.G.2
  • 15
    • 0025886329 scopus 로고
    • Presence of poly(A) in a flavivirus: Significant differences between the 3′ noncoding regions of the genomic RNAs of tick-borne encephalitis virus strains
    • Mandl, C. W., C. Kunz, and F. X. Heinz. 1991. Presence of poly(A) in a flavivirus: significant differences between the 3′ noncoding regions of the genomic RNAs of tick-borne encephalitis virus strains. J. Virol. 65:4070-4077.
    • (1991) J. Virol. , vol.65 , pp. 4070-4077
    • Mandl, C.W.1    Kunz, C.2    Heinz, F.X.3
  • 16
    • 0027172461 scopus 로고
    • Complete genomic sequence of Powassan virus: Evaluation of genetic elements in tick-borne versus mosquito-borne flaviviruses
    • Mandl, C. W., H. Holzmann, C. Kunz, and F. X. Heinz. 1993. Complete genomic sequence of Powassan virus: evaluation of genetic elements in tick-borne versus mosquito-borne flaviviruses. Virology 194:173-184.
    • (1993) Virology , vol.194 , pp. 173-184
    • Mandl, C.W.1    Holzmann, H.2    Kunz, C.3    Heinz, F.X.4
  • 17
    • 0030922352 scopus 로고    scopus 로고
    • Infectious cDNA clones of tick-borne encephalitis virus European subtype prototypic strain Neudoerfl and high virulence strain Hypr
    • Mandl, C. W., M. Ecker, H. Holzmann, C. Kunz, and F. X. Heinz. 1997. Infectious cDNA clones of tick-borne encephalitis virus European subtype prototypic strain Neudoerfl and high virulence strain Hypr. J. Gen. Virol. 78:1049-1057.
    • (1997) J. Gen. Virol. , vol.78 , pp. 1049-1057
    • Mandl, C.W.1    Ecker, M.2    Holzmann, H.3    Kunz, C.4    Heinz, F.X.5
  • 18
    • 85069028060 scopus 로고    scopus 로고
    • Unpublished results
    • 17a. Mandl, C. W., et al. Unpublished results.
    • Mandl, C.W.1
  • 19
    • 0016688840 scopus 로고
    • A live vaccine against tick-borne encephalitis: Integrated studies. I. Basic properties and behaviour of the E5″14″ clone (Langat virus)
    • Mayer, V. 1974. A live vaccine against tick-borne encephalitis: integrated studies. I. Basic properties and behaviour of the E5″14″ clone (Langat virus). Acta Virol. 19:209-218.
    • (1974) Acta Virol. , vol.19 , pp. 209-218
    • Mayer, V.1
  • 20
    • 0016733899 scopus 로고
    • Further virological and clinical investigations on the attenuated E5″14″ virus from the tick-borne encephalitis complex
    • Mayer, V., J. Pogády, D. Orolin, M. Stárek, M. Hudecová, J. Buran, and G. Hrbka. 1975. Further virological and clinical investigations on the attenuated E5″14″ virus from the tick-borne encephalitis complex. Acta Virol. 19:143-149.
    • (1975) Acta Virol. , vol.19 , pp. 143-149
    • Mayer, V.1    Pogády, J.2    Orolin, D.3    Stárek, M.4    Hudecová, M.5    Buran, J.6    Hrbka, G.7
  • 21
    • 0030698026 scopus 로고    scopus 로고
    • The molecular basis of virulence of the encephalitogenic flaviviruses
    • McMinn, P. C. 1997. The molecular basis of virulence of the encephalitogenic flaviviruses. J. Gen. Virol. 78:2711-2722.
    • (1997) J. Gen. Virol. , vol.78 , pp. 2711-2722
    • McMinn, P.C.1
  • 22
    • 0029893436 scopus 로고    scopus 로고
    • Dengue type 4 virus mutants containing deletions in the 3′ noncoding region of the RNA genome: Analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in Rhesus monkeys
    • Men, R., M. Bray, D. Clark, R. M. Chanock, and C.-J. Lai. 1996. Dengue type 4 virus mutants containing deletions in the 3′ noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in Rhesus monkeys. J. Virol. 70:3930-3937.
    • (1996) J. Virol. , vol.70 , pp. 3930-3937
    • Men, R.1    Bray, M.2    Clark, D.3    Chanock, R.M.4    Lai, C.-J.5
  • 23
    • 0001925194 scopus 로고    scopus 로고
    • Flaviviruses
    • B. N. Fields, D. M. Knipe, P. M. Howley, et al. (ed.), Lippincott-Raven Publishers, Philadelphia, Pa.
    • Monath, T. P., and F. X. Heinz. 1996. Flaviviruses, p. 961-1034. In B. N. Fields, D. M. Knipe, P. M. Howley, et al. (ed.), Fields virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.
    • (1996) Fields Virology, 3rd Ed. , pp. 961-1034
    • Monath, T.P.1    Heinz, F.X.2
  • 24
    • 0030030337 scopus 로고    scopus 로고
    • Infectious RNA transcribed from an engineered full-length cDNa template of the genome of a pestivirus
    • Moormann, R. J., H. G. van Gennip, G. K. Miedema, M. M. Hulst, and P. A. van Rijn. 1996. Infectious RNA transcribed from an engineered full-length cDNA template of the genome of a pestivirus. J. Virol. 70:763-770.
    • (1996) J. Virol. , vol.70 , pp. 763-770
    • Moormann, R.J.1    Van Gennip, H.G.2    Miedema, G.K.3    Hulst, M.M.4    Van Rijn, P.A.5
  • 25
    • 0029986182 scopus 로고    scopus 로고
    • Molecular characterization of the Japanese encephalitis serocomplex of the flavivirus genus
    • Poidinger, M., R. A. Hall, and J. S. Mackenzie. 1996. Molecular characterization of the Japanese encephalitis serocomplex of the flavivirus genus. Virology 218:417-421.
    • (1996) Virology , vol.218 , pp. 417-421
    • Poidinger, M.1    Hall, R.A.2    Mackenzie, J.S.3
  • 26
    • 0030746980 scopus 로고    scopus 로고
    • Secondary structure of the 3′ untranslated region of flaviviruses: Similarities and differences
    • Proutski, V., E. A. Gould, and E. C. Holmes. 1997. Secondary structure of the 3′ untranslated region of flaviviruses: similarities and differences. Nucleic Acids Res. 25:1194-1202.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 1194-1202
    • Proutski, V.1    Gould, E.A.2    Holmes, E.C.3
  • 27
    • 0030743734 scopus 로고    scopus 로고
    • Secondary structure of the 3′-untranslated region of yellow fever virus: Implications for virulence, attenuation and vaccine development
    • Proutski, V., M. W. Gaunt, E. A. Gould, and E. C. Holmes. 1997. Secondary structure of the 3′-untranslated region of yellow fever virus: implications for virulence, attenuation and vaccine development. J. Gen. Virol. 78:1543-1549.
    • (1997) J. Gen. Virol. , vol.78 , pp. 1543-1549
    • Proutski, V.1    Gaunt, M.W.2    Gould, E.A.3    Holmes, E.C.4
  • 28
    • 0030759370 scopus 로고    scopus 로고
    • Secondary structure of the 3′-noncoding region of flavivirus genomes: Comparative analysis of base pairing probabilities
    • Rauscher, S., C. Flamm, C. W. Mandl, F. X. Heinz, and P. F. Stadler. 1997. Secondary structure of the 3′-noncoding region of flavivirus genomes: comparative analysis of base pairing probabilities. RNA 3:779-791.
    • (1997) RNA , vol.3 , pp. 779-791
    • Rauscher, S.1    Flamm, C.2    Mandl, C.W.3    Heinz, F.X.4    Stadler, P.F.5
  • 29
    • 85069017754 scopus 로고    scopus 로고
    • Unpublished observation
    • 27a. Rauscher, S., et al. Unpublished observation.
    • Rauscher, S.1
  • 30
    • 33745158157 scopus 로고
    • A simple method for estimating fifty percent endpoints
    • Reed, J. L., and H. Muench. 1938. A simple method for estimating fifty percent endpoints. Am. J. Hyg. 27:493.
    • (1938) Am. J. Hyg. , vol.27 , pp. 493
    • Reed, J.L.1    Muench, H.2
  • 31
    • 0029014434 scopus 로고
    • The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution
    • Rey, F. A., F. X. Heinz, C. Mandl, C. Kunz, and S. C. Harrison. 1995. The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution. Nature 375:291-298.
    • (1995) Nature , vol.375 , pp. 291-298
    • Rey, F.A.1    Heinz, F.X.2    Mandl, C.3    Kunz, C.4    Harrison, S.C.5
  • 32
    • 0029927642 scopus 로고    scopus 로고
    • Structure of the 3′ terminus of the hepatitis C virus genome
    • Tanaka, T., N. Kato, M.-J. Cho, K. Sugiyama, and K. Shimotohno. 1996. Structure of the 3′ terminus of the hepatitis C virus genome. J. Virol. 70:3307-3312.
    • (1996) J. Virol. , vol.70 , pp. 3307-3312
    • Tanaka, T.1    Kato, N.2    Cho, M.-J.3    Sugiyama, K.4    Shimotohno, K.5
  • 33
    • 0028785280 scopus 로고
    • The flavivirus 3′-noncoding region: Extensive size heterogeneity independent of evolutionary relationships among strains of tick-borne encephalitis virus
    • Wallner, G., C. W. Mandl, C. Kunz, and F. X. Heinz. 1995. The flavivirus 3′-noncoding region: extensive size heterogeneity independent of evolutionary relationships among strains of tick-borne encephalitis virus. Virology 213:169-178.
    • (1995) Virology , vol.213 , pp. 169-178
    • Wallner, G.1    Mandl, C.W.2    Kunz, C.3    Heinz, F.X.4
  • 34
    • 0029986085 scopus 로고    scopus 로고
    • Characterization and complete genome sequences of high-and low-virulence variants of tick-borne encephalitis virus
    • Wallner, G., C. W. Mandl, M. Ecker, H. Holzmann, S. Stiasny, C. Kunz, and F. X. Heinz. 1996. Characterization and complete genome sequences of high-and low-virulence variants of tick-borne encephalitis virus. J. Gen. Virol. 77:1035-1042.
    • (1996) J. Gen. Virol. , vol.77 , pp. 1035-1042
    • Wallner, G.1    Mandl, C.W.2    Ecker, M.3    Holzmann, H.4    Stiasny, S.5    Kunz, C.6    Heinz, F.X.7
  • 35
    • 0030589006 scopus 로고    scopus 로고
    • Genetic variation in yellow fever virus: Duplication in the 3′ noncoding region of strains from Africa
    • Wang, E., S. C. Weaver, R. E. Shope, R. B. Tesh, D. M. Watts, and A. D. T. Barrett. 1996. Genetic variation in yellow fever virus: duplication in the 3′ noncoding region of strains from Africa. Virology 225:274-281.
    • (1996) Virology , vol.225 , pp. 274-281
    • Wang, E.1    Weaver, S.C.2    Shope, R.E.3    Tesh, R.B.4    Watts, D.M.5    Barrett, A.D.T.6


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