High-dose atorvastatin is associated with impaired myocardial angiogenesis in response to vascular endothelial growth factor in hypercholesterolemic swine

Journal of Thoracic and Cardiovascular Surgery

Volumn 132, Issue 6, 2006, Pages 1299-1306

  Boodhwani, Munir ^a   Mieno, Shigetoshi ^a   Voisine, Pierre ^a   Feng, Jun ^a   Sodha, Neel ^a   Li, Jian ^a   Sellke, Frank W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ATORVASTATIN; ENDOSTATIN; NITRIC OXIDE SYNTHASE; PROTEIN KINASE B; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL DIET; CONTROLLED STUDY; CORONARY ARTERY CIRCUMFLEX BRANCH; DRUG MEGADOSE; ENDOTHELIAL DYSFUNCTION; ENZYME PHOSPHORYLATION; FEMALE; HEART BLOOD VESSEL; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HYPERCHOLESTEROLEMIA; MALE; MICROVASCULATURE; NONHUMAN; OSMOTIC PUMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE; VASODILATATION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CORONARY VESSELS; FEMALE; HEPTANOIC ACIDS; HYPERCHOLESTEROLEMIA; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; PYRROLES; SWINE; SWINE, MINIATURE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33751399674     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2006.05.060     Document Type: Article

References (32)

1. Tofukuji M., Metais C., Li J., Franklin A., Simons M., and Sellke F.W. Myocardial VEGF expression after cardiopulmonary bypass and cardioplegia. Circulation 98 suppl (1998) II242-II248
2. Sellke F.W., Wang S.Y., Stamler A., Lopez J.J., Li J., and Simons M. Enhanced microvascular relaxations to VEGF and bFGF in chronically ischemic porcine myocardium. Am J Physiol Heart Circ Physiol 271 suppl (1996) H713-H720
3. Metais C., Li J., Simons M., and Sellke F.W. Effects of coronary artery disease on expression and microvascular response to VEGF. Am J Physiol Heart Circ Physiol 275 suppl (1998) H1411-H1418
4. Simons M., Bonow R.O., Chronos N.A., Cohen D.J., Giordano F.J., Hammond H.K., et al. Clinical trials in coronary angiogenesis: issues, problems, consensus: an expert panel summary. Circulation 102 (2000) E73-E86
5. Jang J.J., Ho H.K., Kwan H.H., Fajardo L.F., and Cooke J.P. Angiogenesis is impaired by hypercholesterolemia: role of asymmetric dimethylarginine. Circulation 102 (2000) 1414-1419
6. Duan J., Murohara T., Ikeda H., Katoh A., Shintani S., Sasaki K., et al. Hypercholesterolemia inhibits angiogenesis in response to hindlimb ischemia: nitric oxide-dependent mechanism. Circulation 102 suppl 3 (2000) III370-III376
7. Boodhwani M., Nakai Y., Mieno S., Voisine P., Bianchi C., Araujo E.G., et al. Hypercholesterolemia impairs the myocardial angiogenic response in a swine model of chronic ischemia: role of endostatin and oxidative stress. Ann Thorac Surg 81 (2006) 634-641
8. Ruel M., Wu G.F., Khan T.A., Voisine P., Bianchi C., Li J., et al. Inhibition of the cardiac angiogenic response to surgical FGF-2 therapy in a swine endothelial dysfunction model. Circulation 108 suppl 1 (2003) II335-II340
9. Voisine P., Bianchi C., Ruel M., Malik T., Rosinberg A., Feng J., et al. Inhibition of the cardiac angiogenic response to exogenous vascular endothelial growth factor. Surgery 136 (2004) 407-415
10. Balk E.M., Karas R.H., Jordan H.S., Kupelnick B., Chew P., and Lau J. Effects of statins on vascular structure and function: a systematic review. Am J Med 117 (2004) 775-790
11. Shiojima I., and Walsh K. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res 90 (2002) 1243-1250
12. Mason R.P., Walter M.F., and Jacob R.F. Effects of HMG-CoA reductase inhibitors on endothelial function: role of microdomains and oxidative stress. Circulation 109 suppl 1 (2004) II34-II41
13. Urbich C., Dernbach E., Zeiher A.M., and Dimmeler S. Double-edged role of statins in angiogenesis signaling. Circ Res 90 (2002) 737-744
14. Weis M., Heeschen C., Glassford A.J., and Cooke J.P. Statins have biphasic effects on angiogenesis. Circulation 105 (2002) 739-745
15. Boodhwani M., Nakai Y., Voisine P., Feng J., Li J., Mieno S., et al. High dose atorvastatin improves hypercholesterolemic coronary endothelial dysfunction without improving the angiogenic response. Circulation 114 suppl I (2006) I402-I408
16. LaRosa J.C., Grundy S.M., Waters D.D., Shear C., Barter P., Fruchart J.C., et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med 352 (2005) 1425-1435
17. Voisine P., Bianchi C., Khan T.A., Ruel M., Xu S.H., Feng J., et al. Normalization of coronary microvascular reactivity and improvement in myocardial perfusion by surgical vascular endothelial growth factor therapy combined with oral supplementation of l-arginine in a porcine model of endothelial dysfunction. J Thorac Cardiovasc Surg 129 (2005) 1414-1420
18. Kureishi Y., Luo Z., Shiojima I., Bialik A., Fulton D., Lefer D.J., et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 6 (2000) 1004-1010
19. Nagoshi T., Matsui T., Aoyama T., Leri A., Anversa P., Li L., et al. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest 115 (2005) 2128-2138
20. Boehm T., Folkman J., Browder T., and O'Reilly M.S. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 390 (1997) 404-407
21. O'Reilly M.S., Boehm T., Shing Y., Fukai N., Vasios G., Lane W.S., et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88 (1997) 277-285
22. Dhanabal M., Ramchandran R., Waterman M.J., Lu H., Knebelmann B., Segal M., et al. Endostatin induces endothelial cell apoptosis. J Biol Chem 274 (1999) 11721-11726
23. Abdollahi A., Hahnfeldt P., Maercker C., Grone H.J., Debus J., Ansorge W., et al. Endostatin's antiangiogenic signaling network. Mol Cell 13 (2004) 649-663
24. Hajitou A., Grignet C., Devy L., Berndt S., Blacher S., Deroanne C.F., et al. The antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular endothelial growth factor expression in tumor cells. FASEB J 16 (2002) 1802-1804
25. Vita J.A., Yeung A.C., Winniford M., Hodgson J.M., Treasure C.B., Klein J.L., et al. Effect of cholesterol-lowering therapy on coronary endothelial vasomotor function in patients with coronary artery disease. Circulation 102 (2000) 846-851
26. Treasure C.B., Klein J.L., Weintraub W.S., Talley J.D., Stillabower M.E., Kosinski A.S., et al. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med 332 (1995) 481-487
27. Penny W.F., Ben-Yehuda O., Kuroe K., Long J., Bond A., Bhargava V., et al. Improvement of coronary artery endothelial dysfunction with lipid-lowering therapy: heterogeneity of segmental response and correlation with plasma-oxidized low density lipoprotein. J Am Coll Cardiol 37 (2001) 766-774
28. Frick M., Dulak J., Cisowski J., Jozkowicz A., Zwick R., Alber H., et al. Statins differentially regulate vascular endothelial growth factor synthesis in endothelial and vascular smooth muscle cells. Atherosclerosis 170 (2003) 229-236
29. Blanco-Colio L.M., Villa A., Ortego M., Hernandez-Presa M.A., Pascual A., Plaza J.J., et al. 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. Atherosclerosis 161 (2002) 17-26
30. Erl W., Hristov M., Neureuter M., Yan Z.Q., Hansson G.K., and Weber P.C. HMG-CoA reductase inhibitors induce apoptosis in neointima-derived vascular smooth muscle cells. Atherosclerosis 169 (2003) 251-258
31. Fuchs S., Baffour R., Zhou Y.F., Shou M., Pierre A., Tio F.O., et al. Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia. J Am Coll Cardiol 37 (2001) 1726-1732
32. Radke P.W., Heinl-Green A., Frass O.M., Griesenbach U., Ferrari S., Geddes D.M., et al. Effects of intramyocardial pVEGF165 delivery on regional myocardial blood flow: evidence for a spatial "delivery-efficacy" mismatch. Gene Ther 11 (2004) 1249-1255