메뉴 건너뛰기




Volumn 10, Issue 6, 2006, Pages 793-797

Forthcoming receptor tyrosine kinase inhibitors

Author keywords

Chronic myelogenous leukaemia; Gastrointestinal stromal tumour; Tyrosine kinase inhibitor

Indexed keywords

4 METHYL N [3 (4 METHYL 1 IMIDAZOLYL) 5 (TRIFLUOROMETHYL)PHENYL] 3 [4 (3 PYRIDINYL) 2 PYRIMIDINYLAMINO]BENZAMIDE; ABELSON KINASE; ALPHA INTERFERON; BCR ABL PROTEIN; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; DOCETAXEL; ERLOTINIB; FLT3 LIGAND; GEFITINIB; IMATINIB; LAPATINIB; MONOCLONAL ANTIBODY; N (2 CHLORO 6 METHYLPHENYL) 2 [6 [4 (2 HYDROXYETHYL) 1 PIPERAZINYL] 2 METHYL 4 PYRIMIDINYLAMINO] 5 THIAZOLECARBOXAMIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLACEBO; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN RET; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; STEM CELL FACTOR RECEPTOR; SUNITINIB; TRASTUZUMAB; VANDETANIB; VASCULOTROPIN RECEPTOR;

EID: 33751397762     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.10.6.793     Document Type: Editorial
Times cited : (7)

References (52)
  • 1
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • BLUME-JENSEN P, HUNTER T Oncogenic kinase signalling. Nature (2001) 411:355-365.
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 2
    • 21744462480 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: A model for oncology
    • HEHLMANN R, BERGER U, HOCHHAUS A: Chronic myeloid leukemia: a model for oncology. Ann. Hematol. (2005) 84:487-497.
    • (2005) Ann. Hematol. , vol.84 , pp. 487-497
    • Hehlmann, R.1    Berger, U.2    Hochhaus, A.3
  • 3
    • 33748133844 scopus 로고    scopus 로고
    • Survival advantage from Imatinib compared to the combination Interferon-[alpha] plus cytarabine in chronic phase CML: Historical comparison between two Phase III trials
    • ROY L, GUILHOT J, KRAHNKE T et al: Survival advantage from Imatinib compared to the combination Interferon-[alpha] plus cytarabine in chronic phase CML: historical comparison between two Phase III trials. Blood (2006) 108:1478-1484.
    • (2006) Blood , vol.108 , pp. 1478-1484
    • Roy, L.1    Guilhot, J.2    Krahnke, T.3
  • 4
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • SLAMON DJ, LEYLAND-JONES B, SHAK S et al: Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. (2001) 344:783-792.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 5
    • 0035960428 scopus 로고    scopus 로고
    • Safety and efficacy of imatinib (ST1571) in metastatic gastrointestinal stromal tumours: A Phase I study
    • VAN OOSTEROM AT, JUDSON I. VERWEIJ J et al.: Safety and efficacy of imatinib (ST1571) in metastatic gastrointestinal stromal tumours: a Phase I study. Lancet (2001) 358:1421-1423.
    • (2001) Lancet , vol.358 , pp. 1421-1423
    • Van Oosterom, A.T.1    Judson, I.2    Verweij, J.3
  • 6
  • 7
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • DEMETRI GD, VON MEHREN M, BLANKE CD et al.: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N. Engl. J. Med (2002) 347:472-480.
    • (2002) N. Engl. J. Med , vol.347 , pp. 472-480
    • Demetri, G.D.1    Von Mehren, M.2    Blanke, C.D.3
  • 8
    • 0344987881 scopus 로고    scopus 로고
    • A tyrosine kinase created by fusion of the PDGFRA and FIPILI genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
    • COOLS J, DEANGELO DJ, GOTLIB J et al.: A tyrosine kinase created by fusion of the PDGFRA and FIPILI genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N. Engl. J. Med. (2003) 348:1201-1214.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1201-1214
    • Cools, J.1    Deangelo, D.J.2    Gotlib, J.3
  • 9
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • CUNNINGHAM D, HUMBLET Y, SIENA S et al.: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med. (2004) 351:337-345.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 10
    • 20244381389 scopus 로고    scopus 로고
    • Phase I/II trial evaluating the anti-vascular endothelial. growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer
    • HERBST RS, JOHNSON DH, MININBERG E et al.: Phase I/II trial evaluating the anti-vascular endothelial. growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer. J. Clin. Oncol. (2005) 23:2544-2555.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2544-2555
    • Herbst, R.S.1    Johnson, D.H.2    Mininberg, E.3
  • 11
    • 23844527898 scopus 로고    scopus 로고
    • A Phase I study of erlotinib and bevacizumab for recurrent or metastatic squamous cell carcinoma of the head and neck
    • Abstract 5504
    • VOKES EE, COHEN EE, MAUER AM et al.: A Phase I study of erlotinib and bevacizumab for recurrent or metastatic squamous cell carcinoma of the head and neck. Clin. Oncol. (2005) 23:Abstract 5504.
    • (2005) Clin. Oncol. , vol.23
    • Vokes, E.E.1    Cohen, E.E.2    Mauer, A.M.3
  • 12
    • 21244475037 scopus 로고    scopus 로고
    • Randomized Phase II trial of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer
    • Abstract 3508
    • SALTZ LB, LENZ H, HOCHSTER H et al.: Randomized Phase II trial of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer. J. Clin. Oncol. (2005) 23:Abstract 3508.
    • (2005) J. Clin. Oncol. , vol.23
    • Saltz, L.B.1    Lenz, H.2    Hochster, H.3
  • 13
    • 78650874372 scopus 로고    scopus 로고
    • SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
    • ABRAMS TJ, LEE LB, MURRAY LJ, PRYER NK, CHERRINGTON JM: SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol. Cancer Ther. (2003) 2:471-478.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 471-478
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3    Pryer, N.K.4    Cherrington, J.M.5
  • 14
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • MENDEL DB, LAIRD AD, XIN X et al.: In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin. Cancer Res. (2003) 9:327-337.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 15
    • 33744513575 scopus 로고    scopus 로고
    • Sorafenib (BAY 43-9006, Nexavar®), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR /PDGFR in tumor vasculature
    • ADNANE L, TRAIL PA, TAYLOR I, WILHELM SM: Sorafenib (BAY 43-9006, Nexavar®), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. Methods Enzymol. (2005) 407:597-612.
    • (2005) Methods Enzymol. , vol.407 , pp. 597-612
    • Adnane, L.1    Trail, P.A.2    Taylor, I.3    Wilhelm, S.M.4
  • 16
    • 23844558595 scopus 로고    scopus 로고
    • Randomized Phase III trial of the Raf kinase and VEGFR inhibitor sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC)
    • Abstract 4510
    • ESCUDIER B, SZCZYLIK C, EISEN T et al.: Randomized Phase III trial of the Raf kinase and VEGFR inhibitor sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC). J. Clin. Oncol. (2005) 23:Abstract 4510.
    • (2005) J. Clin. Oncol. , vol.23
    • Escudier, B.1    Szczylik, C.2    Eisen, T.3
  • 17
    • 84906222820 scopus 로고    scopus 로고
    • Clinical benefit of sorafenib in the elderly with advanced renal cell carcinoma: Subgroup analysis of the approaches in renal cancer global evaluation trial (TARGETS)
    • Abstract 446PD
    • EISEN T, OUDARD S, SZCZYLIK C et al.: Clinical benefit of sorafenib in the elderly with advanced renal cell carcinoma: subgroup analysis of the approaches in renal cancer global evaluation trial (TARGETS). Ann. Oncol. (2006) 17:Abstract 446PD.
    • (2006) Ann. Oncol. , vol.17
    • Eisen, T.1    Oudard, S.2    Szczylik, C.3
  • 18
    • 33744954585 scopus 로고    scopus 로고
    • Sunitinib in patients with metastatic renal cell carcinoma
    • MOTZER RJ, RINI BI, BUKOWSKI RM et al.: Sunitinib in patients with metastatic renal cell carcinoma. JAMA (2006) 295:2516-2524.
    • (2006) JAMA , vol.295 , pp. 2516-2524
    • Motzer, R.J.1    Rini, B.I.2    Bukowski, R.M.3
  • 19
    • 33748590610 scopus 로고    scopus 로고
    • Phase III randomized trial of sunitinib malate (SU11248) versus interferon-alfa (IFN-α) as first-line systemic therapy for patients with metastatic renal cell carcinoma (mRCC)
    • MOTZER RJ, HUTSON TE, TOMCZAK P et al.: Phase III randomized trial of sunitinib malate (SU11248) versus interferon-alfa (IFN-α) as first-line systemic therapy for patients with metastatic renal cell carcinoma (mRCC). J. Clin. Oncol. (2006) 24:LBA3.
    • (2006) J. Clin. Oncol. , vol.24
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 20
    • 34247350610 scopus 로고    scopus 로고
    • Phase II study of sunitinib malate (SU11248) in bevacizumab-refractory metastatic renal cell carcinoma
    • Abstract 4380
    • RINI BI, GEORGE DJ, MICHAELSON MD et al.: Phase II study of sunitinib malate (SU11248) in bevacizumab-refractory metastatic renal cell carcinoma. Ann. Oncol. (2006) 17:Abstract 4380.
    • (2006) Ann. Oncol. , vol.17
    • Rini, B.I.1    George, D.J.2    Michaelson, M.D.3
  • 21
    • 33845571367 scopus 로고    scopus 로고
    • Antitumor effects of sorafenib and sunitinib in patients with metastatic renal cell carcinoma who had prior therapy with anti-angiogenic agents
    • Abstract 4597
    • TAMASKAR I, SHAHEEN P, WOOD L et al.: Antitumor effects of sorafenib and sunitinib in patients with metastatic renal cell carcinoma who had prior therapy with anti-angiogenic agents. J. Clin. Oncol. (2006) 24:Abstract 4597.
    • (2006) J. Clin. Oncol. , vol.24
    • Tamaskar, I.1    Shaheen, P.2    Wood, L.3
  • 22
    • 0141719490 scopus 로고    scopus 로고
    • Lapatinib ditosylate GlaxoSmithKline
    • KIM TE, MURREN JR: Lapatinib ditosylate GlaxoSmithKline. IDrugs (2003) 6:886-893.
    • (2003) IDrugs , vol.6 , pp. 886-893
    • Kim, T.E.1    Murren, J.R.2
  • 23
    • 33745906668 scopus 로고    scopus 로고
    • A Phase III randomized, open-label, international study comparing lapatinib and capecitabine versus capecitabine in women with refractory advanced or metastatic breast cancer (EGF100151)
    • Scientific Special Session
    • GEYER CE, FORSTER JK, CAMERON D et al.: A Phase III randomized, open-label, international study comparing lapatinib and capecitabine versus capecitabine in women with refractory advanced or metastatic breast cancer (EGF100151). Proc. Am. Soc. Clin. Oncol. (2006) Scientific Special Session.
    • (2006) Proc. Am. Soc. Clin. Oncol.
    • Geyer, C.E.1    Forster, J.K.2    Cameron, D.3
  • 24
    • 33847707614 scopus 로고    scopus 로고
    • Lapatinib in combination with capecitabine demonstrates superior efficacy compared with capecitabine alone in ERBB2+ advanced or metastatic breast cancer patients pretreated with chemotherapy and trastuzumab
    • Abstract 1410
    • CAMERON D, GEYER CE, CHAN S et al.: Lapatinib in combination with capecitabine demonstrates superior efficacy compared with capecitabine alone in ERBB2+ advanced or metastatic breast cancer patients pretreated with chemotherapy and trastuzumab. Ann. Oncol. (2006) 17:Abstract 1410.
    • (2006) Ann. Oncol. , vol.17
    • Cameron, D.1    Geyer, C.E.2    Chan, S.3
  • 25
    • 33746512271 scopus 로고    scopus 로고
    • Phase II trial of lapatinib for brain metastases in patients with HER2+ breast cancer
    • Abstract 503
    • LIN NU, CAREY LA, LIU MC et al.: Phase II trial of lapatinib for brain metastases in patients with HER2+ breast cancer. J. Clin. Oncol. (2006) 24:Abstract 503.
    • (2006) J. Clin. Oncol. , vol.24
    • Lin, N.U.1    Carey, L.A.2    Liu, M.C.3
  • 26
    • 34250655315 scopus 로고    scopus 로고
    • Cardian safety experience in 3127 patients treated with lapatinib
    • Abstract 1420
    • PEREZ EA, BYRNE JA, HAMMOND IW et al.: Cardian safety experience in 3127 patients treated with lapatinib. Ann. Oncol. (2006) 17:Abstract 1420.
    • (2006) Ann. Oncol. , vol.17
    • Perez, E.A.1    Byrne, J.A.2    Hammond, I.W.3
  • 27
    • 33750087886 scopus 로고    scopus 로고
    • ZD6474 versus gefitinib in patients with advanced NSCLC: Final results from a two-part, double-blind, randomized Phase II trial
    • Abstract 7000
    • NATALE RB, BODKIN D, GOVINDAN R et al.: ZD6474 versus gefitinib in patients with advanced NSCLC: final results from a two-part, double-blind, randomized Phase II trial. J. Clin. Oncol. (2006) 24:Abstract 7000.
    • (2006) J. Clin. Oncol. , vol.24
    • Natale, R.B.1    Bodkin, D.2    Govindan, R.3
  • 28
    • 33750938418 scopus 로고    scopus 로고
    • A Phase II trial of ZD6474 plus docetaxel in patients with previously treated NSCLC: Follow-up results
    • Abstract 7016
    • HEYMACH JV, JOHNSON BE, PRAGER D et al.: A Phase II trial of ZD6474 plus docetaxel in patients with previously treated NSCLC: follow-up results. J. Clin. Oncol. (2005) 24:Abstract 7016.
    • (2005) J. Clin. Oncol. , vol.24
    • Heymach, J.V.1    Johnson, B.E.2    Prager, D.3
  • 29
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • KOBAYASHI S, BOGGON TJ, DAYARAM T et al.: EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. (2005) 352:786-792.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2    Dayaram, T.3
  • 30
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • SHAH NP, NICOLL JM, NAGAR B et al.: Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell (2002) 2:117-125.
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3
  • 31
    • 20844460619 scopus 로고    scopus 로고
    • A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors
    • CHEN LL, TRENT JC, WU EF et al.: A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res. (2004) 64:5913-5919.
    • (2004) Cancer Res. , vol.64 , pp. 5913-5919
    • Chen, L.L.1    Trent, J.C.2    Wu, E.F.3
  • 32
    • 0038375012 scopus 로고    scopus 로고
    • Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib
    • CORBIN AS, LA ROSEE P, STOFFREGEN EP, DRUKER BJ, DEININGER MW: Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib. Blood (2003) 101:4611-4614.
    • (2003) Blood , vol.101 , pp. 4611-4614
    • Corbin, A.S.1    La Rosee, P.2    Stoffregen, E.P.3    Druker, B.J.4    Deininger, M.W.5
  • 33
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • KANTARJIAN H, GILES F, WUNDERLE L et al.: Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N. Engl. J. Med. (2006) 354:2542-2551.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 34
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • TALPAZ M, SHAH NP, KANTARJIAN H et al.: Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N. Engl. J. Med. (2006) 354:2531-2541.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 35
    • 33750060345 scopus 로고    scopus 로고
    • A Phase II study of AMN 107, a novel inhibitor of Bcr-Abl, administered to imatinib resistant and intolerant patients (pts) with chronic myelogenous leukemia in chronic phase
    • Abstract 6534
    • KANTARJIAN H, GATTERMANN N, O'BRIEN S et al.: A Phase II study of AMN 107, a novel inhibitor of Bcr-Abl, administered to imatinib resistant and intolerant patients (pts) with chronic myelogenous leukemia in chronic phase. J. Clin. Oncol. (2006) 24:Abstract 6534.
    • (2006) J. Clin. Oncol. , vol.24
    • Kantarjian, H.1    Gattermann, N.2    O'brien, S.3
  • 36
    • 33750089041 scopus 로고    scopus 로고
    • A Phase II study of AMN107, a novel inhibitor of Bcr-Abl, administered to imatinib-resistant or intolerant patients (pts) with chronic myelogenous leukemia (CML) in accelerated phase (AP)
    • Abstract 6531
    • LE COUTRE PD, OTTMANN O, GATTERMAN N et al.: A Phase II study of AMN107, a novel inhibitor of Bcr-Abl, administered to imatinib-resistant or intolerant patients (pts) with chronic myelogenous leukemia (CML) in accelerated phase (AP). J. Clin. Oncol. (2006) 24:Abstract 6531.
    • (2006) J. Clin. Oncol. , vol.24
    • Le Coutre, P.D.1    Ottmann, O.2    Gatterman, N.3
  • 37
    • 33750073875 scopus 로고    scopus 로고
    • Dasatinib (D) in patients (pts) with chronic myelogenous leukemia (CML) in myeloid blast crisis (MBC) who are imatinib-resistant (IM-R) or IM-intolerant (IM-I): Results of the CA180006 'START-B' study
    • Absrract 6529
    • CORTES JE, KIM DW, ROSTI G et al.: Dasatinib (D) in patients (pts) with chronic myelogenous leukemia (CML) in myeloid blast crisis (MBC) who are imatinib-resistant (IM-R) or IM-intolerant (IM-I): results of the CA180006 'START-B' study. J. Clin. Oncol. (2006) 24:Absrract 6529.
    • (2006) J. Clin. Oncol. , vol.24
    • Cortes, J.E.1    Kim, D.W.2    Rosti, G.3
  • 38
    • 33845739041 scopus 로고    scopus 로고
    • Dasatinib (D) versus high dose imatinib (IM) in patients (pts) with chronic phase chronic myeloid leukemia (CP-CML) resistant to imatinib Results of CA180017 START-R randomized trial
    • Abstract 6507
    • SHAH NP, ROUSSELOT P, PASQUINI R et al.: Dasatinib (D) versus high dose imatinib (IM) in patients (pts) with chronic phase chronic myeloid leukemia (CP-CML) resistant to imatinib. Results of CA180017 START-R randomized trial. J. Clin. Oncol. (2006) 24:Abstract 6507.
    • (2006) J. Clin. Oncol. , vol.24
    • Shah, N.P.1    Rousselot, P.2    Pasquini, R.3
  • 39
    • 33750045494 scopus 로고    scopus 로고
    • Dasatinib (D) in patients with accelerated phase chronic myeloid leukemia (AP-CML) who are resistant or intolerant to imatinib: Results of the CA180005 'START-A' study
    • Abstract 6526
    • TALPAZ M, APPERLEY JF, KIM DW et al.: Dasatinib (D) in patients with accelerated phase chronic myeloid leukemia (AP-CML) who are resistant or intolerant to imatinib: results of the CA180005 'START-A' study. J. Clin. Oncol. (2006) 24:Abstract 6526.
    • (2006) J. Clin. Oncol. , vol.24
    • Talpaz, M.1    Apperley, J.F.2    Kim, D.W.3
  • 40
    • 33750080209 scopus 로고    scopus 로고
    • Dasatinib in patients with chronic phase chronic myeloid leukemia (CP-CML) who are resistant or intolerant to imatinib: Results of the CA180013' START-C' Study
    • Abstract 6508
    • HOCHHAUS A, KANTARJIAN H, BACCARANI M et al.: Dasatinib in patients with chronic phase chronic myeloid leukemia (CP-CML) who are resistant or intolerant to imatinib: results of the CA180013' START-C' Study. J. Clin. Oncol. (2006) 24:Abstract 6508.
    • (2006) J. Clin. Oncol. , vol.24
    • Hochhaus, A.1    Kantarjian, H.2    Baccarani, M.3
  • 41
    • 33751404931 scopus 로고    scopus 로고
    • Dasatinib (BMS354825), a dual Src-Abl inhibitor, is active in Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+CML) following treatment failure with imatinib mesylate and AMN107
    • Abstract 6530
    • ESTROV Z, O'BRIEN S, GILES F et al.: Dasatinib (BMS354825), a dual Src-Abl inhibitor, is active in Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+CML) following treatment failure with imatinib mesylate and AMN107. J. Clin. Oncol. (2006) 24:Abstract 6530.
    • (2006) J. Clin. Oncol. , vol.24
    • Estrov, Z.1    O'brien, S.2    Giles, F.3
  • 42
    • 33751396958 scopus 로고    scopus 로고
    • A Phase I study of AMN107 alone and in combination with imatinib in patients (pts) with imatinib-resistant gastrointestinal stromal tumors (GIST)
    • Abstract 9545
    • REICHARDT P, CASALI PG, BLAY J et al.: A Phase I study of AMN107 alone and in combination with imatinib in patients (pts) with imatinib-resistant gastrointestinal stromal tumors (GIST). J. Clin. Oncol. (2006) 24:Abstract 9545.
    • (2006) J. Clin. Oncol. , vol.24
    • Reichardt, P.1    Casali, P.G.2    Blay, J.3
  • 43
    • 31544459272 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies
    • SCHITTENHELM MM, SHIRAGA S, SCHROEDER A et al: Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res. (2006) 66:473-481.
    • (2006) Cancer Res. , vol.66 , pp. 473-481
    • Schittenhelm, M.M.1    Shiraga, S.2    Schroeder, A.3
  • 44
    • 33745914717 scopus 로고    scopus 로고
    • Phase I dose-escalation study of the SRC and multi-kinase inhibitor BMS-354825 in patients (pts) with GIST and other solid tumors
    • Abstract 3034
    • EVANS TR, MORGAN JA, VAN DEN ABBEELE AD et al.: Phase I dose-escalation study of the SRC and multi-kinase inhibitor BMS-354825 in patients (pts) with GIST and other solid tumors. J. Clin. Oncol. (2005) 23:Abstract 3034.
    • (2005) J. Clin. Oncol. , vol.23
    • Evans, T.R.1    Morgan, J.A.2    Van Den Abbeele, A.D.3
  • 45
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib
    • PAO W, MILLER V, ZAKOWSKI M et al.: EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc. Natl. Acad. Sci. USA (2004) 101:13306-13311.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 46
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • THATCHER N, CHANG A, PARIKH P et al.: Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet (2005) 366:1527-1537.
    • (2005) Lancet , vol.366 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3
  • 47
    • 33751423650 scopus 로고    scopus 로고
    • Clinical benefit of erlotinib in male smokers with squamous-cell NSCLC
    • Abscract 7166
    • CLARK GM, CAMERON T, DAS GUPTA A: Clinical benefit of erlotinib in male smokers with squamous-cell NSCLC. J. Clin. Oncol. (2006) 24:Abscract 7166.
    • (2006) J. Clin. Oncol. , vol.24
    • Clark, G.M.1    Cameron, T.2    Das Gupta, A.3
  • 48
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • EBERHARD DA, JOHNSON BE, AMLER LC et al.: Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J. Clin. Oncol. (2005) 23:5900-5909.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5900-5909
    • Eberhard, D.A.1    Johnson, B.E.2    Amler, L.C.3
  • 49
    • 33845434121 scopus 로고    scopus 로고
    • A prospective Phase II trial of erlotinib in advanced non-small cell lung cancer (NSCLC) patients (p) with mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR)
    • Abstract 7020
    • PAZ-ARES L, SANCHEZ JM, GARCÍA-VELASCO A et al.: A prospective Phase II trial of erlotinib in advanced non-small cell lung cancer (NSCLC) patients (p) with mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR). J. Clin. Oncol. (2006) 24:Abstract 7020.
    • (2006) J. Clin. Oncol. , vol.24
    • Paz-ares, L.1    Sanchez, J.M.2    García-velasco, A.3
  • 50
    • 27744606737 scopus 로고    scopus 로고
    • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
    • MELLINGHOFF IK, WANG MY, VIVANCO I et al.: Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N. Engl. J. Med. (2005) 353:2012-2024.
    • (2005) N. Engl. J. Med. , vol.353 , pp. 2012-2024
    • Mellinghoff, I.K.1    Wang, M.Y.2    Vivanco, I.3
  • 51
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    • HEINRICH MC, CORLESS CL, DEMETRI GD et al.: Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J. Clin. Oncol. (2003) 21:4342-4349.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 4342-4349
    • Heinrich, M.C.1    Corless, C.L.2    Demetri, G.D.3
  • 52
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • PAIK S, SHAK S, TANG G et al.: A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N. Engl. J. Med. (2004) 351:2817-2826.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.