Parallel changes in metabolite and expression profiles in crooked-tail mutant and folate-reduced wild-type mice

Human Molecular Genetics

Volumn 15, Issue 23, 2006, Pages 3387-3393

  Ernest, Sheila ^a   Carter, Michelle ^b   Shao, Haifeng ^a   Hosack, Angela ^c   Lerner, Natalia ^d   Colmenares, Clemencia ^d   Rosenblatt, David S ^c   Pao, Yoh Han ^a   Ross, M Elizabeth ^b   Nadeau, Joseph H ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c MCGILL UNIVERSITY   (Canada)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BIOLOGICAL MARKER; CYSTEINE; FOLIC ACID; GLUTATHIONE; HOMOCYSTEINE; SONIC HEDGEHOG PROTEIN; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRTH DEFECT; CONTROLLED STUDY; DIET RESTRICTION; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DISEASE MODEL; DISEASE SEVERITY; DRUG MECHANISM; FEMALE; GENE EXPRESSION PROFILING; GENE MUTATION; HOMOZYGOSITY; LIVER PARENCHYMA; MOUSE; NEURAL TUBE DEFECT; NONHUMAN; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; TAIL; TREATMENT OUTCOME; WILD TYPE;

ANIMALS; DNA-BINDING PROTEINS; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; GENE EXPRESSION PROFILING; HOMOCYSTEINE; HOMOZYGOTE; MICE; MICE, MUTANT STRAINS; NEURAL TUBE DEFECTS; PROTO-ONCOGENE PROTEINS;

EID: 33751382326     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddl415     Document Type: Article

References (31)

1. Mudd, S.H., Levy, H.L. and Skraus, J.P. (2001) Disorders of transsulfuration. Scriver, C.R., Beaudet, A.L., Sly, W.S. and Valle, D. (eds), The Metabolic and Molecular Bases of Inherited Disease, 8th edn. McGraw Hill, New York, Vol. II, pp. 2007-2056.
2. Rosenblatt, D.S. and Fenton, W.A. (2001) Inherited disorders of folate and cobalamin transport and metabolism. Scriver, C.R., Beaudet, A.L., Sly, W.S. and Valle, D. (eds), The Metabolic and Molecular Bases of Inherited Disease, 8th edn. McGraw Hill, New York, Vol. III, pp. 3897-3933.
3. Heinecke, J.W. (2001) Unique aspects of sulfur chemistry: Homocysteine and lipid oxidation. Carmel, R. and Jacobsen, D.W. (eds), Homocysteine in Health and Disease, Cambridge University Press, Cambridge, pp. 32-38.
4. MRC Vitamin Study Research Group (1991) Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study. Lancet, 338, 131-137.
5. Giovannucci, E., Stampfer, M.J., Colditz, G.A., Hunter, D.J., Fuchs, C., Rosner, B.A., Speizer, F.E. and Willett, W.C. (1998) Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study. Ann. Intern. Med., 129, 517-524.
6. Schnyder, G., Roffi, M., Pin, R., Flammer, Y., Lange, H., Eberli, F.R., Meier, B., Turi, Z.G. and Hess, O.M. (2001) Decreased rate of coronary restenosis after lowering of plasma homocysteine levels. N. Engl. J. Med., 345, 1593-1600.
7. Zhao, Q., Behringer, R.R. and de Crombrugghe, B. (1996) Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene. Nat. Genet., 13, 275-283.
8. Barbera, J.P., Rodriguez, T.A., Greene, N.D., Weninger, W.J., Simeone, A., Copp, A.J., Beddington, R.S. and Dunwoodie, S. (2002) Folic acid prevents exencephaly in Cited2 deficient mice. Hum. Mol. Genet., 11, 283-293.
9. Carter, M., Ulrich, S., Oofuji, Y., Williams, D.A. and Ross, M.E. (1999) Crooked tail (Cd) models human folate-responsive neural tube defects. Hum. Mol. Genet., 8, 2199-2204.
10. Carter, M., Chen, X., Minnerath, S. and Ross, M.E. (2005) Crooked tail (Cd) model of human folate-responsive neural defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6. Proc. Natl Acad. Sci. USA, 102, 12843-12848.
11. Piedrahita, J.A., Oetama, B., Bennett, G.D., van Waes, J., Kamen, B.A., Richardson, Lacey, J., Anderson, R.G. and Finnell, R.H. (1999) Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development. Nat. Genet., 23, 228-232.
12. Zhao, R., Russell, R.G., Wang, Y., Liu, L., Gao, F., Kneitz, B., Edelmann, W. and Goldman, I.D. (2001) Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs. J. Biol. Chem., 276, 10224-10228.
13. Essien, F.B. (1992) Maternal methionine supplementation promotes the remediation of axial defects in Axd mouse neural tube mutants. Teratology, 45, 205-212.
14. Essien, F.B. and Wannberg, S.L. (1993) Methionine but not folinic acid or vitamin B-12 alters the frequency of neural tube defects in Axd mutant mice. J. Nutr., 123, 27-34.
15. Franke, B., Klootwijk, R., Lemmers, B., de Kovel, C.G., Steegers-Theunissen, R.P. and Mariman, E.C. (2003) Phenotype of the neural tube defect mouse model bent tail is not sensitive to maternal folinic acid, myo-inositol, or zinc supplementation. Birth Defects Res. A. Clin. Mol. Teratol., 67, 979-984.
16. Greene, N.D. and Copp, A.J. (1997) Inositol prevents folate-resistant neural tube defects in the mouse. Nat. Med., 3, 60-66.
17. Ernest, S., Christensen, B., Gilfix, B.M., Mamer, O.A., Hosack, A., Rodier, M., Colmenares, C., McGrath, J., Bale, A., Balling, R. et al. (2002) Genetic and molecular control of folate-homocysteine metabolism in mutant mice. Mamm. Genome, 13, 259-267.
18. Legge, M. and Sellens, M.H. (1991) Free radical scavengers ameliorate the 2-cell block in mouse embryo culture. Hum. Reprod., 6, 867-871.
19. Ueland, P.M., Mansoor, M.A., Guttormsen, A.B., Muller, F., Aukrust, P., Refsum, H. and Svardal, A.M. (1996) Reduced, oxidized and protein-bound forms of homocysteine and other aminothiols in plasma comprise the redox thiol status - a possible element of the extracellular antioxidant defense system. J. Nutr., 126, 1281S-1284S.
20. Lynch, M. and Walsh, B. (1998) Sib analysis. Genetics and Analysis of Quantitative Traits, Sinauer Associates, Sunderland, pp. 553-580.
21. Song, J., Medline, A., Mason, J.B., Gallinger, S. and Kim, Y.I. (2000) Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse. Cancer Res., 60, 5434-5440.
22. Fleming, A. and Copp, A.J. (1998) Embryonic folate metabolism and mouse neural tube defects. Science, 280, 2107-2109.
23. Li, D., Pickell, L., Liu, L. and Rosen, R. (2006) Impact of methylenetetrahydrofolate reductase deficiency and low dietary folate on the development of neural tube defects in splotch mice. Birth Defects Res. A. Clin. Mol. Teratol., 76, 55-59.
24. Colmenares, C., Heilstedt, H.A., Shaffer, L.G., Schwartz, S., Berk, M., Murray, J.C. and Stavnezer, E. (2002) Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski -/- mice. Nat. Genet., 30, 106-109.
25. Copp, A.J., Greene, N.D. and Murdoch, J.N. (2003) The genetic basis of mammalian neurulation. Nat. Rev. Genet., 4, 784-793.
26. Ubbink, J.B., Hayward Vermaak, W.J. and Bissbort, S. (1991) Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum. J. Chromatogr., 565, 441-446.
27. Molloy, A.M. and Scott, J.M. (1997) Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method. Meth. Enzymol., 281, 43-53.
28. Berk, M., Desai, S.Y., Heyman, H.C. and Colmenares, C. (1997) Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development. Genes Dev., 11, 2029-2039.
29. Eisen, M.B., Spellman, P.T., Brown, P.O. and Botstein, D. (1998) Cluster analysis and display of genome-wide expression patterns. Proc. Natl Acad. Sci. USA, 95, 14863-14868.
30. Fukunaga, K. and Hostetler, L.D. (1975) The estimation of the gradient of a density function with applications in pattern recognition. IEEE Trans. Inf. Theory, IT-21, 32-40.
31. Cheng, Y. (1995) Mean shift, mode seeking, and clustering. IEEE Trans. Inf. Theory, 17, 790-799.