Infliximab in Fistulizing Crohn's Disease

Gastroenterology Clinics of North America

Volumn 35, Issue 4, 2006, Pages 795-820

  Osterman, Mark T ^a   Lichtenstein, Gary R ^b  

^a PENN PRESBYTERIAN MEDICAL CENTER   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; ANTIBIOTIC AGENT; AZATHIOPRINE; BLOOD CLOTTING FACTOR 13A; CIPROFLOXACIN; CORTICOSTEROID; CYCLOSPORIN A; DISULFIRAM; DNA ANTIBODY; DRUG ANTIBODY; FOLIC ACID; GRANULOCYTE COLONY STIMULATING FACTOR; IMMUNOMODULATING AGENT; INFLIXIMAB; MERCAPTOPURINE; MESALAZINE; METHOTREXATE; METRONIDAZOLE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; THALIDOMIDE; TSUKUBAENOLIDE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ABDOMINAL ABSCESS; ABDOMINAL PAIN; ABSCESS; ALLERGIC PNEUMONITIS; ANTIBIOTIC THERAPY; ANTIBODY PRODUCTION; ASPERGILLOSIS; BONE MARROW SUPPRESSION; BRONCHITIS; CLINICAL TRIAL; COCCIDIOIDOMYCOSIS; COLON FISTULA; COMPUTER ASSISTED TOMOGRAPHY; CONSTIPATION; COST UTILITY ANALYSIS; CROHN DISEASE; DELAYED HYPERSENSITIVITY; DIAGNOSTIC ACCURACY; DIARRHEA; DIET THERAPY; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; DRUG ERUPTION; DRUG HYPERSENSITIVITY; DRUG INDUCED HEADACHE; DRUG INFUSION; DYSPEPSIA; ENDOSCOPY; ENTERITIS; FATIGUE; FISTULOGRAPHY; GASTROENTEROLOGY; GASTROINTESTINAL SYMPTOM; GINGIVA HYPERPLASIA; GLOSSITIS; HIRSUTISM; HISTOPLASMOSIS; HUMAN; HYPERBARIC OXYGEN; HYPERTENSION; INCIDENCE; INFECTION; INJECTION SITE REACTION; INSOMNIA; KIDNEY FAILURE; LEG CRAMP; LEUKOPENIA; LISTERIOSIS; LIVER FIBROSIS; LIVER TOXICITY; LUNG FIBROSIS; LUPUS LIKE SYNDROME; MAINTENANCE THERAPY; MEDICAL SPECIALIST; MUSCLE SPASM; NAUSEA; NONHODGKIN LYMPHOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; OPPORTUNISTIC INFECTION; PANCREATITIS; PARESTHESIA; PATHOGENESIS; PATHOLOGICAL ANATOMY; PATIENT CARE; PELVIS ABSCESS; PERIPHERAL EDEMA; PERIPHERAL NEUROPATHY; PNEUMOCYSTIS PNEUMONIA; PNEUMONIA; PRURITUS; QUALITY OF LIFE; REVIEW; SEBORRHEIC DERMATITIS; SEIZURE; SENSORY NEUROPATHY; SEPSIS; SIDE EFFECT; SOMNOLENCE; SURGEON; TASTE DISORDER; TENDON RUPTURE; TERATOGENICITY; TOTAL PARENTERAL NUTRITION; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; TREMOR; TUBERCULOSIS; ULTRASOUND; UNSPECIFIED SIDE EFFECT; UPPER RESPIRATORY TRACT INFECTION; VOMITING;

ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL; CROHN DISEASE; DIGESTIVE SYSTEM SURGICAL PROCEDURES; GASTROINTESTINAL AGENTS; HUMANS; INTESTINAL FISTULA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33751361319     PISSN: 08898553     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gtc.2006.09.007     Document Type: Review

References (177)

1. Crohn B.B., Ginzburg L., and Oppenheimer G.D. Regional ileitis: a pathologic and clinical entity. JAMA 99 (1932) 1323-1329
2. Bissell A.D. Localized chronic ulcerative colitis. Ann Surg 99 (1934) 957-966
3. Present D.H. Crohn's fistula: current concepts in management. Gastroenterology 124 (2003) 1629-1635
4. American Gastroenterological Association. American Gastroenterological Association medical position statement: perianal Crohn's disease. Gastroenterology 125 (2003) 1503-1507
5. American Gastroenterological Association. AGA technical review on perianal Crohn's disease. Gastroenterology 125 (2003) 1508-1530
6. Scott H.J., and Northover J.M. Evaluation of surgery for perianal Crohn's fistulas. Dis Colon Rectum 39 (1996) 1039-1043
7. Regueiro M., and Mardini H. Treatment of perianal fistulizing Crohn's disease with infliximab alone or as an adjunct to exam under anesthesia with seton placement. Inflamm Bowel Dis 9 (2003) 98-103
8. Topstad D.R., Panaccione R., Heine J.A., et al. Combined seton placement, infliximab infusion, and maintenance immunosuppressives improve healing rates in fistulizing anorectal Crohn's disease: a single center experience. Dis Colon Rectum 46 (2003) 577-583
9. Bell S.J., Williams A.B., Wiesel P., et al. The clinical course of fistulating Crohn's disease. Aliment Pharmacol Ther 17 (2003) 1145-1151
10. Judge T.A., and Lichtenstein G.R. Treatment of fistulizing Crohn's disease. Gastroenterol Clin North Am 33 (2004) 421-454
11. Schwartz D.A., and Herdman C.R. Review article: the medical treatment of Crohn's perianal fistulas. Aliment Pharmacol Ther 19 (2004) 953-967
12. Hughes L. Surgical pathology and management of anorectal Crohn's disease. J R Soc Med 71 (1978) 644-651
13. Parks A. The pathogenesis and treatment of fistula-in-ano. BMJ 1 (1961) 463-469
14. Fielding J.F. Perianal lesions in Crohn's disease. J R Coll Surg Edinb 17 (1972) 32-37
15. Greenstein A.J., Kark A.E., and Drelling D.A. Crohn's disease of the colon I. Fistula in Crohn's disease colon, classification presenting features and management in 63 patients. Am J Gastroenterol 62 (1974) 419-429
16. Farmer R., Hawk W., and Turnbull R.J. Clinical patterns in Crohn's disease: a statistical study of 615 cases. Gastroenterology 68 (1975) 627-635
17. Rankin G.B., Watts H.D., Melnyk C.S., et al. National Cooperative Crohn's Disease Study: extraintestinal manifestations and perianal complications. Gastroenterology 77 (1979) 914-920
18. Buchmann P., Keighly M.R., Allan R.N., et al. Natural history of perianal Crohn's disease. Ten year follow-up: a plea for conservatism. Am J Surg 140 (1980) 642-644
19. Williams D.R., Coller J.A., Corman M.L., et al. Anal complications in Crohn's disease. Dis Colon Rectum 24 (1981) 22-24
20. Marks C.G., Ritchie J.K., and Lockhart-Mummery H.E. Anal fistulas in Crohn's disease. Br J Surg 68 (1981) 525-527
21. Hobbiss J.H., and Schofield P.F. Management of perianal Crohn's disease. J R Soc Med 75 (1982) 414-417
22. Van Dongen L.M., and Lubbers E. Perianal fistulas in patients with Crohn's disease. Arch Surg 121 (1986) 1187-1190
23. Goebell H. Perianal complications in Crohn's disease. Neth J Med 37 (1990) S47-S51
24. Hellers G., Bergstrand O., Ewerth S., et al. Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease. Gut 21 (1980) 525-527
25. Schwartz D.A., Loftus E.V., Tremaine W.J., et al. The natural history of fistulizing Crohn's disease in Olmstead County, Minnesota. Gastroenterology 122 (2002) 875-880
26. Gray B.K., Lockhart-Mummery H.E., and Morson B.C. Crohn's disease of the anal region. Gut 6 (1965) 515-524
27. Halme L., and Sainio A.P. Factors related to frequency, type, and outcome of anal fistulas in Crohn's disease. Dis Colon Rectum 38 (1995) 55-59
28. Bayer I., and Gordon P.H. Selected operative management of fistula-in-ano in Crohn's disease. Dis Colon Rectum 37 (1994) 760-765
29. Makowiec F., Jehle E.C., Becker H.D., et al. Perianal abscess in Crohn's disease. Dis Colon Rectum 40 (1997) 443-450
30. Van Beers B., Grandin C., and Kartheuser A. MRI of complicated anal fistulae: comparison with digital examination. J Comput Assist Tomogr 18 (1994) 87-90
31. Fazio V.W., Wilk P., Turnbull Jr. R.B., et al. The dilemma of Crohn's disease: ileosigmoidal fistula complicating Crohn's disease. Dis Colon Rectum 20 (1977) 381-386
32. Kuijpers H.C., and Schulpen T. Fistulography for fistula-in-ano. Is it useful?. Dis Colon Rectum 28 (1985) 103-104
33. Glass R.E., Ritchie J.K., Lennard-Jones J.E., et al. Internal fistulas in Crohn's disease. Dis Colon Rectum 28 (1985) 557-561
34. Pomerri F., Pittarello F., Dodi G., et al. Radiologic diagnosis of anal fistulae with radio-opaque markers. Radiol Med (Torino) 75 (1988) 632-637
35. Weisman R.I., Orsay C.P., Pearl R.K., et al. The role of fistulography in fistula-in-ano: report of five cases. Dis Colon Rectum 34 (1991) 181-184
36. Berliner L., Redmond P., Purow E., et al. Computed tomography in Crohn's disease. Am J Gastroenterol 77 (1982) 548-553
37. Goldberg H.I., Gore R.M., Margulis A.R., et al. Computed tomography in the evaluation of Crohn's disease. AJR Am J Roentgenol 140 (1983) 277-282
38. Kerber G.W., Greenberg M., and Rubin J.M. Computed tomography evaluation of local and extraintestinal complications of Crohn's disease. Gastrointest Radiol 9 (1984) 143-148
39. Fishman E.K., Wolf E.J., Jones B., et al. CT evaluation of Crohn's disease: effect on patient management. AJR Am J Roentgenol 148 (1987) 537-540
40. Yousem D.M., Fishman E.K., and Jones B. Crohn's disease: perirectal and perianal findings at CT. Radiology 167 (1988) 331-334
41. Van Outryve M.J., Pelckmans P.A., Michielsen P.P., et al. Value of transrectal ultrasonography in Crohn's disease. Gastroenterology 101 (1991) 1171-1177
42. Schratter-Sehn A.U., Lochs H., Vogelsang H., et al. Endoscopic ultrasonography versus computed tomography in the differential diagnosis of perianorectal complications in Crohn's disease. Endoscopy 25 (1993) 582-586
43. Koelbel G., Schmiedl U., Majer M.C., et al. Diagnosis of fistulae and sinus tracts in patients with Crohn's disease: value of MR imaging. AJR Am J Roentgenol 152 (1989) 999-1003
44. Skalej M., Makowiec F., Weinlich M., et al. Magnetic resonance imaging in perianal Crohn's disease. Dtsch Med Wochenschr 118 (1993) 1791-1796
45. Lunniss P.J., Barker P.G., Sultan A.H., et al. Magnetic resonance imaging of fistula-in-ano. Dis Colon Rectum 37 (1994) 708-718
46. Barker P.G., Lunniss P.J., Armstrong P., et al. Magnetic resonance imaging of fistula-in-ano: technique, interpretation, and accuracy. Clin Radiol 49 (1994) 7-13
47. Haggert P.J., Moore N.R., Shearman J.D., et al. Pelvic and perianal complications of Crohn's disease: assessment using magnetic resonance imaging. Gut 36 (1995) 407-410
48. DeSouza N.M., Hall A.S., Puni R., et al. High resolution magnetic resonance imaging of the anal sphincter using a dedicated endoanal coil: comparison of magnetic resonance imaging with surgical finding. Dis Colon Rectum 39 (1996) 926-934
49. Spencer J.A., Chapple K., Wilson D., et al. Outcome after surgery for perianal fistula: predictive value of MR imaging. AJR Am J Roentgenol 171 (1998) 403-406
50. Schwartz D.A., Wiersema M.J., Dudiak K.M., et al. A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn's perianal fistulas. Gastroenterology 121 (2001) 1064-1072
51. Beets-Tan R.G., Beets G.L., van der Hoop A.G., et al. Preoperative MR imaging of anal fistulas: does it really help the surgeon?. Radiology 218 (2001) 75-84
52. Tio T.L., Mulder C.J., Wijers O.B., et al. Endosonography of peri-anal and per-colorectal fistula and/or abscess in Crohn's disease. Gastrointest Endosc 36 (1990) 331-336
53. Wijers O., Tio T., and Tytgat G. Endosonography (transrectal and transvaginal) in the assessment of perianorectal fistulas and abscesses: experience with 127 cases. In: Demling L., and Fruhmorgan P. (Eds). Non-neoplastic diseases of the anorectum (1992), Kluwer, London 65-78
54. Solomon M.J. Fistulae and abscesses in symptomatic perianal Crohn's disease. Int J Colorectal Dis 11 (1996) 222-226
55. Orsoni P., Barthet M., Portier F., et al. Prospective comparison of endosonography, magnetic resonance imaging and surgical findings in anorectal fistula and abscess complicating Crohn's disease. Br J Surg 86 (1999) 360-364
56. Stewart L.K., McGee J., and Wilson S.R. Transperineal and transvaginal sonography of perianal inflammatory bowel disease. AJR Am J Roentgenol 177 (2001) 627-632
57. Sloots C.E., Felt-Bersma R.J., Poen A.C., et al. Assessment and classification of fistula-in-ano in patients with Crohn's disease by hydrogen peroxide enhanced transanal ultrasound. Int J Colorectal Dis 16 (2001) 292-297
58. Sparberg M., and Kirsner J.B. Long-term corticosteroid therapy for regional enteritis: an analysis of 58 courses in 54 patients. Am J Dig Dis 11 (1966) 865-880
59. Jones J.H., and Lennard-Jones J.F. Corticosteroids and corticotropin in the treatment of Crohn's disease. Gut 7 (1966) 181-187
60. Agrawal A., Durrani S., Leiper K., et al. Effect of systemic corticosteroid therapy on risk for intra-abdominal or pelvic abscess in non-operated Crohn's disease. Clin Gastroenterol Hepatol 3 (2005) 1215-1220
61. Ursing B., and Kamme C. Metronidazole for Crohn's disease. Lancet 1 (1975) 775-777
62. Bernstein L.H., Frank M.S., Brandt L.J., et al. Healing of perianal Crohn's disease with metronidazole. Gastroenterology 79 (1980) 357-365
63. Schneider M.U., Strobel S., Riemann J.F., et al. Treatment of Crohn's disease with metronidazole. Dtsch Med Wochenschr 106 (1981) 1126-1129
64. Brandt L.J., Bernstein L.H., Boley S.J., et al. Metronidazole therapy for perianal Crohn's disease: a follow-up study. Gastroenterology 83 (1982) 383-387
65. Jakobovits J., and Schuster M.M. Metronidazole therapy for Crohn's disease and associated fistulae. Am J Gastroenterol 79 (1984) 533-540
66. Schneider M.U., Laudage G., Guggenmoos-Holzmann I., et al. Metronidazole in the treatment of Crohn's disease: results of a controlled randomized prospective study. Dtsch Med Wochenschr 110 (1985) 1724-1730
67. Turunen U., Farkkila M., and Seppala K. Long-term treatment of perianal or fistulous Crohn's disease with ciprofloxacin. Scand J Gastroenterol Suppl 24 (1989) 144
68. Wolf J.L. Ciprofloxacin may be useful in Crohn's disease. [abstract]. Gastroenterology 98 (1990) A212
69. Solomon M.J., McLeod R.S., O'Connor B.I., et al. Combination ciprofloxacin and metronidazole in severe perianal Crohn's disease. Can J Gastroenterol 7 (1993) 571-573
70. Turunen U., Farkkila M., and Valtonen V. Long-term outcome of ciprofloxacin treatment in severe perianal or fistulous Crohn's disease. [abstract]. Gastroenterology 104 (1993) A793
71. Freeman C.D., Klutman N.E., and Lamp K.C. Metronidazole: a therapeutic review and update. Drugs 54 (1997) 679-708
72. Davis R., Markham A., and Balfour J.A. Ciprofloxacin: an updated review of its pharmacology, therapeutic efficacy and tolerability. Drugs 51 (1996) 1019-1074
73. Casparian J.M., Luchi M., Moffat R.E., et al. Quinolones and tendon ruptures. South Med J 93 (2000) 488-491
74. Brooke B.N., Hoffman D.C., and Swarbrick E.T. Azathioprine for Crohn's disease. Lancet 2 (1969) 612-614
75. Willoughby J.M., Beckett J., Kumar P.J., et al. Controlled trial of azathioprine in Crohn's disease. Lancet 2 (1971) 944-947
76. Rhodes J., Bainton D., Beck P., et al. Controlled trial of azathioprine in Crohn's disease. Lancet 2 (1971) 1273-1276
77. Klein M., Binder H.J., Mitchell M., et al. Treatment of Crohn's disease with azathioprine: a controlled evaluation. Gastroenterology 66 (1974) 916-922
78. Rosenberg J.L., Levin B., Wall A.J., et al. A controlled trial of azathioprine in Crohn's disease. Am J Dig Dis 20 (1975) 721-726
79. Present D.H., Korelitz B.I., Wisch N., et al. Treatment of Crohn's disease with mercaptopurine: a long-term, randomized, double-blind study. N Engl J Med 302 (1980) 981-987
80. Pearson D., May G., Fick G., et al. Azathioprine and 6-mercaptopurine in Crohn's disease: a meta analysis. Ann Intern Med 123 (1995) 132-142
81. Korelitz B.I., and Present D.H. Favorable effect of mercaptopurine on fistulae of Crohn's disease. Dig Dis Sci 30 (1985) 58-64
82. Jeshion W.C., Larsen K.L., Jawad A.F., et al. Azathioprine and 6-mercaptopurine for the treatment of perianal Crohn's disease in children. J Clin Gastroenterol 30 (2000) 294-298
83. Dejaco C., Harrer M., Waldhoer T., et al. Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease. Aliment Pharmacol Ther 18 (2003) 1113-1120
84. Arseneau K.O., Cohn S.M., Cominelli F., et al. Cost-utility of initial medical management for Crohn's disease perianal fistulae. Gastroenterology 120 (2001) 1640-1656
85. Osterman M.T., Kundu R., Lichtenstein G.R., et al. Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis. Gastroenterology 130 (2006) 1047-1053
86. Present D.H., Meltzer S.J., Krumholz M.P., et al. 6-Mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity. Ann Intern Med 111 (1989) 641-649
87. Dayharsh G.A., Loftus Jr. E.V., Sandborn W.J., et al. Epstein-Barr virus-positive lymphoma in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine. Gastroenterology 122 (2002) 72-77
88. Vandeputte L., D'Haens G., Beart F., et al. Methotrexate in refractory Crohn's disease. Inflamm Bowel Dis 5 (1999) 11-15
89. Mahadevan U., Marion J.F., and Present D.H. Fistula response to methotrexate in Crohn's disease: a case series. Aliment Pharmacol Ther 18 (2003) 1003-1008
90. Sandborn W.J. A review of immune modifier therapy for inflammatory bowel disease: azathioprine, 6-mercaptopurine, cyclosporine, and methotrexate. Am J Gastroenterol 91 (1996) 423-433
91. Lemann M., Zenjari T., Bouhnik Y., et al. Methotrexate in Crohn's disease: long-term efficacy and toxicity. Am J Gastroenterol 95 (2000) 1730-1734
92. Fukushima T., Sugita A., Masuzawa S., et al. Effects of cyclosporine A on active Crohn's disease. Gastroenterol Jpn 24 (1989) 12-15
93. Lichtiger S. Cyclosporin therapy in inflammatory bowel disease: open-label experience. Mt Sinai J Med 57 (1990) 315-319
94. Markowitz J., Rosa J., Grancher K., et al. Long-term 6-mercaptopurine treatment in adolescents with Crohn's disease. Gastroenterology 99 (1990) 1347-1351
95. Hanauer S.B., and Smith M.B. Rapid closure of Crohn's disease fistulas with continuous intravenous cyclosporin A. Am J Gastroenterol 88 (1993) 646-649
96. Present D.H., and Lichtiger S. Efficacy of cyclosporine in treatment of fistula of Crohn's disease. Dig Dis Sci 39 (1994) 374-380
97. Abreu-Martin J., Vasilauskas E., Gaiennie J., et al. Continuous infusion cyclosporine is effective for acute severe Crohn's disease...but for how long [abstract]?. Gastroenterology 110 (1996) A851
98. O'Neill J., Pathmakanthan S., Goh J., et al. Cyclopsorine A induces remission in fistulous Crohn's disease but relapses occur upon cessation of treatment. [abstract]. Gastroenterology 112 (1997) A1056
99. Hinterleitner T.A., Petritsch W., Aichbichler B., et al. Combination of cyclosporine, azathioprine and prednisone for perianal fistulas in Crohn's disease. Z Gastroenterol 35 (1997) 603-608
100. Egan L.J., Sandborn W.J., and Tremaine W.J. Clinical outcome following treatment of refractory inflammatory and fistulizing Crohn's disease with intravenous cyclosporine. Am J Gastroenterol 93 (1998) 442-448
101. Gurudu S.R., Griffel L.H., Gialanella R.J., et al. Cyclosporine therapy in inflammatory bowel disease: short- and long-term results. J Clin Gastroenterol 29 (1999) 151-154
102. Van Assche G., D'Haens G., Noman M., et al. Randomized, double-blind comparison of 4 mg/kg versus 2 mg/kg intravenous cyclosporine in severe ulcerative colitis. Gastroenterology 125 (2003) 1025-1031
103. Sandborn W.J. A critical review of cyclosporine therapy in inflammatory bowel disease. Inflamm Bowel Dis 1 (1995) 48-63
104. Sandborn W.J. Preliminary report on the use of oral tacrolimus (FK506) in the treatment of complicated proximal small bowel and fistulizing Crohn's disease. Am J Gastroenterol 92 (1997) 876-879
105. Fellerman K., Ludwig D., Stahl M., et al. Steroid-unresponsive acute attacks of inflammatory bowel disease: immunomodulation by tacrolimus (FK506). Am J Gastroenterol 93 (1998) 1860-1866
106. Lowry P.W., Weaver A.L., Tremaine W.J., et al. Combination therapy with oral tacrolimus (FK506) and azathioprine or 6-mercaptopurine for treatment-refractory Crohn's disease perianal fistulae. Inflamm Bowel Dis 5 (1999) 239-245
107. Ierardi E., Principi M., Rendina M., et al. Oral tacrolimus (FK506) in Crohn's disease complicated by fistulae of the perineum. J Clin Gastroenterol 125 (2000) 200-202
108. Sandborn W.J., Present D.H., Isaacs K.L., et al. Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized, placebo-controlled trial. Gastroenterology 125 (2003) 380-388
109. Gonzalez-Lama Y., Abreu L., Vera M.I., et al. Long-term oral tacrolimus therapy in refractory to infliximab fistulizing Crohn's disease: a pilot study. Inflamm Bowel Dis 11 (2005) 8-15
110. Cohen R.D., Tsang J.F., and Hanauer S.B. Infliximab in Crohn's disease: first anniversary clinical experience. Am J Gastroenterol 95 (2000) 3469-3477
111. Farrell R.J., Shah S.A., Lodhavia P.J., et al. Clinical experience with infliximab therapy in 100 patients with Crohn's disease. Am J Gastroenterol 95 (2000) 3490-3497
112. Ricart E., Panaccione R., Loftus E.V., et al. Infliximab for Crohn's disease in clinical practice at the Mayo Clinic: the first 100 patients. Am J Gastroenterol 96 (2001) 722-729
113. Present D.H., Rutgeerts P., Targan S., et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 340 (1999) 1398-1405
114. Sands B.E., Anderson F.H., Bernstein C.N., et al. Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med 350 (2004) 876-885
115. Sands B.E., Blank M.A., Patel K., et al. Long-term treatment of rectovaginal fistulas in Crohn's disease: response to infliximab in the ACCENT II study. Clin Gastroenterol Hepatol 2 (2004) 912-920
116. Cadahia V., Garcia-Carbonero A., Vivas S., et al. Infliximab improves quality of life in the short-term in patients with fistulizing Crohn's disease in clinical practice. Rev Esp Enferm Dig 96 (2004) 369-374
117. Lichtenstein G.R., Yan S., Bala M., et al. Infliximab maintenance treatment reduces hospitalization, surgeries, and procedures in fistulizing Crohn's disease. Gastroenterology 128 (2005) 862-869
118. Agnholt J., Dahlerup J.F., Buntzen S., et al. Response, relapse and mucosal immune regulation after infliximab treatment in fistulating Crohn's disease. Aliment Pharmacol Ther 17 (2003) 703-710
119. Poritz L.S., Rowe W.A., and Koltun W.A. Remicade does not abolish the need for surgery in fistulizing Crohn's disease. Dis Colon Rectum 45 (2002) 771-775
120. West R.L., van der Woude C.J., Hansen B.E., et al. Clinical and endosonographic effect of ciprofloxacin on the treatment of perianal fistulae in Crohn's disease with infliximab: a double-blind placebo-controlled study. Aliment Pharmacol Ther 20 (2004) 1329-1336
121. Ochsenkühn T., Göke B., and Sackmann M. Combining infliximab with 6-mercaptopurine/azathioprine for fistula therapy in Crohn's disease. Am J Gastroenterol 97 (2002) 2022-2025
122. Schröder O., Blumenstein I., Schulte-Buckholt A., et al. Combining infliximab and methotrexate in fistulizing Crohn's disease resistant or intolerant to azathioprine. Aliment Pharmacol Ther 19 (2004) 295-301
123. Van der Hagen S.J., Baeten C.G., Soeters P.B., et al. Anti-TNF-α (infliximab) used as induction treatment in case of active proctitis in a multistep strategy followed by definitive surgery of complex anal fistulas in Crohn's disease: a preliminary report. Dis Colon Rectum 48 (2005) 758-767
124. Talbot C., Sagar P.M., Johnston M.J., et al. Infliximab in the surgical management of complex fistulating anal Crohn's disease. Colorectal Dis 7 (2005) 164-168
125. Sandborn W.J., and Hanauer S.B. Antitumor necrosis factor therapy for inflammatory bowel disease: a review of agents, pharmacology, clinical results, and safety. Inflamm Bowel Dis 5 (1999) 119-133
126. Schaible T.F. Long-term safety of infliximab. Can J Gastroenterol 14 (2000) 29C-32C
127. Remicade (infliximab) for IV injection [package Insert]. Randor, PA: Centocor, Inc.; 2002.
128. Keane J., Gershon S., Wise R.P., et al. Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med 345 (2001) 1098-1104
129. Morelli J., and Wilson F.A. Does administration of infliximab increase susceptibility to listeriosis?. Am J Gastroenterol 95 (2000) 841-842
130. Kamath B.M., Mamula P., Baldassano R.N., et al. Listeria meningitis after treatment with infliximab. J Pediatr Gastroenterol Nutr 34 (2002) 410-412
131. Warris A., Bjorneklett A., and Gaustad P. Invasive pulmonary aspergillosis associated with infliximab therapy. N Engl J Med 344 (2001) 1099-1100
132. Nakelchik M., and Mangino J.E. Reactivation of histoplasmosis after treatment with infliximab. Am J Med 112 (2002) 78
133. Sandborn W.J., Hanauer S.B., Loftus Jr. E.V., et al. An open-label study of the human anti-TNF monoclonal antibody adalimumab in subjects with prior loss of response or intolerance to infliximab for Crohn's disease. Am J Gastroenterol 99 (2004) 1984-1989
134. Feagan B.G., Sandborn W.J., Baker J.P., et al. A randomized, double-blind, placebo-controlled multicenter trial of the engineered human antibody to TNF (CDP571) for steroid sparing and maintenance of remission in patients with steroid-dependent Crohn's disease. [abstract]. Gastroenterology 118 (2000) A655
135. Sandborn W.J., Feagan B.G., Hanauer S.B., et al. An engineered human antibody to TNF (CDP571) for active Crohn's disease: a randomized double-blind placebo-controlled trial. Gastroenterology 120 (2001) 1330-1338
136. Ehrenpreis E.D., Kane S.V., Cohen L.B., et al. Thalidomide therapy for patients with refractory Crohn's disease: an open-label trial. Gastroenterology 117 (1999) 1271-1277
137. Vasiliauskas E.A., Kam L.Y., Abreu-Martin M.T., et al. An open-label pilot study of low-dose thalidomide in chronically active, steroid-dependent Crohn's disease. Gastroenterology 117 (1999) 1278-1287
138. Voitk A.J., Echave V., Brown R.A., et al. Use of elemental during the adaptive stage of short gut syndrome. Gastroenterology 65 (1973) 419-426
139. Segal A.W., Levi A.J., and Loewi G. Levamisole in the treatment of Crohn's disease. Lancet 2 (1977) 382-385
140. Axelsson C., and Jarnum S. Assessment of the therapeutic value of an elemental diet in chronic inflammatory bowel disease. Scand J Gastroenterol 12 (1977) 89-95
141. Russell R.I., and Hall M.J. Elemental diet therapy in the management of complicated Crohn's disease. Scott Med J 24 (1979) 291-295
142. Calam J., Crooks P.E., and Walker R.J. Elemental diets in the management of Crohn's perianal fistulae. J Parenter Enteral Nutr 4 (1980) 4-8
143. Teahon K., Bjarnason I., Pearson M., et al. Ten years' experience with an elemental diet in the management of Crohn's disease. Gut 31 (1990) 1133-1137
144. Jones V.A. Comparison of total parenteral nutrition and elemental diet in induction of remission of Crohn's disease. Dig Dis Sci 32 (1987) 100S-107S
145. Fukuda Y., Kosaka T., Okui M., et al. Efficacy of nutritional therapy for active Crohn's disease. J Gastroenterol 30 (1995) 83-87
146. Harford F.J., and Fazio V.W. Total parenteral nutrition as primary therapy for inflammatory bowel disease of the bowel. Dis Colon Rectum 21 (1978) 555-557
147. Milewski P.J., and Irving M.H. Parenteral nutrition in Crohn's disease. Dis Colon Rectum 23 (1980) 395-400
148. Greenberg G.R., Fleming C.R., Jeejeebhoy K.N., et al. Controlled trial of bowel rest and nutritional support in the management of Crohn's disease. Gut 29 (1988) 1309-1315
149. Fickert P., Hinterleitner T.A., Wenzl H.H., et al. Mycopheylate mofetil in patients with Crohn's disease. Am J Gastroenterol 93 (1998) 2529-2532
150. Vaughan D., and Drumm B. Treatment of fistulas with granulocyte colony-stimulating factor in a patient with Crohn's disease. N Engl J Med 340 (1999) 239-240
151. Korzenik J., and Dieckgraefe B. Immunostimulation in Crohn's disease: results of a pilot study of G-CSF (R-Methug-CSF) in mucosal and fistulizing Crohn's disease. [abstract]. Gastroenterology 118 (2000) A874
152. Dieckgraefe B.K., and Korzenik J.R. Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor. Lancet 360 (2002) 1478-1480
153. Brady III C.E., Cooley B.J., and Davis J.C. Healing of severe perianal and cutaneous Crohn's disease with hyperbaric oxygen. Gastroenterology 97 (1989) 756-760
154. Nelson Jr. E.W., Bright D.E., and Villar L.F. Closure of refractory perianal Crohn's lesion: integration of hyperbaric oxygen into case management. Dig Dis Sci 35 (1990) 1561-1566
155. Brady III C.E. Hyperbaric oxygen and perianal Crohn's disease: a follow-up. Gastroenterology 105 (1993) 1264
156. Lavy A., Weisz G., Adir Y., et al. Hyperbaric oxygen for perianal Crohn's disease. J Clin Gastroenterol 19 (1994) 202-205
157. Colombel J.F., Mathieu D., Bouault J.M., et al. Hyperbaric oxygen in severe perianal Crohn's disease. Dis Colon Rectum 38 (1995) 609-614
158. Oshitani N., Nakamura S., Matsumoto T., et al. Treatment of Crohn's disease fistulas with coagulation factor XIII. Lancet 347 (1996) 119-120
159. Sohn N., Korelitz B.I., and Weinstein M.A. Anorectal Crohn's disease: definitive surgery for fistulas and recurrent abscesses. Am J Surg 139 (1980) 394-397
160. Keighley M.R., and Allan R.N. Current status and influence of operation on perianal Crohn's disease. Int J Colorectal Dis 1 (1986) 104-107
161. Bernard D., Morgan S., and Tasse D. Selective surgical management of Crohn's disease of the anus. Can J Surg 29 (1986) 318-321
162. Fry R.D., Shemesh E.I., Kodner I.J., et al. Techniques and results in the management of anal and perianal Crohn's disease. Surg Gynecol Obstet 168 (1989) 42-48
163. Morrison J.G., Gathright Jr. J.B., Ray J.E., et al. Surgical management of anorectal fistulas in Crohn's disease. Dis Colon Rectum 32 (1989) 492-496
164. Fuhrman G.M., and Larach S.W. Experience with perirectal fistulas in patients with Crohn's disease. Dis Colon Rectum 32 (1989) 847-848
165. Levien D.H., Surrell J., and Mazier W.P. Surgical treatment of anorectal fistula in patients with Crohn's disease. Surg Gynecol Obstet 169 (1989) 133-136
166. Kangas E. Anal lesions complicating Crohn's disease. Ann Chir Gynaecol 80 (1991) 336-339
167. Williams J.G., Rothenberger D.A., Nemer F.D., et al. Fistula-in-ano in Crohn's disease: results of aggressive surgical treatment. Dis Colon Rectum 34 (1991) 378-384
168. Nordgren S., Fasth S., and Hulten L. Anal fistulas in Crohn's disease: incidence and outcome of surgical treatment. Int J Colorectal Dis 7 (1992) 214-218
169. Winter A.M., Banks P.A., and Petros J.G. Healing of transsphincteric perianal fistulas in Crohn's disease using a new technique. Am J Gastroenterol 88 (1993) 2022-2025
170. Williamson P.R., Hellinger M.D., Larach S.W., et al. Twenty-year review of the surgical management of perianal Crohn's disease. Dis Colon Rectum 38 (1995) 389-392
171. McKee R.F., and Keenan R.A. Perianal Crohn's disease - is it all bad news?. Dis Colon Rectum 39 (1996) 136-142
172. Sangwan Y.P., Schoetz Jr. D.J., Murray J.J., et al. Perianal Crohn's disease: results of local surgical treatment. Dis Colon Rectum 39 (1996) 529-535
173. Platell C., Mackay J., Collopy B., et al. Anal pathology in patients with Crohn's disease. Aust N Z J Surg 66 (1996) 5-9
174. Michelassi F., Melis M., Rubin M., et al. Surgical treatment of anorectal complications of Crohn's disease. Surgery 128 (2000) 597-603
175. Joo J.S., Weiss E.G., Nogueras J.J., et al. Endorectal advancement flap in perianal Crohn's disease. Am Surg 64 (1998) 147-150
176. Williams J.G., MacLeod C.A., Rothenberger D.A., et al. Seton treatment of high anal fistulae. Br J Surg 78 (1991) 1159-1161
177. Sugita A., Koganei K., Harada H., et al. Surgery for Crohn's anal fistulas. J Gastroenterol 30 (1995) 143-146