Fistula response to methotrexate in Crohn's disease: A case series

Alimentary Pharmacology and Therapeutics

Volumn 18, Issue 10, 2003, Pages 1003-1008

  Mahadevan, U ^a   Marion, J F ^b   Present, D H ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; CYCLOSPORIN; MERCAPTOPURINE; METHOTREXATE; STEROID;

ADULT; AGED; ALLERGIC PNEUMONITIS; ALOPECIA; ARTICLE; CASE STUDY; CLINICAL ARTICLE; CLINICAL PRACTICE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROHN DISEASE; DRUG HYPERSENSITIVITY; DRUG RESPONSE; DRUG TOLERABILITY; FEMALE; FEVER; FISTULA; HUMAN; LABORATORY TEST; LEUKOPENIA; LIVER FIBROSIS; LIVER FUNCTION TEST; MALE; NAUSEA; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SIDE EFFECT; TREATMENT FAILURE; TREATMENT OUTCOME; UPPER RESPIRATORY TRACT INFECTION; VOMITING;

6-MERCAPTOPURINE; ABDOMINAL WALL; ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; CROHN DISEASE; CUTANEOUS FISTULA; CYCLOSPORINE; FEMALE; GASTROINTESTINAL AGENTS; HUMANS; INJECTIONS, INTRAMUSCULAR; INTESTINAL FISTULA; MALE; MIDDLE AGED; RECTAL DISEASES; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; URINARY BLADDER DISEASES; URINARY FISTULA; VAGINAL FISTULA;

EID: 0344394523     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.2003.01790.x     Document Type: Article

References (23)

1. Hellers G. Bergstrand O, Ewerth S, et al. Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease. Gut 1980; 21: 525-7.
2. Schwartz D, Loftus E, Tremaine WJ, et al. The natural history of fistulizing Crohn's disease: a population based study. Gastroenterology 2000; 118(4): A337(Abstract).
3. Bernstein LH, Frank MS, Brandt LJ, et al. Healing of perineal Crohn's disease with metronidazole. Gastroenterology 1980; 79: 357-65.
4. Brandt LJ, Bernstein LH, Boley SJ, et al. Metronidazole therapy for perineal Crohn's disease: a follow-up study. Gastroenterology 1982; 83: 383-7.
5. Turunen U, Valtonen V. Long-term outcome of ciprofloxacin treatment in severe perianal or fistulous Crohn's disease. Gastroenterology 1993; 104: A793(Abstract).
6. Solomon MJ, McLeod RS, O'Connor B, et al. Combination ciprofloxacin and metronidazole in severe perianal Crohn's disease. Can J Gastroenterol 1993; 7: 571-3.
7. Korelitz BI, Present DH. Favorable effect of 6-mercaptopurine on fistulae of Crohn's disease. Dig Dis Sci 1985; 30: 58-64.
8. Present DH, Lichtiger S. Efficacy of cyclosporine in treatment of fistula of Crohn's disease. Dig Dis Sci 1994; 39: 374-80.
9. Sandborn WJ, Isaacs KL. Tacrolimus (FK506) for the treatment of perianal and enterocutaneous fistulas in patients with Crohn's disease: a randomized, double blind, placebo-controlled trial. Gastroenterology 2002; 122: A81(Abstract).
10. Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 1999; 340: 1398-405.
11. Cutolo M, Sulli A, Pizzorni C, et al. Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis. Ann Rheum Dis 2001; 60: 729-35.
12. Feagan BG, Rochon J, Fedorak RN, et al. Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators. N Engl J Med 1995; 332: 292-7.
13. Feagan BG. Fedorak RN, Irvine EJ, et al. A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators. N Engl J Med 2000; 342: 1627-32.
14. Kozarek RA, Patterson DJ, Gelfand MD, et al. Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease. Ann Intern Med 1989; 110: 353-6.
15. Present DH, Korelitz BI, Wisch N, et al. Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study. N Engl J Med 1980; 302: 981-7.
16. Sands BE, Van Deventer S, Bernstein C, et al Long-term treatment of fistulizing Crohn's disease: response to infliximab in the ACCENT II trial through 54 weeks. Gastroenterology 2002; 122: A81(Abstract).
17. Ochsenkuhn T, Goke B, Sackmann M. Combining infliximab with 6-mercaptopurine/azathioprine for fistula therapy in Crohn's disease. Am J Gastroenterol 2002; 97: 2022-5.
18. Chong RY. Hanauer SB, Cohen RD. Efficacy of parenteral methotrexate in refractory Crohn's disease. Aliment Pharmacol Ther 2001; 15: 35-44.
19. Morgan SL, Baggott JE, Vaughn WH, et al. Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial. Ann Intern Med 1994; 121: 833-41.
20. Goodman TA, Polisson RP. Methotrexate: adverse reactions and major toxicities. Rheum Dis Clin North Am 1994; 20: 513-28.
21. Kremer JM, Alarcon GS, Lightfoot RW Jr., et al. Methotrexate for rheumatoid arthritis. Suggested guidelines for monitoring liver toxicity. American College of Rheumatology. Arthritis Rheum 1994; 37: 316-28.
22. Te HS, Schiano TD, Kuan SF, et al. Hepatic effects of long-term methotrexate use in the treatment of inflammatory bowel disease. Am J Gastroenterol 2000; 95: 3150-6.
23. Lemann M, Zenjari T, Bouhnik Y, et al. Methotrexate in Crohn's disease: long-term efficacy and toxicity. Am J Gastroenterol 2000; 95: 1730-4.