Mechanism of dipyridamole's action in inhibition of venous and arterial smooth muscle cell proliferation

Basic and Clinical Pharmacology and Toxicology

Volumn 99, Issue 6, 2006, Pages 431-439

  Zhuplatov, Sergey B ^a   Masaki, Takahisa ^a   Blumenthal, Donald K ^a   Cheung, Alfred K ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; DIPYRIDAMOLE;

AORTA; ARTICLE; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; CYTOTOXICITY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RESTENOSIS; SAPHENOUS VEIN; VASCULAR SMOOTH MUSCLE;

AORTA; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DIPYRIDAMOLE; ENZYME INHIBITORS; GRAFT OCCLUSION, VASCULAR; HUMANS; L-LACTATE DEHYDROGENASE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHODIESTERASE INHIBITORS; PLATELET AGGREGATION INHIBITORS; SAPHENOUS VEIN; THIONUCLEOTIDES;

EID: 33751356545     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2006.pto_516.x     Document Type: Article

References (45)

1. Adashi, E. Y., C. E. Resnick & B. Jastorff: Blockade of granulosa cell differentiation by an antagonistic analog of adenosine 3′, 5′cyclic monophosphate (cAMP). Mol. Cell Endocrinol. 1990, 72, 1-11.
2. Buchler, W., U. Walter, B. Jastorff & S. M. Lohmann: Catalytic subunit of cAMP-dependent protein kinase is essential for cAMP-mediated mammalian gene expression. FEBS Lett. 1988, 228, 27-32.
3. Bult, H., H. R. Fret, F. H. Jordaens & A. G. Herman: Dipyridamole potentiates the anti-aggregating and vasodilator activity of nitric oxide. Eur. J. Pharmacol. 1991, 199, 1-8.
4. Butt, E., M. Eigenthaler & H. G. Genieser: (Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor. Eur. J. Pharmacol. 1994, 269, 265-268.
5. Depre, C., F. Ribichini & W. Wijns: Morphological analysis of atherosclerotic plaque retrieved by coronary atherectomy. Semin. Interv. Cardiol. 2000, 5, 175-184.
6. Derendorf, H., C. P. VanderMaelen, R. S. Brickl, T. R. MacGregor & W. Eisert: Dipyridamole bioavailability in subjects with reduced gastric acidity. J. Clin. Pharmacol. 2005, 45, 845-550.
7. Dixon, B. S., G. J. Beck, L. M. Dember, T. A. Depner, J. J. Gassman, T. Greene et al.: Design of the Dialysis Access Consortium (DAC) Aggrenox Prevention Of Access Stenosis Trial. Clin. Trials 2005, 21, 400-412.
8. Dubey, R. K., D. G. Gillespie, Z. Mi, F. Suzuki & E. K. Jackson: Smooth muscle cell-derived adenosine inhibits cell growth. Hypertension 1996, 27, 766-773.
9. Dubey, R. K., Z. Mi, D. G. Gillespie & E. K. Jackson: Cyclic AMP-adenosine pathway inhibits vascular smooth muscle cell growth. Hypertension 1996, 28, 765-771.
10. Fukawa, K., K. Saitoh, O. Irino, K. Ohkubo & S. Hashimoto: Inhibitory mechanism of dipyridamole on platelet aggregation ex vivo. Thromb. Res. 1982, 27, 333-340.
11. Gillespie, P. G. & J. A. Beavo: Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M&B 22,948. Mol. Pharmacol. 1989, 36, 773-781.
12. Harker, L. A. & R. A. Kadatz: Mechanism of action of dipyridamole. Thromb. Res. 1983, 4 (Suppl.), 39-46.
13. Hayashi, S., R. Morishita, H. Matsushita, H. Nakagami, Y. Taniyama, T. Nakamura et al.: Cyclic AMP inhibited proliferation of human aortic vascular smooth muscle cells, accompanied by induction of p53 and p21. Hypertension 2000, 35, 237-243.
14. Hewitson, T. D., M. G. Tait, K. J. Kelynack, M. Martic & G. J. Becker: Dipyridamole inhibits in vitro renal fibroblast proliferation and collagen synthesis. J. Lab. Clin. Med. 2002, 140, 199-208.
15. Himmelfarb, J. & L. Couper: Dipyridamole inhibits PDGF- and bFGF-induced vascular smooth muscle cell proliferation. Kidney Int. 1997, 52, 1671-1677.
16. Hung, K. Y., C. T. Chen, C. J. Yen, P. H. Lee, T. J. Tsai & B. S. Hsieh: Dipyridamole inhibits PDGF-stimulated human peritoneal mesothelial cell proliferation. Kidney Int. 2001, 60, 872-881.
17. Kanterman, R. Y., T. M. Vesely, T. K. Pilgram, B. W. Guy, D. W. Windus & D. Picus: Dialysis access grafts: anatomic location of venous stenosis and results of angioplasty. Radiology 1995, 195, 135-139.
18. Kim, S. J., T. Masaki, J. K. Leypoldt, C. D. Kamerath, S. F. Mohammad & A. K. Cheung: Arterial and venous smooth-muscle cells differ in their responses to antiproliferative drugs. J. Lab. Clin. Med. 2004, 144, 156-162.
19. Kim, S. J., T. Masaki, R. Rowley, J. K. Leypoldt, S. F. Mohammad & A. K. Cheung: Different responses by cultured aortic and venous smooth muscle cells to gamma radiation. Kidney Int. 2005, 68, 371-377.
20. Klemm, D. J., P. A. Watson, M. G. Frid, E. C. Dempsey, J. Schaack, L. A. Colton et al.: cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migration. J. Biol. Chem. 2001, 276, 46132-16141.
21. Koyama, H., K. E. Bornfeldt, S. Fukumoto & Y. Nishizawa: Molecular pathways of cyclic nucleotide-induced inhibition of arterial smooth muscle cell proliferation. J. Cell Physiol. 2001, 186, 1-10.
22. Masaki, T., C. D. Kamerath, S. J. Kim, J. K. Leypoldt, S. F. Mohammad & A. K. Cheung: In vitro pharmacological inhibition of human vascular smooth muscle cell proliferation for the prevention of hemodialysis vascular access stenosis. Blood Purif. 2004, 22, 307-312.
23. Masaki, T., R. Rathi, G. Zentner, J. K. Leypoldt, S. F. Mohammad, G. L. Burns et al.: Inhibition of neointimal hyperplasia in vascular grafts by sustained perivascular delivery of paclitaxel. Kidney Int. 2004, 66, 2061-2069.
24. Maurice, D. H.: Cyclic nucleotide phosphodiesterase-mediated integration of cGMP and cAMP signaling in cells of the cardiovascular system. Front Biosci. 2005, 10, 1221-1228.
25. Maurice, D. H., D. Palmer, D. G. Tilley, H. A. Dunkerley, S. J. Netherton, D. R. Raymond, H. S. Elbatamy & S. L. Jimmo: Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system. Mol. Pharmacol. 2003, 64, 533-546.
26. Osinski, M. T., B. H. Rauch & K. Schror: Antimitogenic actions of organic nitrates are potentiated by sildenafil and mediated via activation of protein kinase A. Mol. Pharmacol. 2001, 59, 1044-1050.
27. Polson, J. B. & S. J. Strada: Cyclic nucleotide phosphodiesterases and vascular smooth muscle. Annu. Rev. Pharmacol. Toxicol. 1996, 36, 403-427.
28. Rajah, S. M., M. J. Crow, A. F. Penny, R. Ahmad & D. A. Watson: The effect of dipyridamole on platelet function: correlation with blood levels in man. Brit. J. Clin. Pharmacol. 1977, 4, 129-133.
29. Roy-Chaudhury, P., B. S. Kelly, M. A. Miller, A. Reaves, J. Armstrong, N. Nanayakkara et al.: Venous neointimal hyperplasia in polytetrafluoroethylene dialysis grafts. Kidney Int. 2001, 59, 2325-2334.
30. Rybalkin, S. D., I. Rybalkina, J. A. Beavo & K. E. Bornfeldt: Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation. Circ. Res. 2002, 90, 151-157.
31. Rybalkin, S. D., C. Yan, K. E. Bornfeldt & J. A. Beavo: Cyclic GMP phosphodiesterases and regulation of smooth muscle function. Circ. Res. 2003, 93, 280-291.
32. Rybalkin, S. D. & K. E. Bornfeldt: Cyclic nucleotide phosphodiesterases and human arterial smooth muscle cell proliferation. Thromb. Haemost. 1999, 82, 424-434.
33. Schlossmann, J., R. Feil & F. Hofmann: Signaling through NO and cGMP-dependent protein kinases. Ann. Med. 2003, 35, 21-27.
34. Schwab, S. J., J. T. Harrington, A. Singh, R. Roher, S. A. Shohaib, R. D. Perrone et al.: Vascular access for hemodialysis. Kidney Int. 1999, 55, 2078-2090.
35. Sreedhara, R., J. Himmelfarb, J. M. Lazarus & R. M. Hakim: Anti-platelet therapy in graft thrombosis: results of a prospective, randomized, double-blind study. Kidney Int. 1994, 45, 1477-1483.
36. Stork, P. J. & J. M. Schmitt: Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol. 2002, 12, 258-266.
37. Tantini, B., A. Manes, E. Fiumana, C. Pignatti, C. Guarnieri & R. Zannoli: Antiproliferative effect of sildenafil on human pulmonary artery smooth muscle cells. Basic Res. Cardiol. 2005, 100, 131-138.
38. Thompson, W. J.: Cyclic nucleotide phosphodiesterases. Pharmacol. Ther. 1991, 51, 13-33.
39. Thyberg, J.: Phenotypic modulation of smooth muscle cells during formation of neointimal thickenings following vascular injury. Histol. Histopathol. 1998, 13, 871-891.
40. Trerotola, S. O., S. W. Stavropoulos, R. Shlansky-Goldberg, C. M. Tuite, S. Kobrin & M. R. Rudnick: Hemodialysis-related venous stenosis: treatment with ultrahigh-pressure angioplasty balloons. Radiology 2004, 231, 259-262.
41. Wan, S., S. J. George, S. A. Nicklin, A. P. Yim & A. H. Baker: Overexpression of p53 increases lumen size and blocks neointima formation in porcine interposition vein grafts. Mol. Ther. 2004, 9, 689-698.
42. Wharton, J., J. W. Strange, G. M. Moller, E. J. Growcott, X. Ren, A. P. Franklyn et al.: Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells. Am. J. Respir. Crit. Care Med. 2005, 172, 105-113.
43. White, R. E., J. P. Kryman, A. M. El-Mowafy, G. Han & G. O. Carrier: cAMP-dependent vasodilators cross-activate the cGMP-dependent protein kinase to stimulate BK(Ca) channel activity in coronary artery smooth muscle cells. Circ. Res. 2000, 86, 897-905.
44. Zahavi, M., J. Zahavi & V. V. Kakkar: Effect of adenyl-cyclase activators, phosphodiesterase inhibitors and pyridoxal-5-phosphate on platelet aggregation and adenosine-3′-5′-cyclic monophosphate accumulation. Thromb. Haemost. 1984, 52, 205-209.
45. Zhu, W., T. Masaki, Y. H. Bae, R. Rathi, A. K. Cheung & S. E. Kern: Development of a sustained-release system for perivascular delivery of dipyridamole. J. Biomed. Mater Res. B Appl. Biomater. 2006, 77, 135-143.