Dipyridamole bioavailability in subjects with reduced gastric acidity

Journal of Clinical Pharmacology

Volumn 45, Issue 7, 2005, Pages 845-850

  Derendorf, Hartmut ^a   VanderMaelen, Cam P ^b   Brickl, Rolf Stefan ^c   MacGregor, Tom R ^b   Eisert, Wolfgang ^c  

^a UNIVERSITY OF FLORIDA   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Antiplatelet agents; Dipyridamole; Elderly; Gastric pH; Stroke prevention

Indexed keywords

ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID PLUS DIPYRIDAMOLE; DIPYRIDAMOLE; LANSOPRAZOLE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG FORMULATION; FEMALE; HUMAN; LOW DRUG DOSE; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; STOMACH PH;

ACHLORHYDRIA; ADULT; ASPIRIN; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; DIPYRIDAMOLE; DRUG COMBINATIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; TABLETS, ENTERIC-COATED;

EID: 21044453448     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/0091270005276738     Document Type: Article

References (19)

1. Patrono C, Coller B, Dalen JE, et al. Platelet-active drugs: the relationships among dose, effectiveness, and side effects. Chest. 2001;119:39S-63S
2. Eisert WG. Dipyridamole. In: Michelson A, ed. Platelets. New York, NY: Academic Press; 2002:803-815.
3. Hervey PS, Goa KL. Extended-release dipyridamole/aspirin. Drugs. 1999;58:469-475.
4. Lenz T, Wilson A. Clinical pharmacokinetics of antiplatelet agents used in the secondary prevention of stroke. Clin Pharmacokinet. 2003;42:909-920.
5. De Schryver EL, Algra A, van Gijn J. Cochrane review: dipyridamole for preventing major vascular events in patients with vascular disease. Stroke. 2003;34:2072-2080.
6. Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A. European Stroke Prevention Study, 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci. 1996;143:1-13.
7. Russell TL, Berardi RR, Barnett JL, O'Sullivan TL, Wagner JG, Dressman JB. pH-related changes in the absorption of dipyridamole in the elderly. Pharm Res. 1994;11:136-143.
8. VanderMaelen C, MacGregor T, Street J, Mueller T. Dipyridamole absorption from a composite capsule vs immediate-release tablets co-administered with aspirin in subjects with reduced stomach acidity. Neurology. 2002;58:A312.
9. Dresse A, Chevolet C, Delapierre D, et al. Pharmacokinetics of oral dipyridamole (Persantine) and its effect on platelet adenosine uptake in man. Eur J Clin Pharmacol. 1982;23:229-234.
10. Aggrenox [prescribing information]. Biberach, Germany: Boehringer-Ingelheim; 2004.
11. Huang SM, Lesko LJ. Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions: what have we learned? J Clin Pharmacol. 2004;44:559-569.
12. Jacobson BC, Ferris TG, Shea TL, Mahlis EM, Lee TH, Wang TC. Who is using chronic acid suppression therapy and why? Am J Gastroenterol. 2003;98:51-58.
13. Albengres E, Le Louet H, Tillement JP. Systemic antifungal agents: drug interactions of clinical significance. Drug Saf. 1998;18:83-97.
14. Barr WH, Gerbracht LM, Letcher K, Plaut M, Strahl N. Assessment of the biologic availability of tetracycline products in man. Clin Pharmacol Ther. 1972;13:97-108.
15. Hurwitz A. Antacid therapy and drug kinetics. Clin Pharmacokinet. 1977;2:269-280.
16. Taburet AM, Singlas E. Drug interactions with antiviral drugs. Clin Pharmacokinet. 1996;30:385-401.
17. Greenblatt DJ, Abernethy DR, Divoll M, Locniskar A, Harmatz JS, Shader RI. Noninteraction of temazepam and cimetidine. J Pharm Sci. 1984;73:399-401.
18. Ochs HR, Greenblatt DJ, Allen MD, Harmatz JS, Shader RI, Bodem G. Effect of age and Billroth gastrectomy on absorption of desmethyldiazepam from clorazepate. Clin Pharmacol Ther. 1979;26:449-456.
19. Charman WN, Porter CJ, Mithani S, Dressman JB. Physiochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH. J Pharm Sci. 1997;86:269-282.