메뉴 건너뛰기




Volumn 12, Issue 41, 2006, Pages 6658-6664

Effects of IκBα and its mutants on NF-κB and p53 signaling pathways

Author keywords

Inhibitor of NF B alpha; Nuclear factor B; p53; Real time QT PCR

Indexed keywords

BETA ACTIN; CHOLECYSTOKININ OCTAPEPTIDE; COMPLEMENTARY DNA; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MUTANT PROTEIN; PROTEIN BAX; PROTEIN P53; SYNAPTOTAGMIN; TUMOR NECROSIS FACTOR ALPHA; YELLOW FLUORESCENT PROTEIN; FLUORESCENT DYE; FLUORESCENT PROTEIN 583; I KAPPA B; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; PHOTOPROTEIN;

EID: 33751287346     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i41.6658     Document Type: Article
Times cited : (12)

References (40)
  • 1
    • 0022481133 scopus 로고
    • Multiple nuclear factors interact with the immunoglobulin enhancer sequences
    • Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986; 46: 705-716
    • (1986) Cell , vol.46 , pp. 705-716
    • Sen, R.1    Baltimore, D.2
  • 2
    • 0031126702 scopus 로고    scopus 로고
    • Rel/NF-kappa B and I kappa B proteins: An overview
    • May MJ, Ghosh S. Rel/NF-kappa B and I kappa B proteins: an overview. Semin Cancer Biol 1997; 8: 63-73
    • (1997) Semin Cancer Biol , vol.8 , pp. 63-73
    • May, M.J.1    Ghosh, S.2
  • 6
    • 0032217264 scopus 로고    scopus 로고
    • Structure of an IkappaBalpha/NF-kappaB complex
    • Jacobs MD, Harrison SC. Structure of an IkappaBalpha/NF-kappaB complex. Cell 1998; 95: 749-758
    • (1998) Cell , vol.95 , pp. 749-758
    • Jacobs, M.D.1    Harrison, S.C.2
  • 7
    • 0031469580 scopus 로고    scopus 로고
    • Rel/NF-kappa B transcription factors and I kappa B inhibitors: Evolution from a unique common ancestor
    • Huguet C, Crepieux P, Laudet V. Rel/NF-kappa B transcription factors and I kappa B inhibitors: evolution from a unique common ancestor. Oncogene 1997; 15: 2965-2974
    • (1997) Oncogene , vol.15 , pp. 2965-2974
    • Huguet, C.1    Crepieux, P.2    Laudet, V.3
  • 8
    • 0031126395 scopus 로고    scopus 로고
    • I kappa B proteins: Structure, function and regulation
    • Whiteside ST, Israel A. I kappa B proteins: structure, function and regulation. Semin Cancer Biol 1997; 8: 75-82
    • (1997) Semin Cancer Biol , vol.8 , pp. 75-82
    • Whiteside, S.T.1    Israel, A.2
  • 9
    • 0442307969 scopus 로고    scopus 로고
    • IkappaB kinases: Key regulators of the NF-kappaB pathway
    • Yamamoto Y, Gaynor RB. IkappaB kinases: key regulators of the NF-kappaB pathway. Trends Biochem Sci 2004; 29: 72-79
    • (2004) Trends Biochem Sci , vol.29 , pp. 72-79
    • Yamamoto, Y.1    Gaynor, R.B.2
  • 11
    • 0034741259 scopus 로고    scopus 로고
    • Degradation of IkappaBalpha is limited by a postphosphorylation/ ubiquitination event
    • Yang L, Chen H, Qwarnstrom E. Degradation of IkappaBalpha is limited by a postphosphorylation/ubiquitination event. Biochem Biophys Res Commun 2001; 285: 603-608
    • (2001) Biochem Biophys Res Commun , vol.285 , pp. 603-608
    • Yang, L.1    Chen, H.2    Qwarnstrom, E.3
  • 13
    • 0032052253 scopus 로고    scopus 로고
    • Signal-dependent degradation of IκBα is mediated by an inducible destruction box that can be transferred to NF-κB, Bcl-3 or p53
    • Wulczyn FG, Krappmann D, Scheidereit C. Signal-dependent degradation of IκBα is mediated by an inducible destruction box that can be transferred to NF-κB, Bcl-3 or p53. Nucleic Acids Res 1998; 26: 1724-1730
    • (1998) Nucleic Acids Res , vol.26 , pp. 1724-1730
    • Wulczyn, F.G.1    Krappmann, D.2    Scheidereit, C.3
  • 14
    • 0028148227 scopus 로고
    • A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B
    • Traenckner EB, Wilk S, Baeuerle PA. A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B. EMBO J 1994; 13: 5433-5441
    • (1994) EMBO J , vol.13 , pp. 5433-5441
    • Traenckner, E.B.1    Wilk, S.2    Baeuerle, P.A.3
  • 16
    • 0032943591 scopus 로고    scopus 로고
    • The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
    • Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR, Chiao PJ. The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 1999; 5: 119-127
    • (1999) Clin Cancer Res , vol.5 , pp. 119-127
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3    Larry, L.4    Cleary, K.R.5    Chiao, P.J.6
  • 17
    • 0032559888 scopus 로고    scopus 로고
    • Defective IkappaBalpha in Hodgkin cell lines with constitutively active NF-kappaB
    • Wood KM, Roff M, Hay RT. Defective IkappaBalpha in Hodgkin cell lines with constitutively active NF-kappaB. Oncogene 1998; 16: 2131-2139
    • (1998) Oncogene , vol.16 , pp. 2131-2139
    • Wood, K.M.1    Roff, M.2    Hay, R.T.3
  • 18
    • 0037376895 scopus 로고    scopus 로고
    • NF-kappaB in cancer: A marked target
    • Lin A, Karin M. NF-kappaB in cancer: a marked target. Semin Cancer Biol 2003; 13: 107-114
    • (2003) Semin Cancer Biol , vol.13 , pp. 107-114
    • Lin, A.1    Karin, M.2
  • 19
    • 0442323562 scopus 로고    scopus 로고
    • NF-kappaB: Tumor promoter or suppressor?
    • Perkins ND. NF-kappaB: tumor promoter or suppressor? Trends Cell Biol 2004; 14: 64-69
    • (2004) Trends Cell Biol , vol.14 , pp. 64-69
    • Perkins, N.D.1
  • 21
    • 0035849720 scopus 로고    scopus 로고
    • Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
    • Huang S, Pettaway CA, Uehara H, Bucana CD, Fidler IJ. Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 2001; 20: 4188-4197
    • (2001) Oncogene , vol.20 , pp. 4188-4197
    • Huang, S.1    Pettaway, C.A.2    Uehara, H.3    Bucana, C.D.4    Fidler, I.J.5
  • 22
    • 0034306969 scopus 로고    scopus 로고
    • Blockade of nuclear factor-κB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8
    • Huang S, Robinson JB, Deguzman A, Bucana CD, Fidler IJ. Blockade of nuclear factor-κB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res 2000; 60: 5334-5339
    • (2000) Cancer Res , vol.60 , pp. 5334-5339
    • Huang, S.1    Robinson, J.B.2    Deguzman, A.3    Bucana, C.D.4    Fidler, I.J.5
  • 23
    • 0037155893 scopus 로고    scopus 로고
    • The non-ankyrin C terminus of IκBα physically interacts with p53 in vivo and dissociates in response to apoptotic stresss, hypoxia, DNA damage, and transforming growth factor-β1-mediated growth suppression
    • Chang NS. The non-ankyrin C terminus of IκBα physically interacts with p53 in vivo and dissociates in response to apoptotic stresss, hypoxia, DNA damage, and transforming growth factor-β1-mediated growth suppression. J Biol Chem 2002; 277: 10323-10331
    • (2002) J Biol Chem , vol.277 , pp. 10323-10331
    • Chang, N.S.1
  • 25
    • 0037134431 scopus 로고    scopus 로고
    • The Phosphatidylinositol 3-Kinase (PI3K)-Akt Pathway Suppresses Bax Translocation to Mitochondria
    • Tsuruta F, Masuyama N, Gotoh Y. The Phosphatidylinositol 3-Kinase (PI3K)-Akt Pathway Suppresses Bax Translocation to Mitochondria. J Biol Chem 2002; 277: 14040-14047
    • (2002) J Biol Chem , vol.277 , pp. 14040-14047
    • Tsuruta, F.1    Masuyama, N.2    Gotoh, Y.3
  • 26
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl HL. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999; 18: 6853-6866
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 28
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29: 2002-2007
    • (2001) Nucleic Acids Res , vol.29 , pp. 2002-2007
    • Pfaffl, M.W.1
  • 29
    • 0029845760 scopus 로고    scopus 로고
    • Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies
    • Harris CC. Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies. J Natl Cancer Inst 1996; 88: 1442-1455
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1442-1455
    • Harris, C.C.1
  • 30
    • 0030448650 scopus 로고    scopus 로고
    • Identification of a novel p53 functional domain that is necessary for efficient growth suppression
    • Walker KK, Levine AJ. Identification of a novel p53 functional domain that is necessary for efficient growth suppression. PNAS 1996; 93: 15335-15340
    • (1996) PNAS , vol.93 , pp. 15335-15340
    • Walker, K.K.1    Levine, A.J.2
  • 32
    • 0032566439 scopus 로고    scopus 로고
    • IκBα Functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-κB
    • Malek S, Huxford T, Ghosh G. IκBα Functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-κB. J Biol Chem 1998; 273: 25427-25435
    • (1998) J Biol Chem , vol.273 , pp. 25427-25435
    • Malek, S.1    Huxford, T.2    Ghosh, G.3
  • 34
    • 0345256337 scopus 로고    scopus 로고
    • Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: Interaction of IkBm. and p53
    • Zhou M, Gu L, Zhu N, Woods WG, Findley HW. Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: interaction of IkBm. and p53. Oncogene 2003; 22: 8137-8144
    • (2003) Oncogene , vol.22 , pp. 8137-8144
    • Zhou, M.1    Gu, L.2    Zhu, N.3    Woods, W.G.4    Findley, H.W.5
  • 35
    • 0033558155 scopus 로고    scopus 로고
    • Stable inhibition of nuclear factor κB in cancer cells does not increase sensitivity to cytotoxic drugs
    • Bentires-Alj M, Hellin AC, Ameyar M, Chouaib S, Merville MP, Bours V. Stable inhibition of nuclear factor κB in cancer cells does not increase sensitivity to cytotoxic drugs. Cancer Res 1999; 59: 811-815
    • (1999) Cancer Res , vol.59 , pp. 811-815
    • Bentires-Alj, M.1    Hellin, A.C.2    Ameyar, M.3    Chouaib, S.4    Merville, M.P.5    Bours, V.6
  • 38
    • 0034689773 scopus 로고    scopus 로고
    • Role of NF-kappaB in p53-mediated programmed cell death
    • Ryan KM, Ernst MK, Rice NR, Vousden KH. Role of NF-kappaB in p53-mediated programmed cell death. Nature 2000; 404: 892-897
    • (2000) Nature , vol.404 , pp. 892-897
    • Ryan, K.M.1    Ernst, M.K.2    Rice, N.R.3    Vousden, K.H.4
  • 40
    • 0036546501 scopus 로고    scopus 로고
    • NF-kappaB in cancer: From innocent bystander to major culprit
    • Karin M, Cao Y, Greten FR, Li ZW. NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2002; 2: 301-310
    • (2002) Nat Rev Cancer , vol.2 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3    Li, Z.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.