Evaluation of porous carrier-based floating orlistat microspheres for gastric delivery

AAPS PharmSciTech

Volumn 7, Issue 4, 2006, Pages

  Jain, Sunil K ^a   Agrawal, Govind P ^b   Jain, Narendra K ^b  

^a GURU GHASIDAS UNIVERSITY   (India)

^b DR H S GOUR UNIVERSITY   (India)

Author keywords

Calcium silicate; Floating drug delivery; Gamma scintigraphy; Microspheres; Orlistat; Pharmacokinetic study

Indexed keywords

CALCIUM SILICATE; DRUG CARRIER; EUDRAGIT; MICROSPHERE; POLYMER; SOLVENT; TETRAHYDROLIPSTATIN; LACTONE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG HALF LIFE; EVAPORATION; GAMMA SCINTIGRAPHY; GASTROINTESTINAL ABSORPTION; IN VITRO STUDY; MALE; MORPHOLOGY; NONHUMAN; RABBIT; STOMACH JUICE; ANIMAL; BODY FLUID; CHEMISTRY; ENTERIC COATED TABLET; EVALUATION; MATERIALS TESTING; METABOLISM; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; POROSITY; STOMACH;

ADMINISTRATION, ORAL; ANIMALS; BODY FLUIDS; DRUG CARRIERS; GASTRIC JUICE; LACTONES; MATERIALS TESTING; MICROSPHERES; PARTICLE SIZE; POROSITY; RABBITS; STOMACH; TABLETS, ENTERIC-COATED;

EID: 33751253485     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt070490     Document Type: Article

References (22)

1. Singh BM, Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Control Release. 2000;63:235-259.
2. Srivastava AK, Ridhurkar DN, Wadhwa S. Floating microspheres of cimetidine: formulation, characterization and in vitro evaluation. Acta Pharm. 2005;55:277-285.
3. Sato Y, Kawashima Y, Takeuchi H, Yamamoto H. Physicochemical properties to determine the buoyancy of hollow microspheres (microballons) prepared by the emulsion solvent diffusion method. Eur J Pharm Biopharm. 2003;55:297-304.
4. Sato Y, Kawashima Y, Takeuchi H, Yamamoto H. In vivo evaluation of riboflavin containing microballons for floating controlled drug delivery system in healthy human volunteers. J Control Release. 2003;93:39-47.
5. Streubel A, Siepmann J, Bodmeier R. Floating microparticles based on low density foam powder. Int J Pharm. 2002;241:279-292.
6. Jain SK, Awasthi AM, Jain NK, Agrawal GP. Calcium silicate based microspheres of repaglinide for gastro-retentive floating drug delivery: preparation and in vitro characterization. J Control Release. 2005;107:300-309.
7. Jain SK, Agrawal GP, Jain NK. A novel calcium silicate based microspheres of repaglinide: in vivo investigations. J Control Release. 2006;113:111-116.
8. Jain AK, Jain SK, Yadav A, Agrawal GP. Controlled release calcium silicate based floating granular delivery system of ranitidine hydrochloride. Curr Drug Deliv. 2006; In press.
9. Keating GM, Jarvis B. Orlistat. Drugs. 2001;61:2107-2119.
10. Yuasa H, Takashima Y, Kanaya Y. Studies on the development of intragastric floating and sustained release preparation. I. Application of calcium silicate as a floating carrier. Chem Pharm Bull (Tokyo). 1996;44:1361-1366.
11. Kawashima Y, Niwa T, Takeuchi H, Hino T, Itoh Y. Hollow microspheres for use as a floating controlled drug delivery system in the stomach. J Pharm Sci. 1992;81:135-140.
12. Choi HK, Lee JH, Park TG. Effect of formulation and processing variables on the characteristics of microspheres for water-soluble drugs prepared by w/o/o double emulsion solvent diffusion method. Int J Pharm. 2000;196:75-83.
13. Martin A. ed. Micrometrics. In: Physical Pharmacy. 4th ed. Philadelphia, PA: Lea Febiger; 1993:431-432.
14. Bennett PK, Li YT, Edom R, Henion J. Quantitative determination of Orlistat (tetrahydrolipostatin, Ro 18-0647) in human plasma by high-performance liquid chromatography coupled with ion spray tandem mass spectrometry. J Mass Spectrom. 1997;32:739-749.
15. Wieboldt R, Campbell DA, Henion J. Quantitative liquid chromatographic-tandem mass spectrometric determination of orlistat in plasma with a quadrupole ion trap. J Chromatogr B Biomed Sci Appl. 1998;708:121-129.
16. Polli JE, Rehki GS, Augsburger LL, Shah VP. Methods to compare dissolution profiles and a rationale for wide dissolution specification for metoprolol tartrate tablets. J Pharm Sci. 1997; 86:690-700.
17. Wu PC, Tsai MJ, Huang YB, Cheng JS, Tsai YH. In vitro and in vivo evaluation of potassium chloride sustained release formulation prepared with saturated polyglycolyed glycerides matrices. Int J Pharm. 2002;243:119-124.
18. Atyabi F, Sharma HL, Mohammad HAH, Fell JT. In vivo evaluation of a novel gastro-retentive formulation based on ion exchange resins. J Control Release. 1996;42:105-113.
19. El-Kamel AH, Sokar MS, Al-Gamal SS, Naggar VF. Preparation and evaluation of ketoprofen floating oral delivery system. Int J Pharm. 2001;220:13-21.
20. Desai S, Bolton S. A floating controlled-release drug delivery system: in vitro-in vivo evaluation. Pharm Res. 1993;10: 1321-1325.
21. Khattar D, Ahuja A, Khar RK. Hydrodynamically balanced systems as sustained release dosage forms for propranolol hydrochloride. Pharmazie. 1990;45:356-358.
22. Saha GB. ed. Fundamentals of Nuclear Pharmacy. In: Radiolabeling of Compounds. New York, NY: Springer-Verlag; 1979:86-91.