In vivo evaluation of riboflavin-containing microballoons for floating controlled drug delivery system in healthy human volunteers

Journal of Controlled Release

Volumn 93, Issue 1, 2003, Pages 39-47

  Sato, Yasunori ^a   Kawashima, Yoshiaki ^b   Takeuchi, Hirofumi ^b   Yamamoto, Hiromitsu ^b  

^a Grelan Pharmaceutical Co Ltd   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Emulsion solvent diffusion method; Floating controlled drug delivery system; Gastric residence time (GRT); Hollow microsphere (microballoon); Urinary excretion

Indexed keywords

ACRYLICS; DRUG INFUSION; EMULSIONS; SOLVENTS;

RIBOFLAVINS;

DRUG INTERACTIONS;

DISPERSANT; EUDRAGIT; GLYCEROL STEARATE; HYDROXYPROPYLMETHYLCELLULOSE; MICROSPHERE; POLYVINYL ALCOHOL; RIBOFLAVIN;

ACIDITY; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG SOLUBILITY; DRUG URINE LEVEL; EVALUATION; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; NORMAL HUMAN; POWDER; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; SUSTAINED DRUG RELEASE;

EID: 0242321140     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(03)00370-5     Document Type: Article

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