Ion pair-mediated transport of metoprolol across a three lipid-component PAMPA system

Journal of Controlled Release

Volumn 116, Issue 1, 2006, Pages 50-57

  Teksin, Zeynep S ^a,b   Hom, Kelli ^a   Balakrishnan, Anand ^a   Polli, James E ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b GAZI UNIVERSITY   (Turkey)

Author keywords

Fluidity; Ion pair; Membrane transport; Metoprolol; PAMPA; Permeability

Indexed keywords

ANISOTROPY; FLUIDITY; LIPIDS; MATHEMATICAL MODELS; NUCLEAR MAGNETIC RESONANCE; TRANSPORT PROPERTIES;

ION PAIRS; MEMBRANE TRANSPORT; METOPROLOLS; PARALLEL ARTIFICIAL MEMBRANE PERMEABILITY ASSAY (PAMPA);

DRUG PRODUCTS;

CATION; DIOLEOYLPHOSPHATIDYLSERINE; LIPID; METOPROLOL;

ANISOTROPY; ARTICLE; CELL MEMBRANE; DRUG PENETRATION; DRUG SCREENING; DRUG TRANSPORT; IONIC STRENGTH; LIPID COMPOSITION; MEMBRANE FLUIDITY; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; PARALLEL ARTIFICIAL MEMBRANE PERMEABILITY ASSAY; PH; PRIORITY JOURNAL;

ADRENERGIC BETA-ANTAGONISTS; ALGORITHMS; ANISOTROPY; BENZOIC ACID; IONS; LIPIDS; LIPOSOMES; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANES, ARTIFICIAL; METOPROLOL; PERMEABILITY; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLSERINES; QUATERNARY AMMONIUM COMPOUNDS;

EID: 33751249620     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.08.020     Document Type: Article

References (32)

1. Kansy M., Senner F., and Gubernator K. Physicochemical high throughput screening: Parallel Artificial Membrane Permeability Assay in the description of passive absorption processes. J. Med. Chem. 41 (1998) 1007-1010
2. Wohnsland F., and Faller B. Permeability pH profile and high-throughput alkane/water log P artificial membranes. J. Med. Chem. 44 (2001) 923-930
3. B. Faller, F. Wohnsland, Physicochemical Parameters as Tools in Drug Discovery and Lead Optimization. in: B. Testa, H. van de Waterbeemd, G. Folkers, R. Guy (Eds.) Pharmacokinetic Optimization in Drug Research, Weinheim: Verlag Helvetica Chimica Acta: Zürich and Wiley - VCH, 2001, pp. 257-274.
4. Avdeef A. High-throughput measurement of permeability profiles. In: van de Waterbeemd H., Lennernas H., and Artusson P. (Eds). Drug Bioavailability - Estimation of Solubility, Permeability and Absorption (2002), Wiley-VCH, Weinheim 1-14
5. Balimane P.V., Han Y.-H., and Chong S. Current industrial practices of assessing permeability and P-glycoprotein interaction. AAPS J. 8 1 (2006) E1-E13 10.1208/aapsj080101
6. Kerns E.H., Li D., Petusky S., Farris M., Ley R., and Jupp P. Combined application of parallel artificial membrane permeability assay and Caco-2 permeability assays in drug discovery. J. Pharm. Sci. 93 (2004) 1440-1453
7. Sugano K., Hamada H., Machida M., and Ushio H. High throughput prediction of oral absorption: improvement of the composition of the lipid solution used in parallel artificial membrane permeation assay. J. Biomol. Screen. 6 (2001) 189-196
8. Sugano K., Nabuchi Y., Machida M., and Asoh Y. Prediction of human intestinal permeability using artificial membrane permeability. Int. J. Pharm. 257 (2003) 245-251
9. Bermejo M., Avdeef A., Ruiz A., Nalda R., Ruell J.A., Tsinman O., Gonzales I., Fernandez C., Sanchez G., Garrigues T.M., and Merino V. PAMPA-a drug absorption in vitro model 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones. Eur. J. Pharm. Sci. 21 (2004) 429-441
10. Polli J.E., Balakrishnan A., and Seo P.R. Human intestinal cellular characteristics and drug permeability. In: Lu D.R., and θie S. (Eds). Cellular Drug Delivery (2004), Humana Press Inc., Totowa, NJ 163-180
11. P.R. Seo, Z.S. Teksin, J.P.Y. Kao, J.E. Polli, Lipid composition effect on permeability across PAMPA. Eur. J. Pharm. Sci. in press. Available at: http://www.sciencedirect.com/science/journal/09280987.
12. Sugano K., Nabuchi Y., Machida M., and Asoh Y. Permeation characteristics of a hydrophilic basic compound across a bio-mimetic artificial membrane. Int. J. Pharm. 275 (2004) 271-278
13. Proulx P. Structure-function relationships in intestinal brush border membranes. Biochim. Biophys. Acta 1071 (1991) 255-271
14. Hubner C., Lindner S.G., Stern M., Claussen M., and Kohlschutter A. Membrane fluidity and lipid composition of rat small intestinal brush-border membranes during postnatal maturation. Biochim. Biophys. Acta 939 (1988) 145-150
15. Brasitus T.A., and Dudeja P.K. Effect of hypothyroidism on the lipid composition and fluidity of rat colonic apical plasma membranes. Biochim. Biophys. Acta. 939 (1988) 189-196
16. Pillay V., and Fassihi R. A novel approach for constant rate delivery of highly soluble bioactives from a simple monolithic system. J. Control. Release 67 (2000) 67-78
17. Rekhi G.S., Nellore R.V., Hussain A.S., Tillman L.G., Malinowski H.J., and Augsburger L.L. Identification of critical formulation and processing variables for metoprolol tartrate extended-release (ER) matrix tablets. J. Control. Release 59 (1999) 327-342
18. Lentz K.A., Hayashi J., Lucisano L.J., and Polli J.E. Development of a more rapid, reduced serum culture system for Caco-2 monolayers and application to the biopharmaceutics classification system. Int. J. Pharm. 200 (2000) 41-51
19. a-flux method. Eur. J. Pharm. Sci. 24 (2005) 333-349
20. Tolle-Sander S., Grill A., Joshi H., Kapil R., Persiani S., and Polli J.E. Characterization of dexloiglumide in vitro biopharmaceutical properties and active transport. J. Pharm. Sci. 92 (2003) 1968-1980
21. Straume M., and Litman B.J. Influence of cholesterol on equilibrium and dynamic bilayer structure of unsaturated acyl chain phosphatidylcholine vesicles as determined from higher order analysis of fluorescence anisotropy decay. Biochemistry 26 (1987) 5121-5126
22. Rege B.D., Kao J.P., and Polli J.E. Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers. Eur. J. Pharm. Sci. 16 (2002) 237-246
23. Delaglio F., Grzesiek S., Vuister G.W., Zhu G., Pfeifer J., and Bax A. NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J. Biomol. NMR 6 (1995) 277-293
24. Goddard T.D., and Kneller D.G. SPARKY 3 (2003), University of California, San Francisco, CA
25. Marat K. SpinWorks (2004), University of Manitoba, Manitoba, Canada
26. Artursson P., Palm K., and Luthman K. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv. Drug Deliv. Rev. 46 (2001) 27-43
27. Okada M., Watanabe T., Imamura K., Tsurumi T., Suma Y., and Sakai K. Ionic strength affects diffusive permeability to an inorganic phosphate ion of negatively charged dialysis membranes. ASAIO Trans. 36 (1990) 324-327
28. Seimiya T., Miyasaka H., Kato T., Shirakawa T., Ohbu K., and Iwahashi M. Effects of composition and molecular packing on ionic properties of lipid monolayer having both cationic and anionic head groups. Chem. Phys. Lipids 43 (1987) 161-177
29. Quintanar-Guerrero D., Allemann E., Fessi H., and Doelker E. Applications of the ion-pair concept to hydrophilic substances with special emphasis on peptides. Pharm. Res. 14 (1997) 119-127
30. Bernkop-Schnurch A., Pinter Y., Guggi D., Kahlbacher H., Schoffmann G., Schuh M., Schmerold I., Del Curto M.D., D'Antonio M., Esposito P., and Huck C. The use of thiolated polymers as carrier matrix in oral peptide delivery-proof of concept. J. Control. Release 106 (2005) 26-33
31. Jain S.K., Awasthi A.M., Jain N.K., and Agrawal G.P. Calcium silicate based microspheres of repaglinide for gastroretentive floating drug delivery: preparation and in vitro characterization. J. Control. Release 107 (2005) 300-309
32. Ravishankar H., Patil P., Samel A., Petereit H.U., Lizio R., and Iyer-Chavan J. Modulated release metoprolol succinate fonnulation based on ionic interactions: in vivo proof of concept. J. Control. Release 111 (2006) 65-72