메뉴 건너뛰기




Volumn 17, Issue 6, 2006, Pages 580-588

Functional DNA nanotechnology: emerging applications of DNAzymes and aptamers

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; ENZYMES; GENETIC ENGINEERING; NANOSTRUCTURED MATERIALS; NANOTECHNOLOGY;

EID: 33751247017     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.copbio.2006.10.004     Document Type: Review
Times cited : (267)

References (61)
  • 1
    • 0029781508 scopus 로고    scopus 로고
    • A DNA-based method for rationally assembling nanoparticles into macroscopic materials
    • Mirkin C.A., Letsinger R.L., Mucic R.C., and Storhoff J.J. A DNA-based method for rationally assembling nanoparticles into macroscopic materials. Nature 382 (1996) 607-609
    • (1996) Nature , vol.382 , pp. 607-609
    • Mirkin, C.A.1    Letsinger, R.L.2    Mucic, R.C.3    Storhoff, J.J.4
  • 3
    • 0347417135 scopus 로고    scopus 로고
    • Programmed materials synthesis with DNA
    • Storhoff J.J., and Mirkin C.A. Programmed materials synthesis with DNA. Chem Rev 99 (1999) 1849-1862
    • (1999) Chem Rev , vol.99 , pp. 1849-1862
    • Storhoff, J.J.1    Mirkin, C.A.2
  • 4
    • 85015106657 scopus 로고    scopus 로고
    • DNA in a material world
    • Seeman N.C. DNA in a material world. Nature 421 (2003) 427-431
    • (2003) Nature , vol.421 , pp. 427-431
    • Seeman, N.C.1
  • 5
    • 10044258525 scopus 로고    scopus 로고
    • Nanobiotechnology: integrated nanoparticle-biomolecule hybrid systems: synthesis, properties, and applications
    • Katz E., and Willner I. Nanobiotechnology: integrated nanoparticle-biomolecule hybrid systems: synthesis, properties, and applications. Angew Chem Int Ed Engl 43 (2004) 6042-6108
    • (2004) Angew Chem Int Ed Engl , vol.43 , pp. 6042-6108
    • Katz, E.1    Willner, I.2
  • 6
    • 33646587741 scopus 로고    scopus 로고
    • Rational design of DNA nanoarchitectures
    • Feldkamp U., and Niemeyer C.M. Rational design of DNA nanoarchitectures. Angew Chem Int Ed Engl 45 (2006) 1856-1876
    • (2006) Angew Chem Int Ed Engl , vol.45 , pp. 1856-1876
    • Feldkamp, U.1    Niemeyer, C.M.2
  • 8
    • 0141534348 scopus 로고    scopus 로고
    • DNA-templated self-assembly of protein arrays and highly conductive nanowires
    • Yan H., Park S.H., Finkelstein G., Reif J.H., and LaBean T.H. DNA-templated self-assembly of protein arrays and highly conductive nanowires. Science 301 (2003) 1882-1884
    • (2003) Science , vol.301 , pp. 1882-1884
    • Yan, H.1    Park, S.H.2    Finkelstein, G.3    Reif, J.H.4    LaBean, T.H.5
  • 9
    • 31444440039 scopus 로고    scopus 로고
    • DNA-templated self-assembly of two-dimensional and periodical gold nanoparticle arrays
    • Sharma J., Chhabra R., Liu Y., Ke Y., and Yan H. DNA-templated self-assembly of two-dimensional and periodical gold nanoparticle arrays. Angew Chem Int Ed Engl 45 (2006) 730-735
    • (2006) Angew Chem Int Ed Engl , vol.45 , pp. 730-735
    • Sharma, J.1    Chhabra, R.2    Liu, Y.3    Ke, Y.4    Yan, H.5
  • 10
    • 20644466231 scopus 로고    scopus 로고
    • DNA-encoded self-assembly of gold nanoparticles into one-dimensional arrays
    • Deng Z., Tian Y., Lee S.-H., Ribbe A.E., and Mao C. DNA-encoded self-assembly of gold nanoparticles into one-dimensional arrays. Angew Chem Int Ed Engl 44 (2005) 3582-3585
    • (2005) Angew Chem Int Ed Engl , vol.44 , pp. 3582-3585
    • Deng, Z.1    Tian, Y.2    Lee, S.-H.3    Ribbe, A.E.4    Mao, C.5
  • 11
    • 33746317783 scopus 로고    scopus 로고
    • DNA polymerization on gold nanoparticles through rolling circle amplification: towards novel scaffolds for three-dimensional periodic nanoassemblies
    • Zhao W., Gao Y., Kandadai S.A., Brook M.A., and Li Y. DNA polymerization on gold nanoparticles through rolling circle amplification: towards novel scaffolds for three-dimensional periodic nanoassemblies. Angew Chem Int Ed Engl 45 (2006) 2409-2413
    • (2006) Angew Chem Int Ed Engl , vol.45 , pp. 2409-2413
    • Zhao, W.1    Gao, Y.2    Kandadai, S.A.3    Brook, M.A.4    Li, Y.5
  • 12
    • 0025074907 scopus 로고
    • In vitro selection of RNA molecules that bind specific ligands
    • Ellington A.D., and Szostak J.W. In vitro selection of RNA molecules that bind specific ligands. Nature 346 (1990) 818-822
    • (1990) Nature , vol.346 , pp. 818-822
    • Ellington, A.D.1    Szostak, J.W.2
  • 13
    • 0025194307 scopus 로고
    • Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
    • Tuerk C., and Gold L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249 (1990) 505-510
    • (1990) Science , vol.249 , pp. 505-510
    • Tuerk, C.1    Gold, L.2
  • 14
    • 0032853242 scopus 로고    scopus 로고
    • In vitro selection of functional nucleic acids
    • Wilson D.S., and Szostak J.W. In vitro selection of functional nucleic acids. Annu Rev Biochem 68 (1999) 611-647
    • (1999) Annu Rev Biochem , vol.68 , pp. 611-647
    • Wilson, D.S.1    Szostak, J.W.2
  • 15
    • 0028675028 scopus 로고
    • A DNA enzyme that cleaves RNA
    • Breaker R.R., and Joyce G.F. A DNA enzyme that cleaves RNA. Chem Biol 1 (1994) 223-229
    • (1994) Chem Biol , vol.1 , pp. 223-229
    • Breaker, R.R.1    Joyce, G.F.2
  • 16
    • 11144330098 scopus 로고    scopus 로고
    • Natural and engineered nucleic acids as tools to explore biology
    • This review emphasizes the biological applications of both natural and synthetic functional nucleic acids, including aptamers, aptazymes and riboswitches.
    • Breaker R.R. Natural and engineered nucleic acids as tools to explore biology. Nature 432 (2004) 838-845. This review emphasizes the biological applications of both natural and synthetic functional nucleic acids, including aptamers, aptazymes and riboswitches.
    • (2004) Nature , vol.432 , pp. 838-845
    • Breaker, R.R.1
  • 17
    • 3042737151 scopus 로고    scopus 로고
    • Colorimetric biosensors based on DNAzyme-assembled gold nanoparticles
    • Liu J.W., and Lu Y. Colorimetric biosensors based on DNAzyme-assembled gold nanoparticles. J Fluoresc 14 (2004) 343-354
    • (2004) J Fluoresc , vol.14 , pp. 343-354
    • Liu, J.W.1    Lu, Y.2
  • 18
    • 33744548059 scopus 로고    scopus 로고
    • Nucleic acid aptamers and enzymes as sensors
    • Navani N.K., and Li Y. Nucleic acid aptamers and enzymes as sensors. Curr Opin Chem Biol 10 (2006) 272-281
    • (2006) Curr Opin Chem Biol , vol.10 , pp. 272-281
    • Navani, N.K.1    Li, Y.2
  • 19
  • 20
    • 0037131433 scopus 로고    scopus 로고
    • New transition metal-dependent DNAzymes as efficient endonucleases and as selective metal biosensors
    • Lu Y. New transition metal-dependent DNAzymes as efficient endonucleases and as selective metal biosensors. Chem Eur J 8 (2002) 4588-4596
    • (2002) Chem Eur J , vol.8 , pp. 4588-4596
    • Lu, Y.1
  • 21
    • 3042732096 scopus 로고    scopus 로고
    • Directed evolution of nucleic acid enzymes
    • Joyce G.F. Directed evolution of nucleic acid enzymes. Annu Rev Biochem 73 (2004) 791-836
    • (2004) Annu Rev Biochem , vol.73 , pp. 791-836
    • Joyce, G.F.1
  • 23
    • 0038209225 scopus 로고    scopus 로고
    • A colorimetric lead biosensor using DNAzyme-directed assembly of gold nanoparticles
    • 2+-responsive system was also demonstrated.
    • 2+-responsive system was also demonstrated.
    • (2003) J Am Chem Soc , vol.125 , pp. 6642-6643
    • Liu, J.1    Lu, Y.2
  • 25
    • 4644238630 scopus 로고    scopus 로고
    • 2+ detection
    • 2+ detection. J Am Chem Soc 126 (2004) 12298-12305
    • (2004) J Am Chem Soc , vol.126 , pp. 12298-12305
    • Liu, J.1    Lu, Y.2
  • 26
    • 24744458576 scopus 로고    scopus 로고
    • Stimuli-responsive disassembly of nanoparticle aggregates for light-up colorimetric sensing
    • 2+ was also shown.
    • 2+ was also shown.
    • (2005) J Am Chem Soc , vol.127 , pp. 12677-12683
    • Liu, J.1    Lu, Y.2
  • 27
    • 27844538979 scopus 로고    scopus 로고
    • Proofreading and error removal in a nanomaterial assembly
    • This paper first proposed and demonstrated the concept of using functional biomolecules not only to template nanomaterial assembly, but also to perform proofreading and error correction functions in a way similar to biological systems.
    • Liu J., Wernette D.P., and Lu Y. Proofreading and error removal in a nanomaterial assembly. Angew Chem Int Ed Engl 44 (2005) 7290-7293. This paper first proposed and demonstrated the concept of using functional biomolecules not only to template nanomaterial assembly, but also to perform proofreading and error correction functions in a way similar to biological systems.
    • (2005) Angew Chem Int Ed Engl , vol.44 , pp. 7290-7293
    • Liu, J.1    Wernette, D.P.2    Lu, Y.3
  • 28
    • 33748260175 scopus 로고    scopus 로고
    • Design of asymmetric DNAzymes for dynamic control of nanoparticle aggregation states in response to chemical stimuli
    • Liu J., and Lu Y. Design of asymmetric DNAzymes for dynamic control of nanoparticle aggregation states in response to chemical stimuli. Org Biomol Chem 4 (2006) 3435-3441
    • (2006) Org Biomol Chem , vol.4 , pp. 3435-3441
    • Liu, J.1    Lu, Y.2
  • 29
    • 24644519793 scopus 로고    scopus 로고
    • Highly active and stable DNAzyme-carbon nanotube hybrids
    • 2+-specific DNAzyme was immobilized onto carbon nanotubes to form stable and highly active hybrids capable of performing over 400 catalytic turnovers.
    • 2+-specific DNAzyme was immobilized onto carbon nanotubes to form stable and highly active hybrids capable of performing over 400 catalytic turnovers.
    • (2005) J Am Chem Soc , vol.127 , pp. 12200-12201
    • Yim, T.-J.1    Liu, J.2    Lu, Y.3    Kane, R.S.4    Dordick, J.S.5
  • 31
    • 30944468517 scopus 로고    scopus 로고
    • Incorporation of a DNAzyme into Au-coated nanocapillary array membranes with an internal standard for Pb(II) sensing
    • Wernette D.P., Swearingen C.B., Cropek D.M., Lu Y., Sweedler J.V., and Bohn P.W. Incorporation of a DNAzyme into Au-coated nanocapillary array membranes with an internal standard for Pb(II) sensing. Analyst 131 (2006) 41-47
    • (2006) Analyst , vol.131 , pp. 41-47
    • Wernette, D.P.1    Swearingen, C.B.2    Cropek, D.M.3    Lu, Y.4    Sweedler, J.V.5    Bohn, P.W.6
  • 36
    • 4544365768 scopus 로고    scopus 로고
    • An autonomous DNA nanomotor powered by a DNA enzyme
    • Chen Y., Wang M., and Mao C. An autonomous DNA nanomotor powered by a DNA enzyme. Angew Chem Int Ed Engl 43 (2004) 3554-3557
    • (2004) Angew Chem Int Ed Engl , vol.43 , pp. 3554-3557
    • Chen, Y.1    Wang, M.2    Mao, C.3
  • 37
    • 3242741738 scopus 로고    scopus 로고
    • Putting a brake on an autonomous DNA nanomotor
    • A DNAzyme-based free-running nanomotor was previously reported. This paper demonstrated a way to control the free-running nanomotor by using inactive, but structurally related, DNA sequences.
    • Chen Y., and Mao C. Putting a brake on an autonomous DNA nanomotor. J Am Chem Soc 126 (2004) 8626-8627. A DNAzyme-based free-running nanomotor was previously reported. This paper demonstrated a way to control the free-running nanomotor by using inactive, but structurally related, DNA sequences.
    • (2004) J Am Chem Soc , vol.126 , pp. 8626-8627
    • Chen, Y.1    Mao, C.2
  • 38
    • 22744435354 scopus 로고    scopus 로고
    • A DNAzyme that walks processively and autonomously along a one-dimensional track
    • A sophisticated system was designed to transport a DNAzyme along a DNA track. In this 'walking' system, the walker carries an enzymatic function that enables it to move forward.
    • Tian Y., He Y., Chen Y., Yin P., and Mao C. A DNAzyme that walks processively and autonomously along a one-dimensional track. Angew Chem Int Ed Engl 44 (2005) 4355-4358. A sophisticated system was designed to transport a DNAzyme along a DNA track. In this 'walking' system, the walker carries an enzymatic function that enables it to move forward.
    • (2005) Angew Chem Int Ed Engl , vol.44 , pp. 4355-4358
    • Tian, Y.1    He, Y.2    Chen, Y.3    Yin, P.4    Mao, C.5
  • 39
    • 0037462083 scopus 로고    scopus 로고
    • Structure-switching signaling aptamers
    • Nutiu R., and Li Y. Structure-switching signaling aptamers. J Am Chem Soc 125 (2003) 4771-4778
    • (2003) J Am Chem Soc , vol.125 , pp. 4771-4778
    • Nutiu, R.1    Li, Y.2
  • 40
    • 2342421271 scopus 로고    scopus 로고
    • Structure-switching signaling aptamers: transducing molecular recognition into fluorescence signalling
    • Contains a detailed description of how to tune aptamer binding states between the cognate analyte and the complementary DNA.
    • Nutiu R., and Li Y. Structure-switching signaling aptamers: transducing molecular recognition into fluorescence signalling. Chem Eur J 10 (2004) 1868-1876. Contains a detailed description of how to tune aptamer binding states between the cognate analyte and the complementary DNA.
    • (2004) Chem Eur J , vol.10 , pp. 1868-1876
    • Nutiu, R.1    Li, Y.2
  • 41
    • 4644361133 scopus 로고    scopus 로고
    • Aptamer-functionalized Au nanoparticles for the amplified optical detection of thrombin
    • Pavlov V., Xiao Y., Shlyahovsky B., and Willner I. Aptamer-functionalized Au nanoparticles for the amplified optical detection of thrombin. J Am Chem Soc 126 (2004) 11768-11769
    • (2004) J Am Chem Soc , vol.126 , pp. 11768-11769
    • Pavlov, V.1    Xiao, Y.2    Shlyahovsky, B.3    Willner, I.4
  • 42
  • 43
    • 24644523302 scopus 로고    scopus 로고
    • Aptamer-modified gold nanoparticles for colorimetric determination of platelet-derived growth factors and their receptors
    • Platelet-derived growth factors (PDGF) were used to assemble PDGF aptamer-functionalized gold nanoparticles, taking advantage of the fact that each PDGF can bind to two PDGF aptamers. The assembly process was monitored through the use of a color-change assay.
    • Huang C.-C., Huang Y.-F., Cao Z., Tan W., and Chang H.-T. Aptamer-modified gold nanoparticles for colorimetric determination of platelet-derived growth factors and their receptors. Anal Chem 77 (2005) 5735-5741. Platelet-derived growth factors (PDGF) were used to assemble PDGF aptamer-functionalized gold nanoparticles, taking advantage of the fact that each PDGF can bind to two PDGF aptamers. The assembly process was monitored through the use of a color-change assay.
    • (2005) Anal Chem , vol.77 , pp. 5735-5741
    • Huang, C.-C.1    Huang, Y.-F.2    Cao, Z.3    Tan, W.4    Chang, H.-T.5
  • 44
    • 29344462970 scopus 로고    scopus 로고
    • Fast colorimetric sensing of adenosine and cocaine based on a general sensor design involving aptamers and nanoparticles
    • Two chemical responsive systems were demonstrated that use aptamer DNA to template the assembly of nanoparticles. In the presence of target molecules, aggregated nanoparticles disassembled into a dispersed state in seconds, accompanied by a purple-to-red color change. Such materials are useful for colorimetric sensing of a broad range of analytes.
    • Liu J., and Lu Y. Fast colorimetric sensing of adenosine and cocaine based on a general sensor design involving aptamers and nanoparticles. Angew Chem Int Ed Engl 45 (2006) 90-94. Two chemical responsive systems were demonstrated that use aptamer DNA to template the assembly of nanoparticles. In the presence of target molecules, aggregated nanoparticles disassembled into a dispersed state in seconds, accompanied by a purple-to-red color change. Such materials are useful for colorimetric sensing of a broad range of analytes.
    • (2006) Angew Chem Int Ed Engl , vol.45 , pp. 90-94
    • Liu, J.1    Lu, Y.2
  • 45
    • 33745818513 scopus 로고    scopus 로고
    • Smart nanomaterials responsive to multiple chemical stimuli with controllable cooperativity
    • Materials whose assembly could be controlled by multiple chemicals were prepared on the basis of aptamer-linked nanoparticle aggregates; the cooperativity between chemical stimuli can be controlled by different material designs. Any two combinations of adenosine, cocaine or potassium ions were demonstrated to control nanoparticle assembly states and optical properties.
    • Liu J., and Lu Y. Smart nanomaterials responsive to multiple chemical stimuli with controllable cooperativity. Adv Mater 18 (2006) 1667-1671. Materials whose assembly could be controlled by multiple chemicals were prepared on the basis of aptamer-linked nanoparticle aggregates; the cooperativity between chemical stimuli can be controlled by different material designs. Any two combinations of adenosine, cocaine or potassium ions were demonstrated to control nanoparticle assembly states and optical properties.
    • (2006) Adv Mater , vol.18 , pp. 1667-1671
    • Liu, J.1    Lu, Y.2
  • 46
    • 22744459539 scopus 로고    scopus 로고
    • Aptamer-directed self-assembly of protein arrays on a DNA nanostructure
    • In this study, a thrombin aptamer was incorporated into a DNA periodic structure. Binding of thrombin to the DNA structure enabled the generation of a thrombin array.
    • Liu Y., Lin C., Li H., and Yan H. Aptamer-directed self-assembly of protein arrays on a DNA nanostructure. Angew Chem Int Ed Engl 44 (2005) 4333-4338. In this study, a thrombin aptamer was incorporated into a DNA periodic structure. Binding of thrombin to the DNA structure enabled the generation of a thrombin array.
    • (2005) Angew Chem Int Ed Engl , vol.44 , pp. 4333-4338
    • Liu, Y.1    Lin, C.2    Li, H.3    Yan, H.4
  • 47
    • 33745610353 scopus 로고    scopus 로고
    • Quantum-dot aptamer beacons for the detection of proteins
    • A quencher-labeled DNA was positioned close to a quantum dot by hybridization to an attached thrombin aptamer. The addition of thrombin released the quencher labeled DNA, unmasking the fluorescence. This device has been used for sensing applications.
    • Levy M., Cater S.F., and Ellington A.D. Quantum-dot aptamer beacons for the detection of proteins. ChemBioChem 6 (2005) 2163-2166. A quencher-labeled DNA was positioned close to a quantum dot by hybridization to an attached thrombin aptamer. The addition of thrombin released the quencher labeled DNA, unmasking the fluorescence. This device has been used for sensing applications.
    • (2005) ChemBioChem , vol.6 , pp. 2163-2166
    • Levy, M.1    Cater, S.F.2    Ellington, A.D.3
  • 48
    • 33645695504 scopus 로고    scopus 로고
    • Nucleic acid-functionalized Pt nanoparticles: catalytic labels for the amplified electrochemical detection of biomolecules
    • Polsky R., Gill R., Kaganovsky L., and Willner I. Nucleic acid-functionalized Pt nanoparticles: catalytic labels for the amplified electrochemical detection of biomolecules. Anal Chem 78 (2006) 2268-2271
    • (2006) Anal Chem , vol.78 , pp. 2268-2271
    • Polsky, R.1    Gill, R.2    Kaganovsky, L.3    Willner, I.4
  • 49
    • 0037952722 scopus 로고    scopus 로고
    • A single DNA molecule nanomotor
    • Li J.J., and Tan W. A single DNA molecule nanomotor. Nano Lett 2 (2002) 315-318
    • (2002) Nano Lett , vol.2 , pp. 315-318
    • Li, J.J.1    Tan, W.2
  • 50
    • 0026575221 scopus 로고
    • Selection of single-stranded DNA molecules that bind and inhibit human thrombin
    • Bock L.C., Griffin L.C., Latham J.A., Vermaas E.H., and Toole J.J. Selection of single-stranded DNA molecules that bind and inhibit human thrombin. Nature 355 (1992) 564-566
    • (1992) Nature , vol.355 , pp. 564-566
    • Bock, L.C.1    Griffin, L.C.2    Latham, J.A.3    Vermaas, E.H.4    Toole, J.J.5
  • 51
    • 4043094730 scopus 로고    scopus 로고
    • A DNA-based machine that can cyclically bind and release thrombin
    • This paper demonstrated the concept of using aptamer-binding to control the conformation of DNA. Importantly, the aptamer can be used as a 'nanohand' to grab and release proteins.
    • Dittmer W.U., Reuter A., and Simmel F.C. A DNA-based machine that can cyclically bind and release thrombin. Angew Chem Int Ed Engl 43 (2004) 3550-3553. This paper demonstrated the concept of using aptamer-binding to control the conformation of DNA. Importantly, the aptamer can be used as a 'nanohand' to grab and release proteins.
    • (2004) Angew Chem Int Ed Engl , vol.43 , pp. 3550-3553
    • Dittmer, W.U.1    Reuter, A.2    Simmel, F.C.3
  • 52
    • 24644464757 scopus 로고    scopus 로고
    • A DNA-protein nanoengine for 'on-demand' release and precise delivery of molecules
    • Most previously reported DNA machines require the use of DNA hybridization as an energy source. This paper, however, reports the first DNA machine to be run with non-DNA fuel. Here, a protein enzyme was employed to chemically modify the target of an aptamer thus controlling aptamer conformation in solution, with the target molecule functioning as fuel for the system.
    • Nutiu R., and Li Y. A DNA-protein nanoengine for 'on-demand' release and precise delivery of molecules. Angew Chem Int Ed Engl 44 (2005) 5464-5467. Most previously reported DNA machines require the use of DNA hybridization as an energy source. This paper, however, reports the first DNA machine to be run with non-DNA fuel. Here, a protein enzyme was employed to chemically modify the target of an aptamer thus controlling aptamer conformation in solution, with the target molecule functioning as fuel for the system.
    • (2005) Angew Chem Int Ed Engl , vol.44 , pp. 5464-5467
    • Nutiu, R.1    Li, Y.2
  • 53
    • 18644363565 scopus 로고    scopus 로고
    • Fluorescence detection of DNA by the catalytic activation of an aptamer/thrombin complex
    • Thrombin activity was inhibited by a covalently attached DNA aptamer; the activity can be rescued by removal of aptamer binding with complementary DNA.
    • Pavlov V., Shlyahovsky B., and Willner I. Fluorescence detection of DNA by the catalytic activation of an aptamer/thrombin complex. J Am Chem Soc 127 (2005) 6522-6523. Thrombin activity was inhibited by a covalently attached DNA aptamer; the activity can be rescued by removal of aptamer binding with complementary DNA.
    • (2005) J Am Chem Soc , vol.127 , pp. 6522-6523
    • Pavlov, V.1    Shlyahovsky, B.2    Willner, I.3
  • 54
    • 22944456232 scopus 로고    scopus 로고
    • DNA constraints allow rational control of macromolecular conformation
    • Miduturu C.V., and Silverman S.K. DNA constraints allow rational control of macromolecular conformation. J Am Chem Soc 127 (2005) 10144-10145
    • (2005) J Am Chem Soc , vol.127 , pp. 10144-10145
    • Miduturu, C.V.1    Silverman, S.K.2
  • 55
    • 33746295027 scopus 로고    scopus 로고
    • Modulation of DNA constraints that control macromolecular folding
    • Several methods to control the folding of a DNA-modified RNA molecule were demonstrated, including the use of a hemin aptamer to control RNA folding by hemin.
    • Miduturu C.V., and Silverman S.K. Modulation of DNA constraints that control macromolecular folding. Angew Chem Int Ed Engl 45 (2006) 1918-1921. Several methods to control the folding of a DNA-modified RNA molecule were demonstrated, including the use of a hemin aptamer to control RNA folding by hemin.
    • (2006) Angew Chem Int Ed Engl , vol.45 , pp. 1918-1921
    • Miduturu, C.V.1    Silverman, S.K.2
  • 56
    • 0033485863 scopus 로고    scopus 로고
    • Nucleic acid molecular switches
    • Soukup G.A., and Breaker R.R. Nucleic acid molecular switches. Trends Biotechnol 17 (1999) 469-476
    • (1999) Trends Biotechnol , vol.17 , pp. 469-476
    • Soukup, G.A.1    Breaker, R.R.2
  • 57
    • 1542408632 scopus 로고    scopus 로고
    • Adenosine-dependent assembly of aptazyme-functionalized gold nanoparticles and its application as a colorimetric biosensor
    • Liu J., and Lu Y. Adenosine-dependent assembly of aptazyme-functionalized gold nanoparticles and its application as a colorimetric biosensor. Anal Chem 76 (2004) 1627-1632
    • (2004) Anal Chem , vol.76 , pp. 1627-1632
    • Liu, J.1    Lu, Y.2
  • 58
    • 0036301260 scopus 로고    scopus 로고
    • A general strategy for effector-mediated control of RNA-cleaving ribozymes and DNA enzymes
    • Wang D.Y., Lai B.H.Y., and Sen D. A general strategy for effector-mediated control of RNA-cleaving ribozymes and DNA enzymes. J Mol Biol 318 (2002) 33-43
    • (2002) J Mol Biol , vol.318 , pp. 33-43
    • Wang, D.Y.1    Lai, B.H.Y.2    Sen, D.3
  • 59
    • 17144380787 scopus 로고    scopus 로고
    • Allosteric aptamers and aptazymes as probes for screening approaches
    • Famulok M. Allosteric aptamers and aptazymes as probes for screening approaches. Curr Opin Mol Ther 7 (2005) 137-143
    • (2005) Curr Opin Mol Ther , vol.7 , pp. 137-143
    • Famulok, M.1
  • 61
    • 33747893739 scopus 로고    scopus 로고
    • Self-assembled signaling aptamer DNA arrays for protein detection
    • Lin C., Katilius E., Liu Y., Zhang J., and Yan H. Self-assembled signaling aptamer DNA arrays for protein detection. Angew Chem Int Ed 45 (2006) 5296
    • (2006) Angew Chem Int Ed , vol.45 , pp. 5296
    • Lin, C.1    Katilius, E.2    Liu, Y.3    Zhang, J.4    Yan, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.