Theophylline does not potentiate the effects of a low dose of dexamethasone in horses with recurrent airway obstruction

Equine Veterinary Journal

Volumn 38, Issue 6, 2006, Pages 570-573

  Cesarini, C ^a   Hamilton, E ^a   Picandet, V ^a   Lavoie, J P ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Dexamethasone; Heaves; Horse; RAO; Theophylline

Indexed keywords

BRONCHODILATING AGENT; DEXAMETHASONE; GLUCOCORTICOID; THEOPHYLLINE;

ANIMAL; ANIMAL DISEASE; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DRUG COMBINATION; FEMALE; HORSE; HORSE DISEASE; INTRAVENOUS DRUG ADMINISTRATION; MALE; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; TIME; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ANIMALS; BRONCHODILATOR AGENTS; CROSS-OVER STUDIES; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; GLUCOCORTICOIDS; HORSE DISEASES; HORSES; INJECTIONS, INTRAVENOUS; LUNG DISEASES, OBSTRUCTIVE; MALE; RECURRENCE; THEOPHYLLINE; TIME FACTORS; TREATMENT OUTCOME;

EQUIDAE; EQUUS CABALLUS;

EID: 33751240790     PISSN: 04251644     EISSN: 04251644     Source Type: Journal    
DOI: 10.2746/042516407X153048     Document Type: Article

References (26)

1. Arthur, K., Wolff, J. and Carrier, D. (2004) Analysis of betamethasone, dexamethasone and related compounds by liquid chromatography/electrospray mass spectometry. Rapid Commun. Mass Spectrom. 6, 678-684.
2. Barnes, P.J. (2003) Theophylline: new perspectives for an old drug. Am. J. Respir. crit. care Med. 167, 813-818.
3. Beaudry, F., Lavoie, J.P. and Vachon, P. (2005) Development of an electrospray ionization mass spectrometric method for the quantification of theophylline in horse serum. Biomed. Chromatogr. 19, 643-648.
4. Button, C., Errecalde, J.O. and Mulders, M.S. (1985) Loading and maintenance dosage regimens for theophylline in horses. J. vet. Pharmacol. Therap. 8, 328-330.
5. Cornelisse, C.J., Robinson, N.E., Berney, C.E., Kobe, C.A., Boruta, D.T. and Derksen, F.J. (2004) Efficacy of oral and intravenous dexamethasone in horses with recurrent airway obstruction. Equine vet. J. 36, 426-430.
6. Eiler, H., Oliver, J. and Goble, D. (1979) Adrenal gland function in the horse: effect of dexamethasone on hydrocortisone secretion and blood cellularity and plasma electrolyte concentrations. Am. J. vet. Res. 40, 727-729.
7. Evans, D.J., Taylor, D.A., Zetterstrom, O., Chung, K.F., O'Connor, B.J. and Barnes, P.J. (1997) A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma. N. Engl. J. Med. 337, 1412-1418.
8. Eyre, P., Elmes, P.J. and Strickland, S. (1979) Corticosteroid- potentiated vascular responses of the equine digit: a possible pharmacologic basis for laminitis. Am. J. vet. Res. 40, 135-138.
9. Goetz, T.E., Munsiff, I.J. and McKiernan, B.C. (1989) Pharmacokinetic disposition of an immediate-release aminophylline and a sustained-release theophylline formulation in the horse. J. vet. Pharmacol. Therap. 12, 369-377.
10. Ingvast-Larsson, C., Paalzow, G., Paalzow, L., Ottosson, T., Lindholm, A. and Appelgren, L.E. (1985) Pharmacokinetic studies of theophylline in horses. J. vet. Pharmacol. Therap. 8, 76-81.
11. Ito, K., Lim, S., Caramori, G., Cosio, B., Chung, K.F., Adcock, I.M. and Barnes, P.J. (2002) A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc. Natl. Acad. Sci. USA 99, 8921-8926.
12. Lavoie, J.P., Leguillette, R., Pasloske, K., Charette, L., Sawyer, N., Guay, D., Murphy, T. and Hickey, G.J. (2002) Comparison of effects of dexamethasone and the leukotriene D4 receptor antagonist L-708,738 on lung function and airway cytologic findings in horses with recurrent airway obstruction. Am. J. vet. Res. 63, 579-585.
13. Lepage, O.M., Laverty, S., Marcoux, M. and Dumas, G. (1993) Serum osteocalcin concentration in horses treated with triamcinolone acetonide. Am. J. vet. Res. 54, 1209-1212.
14. Lim, S., Jatakanon, A., Gordon, D., Macdonald, C., Chung, K.F. and Barnes, P.J. (2000) Comparison of high dose inhaled steroids, low dose inhaled steroids plus low dose theophylline, and low dose inhaled steroids alone in chronic asthma in general practice. Thorax 55, 837-841.
15. MacHarg, M.A., Bottoms, G.D., Carter, G.K. and Johnson, M.A. (1985) Effects of multiple intramuscular injections and doses of dexamethasone on plasma cortisol concentrations and adrenal responses to ACTH in horses. Am. J. vet. Res. 46, 2285-2287.
16. Mair, T.S. (1996) Bacterial pneumonia associated with corticosteroid therapy in three horses. Vet. Rec. 138, 205-207.
17. Maxwell, L.K., Stanley, S.D. and Kollias-Baker, C. (2003) Bioequivalence testing and cortisol supression of two dexamethasone formulations administered orally to horses. Proc. Am. Coll. vet. int. Med. 21, 111.
18. McKiernan, B.C., Koritz, G.D., Scott, J.S., Berney, C. and Robinson, N.E. (1990) Plasma theophylline concentration and lung function in ponies with recurrent obstructive lung disease. Equine vet. J. 22, 194-197.
19. Pearson, E.G. and Riebold, T.W. (1989) Comparison of bronchodilators in alleviating clinical signs in horses with chronic obstructive pulmonary disease. J. Am. vet. med. Ass. 194, 1287-1291.
20. Robinson, N. (2003) Current Therapy in Equine Medicine 5, 5th edn., W.B. Saunders Co., Philadelphia. p 862.
21. Roncada, P., Tomasi, L., Montesissa, C., Grossi, G., Stracciari, G.L. and Anfossi, P. (1995) Absorption and dosage of theophylline in the horse after single and repeated administration of a microencapsulated preparation. Equine vet. J. 27, 13-18.
22. Rush, B.R., Worster, A.A., Flaminio, M.J., Matson, C.J. and Hakala, J.E. (1998) Alteration in adrenocortical function in horses with recurrent airway obstruction after aerosol and parenteral administration of beclomethasone dipropionate and dexamethasone, respectively. Am. J. vet. Res. 59, 1044-1047.
23. Ryu, S.H., Kim, B.S., Lee, C.W., Yoon, J. and Lee, Y.L. (2004) Glucocorticoid-induced laminitis with hepatopathy in a Thoroughbred filly. J. vet. Sci. 5, 271-274.
24. Singh, A., Jiang, Y., White, T. and Spassova, D. (1997) Validation of nonradioactive chemiluminescent immunoassay methods for the analysis of thyroxine and cortisol in blood samples obtained from dogs, cats and horses. J. vet. diagn. Invest. 3, 261-268.
25. Toutain, P.L., Brandon, R.A., de Pomyers, H., Alvinerie, M. and Baggot, J.D. (1984) Dexamethasone and prednisolone in the horse: pharmacokinetics and action on the adrenal gland. Am. J. vet. Res. 45, 1750-1756.
26. Ukena, D., Harnest, U., Sakalauskas, R., Magyar, P., Vetter, N., Steffen, H., Leichtl, S., Rathgeb, F., Keller, A. and Steinijans, V.W. (1997) Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma. Eur. respir. J. 10, 2754-2760.