L-arginine attenuates acute pulmonary embolism-induced increases in lung matrix metalloproteinase-2 and matrix metalloproteinase-9

Chest

Volumn 128, Issue 5, 2005, Pages 3705-3710

  Souza Costa, Debora C ^a   Zerbini, Talita ^a   Palei, Ana C ^a   Gerlach, Raquel F ^a   Tanus Santos, Jose E ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Embolism; L arginine; Matrix metalloproteinases; Nitric oxide; Pathophysiology; Pulmonary hypertension

Indexed keywords

ARGININE; DOXYCYCLINE; GELATINASE A; GELATINASE B; MICROSPHERE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ISOLATED ORGAN; LUNG EMBOLISM; MALE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; ZYMOGRAPHY;

EID: 28144435830     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.128.5.3705     Document Type: Article

References (34)

1. Sadosty AT, Boie ET, Stead LG. Pulmonary embolism. Emerg Med Clin North Am 2003; 21:363-384
2. Tanus-Santos JE, Gordo WM, Udelsmann A, et al. Nonselective endothelin-receptov antagonism attenuates hemodynamic changes after massive pulmonary air embolism in dogs. Chest 2000; 118:175-179
3. Smulders YM. Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstriction. Cardiovasc Res 2000; 48:23-33
4. Lualdi JC, Goldhaber SZ. Right ventricular dysfunction after acute pulmonary embolism: pathophysiologic factors, detection, and therapeutic implications. Am Heart J 1995; 130:1276-1282
5. Tanus-Santos JE, Theodorakis MJ. Is there a place for inhaled nitric oxide in the therapy of acute pulmonary embolism? Am J Respir Med 2002; 1:167-176
6. Tanus-Santos JE, Moreno H Jr, Moreno RA, et al. Inhaled nitric oxide improves hemodynamics during a venous air infusion (VAI) in dogs. Intensive Care Med 1999; 25:983-989
7. Dias-Junior CA, Vieira TF, Moreno H Jr, et al. Sildenafil selectively inhibits acute pulmonary embolism-induced pulmonary hypertension. Pulm Pharmacol Ther 2005; 18:181-186
8. Tanus-Santos JE, Moreno H Jr, Zappellini A, et al. Small-dose inhaled nitric oxide attenuates hemodynamic changes after pulmonary air embolism in dogs. Anesth Analg 1999; 88:1025-1029
9. Palei ACT, Zaneti RAG, Fortuna GM, et al. Hemodynamic benefits of matrix metalloproteinase-9 inhibition by doxycycline during experimental acute pulmonary embolism. Angiology 2005 (in press)
10. Frisdal E, Gest V, Vieillard-Baron A, et al. Gelatinase expression in pulmonary arteries during experimental pulmonary hypertension. Eur Respir J 2001; 18:838-845
11. Fernandez-Patron C, Radomski MW, Davidge ST. Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor. Circ Res 1999; 85:906-911
12. Fernandez-Patron C, Zouki C, Whittal R, et al. Matrix metalloproteinases regulate neutrophil-endothelial cell adhesion through generation of endothelin-1[1-32]. FASEB J 2001; 15:2230-2240
13. Tanus-Santos JE, Gordo WM, Udelsmann A, et al. The hemodynamic effects of endothelin receptor antagonism during a venous air infusion in dogs. Anesth Analg 2000; 90:102-106
14. Battistini B. Modulation and roles of the endothelins in the pathophysiology of pulmonary embolism. Can J Physiol Pharmacol 2003; 81:555-569
15. Fernandez-Patron C, Stewart KG, Zhang Y, et al. Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction. Circ Res 2000; 87:670-676
16. Martinez A, Oh H, Unsworth EJ, et al. Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator. Biochem J 2004; 383:413-418
17. Mehta S, Stewart DJ, Langleben D, et al. Short-term pulmonary vasodilation with L-arginine in pulmonary hypertension. Circulation 1995; 92:1539-1545
18. Fagan JM, Rex SE, Hayes-Licitra SA, et al. L-arginine reduces right heart hypertrophy in hypoxia-induced pulmonary hypertension. Biochem Biophys Res Commun 1999; 254:100-103
19. Souza-Costa DC, Zerbini T, Metzger IF. et al. L-arginine attenuates acute pulmonary embolism-induced oxidative stress and pulmonary hypertension. Nitric Oxide 2005; 12:9-14
20. Wang D, Li MH, Hsu K, et al. Air embolism-induced lung injury in isolated rat lungs. J Appl Physiol 1992; 72:1235-1242
21. Bottiger BW, Motsch J, Dorsam J, et al. Inhaled nitric oxide selectively decreases pulmonary artery pressure and pulmonary vascular resistance following acute massive pulmonary microembolism in piglets. Chest 1996; 110:1041-1047
22. Rubanyi GM, Ho EH, Cantor EH, et al. Cytoprotective function of nitric oxide: inactivation of Superoxide radicals produced by human leukocytes. Biochem Biophys Res Commun 1991; 181:1392-1397
23. Lass A, Suessenbacher A, Wolkart G, et al. Functional and analytical evidence for scavenging of oxygen radicals by L-arginine. Mol Pharmacol 2002; 61:1081-1088
24. Jeffery TK, Morrell NW. Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension. Prog Cardiovasc Dis 2002; 45:173-202
25. Ohbayashi H. Matrix metalloproteinases in lung diseases. Curr Protein Pept Sci 2002; 3:409-421
26. Eagleton MJ, Henke PK, Luke CE, et al. Inflammation and intimal hyperplasia associated with experimental pulmonary embolism. J Vasc Surg 2002; 36:581-588
27. Van den Steen PE, Dubois B, Nelissen I, et al. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit Rev Biochem Mol Biol 2002; 37:375-536
28. Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res 2002; 90:251-262
29. Grote K, Flach I, Luchtefeld M, et al. Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD(P)H oxidase-derived reactive oxygen species. Circ Res 2003; 92:e80-86
30. Dias-Junior CA, Souza-Costa DC, Zerbini T, et al. Effect of sildenafil on pulmonary embolism-induced oxidative stress and pulmonary hypertension. Anesth Analg 2005; 101:115-120
31. Dikshit M, Srivastava R, Srimal RC. Role of free radicals in pulmonary thromboembolisin in mice. Thromb Res 1989; 55:549-557
32. Joshi MS, Ponthier JL, Lancaster JR Jr. Cellular antioxidant and pro-oxidant actions of nitric oxide. Free Radic Biol Med 1999; 27:1357-1366
33. Herget J, Novotna J, Bibova J, et al. Metalloproteinase inhibition by Batimastat attenuates pulmonary hypertension in chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 2003; 285:L199-208
34. Behrendt CE, Ruiz RB. Venous thromboembolism among patients with advanced lung cancer randomized to prinomastat or placebo, plus chemotherapy. Thromb Haetmost 2003; 90:734-737