Importance of the structure of vancomycin binding pocket in designing compounds active against vancomycin-resistant enterococci (VRE)

Journal of Antibiotics

Volumn 59, Issue 9, 2006, Pages 543-552

  Jia, Yanxing ^a   Bois Choussy, Michèle ^a   Malabarba, Adriano ^b   Brunati, Cristina ^b   Zhu, Jieping ^a  

^a CNRS   (France)

^b Italy Research Center   (Italy)

Author keywords

Antibiotic; Glycopeptide; Intramolecular nucleophilic aromatic substitution; Macrocycle; Vancomycin; Vancomycin resistant enterococci (VRE)

Indexed keywords

AMINO ACID DERIVATIVE; ANTIINFECTIVE AGENT; CARBOXYL GROUP; MACROCYCLIC COMPOUND; TEICOPLANIN; VANCOMYCIN; VANCOMYCIN DERIVATIVE;

AMINO TERMINAL SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DILUTION; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ETHERIFICATION; HYDROGEN BOND; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SUBSTITUTION REACTION; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANTI-BACTERIAL AGENTS; BINDING SITES; CHEMISTRY, PHARMACEUTICAL; ENTEROCOCCUS; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; MICROBIAL SENSITIVITY TESTS; VANCOMYCIN; VANCOMYCIN RESISTANCE;

ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM;

EID: 33751220190     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2006.75     Document Type: Article

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