Non-genomic steroid hormone effects: Membrane or intracellular receptors?

Journal of Steroid Biochemistry and Molecular Biology

Volumn 102, Issue 1-5 SPEC. ISS., 2006, Pages 180-183

  Wehling, Martin ^a,b   Lösel, Ralf ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; CELL MEMBRANE; GENE EXPRESSION REGULATION; GENOME; HORMONES; HUMANS; RECEPTORS, STEROID;

EID: 33751210104     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2006.09.016     Document Type: Article

References (31)

1. Osman R.A., Andria M.L., Jones A.D., and Meizel S. Steroid induced exocytosis: the human sperm acrosome reaction. Biochem. Biophys. Res. Commun. 160 (1989) 828-833
2. Mendelsohn M.E. Nongenomic, ER-mediated activation of endothelial nitric oxide synthase: how does it work? What does it mean?. Circ. Res. 87 (2000) 956-960
3. Levin E.R. Integration of the extranuclear and nuclear actions of estrogen. Mol. Endocrinol. 19 (2005) 1951-1959
4. Wong C.W., McNally C., Nickbarg E., Komm B.S., and Cheskis B.J. Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade. Proc. Natl. Acad. Sci. USA 99 (2002) 14783-14788
5. Kousteni S., Bellido T., Plotkin L.I., O'Brien C.A., Bodenner D.L., Han L., Han K., DiGregorio G.B., Katzenellenbogen J.A., Katzenellenbogen B.S., Roberson P.K., Weinstein R.S., Jilka R.L., and Manolagas S.C. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 104 (2001) 719-730
6. Centrella M., McCarthy T.L., Chang W.Z., Labaree D.C., and Hochberg R.B. Estren (4-estren-3alpha, 17beta-diol) is a prohormone that regulates both androgenic and estrogenic transcriptional effects through the androgen receptor. Mol. Endocrinol. 18 (2004) 1120-1130
7. Norman A.W., Song X., Zanello L., Bula C., and Okamura W.H. Rapid and genomic biological responses are mediated by different shapes of the agonist steroid hormone, 1alpha, 25(OH)2vitamin D3. Steroids 64 (1999) 120-128
8. Zanello L.P., and Norman A.W. Rapid modulation of osteoblast ion channel responses by 1alpha, 25(OH)2-Vitamin D3 requires the presence of a functional Vitamin D nuclear receptor. Proc. Natl. Acad. Sci. USA 101 (2004) 1589-1594
9. Vertino A.M., Bula C.M., Chen J.R., Almeida M., Han L., Bellido T., Kousteni S., Norman A.W., and Manolagas S.C. Nongenotropic, anti-apoptotic signaling of 1alpha, 25(OH)2-Vitamin D3 and analogs through the ligand binding domain of the Vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases. J. Biol. Chem. 280 (2005) 14130-14137
10. Norman A.W., Mizwicki M.T., and Norman D.P. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat. Rev. Drug. Discov. 3 (2004) 27-41
11. Srivastava D.P., Yu E.J., Kennedy K., Chatwin H., Reale V., Hamon M., Smith T., and Evans P.D. Rapid, nongenomic responses to ecdysteroids and catecholamines mediated by a novel Drosophila G-protein-coupled receptor. J. Neurosci. 25 (2005) 6145-6155
12. Nadal A., Ropero A.B., Laribi O., Maillet M., Fuentes E., and Soria B. Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor alpha and estrogen receptor beta. Proc. Natl. Acad. Sci. USA 97 (2000) 11603-11608
13. Filardo E.J., Quinn J.A., Bland K.I., and Frackelton Jr. A.R. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol. Endocrinol. 14 (2000) 1649-1660
14. Filardo E.J., Quinn J.A., Frackelton Jr. A.R., and Bland K.I. Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. Mol. Endocrinol. 16 (2002) 70-84
15. Revankar C.M., Cimino D.F., Sklar L.A., Arterburn J.B., and Prossnitz E.R. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307 (2005) 1625-1630
16. Bologa C.G., Revankar C.M., Young S.M., Edwards B.S., Arterburn J.B., Kiselyov A.S., Parker M.A., Tkachenko S.E., Savchuck N.P., Sklar L.A., Oprea T.I., and Prossnitz E.R. Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat. Chem. Biol. 2 (2006) 207-212
17. Zhu Y., Rice C.D., and Thomas P. Cloning, expression, and characterization of a putative membrane progestin receptor in a fish model, spotted seatrout (Abstract). Proceedings of the 84th Annual Meeting. The Endocrine Society, San Francisco (2002) P1-P448
18. Zhu Y., and Thomas P. Discovery of a new family of cDNAs encoding putative membrane progesterone receptors in vertebrates (Abstract). Proceedings of the 84th Annual Meeting. The Endocrine Society, San Francisco (2002) P1-P451
19. Y.T. Tang, T. Hu, M. Arterburn, B. Boyle, J.M. Bright, P.C. Emtage, W.D. Funk, PAQR proteins: a novel membrane receptor family defined by an ancient7-transmembrane pass motif, J. Mol. Evol., in press.
20. Falkenstein E., Heck M., Gerdes D., Grube D., Christ M., Weigel M., Buddhikot M., Meizel S., and Wehling M. Specific progesterone binding to a membrane protein and related nongenomic effects on Ca2+-fluxes in sperm. Endocrinology 140 (1999) 5999-6002
21. Peluso J.J., Pappalardo A., Losel R., and Wehling M. Progesterone membrane receptor component 1 expression in the immature rat ovary and its role in mediating progesterone's antiapoptotic action. Endocrinology 147 (2006) 3133-3140
22. 2D3 are retained in growth plate cartilage cells from Vitamin D receptor knockout mice. J. Cell. Biochem. 90 (2003) 1207-1223
23. Wali R.K., Kong J., Sitrin M.D., Bissonnette M., and Li Y.C. Vitamin D receptor is not required for the rapid actions of 1, 25-dihydroxyvitamin D3 to increase intracellular calcium and activate protein kinase C in mouse osteoblasts. J. Cell. Biochem. 88 (2003) 794-801
24. 2D3 dependent PKC signaling in chondrocytes and osteoblasts. Steroids 71 (2006) 286-290
25. Barbato J.C., Mulrow P.J., Shapiro J.I., and Franco-Saenz R. Rapid effects of aldosterone and spironolactone in the isolated working rat heart. Hypertension 40 (2002) 130-135
26. Selye H. The anaesthetic effect of steroid hormones. Proc. Soc. Exp. Biol. Med. 46 (1941) 116-121
27. Callachan H., Cottrell G.A., Hather N.Y., Lambert J.J., Nooney J.M., and Peters J.A. Modulation of the GABAA receptor by progesterone metabolites. Proc. R Soc. Lond. B Biol. Sci. 231 (1987) 359-369
28. Lambert J.J., Belelli D., Hill-Venning C., and Peters J.A. Neurosteroids GABAA receptor function. Trends. Pharmacol. Sci. 16 (1995) 295-303
29. Lösel R.M., Falkenstein E., Feuring M., Schultz A., Tillmann H.C., Rossol-Haseroth K., and Wehling M. Nongenomic steroid action: controversies, questions, and answers. Physiol. Rev. 83 (2003) 965-1016
30. Bagowski C.P., Myers J.W., and Ferrell Jr. J.E. The classical progesterone receptor associates with p42 MAPK and is involved in phosphatidylinositol 3-kinase signaling in Xenopus oocytes. J. Biol. Chem. 276 (2001) 37708-37714
31. Hisamoto K., and Bender J.R. Vascular cell signaling by membrane estrogen receptors. Steroids 70 (2005) 382-387