-
1
-
-
0037199930
-
A model for constitutive lutropin receptor activation based on molecular simulation and engineered mutations in transmembrane helices 6 and 7
-
Angelova K., Fanelli F., and Puett D. A model for constitutive lutropin receptor activation based on molecular simulation and engineered mutations in transmembrane helices 6 and 7. J. Biol. Chem. 277 (2002) 32202-32213
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 32202-32213
-
-
Angelova, K.1
Fanelli, F.2
Puett, D.3
-
2
-
-
0036217072
-
The lutropin/choriogonadotropin receptor: a 2002 perspective
-
Ascoli M., Fanelli F., and Segaloff D.L. The lutropin/choriogonadotropin receptor: a 2002 perspective. Endocr. Rev. 23 (2002) 141-174
-
(2002)
Endocr. Rev.
, vol.23
, pp. 141-174
-
-
Ascoli, M.1
Fanelli, F.2
Segaloff, D.L.3
-
3
-
-
77957055780
-
Integrated methods for the construction of three-dimensional models of structure-funcion relations in G protein-coupled receptors
-
Ballesteros J.A., and Weinstein H. Integrated methods for the construction of three-dimensional models of structure-funcion relations in G protein-coupled receptors. Methods Neurosci. 25 (1995) 366-428
-
(1995)
Methods Neurosci.
, vol.25
, pp. 366-428
-
-
Ballesteros, J.A.1
Weinstein, H.2
-
4
-
-
0030733509
-
Long-term outcome of male-limited gonadotropin-independent precocious puberty
-
Bertelloni S., Baroncelli G.I., Lala R., Cappa M., Matarazzo P., De Sanctis C., and Saggese G. Long-term outcome of male-limited gonadotropin-independent precocious puberty. Horm. Res. 48 (1997) 235-239
-
(1997)
Horm. Res.
, vol.48
, pp. 235-239
-
-
Bertelloni, S.1
Baroncelli, G.I.2
Lala, R.3
Cappa, M.4
Matarazzo, P.5
De Sanctis, C.6
Saggese, G.7
-
5
-
-
0030058087
-
A new point mutation in the luteinising hormone receptor gene in familial and sporadic male limited precocious puberty: genotype does not always correlate with phenotype
-
Evans B.A.J., Bowen D.J., Smith P.J., Clayton P.E., and Gregory J.W. A new point mutation in the luteinising hormone receptor gene in familial and sporadic male limited precocious puberty: genotype does not always correlate with phenotype. J. Med. Genet. 33 (1996) 143-147
-
(1996)
J. Med. Genet.
, vol.33
, pp. 143-147
-
-
Evans, B.A.J.1
Bowen, D.J.2
Smith, P.J.3
Clayton, P.E.4
Gregory, J.W.5
-
6
-
-
0034628894
-
Theoretical study on mutation-induced activation of the luteinizing hormone receptor
-
Fanelli F. Theoretical study on mutation-induced activation of the luteinizing hormone receptor. J. Mol. Biol. 296 (2000) 1333-1351
-
(2000)
J. Mol. Biol.
, vol.296
, pp. 1333-1351
-
-
Fanelli, F.1
-
7
-
-
2542498612
-
Insight into mutation-induced activation of the luteinizing hormone receptor: molecular simulations predict the functional behavior of engineered mutants at M398
-
Fanelli F., Verhoef-Post M., Timmerman M., Zeilemaker A., Martens J.W., and Themmen A.P. Insight into mutation-induced activation of the luteinizing hormone receptor: molecular simulations predict the functional behavior of engineered mutants at M398. Mol. Endocrinol. 18 (2004) 1499-1508
-
(2004)
Mol. Endocrinol.
, vol.18
, pp. 1499-1508
-
-
Fanelli, F.1
Verhoef-Post, M.2
Timmerman, M.3
Zeilemaker, A.4
Martens, J.W.5
Themmen, A.P.6
-
8
-
-
0035083109
-
Inverse, protein, and ligand-selective agonism: matters of receptor conformation
-
Kenakin T. Inverse, protein, and ligand-selective agonism: matters of receptor conformation. FASEB J. 15 (2001) 598-611
-
(2001)
FASEB J.
, vol.15
, pp. 598-611
-
-
Kenakin, T.1
-
9
-
-
0036463901
-
Efficacy at G-protein-coupled receptors
-
Kenakin T. Efficacy at G-protein-coupled receptors. Nat. Rev. Drug Discov. 1 (2002) 103-110
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 103-110
-
-
Kenakin, T.1
-
10
-
-
0033361906
-
Naturally occurring mutations of the luteinizing hormone receptor: lessons learned about reproductive physiology and G protein-coupled receptors
-
Latronico A., and Segaloff D. Naturally occurring mutations of the luteinizing hormone receptor: lessons learned about reproductive physiology and G protein-coupled receptors. Am. J. Hum. Genet. 65 (1999) 949-958
-
(1999)
Am. J. Hum. Genet.
, vol.65
, pp. 949-958
-
-
Latronico, A.1
Segaloff, D.2
-
11
-
-
0031728024
-
A unique constitutively activating mutation in the third transmembrane helix of the luteinizing hormone receptor causes sporadic male gonadotropin independent precocious puberty
-
Latronico A.C., Abell A.N., Arnhold I.J.P., Liu X., Lins T.S.S., Brito V.N., Billerbeck A.E., Segaloff D.L., and Mendonca B.B. A unique constitutively activating mutation in the third transmembrane helix of the luteinizing hormone receptor causes sporadic male gonadotropin independent precocious puberty. J. Clin. Endocrinol. Metab. 83 (1998) 2435-2440
-
(1998)
J. Clin. Endocrinol. Metab.
, vol.83
, pp. 2435-2440
-
-
Latronico, A.C.1
Abell, A.N.2
Arnhold, I.J.P.3
Liu, X.4
Lins, T.S.S.5
Brito, V.N.6
Billerbeck, A.E.7
Segaloff, D.L.8
Mendonca, B.B.9
-
12
-
-
0033748221
-
The effect of distinct activating mutations of the luteinizing hormone receptor gene on the pituitary-gonadal axis in both sexes
-
Latronico A.C., Lins T.S., Brito V.N., Arnhold I.J., and Mendonca B.B. The effect of distinct activating mutations of the luteinizing hormone receptor gene on the pituitary-gonadal axis in both sexes. Clin. Endocrinol. 53 (2000) 609-613
-
(2000)
Clin. Endocrinol.
, vol.53
, pp. 609-613
-
-
Latronico, A.C.1
Lins, T.S.2
Brito, V.N.3
Arnhold, I.J.4
Mendonca, B.B.5
-
13
-
-
0027399806
-
Treatment of familial male precocious puberty with spironolactone, testolactone, and deslorelin
-
Laue L., Jones J., Barnes K.M., and Cutler Jr. G.B. Treatment of familial male precocious puberty with spironolactone, testolactone, and deslorelin. J. Clin. Endocrinol. Metab. 76 (1993) 151-155
-
(1993)
J. Clin. Endocrinol. Metab.
, vol.76
, pp. 151-155
-
-
Laue, L.1
Jones, J.2
Barnes, K.M.3
Cutler Jr., G.B.4
-
14
-
-
0030912536
-
A model of the lutropin/choriogonadotropin receptor: insights into the structural and functional effects of constitutively activating mutations
-
Lin Z., Shenker A., and Pearlstein R. A model of the lutropin/choriogonadotropin receptor: insights into the structural and functional effects of constitutively activating mutations. Prot. Eng. 10 (1997) 501-510
-
(1997)
Prot. Eng.
, vol.10
, pp. 501-510
-
-
Lin, Z.1
Shenker, A.2
Pearlstein, R.3
-
15
-
-
0037452868
-
Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin
-
Mirzadegan T., Benko G., Filipek S., and Palczewski K. Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry 42 (2003) 2759-2767
-
(2003)
Biochemistry
, vol.42
, pp. 2759-2767
-
-
Mirzadegan, T.1
Benko, G.2
Filipek, S.3
Palczewski, K.4
-
16
-
-
0031976756
-
Severe testotoxicosis phenotype associated with Asp578 → Tyr mutation of the lutrophin/choriogonadotrophin receptor gene
-
Muller J., Gondos B., Kosugi S., Mori T., and Shenker A. Severe testotoxicosis phenotype associated with Asp578 → Tyr mutation of the lutrophin/choriogonadotrophin receptor gene. J. Med. Genet. 35 (1998) 340-341
-
(1998)
J. Med. Genet.
, vol.35
, pp. 340-341
-
-
Muller, J.1
Gondos, B.2
Kosugi, S.3
Mori, T.4
Shenker, A.5
-
17
-
-
0029840021
-
Response to challenge with gonadotropin-releasing hormone agonist in a mother and her two sons with a constitutively activating mutation of the luteinizing hormone receptor-a clinical research center study
-
Rosenthal I.M., Refetoff S., Rich B., Barnes R.B., Sunthornthepvarakul T., Parma J., and Rosenfield R.L. Response to challenge with gonadotropin-releasing hormone agonist in a mother and her two sons with a constitutively activating mutation of the luteinizing hormone receptor-a clinical research center study. J. Clin. Endocrinol. Metab. 81 (1996) 3802-3806
-
(1996)
J. Clin. Endocrinol. Metab.
, vol.81
, pp. 3802-3806
-
-
Rosenthal, I.M.1
Refetoff, S.2
Rich, B.3
Barnes, R.B.4
Sunthornthepvarakul, T.5
Parma, J.6
Rosenfield, R.L.7
-
19
-
-
0027372340
-
A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty
-
Shenker A., Laue L., Kosugi S., Merendino Jr. J.J., Minegishi T., and Cutler Jr. G.B. A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature 365 (1993) 652-654
-
(1993)
Nature
, vol.365
, pp. 652-654
-
-
Shenker, A.1
Laue, L.2
Kosugi, S.3
Merendino Jr., J.J.4
Minegishi, T.5
Cutler Jr., G.B.6
-
20
-
-
0037341869
-
Desensitization of Gs-coupled receptor signaling by constitutively active mutants of the human lutropin/choriogonadotropin receptor
-
Shinozaki H., Butnev V., Tao Y.X., Ang K.L., Conti M., and Segaloff D.L. Desensitization of Gs-coupled receptor signaling by constitutively active mutants of the human lutropin/choriogonadotropin receptor. J. Clin. Endocrinol. Metab. 88 (2003) 1194-1204
-
(2003)
J. Clin. Endocrinol. Metab.
, vol.88
, pp. 1194-1204
-
-
Shinozaki, H.1
Butnev, V.2
Tao, Y.X.3
Ang, K.L.4
Conti, M.5
Segaloff, D.L.6
-
21
-
-
0034982278
-
Pleiotropic effects of substitutions of a highly conserved leucine in transmembrane helix III of the human lutropin/choriogonadotropin receptor with respect to constitutive activation and hormone responsiveness
-
Shinozaki H., Fanelli F., Liu X., Jaquette J., Nakamura K., and Segaloff D.L. Pleiotropic effects of substitutions of a highly conserved leucine in transmembrane helix III of the human lutropin/choriogonadotropin receptor with respect to constitutive activation and hormone responsiveness. Mol. Endocrinol. 15 (2001) 972-984
-
(2001)
Mol. Endocrinol.
, vol.15
, pp. 972-984
-
-
Shinozaki, H.1
Fanelli, F.2
Liu, X.3
Jaquette, J.4
Nakamura, K.5
Segaloff, D.L.6
-
22
-
-
12244269062
-
Adult height after ketoconazole treatment in patients with familial male-limited precocious puberty
-
Soriano-Guillen L., Lahlou N., Chauvet G., Roger M., Chaussain J.L., and Carel J.C. Adult height after ketoconazole treatment in patients with familial male-limited precocious puberty. J. Clin. Endocrinol. Metab. 90 (2005) 147-151
-
(2005)
J. Clin. Endocrinol. Metab.
, vol.90
, pp. 147-151
-
-
Soriano-Guillen, L.1
Lahlou, N.2
Chauvet, G.3
Roger, M.4
Chaussain, J.L.5
Carel, J.C.6
-
23
-
-
0036020508
-
Chimeras of the rat and human FSH receptors (FSHRs) identify residues that permit or suppress transmembrane 6 mutation-induced constitutive activation of the FSHR via rearrangements of hydrophobic interactions between helices 6 and 7
-
Tao Y.-X., Mizrachi D., and Segaloff D.L. Chimeras of the rat and human FSH receptors (FSHRs) identify residues that permit or suppress transmembrane 6 mutation-induced constitutive activation of the FSHR via rearrangements of hydrophobic interactions between helices 6 and 7. Mol. Endocrinol. 16 (2002) 1881-1892
-
(2002)
Mol. Endocrinol.
, vol.16
, pp. 1881-1892
-
-
Tao, Y.-X.1
Mizrachi, D.2
Segaloff, D.L.3
-
24
-
-
0033711033
-
Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function
-
Themmen A.P.N., and Huhtaniemi I.T. Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function. Endocr. Rev. 21 (2000) 551-583
-
(2000)
Endocr. Rev.
, vol.21
, pp. 551-583
-
-
Themmen, A.P.N.1
Huhtaniemi, I.T.2
-
25
-
-
22544468863
-
The formation of a salt bridge between helices 3 and 6 is responsible for the constitutive activity and lack of hormone responsiveness of the naturally occurring L457R mutation of the human lutropin receptor
-
Zhang M., Mizrachi D., Fanelli F., and Segaloff D.L. The formation of a salt bridge between helices 3 and 6 is responsible for the constitutive activity and lack of hormone responsiveness of the naturally occurring L457R mutation of the human lutropin receptor. J. Biol. Chem. 280 (2005) 26169-26176
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26169-26176
-
-
Zhang, M.1
Mizrachi, D.2
Fanelli, F.3
Segaloff, D.L.4
|