Protein kinase A-mediated phosphorylation contributes to enhanced contraction observed in mice that overexpress β-adrenergic receptor kinase-1

Journal of Pharmacology and Experimental Therapeutics

Volumn 319, Issue 3, 2006, Pages 1307-1316

  Mueller, Erin E ^a   Grandy, Scott A ^a   Howlett, Susan Ellen ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; ADENOSINE TRIPHOSPHATE MAGNESIUM; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR KINASE 1; CALCIUM CHLORIDE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; EGTAZIC ACID; MAGNESIUM CHLORIDE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ADRENERGIC STIMULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG EFFECT; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; MALE; MICROELECTRODE; MOUSE; MUSCLE CELL; MUSCLE FIBER CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VOLTAGE CLAMP;

ADENYLATE CYCLASE; ANIMALS; BETA-ADRENERGIC RECEPTOR KINASE; CALCIUM CHANNELS, L-TYPE; CARDIAC PACING, ARTIFICIAL; CELL SEPARATION; CELL SIZE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DATA INTERPRETATION, STATISTICAL; DIALYSIS; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEART VENTRICLES; ISOQUINOLINES; MALE; MICE; MICRODIALYSIS; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 33751191883     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.107888     Document Type: Article

References (35)

1. Bassani RA, Mattiazzi A, and Bers DM (1995) CaMKII is responsible for activity-dependent acceleration of relaxation in rat ventricular myocytes. Am J Physiol 268:H703-H712.
2. Bers DM (2001) Excitation-Contraction Coupling and Cardiac Contractile Force, 2nd ed., Kluwer Academic Publishers, Boston, MA.
3. Canadian Council on Animal Care (1980) Guide to the Care and Use of Experimental Animals, Vol. 1, Council on Animal Care, Ottawa, ON, Canada.
4. Canadian Council on Animal Care (1984) Guide to the Care and Use of Experimental Animals, Vol. 2, Council on Animal Care, Ottawa, ON, Canada.
5. Chen EP, Bittner HB, Akhter SA, Koch WJ, and Davis RD (1998) Myocardial recovery after ischemia and reperfusion injury is significantly impaired in hearts with transgenic overexpression of beta-adrenergic receptor kinase. Circulation 98:II249 -II253.
6. El-Armouche A, Rau T, Zolk O, Ditz D, Pamminger T, Zimmermann WH, Jackel E, Harding SE, Boknik P, Neumann J, et al. (2003) Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes. FASEB J 17:437-439.
7. Ferrier GR and Howlett SE (2003) Differential effects of phosphodiesterase-sensitive and -resistant analogs of cAMP on initiation of contraction in cardiac ventricular myocytes. J Pharmacol Exp Ther 306:166-178.
8. Ferrier GR, Smith RH, and Howlett SE (2003) Calcium sparks in mouse ventricular myocytes at physiological temperature. Am J Physiol 285:H1495-H1505.
9. Ferrier GR, Zhu J, Redondo IM, and Howlett SE (1998) Role of cAMP-dependent protein kinase A in activation of a voltage-sensitive release mechanism for cardiac contraction in guinea-pig myocytes. J Physiol (Lond) 513:185-201.
10. + current modulates repolarization and excitation-contraction coupling in adult mouse ventricle. J Physiol (Lond) 504:557-563.
11. Francis SH, Turko IV, and Corbin JD (2001) Cyclic nucleotide phosphodiesterases: relating structure and function. Prog Nucleic Acid Res Mol Biol 65:1-52.
12. Frank K and Kranias EG (2000) Phospholamban and cardiac contractility. Ann Med 32:572-578.
13. 2+-ATPase modulates cardiac contraction and relaxation. Cardiovasc Res 57:20-27.
14. Hausdorff WP, Caron MG, and Lefkowitz RJ (1990) Turning off the signal: desensitization of beta-adrenergic receptor function. FASEB J 4:2881-2889.
15. Kapiloff MS (2002) Contributions of protein kinase A anchoring proteins to compartmentation of cAMP signaling in the heart. Mol Pharmacol 62:193-199.
16. Keys JR and Koch WJ (2004) The adrenergic pathway and heart failure. Recent Prog Horm Res 59:13-30.
17. Knollmann BC, Knollmann-Ritschel BE, Weissman NJ, Jones LR, and Morad M (2000) Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin. J Physiol (Lond) 525:483-498.
18. Koch WJ, Rockman HA, Samama P, Hamilton RA, Bond RA, Milano CA, and Lefkowitz RJ (1995) Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a βARK inhibitor. Science (Wash DC) 268:1350-1353.
19. Korzick DH, Xiao RP, Ziman BD, Koch WJ, Lefkowitz RJ, and Lakatta EG (1997) Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine. Am J Physiol 272:H590-H596.
20. Lohse MJ, Benovic JL, Caron MG, and Lefkowitz RJ (1990) Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. J Biol Chem 265:3202-3211.
21. Marks AR (2001) Ryanodine receptors/calcium release channels in heart failure and sudden cardiac death. J Mol Cell Cardiol 33:615-624.
22. Marks AR, Marx SO, and Reiken S (2002) Regulation of ryanodine receptors via macromolecular complexes: a novel role for leucine/isoleucine zippers. Trends Cardiovasc Med 12:166-170.
23. Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, and Kass RS (2002) Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science (Wash DC) 295:496-499.
24. Meyer RB Jr and Miller JP (1974) Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity. Life Sci 14:1019-1040.
25. Olsson MC, Palmer BM, Stauffer BL, Leinwand LA, and Moore RL (2004) Morphological and functional alterations in ventricular myocytes from male transgenic mice with hypertrophic cardiomyopathy. Circ Res 94:201-207.
26. Penela P, Murga C, Ribas C, Tutor AS, Peregrin S, and Mayor F Jr (2006) Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease. Cardiovasc Res 69:46-56.
27. 2+ load in human heart failure. Basic Res Cardiol 97:I63-I71.
28. Post SR, Hammond HK, and Insel PA (1999) Beta-adrenergic receptors and receptor signaling in heart failure. Annu Rev Pharmacol Toxicol 39:343-360.
29. Rockman HA, Choi DJ, Rahman NU, Akhter SA, Lefkowitz RJ, and Koch WJ (1996) Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. Proc Natl Acad Sci USA 93:9954-9959.
30. Rockman HA, Koch WJ, and Lefkowitz RJ (2002) Seven-transmembrane-spanning receptors and heart function. Nature (Lond) 415:206-212.
31. 2+ channels. Cell Physiol Biochem 9:242-269.
32. Ungerer M, Bohm M, Elce JS, Erdmann E, and Lohse MJ (1993) Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. Circulation 87:454-463.
33. Wallukat G (2002) The beta-adrenergic receptors. Herz 27:683-690.
34. Yatani A, Frank K, Sako H, Kranias EG, and Dorn GW 2nd (1999) Cardiac-specific overexpression of Gαq alters excitation-contraction coupling in isolated cardiac myocytes. J Mol Cell Cardiol 31:1327-1336.
35. Yoshida A, Takahashi M, Imagawa T, Shigekawa M, Takisawa H, and Nakamura T (1992) Phosphorylation of ryanodine receptors in rat myocytes during beta-adrenergic stimulation. J Biochem (Tokyo) 111:186-190.