Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetic subjects

American Journal of Physiology - Endocrinology and Metabolism

Volumn 291, Issue 5, 2006, Pages

  Salinari, Serenella ^a   Bertuzzi, Alessandro ^b   Gandolfi, Alberto ^b   Greco, Aldo V ^c   Scarfone, Antonino ^c   Manco, Melania ^c   Mingrone, Geltrude ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CNR   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

Dodecanedioic acid; Energy substrate; Mathematical modeling; Physical exercise

Indexed keywords

DICARBOXYLIC ACID; DODECANEDIOIC ACID; FATTY ACID; GLUCOSE; UNCLASSIFIED DRUG; WATER;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY EXPENDITURE; EXERCISE; HUMAN; INSULIN RELEASE; LIPOLYSIS; MALE; MATHEMATICAL MODEL; MUSCLE FATIGUE; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATION; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ADULT; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DICARBOXYLIC ACIDS; ENERGY METABOLISM; EXERTION; FATTY ACIDS, NONESTERIFIED; GLYCOGEN; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MUSCLE FATIGUE; MUSCLE, SKELETAL; OXIDATION-REDUCTION;

EID: 33751166586     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00631.2005     Document Type: Article

References (34)

1. Ahlborg G and Felig P. Influence of glucose ingestion on fuel-hormone response during prolonged exercise. J Appl Physiol 41: 683-688, 1976.
2. Alexander JJ, Snyder A, and Tonsgard JH. Omega-oxidation of monocarboxylic acids in rat brain. Neurochem Res 23: 227-233, 1998.
3. Ashbrook JD, Spector AA, Santos EC, and Fletcher JE. Long chain fatty acid binding to human plasma albumin. J Biol Chem 250: 2333-2338, 1975.
4. 13C]bicarbonate washout kinetics. Am J Physiol Regul Integr Comp Physiol 259: R163-R171, 1990.
5. Basu A, Basu R, Shah P, Vella A, Johnson CN, Nair KS, Jensen MD, Schwenk WF, and Rizza RA. Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity. Diabetes 49: 272-283, 2000.
6. Bergstrom J, Hermansen L, Hultman E, and Saltin B. Diet, muscle glycogen, and physical performance. Acta Physiol Scand 71: 140-150, 1967.
7. Bertuzzi A, Finotti E, Mingrone G, and Greco AV. Sebacic acid binding by human plasma albumin. Biochem Pharmacol 45: 697-702, 1993.
8. Bertuzzi A, Mingrone G, Gandolfi A, Greco AV, and Salinari S. Pharmacokinetic analysis of dodecanedioic acid in humans from bolus data. J Parenter Enteral Nutr 78: 143-153, 1995.
9. Bertuzzi A, Mingrone G, Gandolfi A, Greco AV, and Salinari S. Disposition of dodecanedioic acid in humans. J Pharmacol Exp Ther 292: 846-852, 2000.
10. Borg GAV. Psychophysical basis of perceived exertion. Med Sci Sport Exerc 14: 377-381, 1982.
11. Borghouts LB, Wagenmakers AJ, Goyens PL, and Keizer HA. Substrate utilization in non-obese type II diabetic patients at rest, and during exercise. Clin Sci 103: 559-566, 2002.
12. Campbell PJ, Carlson MG, Hill JO, and Nurjhan N. Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis, and reesterification. Am J Physiol Endocrinol Metab 263: E1063-E1069, 1992.
13. Caro JF, Triester S, Patel VK, Tapscott EB, Leggett Frazier N, and Dohm GL. Liver glucokinase: decreased activity in patients with type II diabetes. Horm Metab Res 27: 19-22, 1995.
14. Coyle EF, Jeukendrup AE, Wagenmakers AJ, and Saris WH. Fatty acid oxidation is directly regulated by carbohydrate metabolism during exercise. Am J Physiol Endocrinol Metab 273: E268-E275, 1997.
15. Ferrannini E. The theoretical bases of indirect calorimetry: a review. Metabolism 37: 287-301, 1988.
16. Gastaldelli A, Miyazaki Y, Pettiti M, Buzzignoli E, Mahankali S, Ferrannini E, and De Fronzo RA. Separate contribution of diabetes, total fat mass, and fat topography to glucose production, gluconeogenesis, and glycogenolysis. J Clin Endocrinol Metab 89: 3914-3921, 2004.
17. Greco AV, Mingrone G, Capristo E, Benedetti G, De Gaetano A, and Gasbarrini G. The metabolic effect of dodecanedioic acid infusion in non-insulin-dependent diabetic patients. Nutrition 14: 351-357, 1998.
18. Green HJ, Jones LL, Houston ME, Ball-Burnett ME, and Farrance BW. Muscle energetics during prolonged cycling after exercise hypervolemia. J Appl Physiol 66: 622-631, 1989.
19. Henriksen EJ. Invited Review: Effects of acute exercise and exercise training on insulin resistance J Appl Physiol 93: 788-796, 2002.
20. Horowitz JF, Mora-Rodriguez R, Byerley LO, and Coyle EF. Lipolytic suppression following carbohydrate ingestion limits fat oxidation during exercise. Am J Physiol Endocrinol Metab 273: E768-E775, 1997.
21. Kelley DE. Skeletal muscle fat oxidation: timing and flexibility are everything J. Clin Invest 115: 1699-1702, 2005.
22. Ladriere L and Malaisse WJ. Effects of the dimethyl ester on succinic acid on the hormonal and metabolic response to exercise in hereditarily diabetic starved rats. Cell Biochem Funct 18: 153-160, 2000.
23. Landaw EM and DiStefano JJ III. Multiexponential, multicompartmental, and noncompartmental modeling. II. Data analysis and statistical considerations. Am J Physiol Regul Integr Comp Physiol 246: R665-R677, 1984.
24. Memon RA, Bessman SP, and Mohan C. Impaired mitochondrial metabolism, and reduced amphibolic Krebs cycle activity in diabetic rat hepatocytes Biochem Mol Biol Int 37: 1079-1089, 1995.
25. Mendenhall LA, Swanson SC, Habash DL, and Coggan AR. Ten days of exercise training reduces glucose production and utilization during moderate-intensity exercise. Am J Physiol Endocrinol Metab 266: E136-E143, 1994.
26. Mingrone G, Greco AV, Bertuzzi A, Arcieri-Mastromattei E, Tacchino RM, Marino F, Finotti E, and Castagneto M. Tissue uptake and oxidation of disodium sebacate in man. J Parenter Enteral Nutr 15: 454-459, 1991.
27. Mingrone G, De Gaetano A, Greco AV, Capristo E, Benedetti G, Castagneto M, and Gasbarrini G. Dodecanedioic acid infusion induces a sparing effect on whole-body glucose uptake, mainly in non-insulin-dependent diabetes mellitus. Br J Nutr 78: 723-735, 1997.
28. Panagiotis H, Short KR, Bigelow M, and Nair KS. Synthesis rate of muscle proteins, muscle functions, and amino acid kinetics in type 2 diabetes. Diabetes 51: 2395-2404, 2002.
29. Parish R and Petersen KF. Mitochondrial dysfunction and type 2 diabetes. Curr Diab Rep 5: 177-183, 2005.
30. Passi S, Nazzaro-Porro M, Picardo M, Mingrone G, and Fasella P. Metabolism of straight saturated medium chain length (C9 to C12) dicarboxylic acids. J Lipid Res 24: 1140-1147, 1983.
31. Shao J and Thu D. The Jackknife and Bootstrap. New York, NY: Springer Verlag, 1995.
32. Stumvoll M, Goldenstein BJ, and van Haeften TW. Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365: 1333-1346, 2005.
33. Vajda S, Godfrey KR, and Rabitz H. Similarity transformation approach to identifiability analysis of nonlinear compartmental models. Math Biosci 93: 217-248, 1989.
34. Wolfe RR, Klein S, Carraro F, and Weber JM. Role of triglyceride-fatty acid cycle in controlling fat metabolism in humans during and after exercise. Am J Physiol Endocrinol Metab 258: E382-E389, 1990.