Bisphosphonate-induced, hemichannel-mediated, anti-apoptosis through the Src/ERK pathway: A gap junction-independent action of connexin43

Cell Adhesion and Communication

Volumn 8, Issue 4-6, 2000, Pages 377-382

  Plotkin, L I ^a   Bellido, T ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Apoptosis; Bisphosphonates; Bone; Connexin43; ERKs; Src

Indexed keywords

EID: 33751145145     PISSN: 10615385     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Beyer, E. C., Paul, D. L., and Goodenough, D. A. 1990. Connexin family of gap junction proteins. J. Membr. Biol. 116:187-194.
2. Civitelli, R., Beyer, E. C., Warlow, P. M., Robertson, A. J., Geist, S. T., and Steinberg, T. H. 1993. Connexin43 mediates direct intercellular communication in human osteoblastic cell networks. J. Clin. Invest. 91:1888-1896.
3. Davidson, J. S., and Baumgarten, I. M. 1988. Glycyrrhetinic acid derivatives: a novel class of inhibitors of gap-junctional intercellular communication. Structure-activity relationships. J. Pharmacol. Exp. Ther. 246:1104-1107.
4. Homma, N., Alvarado, J. L., Coombs, W., Stergiopoulos, K., Taflet, S. M., Lau, A. F., and Delmar, M. 1998. A particle-receptor model for the insulin-induced closure of connexin43 channels. Circ. Res. 83:27-32.
5. Hoshi, T., Zagotta, W. N., and Aldrich, R. W. 1990. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250:533-538.
6. John, S. A., Kondo, R., Wang, S. Y., Goldhaber, J. I., and Weiss, J. N. 1999. Connexin-43 hemichannels opened by metabolic inhibition. J. Biol. Chem. 274:236-240.
7. Kancmitsu, M. Y., Loo, L. W., Simon, S., Lau, A. F., and Eckhart, W. 1997. Tyrosine phosphorylation of connexin 43 by v-Src is mediated by SH2 and SH3 domain interactions. J. Biol. Chem. 272:22824-22831.
8. Kelsell, D. P., Dunlop, J., and Hodgins, M. B. 2001. Human diseases: clues to cracking the connexin code? Trends Cell Biol. 11:2-6.
9. Klinghoffer, R. A., Sachsenmaier, C., Cooper, J. A., and Soriano, P. 1999. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 18:2459-2471.
10. Kousteni, S., Bellido, T., Plotkin, L. I., O'Brien, C. A., Bodenner, D. L., Han, L., Han, K., Di Gregorio, G. B., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Roberson, P. K., Weinstein, R. S., Jilka, R. L., and Manolagas, S. C. 2001. Sex non-specific anti-apoptotic signaling through the classical estrogen (alpha or beta) or androgen receptors: dissociation from transcriptional activity. Cell 104:719-730.
11. Lecanda, F., Towler, D. A., Ziambaras, K., Cheng, S. L., Koval, M., Steinberg, T. H., and Civitelli, R. 1998. Gap junctional communication modulates gene expression in osteoblastic cells. Mol. Biol. Cell 9:2249-2258.
12. Lecanda, F., Warlow, P. M., Sheikh, S., Furlan, F., Steinberg, T. H., and Civitelli, R. 2000. Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction. J. Cell Biol. 151:931-944.
13. Manolagas, S. C. 2000. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr. Rev. 21:115-137.
14. Marotti, G., Cane, V., Palazziri, S., and Palumbo, C. 1990. Structure-function relationships in the osteocyte. Ital. J. Min. Electrol. Metab. 4:93-106.
15. Martyn, K. D., Kurata, W. E., Warn-Cramer, B. J., Burt, J. M., TenBroek, E., and Lau, A. F. 1997. Immortalized connexin43 knockout cell lines display a subset of biological properties associated with the transformed phenotype. Cell Growth Differ. 8:1015-1027.
16. Morley, G. E., Taffet, S. M., and Delmar, M. 1996. Intramolecular interactions mediate pH regulation of connexin43 channels. Biophys. J. 70:1294-1302.
17. Musil, L. S., and Goodenough, D. A. 1991. Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques. J. Cell Biol. 115:1357-1374.
18. Plotkin, L. I., Weinstein, R. S., Parfitt, A. M., Roberson, P. K., Manolagas, S. C., and Bellido, T. 1999. Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J. Clin. Invest. 104:1363-1374.
19. Quist, A. P., Rhee, S. K., Lin, H., and Lal, R. 2000. Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation. J. Cell Biol. 148:1063-1074.
20. Romanello, M., and D'Andrea, P. 2001. Dual mechanism of intercellular communication in HOBIT osteoblastic cells: a role for gap-junctional hemichannels. J. Bone Miner. Res. 16:1465-1476.
21. Warn-Cramer, B. J., Lampe, P. D., Kurata, W. E., Kanemitsu, M. Y., Loo, L. W., Eckhart, W., and Lau, A. F. 1996. Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J. Biol. Chem. 271:3779-3786.
22. White, T. W., and Paul, D. L. 1999. Genetic diseases and gene knockouts reveal diverse connexin functions. Annu. Rev. Physiol. 61:283-310.
23. Zhou, L., Kasperek, E. M., and Nicholson, B. J. 1999. Dissection of the molecular basis of pp60(v-src) induced gating of connexin 43 gap junction channels. J. Cell Biol. 144:1033-1045.