Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides

Journal of Medicinal Chemistry

Volumn 49, Issue 14, 2006, Pages 4409-4424

  Pryde, David C ^a   Maw, Graham N ^a   Planken, Simon ^a   Platts, Michelle Y ^a   Sanderson, Vivienne ^a   Corless, Martin ^a   Stobie, Alan ^a   Barber, Christopher G ^a   Russell, Rachel ^a   Foster, Laura ^a   Barker, Laura ^a   Wayman, Christopher ^a   Van Der Graaf, Piet ^a   Stacey, Peter ^a   Morren, Debbie ^a   Kohl, Christopher ^a   Beaumont, Kevin ^a   Coggon, Sara ^a   Tute, Michael ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; BACLOFEN; CADOXATRILAT; CIPROFLOXACIN; DICLOFENAC; ENKEPHALINASE INHIBITOR; FLUINDOSTATIN; FLURBIPROFEN; FUROSEMIDE; GABAPENTIN; GLUTARAMIC ACID DERIVATIVE; IBUPROFEN; KETOPROFEN; SULINDAC; TOLMETIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SPECIFICITY; FEMALE; FEMALE SEXUAL DYSFUNCTION; MALE; MOLECULAR WEIGHT; NONHUMAN; PREVALENCE; RAT; SEXUAL AROUSAL DISORDER; STRUCTURE ACTIVITY RELATION;

ACIDS, CARBOCYCLIC; AMIDES; ANIMALS; CHO CELLS; CLITORIS; CRICETINAE; CRICETULUS; DOGS; FEMALE; HUMANS; MALE; NEPRILYSIN; PENTANOIC ACIDS; PYRIDINES; RABBITS; RATS; RECOMBINANT PROTEINS; REGIONAL BLOOD FLOW; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL; SPECIES SPECIFICITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; VAGINA;

EID: 33745872565     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060133g     Document Type: Article

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