Functional involvement of rat organic anion transporter 2 (Slc22a7) in the hepatic uptake of the nonsteroidal anti-inflammatory drug ketoprofen

Drug Metabolism and Disposition

Volumn 33, Issue 8, 2005, Pages 1151-1157

  Morita, Naomi ^a   Kusuhara, Hiroyuki ^a   Nozaki, Yoshitane ^a   Endou, Hitoshi ^b   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYORIN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOHIPPURIC ACID; DIGOXIN; GLIBENCLAMIDE; INDOCYANINE GREEN; INDOMETACIN; KETOPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; ORGANIC ANION TRANSPORTER; PRAVASTATIN; PROBENECID; SALICYLIC ACID; TAUROCHOLIC ACID;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DRUG UPTAKE; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYBURIDE; HEPATOCYTES; INDOCYANINE GREEN; KETOPROFEN; LLC-PK1 CELLS; MALE; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PROBENECID; RATS; RATS, SPRAGUE-DAWLEY; SWINE;

EID: 22944438439     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.104.001552     Document Type: Article

References (39)

1. Bezek S, Kukan M, and Bohov P (1994) Hepatobiliary disposition of 3′-azido-3′-deoxythymidine (AZT) in the rat: effect of phenobarbitone induction. J Pharm Pharmacol 46:575-580.
2. Cattori V, van Montfoort JE, Stieger B, Landmann L, Meijer DK, Winterhalter KH, Meier PJ, and Hagenbuch B (2001) Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflugers Arch 443:188-195.
3. Cayen MN, Kraml M, Ferdinandi ES, Greselin E, and Dvornik D (1981) The metabolic disposition of etodolac in rats, dogs and man. Drug Metab Rev 12:339-362.
4. Dietzel K, Beck WS, Schneider HT, Geisslinger G, and Brune K (1990) The biliary elimination and enterohepatic circulation of ibuprofen in rats. Pharm Res (NY) 7:87-90.
5. Duggan DE, Hooke KF, and Hwang SS (1980) Kinetics of the tissue distributions of sulindac and metabolites. Relevance to sites and rates of bioactivation. Drug Metab Dispos 8:241-246.
6. Faber KN, Muller M, and Jansen PL (2003) Drug transport proteins in the liver. Adv Drug Deliv Rev 55:107-124.
7. Foster RT and Jamali F (1988) Stereoselective pharmacokinetics of ketoprofen in the rat. Influence of route of administration. Drug Metab Dispos 16:623-626.
8. Hagenbuch B and Meier PJ (2003) The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta 1609:1-18.
9. Hasegawa M, Kusuhara H, Endou H, and Sugiyama Y (2003) Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat. J Pharmacol Exp Ther 305:1087-1097.
10. Hasegawa M, Kusuhara H, Sugiyama D, Ito K, Ueda S, Endou H, and Sugiyama Y (2002) Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. J Pharmacol Exp Ther 300:746-753.
11. Hirano M, Maeda K, Shitara Y, and Sugiyama Y (2004) Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther 311:139-146.
12. Honscha W, Schulz K, Muller D, and Petzinger E (1993) Two different mRNAs from rat liver code for the transport of bumetanide and taurocholate in Xenopus laevis oocytes. Eur J Pharmacol 246:227-232.
13. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, and Kirchgessner TG (1999) A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem 274:37161-37168.
14. Insel P (1995) Analgesic-antipyretic and antiinflammatory agents and drugs employed in the treatment of gout, in Goodman & Gilman's the Pharmacological Basis of Therapeutics, pp 617-658, McGraw-Hill, New York.
15. Iwakawa S, Spahn H, Benet LZ, and Lin ET (1991) Stereoselective disposition of carprofen, flunoxaprofen, and naproxen in rats. Drug Metab Dispos 19:853-857.
16. Jamali F and Brocks DR (1990) Clinical pharmacokinetics of ketoprofen and its enantiomers. Clin Pharmacokinet 19:197-217.
17. Kato Y, Kuge K, Kusuhara H, Meier PJ, and Sugiyama Y (2002) Gender difference in the urinary excretion of organic anions in rats. J Pharmacol Exp Ther 302:483-489.
18. Khamdang S, Takeda M, Noshiro R, Narikawa S, Enomoto A, Anzai N, Piyachaturawat P, and Endou H (2002) Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 303:534-539.
19. Khamdang S, Takeda M, Shimoda M, Noshiro R, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, and Endou H (2004) Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci 94:197-202.
20. Koepsell H and Endou H (2004) The SLC22 drug transporter family. Pflugers Arch 447:666-676.
21. Kojima R, Sekine T, Kawachi M, Cha SH, Suzuki Y, and Endou H (2002) Immunolocalization of multispecific organic anion transporters, OAT1, OAT2 and OAT3, in rat kidney. J Am Soc Nephrol 13:848-857.
22. Kouzuki H, Suzuki H, and Sugiyama Y (2000) Pharmacokinetic study of the hepatobiliary transport of indomethacin. Pharm Res (NY) 17:432-438.
23. Kullak-Ublick GA, Stieger B, Hagenbuch B, and Meier PJ (2000) Hepatic transport of bile salts. Semin Liver Dis 20:273-292.
24. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, and Endou H (1999) Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem 274:13675-13680.
25. Morita N, Kusuhara H, Sekine T, Endou H, and Sugiyama Y (2001) Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells. J Pharmacol Exp Ther 298:1179-1184.
26. Nagata Y, Kusuhara H, Endou H, and Sugiyama Y (2002) Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Mol Pharmacol 61:982-988.
27. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, and Endou H (1998) Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett 429:179-182.
28. Sekine T, Watanabe N, Hosoyamada M, Kanai Y, and Endou H (1997) Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 272:18526-18529.
29. Simonson GD, Vincent AC, Roberg KJ, Huang Y, and Iwanij V (1994) Molecular cloning and characterization of a novel liver-specific transport protein. J Cell Sci 107:1065-1072.
30. Stierlin H and Faigle JW (1979) Biotransformation of diclofenac sodium (Voltaren) in animals and in man. II. Quantitative determination of the unchanged drug and principal phenolic metabolites, in urine and bile. Xenobiotica 9:611-621.
31. Sumner DD, Dayton PG, Cucinell SA, and Plostnieks J (1975) Metabolism of tolmetin in rat, monkey and man. Drug Metab Dispos 3:283-286.
32. Tokui T, Nakai D, Nakagomi R, Yawo H, Abe T, and Sugiyama Y (1999) Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2. Pharm Res (NY) 16:904-908.
33. van Montfoort JE, Hagenbuch B, Groothuis GM, Koepsell H, Meier PJ, and Meijer DK (2003) Drug uptake systems in liver and kidney. Curr Drug Metab 4:185-211.
34. Yamaoka K, Tanaka H, Okumura K, Yasuhara M, and Hori R (1986) An analysis program MULTI(ELS) based on extended nonlinear least squares method for microcomputers. J Pharmacobiodyn 9:161-173.
35. Yamazaki M, Suzuki H, Hanano M, Tokui T, Komai T, and Sugiyama Y (1993) Na(+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver. Am J Physiol 264:G36-G44.
36. Yamazaki M, Suzuki H, Sugiyama Y, Iga T, and Hanano M (1992) Uptake of organic anions by isolated rat hepatocytes. A classification in terms of ATP-dependency. J Hepatol 14:41-47.
37. Yesair DW, Callahan M, Remington L, and Kensler CJ (1970) Role of the entero-hepatic cycle of indomethacin on its metabolism, distribution in tissues and its excretion by rats, dogs and monkeys. Biochem Pharmacol 19:1579-1590.
38. Youngblood GL and Sweet DH (2004) Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Am J Physiol 287:F236-F244.
39. Yue TL and Varma DR (1982) Pharmacokinetics, metabolism and disposition of salicylate in protein-deficient rats. Drug Metab Dispos 10:147-152.