Inhibition of human glutathione transferases by multidrug resistance chemomodulators in vitro

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 21, Issue 5, 2006, Pages 581-587

  Hayeshi, Rose ^a   Chinyanga, Farai ^a   Chengedza, Shylet ^a   Mukanganyama, Stanley ^a  

^a UNIVERSITY OF ZIMBABWE   (Zimbabwe)

Author keywords

BCNU; Chemomodulators; Glutathione S transferases; Inhibition; Multidrug resistance; O6 benzylguanine; P glycoprotein

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 1,3 BIS (2 CHLOROETHYL) 1 NITROSOUREA; 6 O BENZYLGUANINE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CUMENE HYDROPEROXIDE; DEXAMETHASONE; ETACRYNIC ACID; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE ALPHA; GLUTATHIONE TRANSFERASE INHIBITOR; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; INDOMETACIN; MEPACRINE; METHYLENE BLUE; MULTIDRUG RESISTANCE CHEMOMODULATOR; NICARDIPINE; NITROSOUREA; PROBENECID; PROGESTERONE; SALAZOSULFAPYRIDINE; SULFINPYRAZONE; TAMOXIFEN; TESTOSTERONE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

DRUG RESISTANCE, MULTIPLE; ENZYME INHIBITORS; GENE EXPRESSION; GLUTATHIONE TRANSFERASE; HUMANS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 33751080726     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360600756105     Document Type: Article

References (32)

1. Gottesman, MM and Pastan, I. (1993) Biochemistry of the multidrug resistance mediated by multidrug transporter Ann Rev Biochem, 62, pp. 385-427.
2. Volm, M. (1998) Multidrug resistance and its reversal Anticancer Res, 18, pp. 2905-2918.
3. Stammler, G and Koomági, R and Mattern, J and Volm, M. (1996) Comparison of the mRNA expression of factors related to drug resistance in lung tumours and adjacent normal tissue Int J Oncol, 8, pp. 537-542.
4. Hayes, JD and Flanagan, JU and Jowsey, IR. (2005) Glutathione transferases Ann Rev Pharmacol, 45, pp. 51-88.
5. MacLellan, IM and Wolf, CR. (1999) Glutathione and glutathione-dependent enzymes in cancer drug resistance Drug Resist Updat, 2, pp. 153-164.
6. Morrow, CS and Smitherman, PK and Townsend, AJ. (2000) Role of multidrug-resistance protein 2 in glutathione S-transferase P1-1-mediated resistance to 4-nitroquinoline 1-oxide toxicities in HepG2 cells Mol Carcinogen, 29, pp. 170-178.
7. Townsend, AJ and Kiningham, KK and St. Clair, D and Tephly, TR and Morrow, CS and Guengerich, FP. (1999) Symposium overview: Characterisation of xenobiotic metabolising enzyme function using heterologous expression systems Toxicol Sci, 48, pp. 143-150.
8. Morrow, CS and Smitherman, PK and Diah, SK and Schneider, E and Townsend, AJ. (1998) Co-ordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1(MRP1) in anti-neoplastic drug detoxification J Biol Chem, 273, pp. 20114-20120.
9. Choi, C-H. (2005) ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal Cancer Cell Internat, 5, pp. 30.
10. Chen, CL and Sheen, T-S and Lou, I-U and Huang, A-C. (2001) Expression of multidrug resistance 1 and glutathione -S-transferase pi protein in narsopharngeal carcinoma Human Pathol, 32, pp. 1240-1244.
11. Dolan, ME and Roy, SK and Garbiras, BJ and Helft, P and Paras, P and Chae, M-Y and Moschel, RC and Pegg, AE. (1998) O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases Biochem Pharmacol, 55, pp. 1701-1709.
12. Berhane, K and Hao, X-Y and Egyh̊zi, S and Hansson, J and Ringborg, U and Mannervik, B. (1993) Contribution of glutathione transferase M3-3 to 1,3-bis (2-chloroerthyl)-1-nitrosourea resistance in a human non-small cell lung cancer cell line Cancer Res, 53, pp. 4257-4261.
13. Awasthi, S and Singhal, SS and He, N and Chaubey, M and Zimniak, P and Srivatstava, SK and Singh, S and Awasthi, YC. (1996) Modulation of doxorubicin cytotoxicity by ethacrynic acid Int J Cancer, 68, pp. 333-339.
14. Mukanganyama, S and Naik, YS and Widersten, M and Mannervik, B and Hasler, JA. (2002) Inhibition of glutathione S-transferases by antimalarial drugs-possible implications for circumventing anticancer drug resistance Int J Cancer, 97, pp. 700-705.
15. Kolm, RH and Stenberg, G and Widersten, M and Mannervik, B. (1995) High-level bacteria expression of human glutathione transferase P1-1 by semi-synthetic DNA Prot Expr Purif, 6, pp. 265-271.
16. Lowry, OH and Roseborough, NJ and Farr, AL and Randall, RL. (1951) Protein measurement with Folin phenol reagent J Biol Chem, 193, pp. 265-275.
17. Laemmli, UK. (1970) Most commonly used discontinuous buffer systems for SDS electrophoresis Nature, 227, pp. 680-685.
18. Tirona, RG and Tan, E and Meier, G and Pang, KS. (1999) Uptake and glutathione conjugation of ethacrynic acid and efflux of the glutathione adduct by periportal and perivenous rat hepatocytes J Pharmacol Exp Therap, 291, pp. 1210-1219.
19. Habig, WH and Pabst, MJ and Jakoby, WB. (1974) Glutathione S-transferases: The first enzymatic step in mercapturic acid formation J Biol Chem, 249, pp. 7130-7139.
20. Simmons, TW and Jamall, IS and Lockshin, RA. (1989) Selenium-independent glutathione peroxidase activity associated with glutathione S-transferase from the housefly, Musca domestica Comp Biochem Physiol B Biochem Mol Biol, 94B, pp. 323-327.
21. Mannervik, B and Widersten, W.(1995) Human glutathione transferases, tissue distribution, structure and functional properties. In Advances in drug metabolism in man. (pp. 408-459). Brussels: European Union. EUR15439, ECDGX11-E-4,
22. Ferry, DR. (1998) Testing the role of P-glycoprotein expression in clinical trials; applying pharmacological principles and best methods for detection together with good clinical trials methodology Int J Clin Pharmacol Ther, 36, pp. 29-40.
23. Ishikawa, T and Akimura, K.(1996) Transport of glutathione S-conjugates from cancer cells: Function and structure of the GS-X pump. In Glutathione S-transferases, structure, function and clinical implications. (pp. 199-211). London: Taylor and Francis.
24. Zaman, GJR and Lankema, J and van Tellingen, O and Beijnen, J and Dekker, H and Paulusma, C and Elfferink, RPJO and Baas, F and Borst, P. (1995) Role of glutathione in the export of compounds from cells by the multidrug-associated protein Proc Natl Acad Sci USA, 92, pp. 7690-7694.
25. Trindade, GS and Farias, SLA and Rumjanek, VM and Capella, MAM. (2000) Methylene blue reverts multidrug resistance: Sensitivity of multidrug resistant cells to this dye and its photodynamic action Cancer Lett, 151, pp. 16-167.
26. Ogino, M and Minoura, S. (2001) Indomethacin increases the cytotoxicity of cis-platinum and 5-flourorracil in the human uterine cervical cancer cell lines SKG-2 and HKUS by increasing the intracellular uptake of the agents Int J Clin Oncol, 6, pp. 84-89.
27. Draper, MP and Martell, RL and Levy, SB. (1997) Indomethacin mediated reversal of multidrug resistance and drug efflux in human and murine lines expressing MRP but not P-glycoprotein British J Canc, 75, pp. 810-815.
28. Zhang, K and Das, NP. (1994) Inhibitory effects of plant polyphenols on rat liver glutathione S-transferases Biochem Pharmacol, 47, pp. 2063-2068.
29. Mulder, GJ and Ouwerkerk-Mahadevan, S. (1997) Inhibition and Modulation of glutathione conjugation in vivo: How to decrease glutathione conjugation in vivo or in intact cellular systems in vitro Chem Biol Interact, 105, pp. 17-34.
30. Peklack-Scott, C and Townsen, AJ and Morrow, CS. (2005) Dynamics of glutathione conjugation and conjugate efflux in detoxification of the carcinogen, 4-nitroquinoline1-oxide: Contributions of glutathione, glutathione S-transferase, and MRP1 Biochemistry, 44, pp. 4426-4433.
31. Johansson, A-F and Stenberg, GM and Widersten, M and Mannervik, B. (1998) Structure -activity relationships and thermal stability of human glutathione transferase P1-1 governed by H-site residue 105 J Mol Biol, 278, pp. 687-698.
32. Smith, MT and Evans, CG and Doane-Setzter, P and Castro, VM and Tahir, KM and Mannervik, B. (1989) Denitrosation of 1,3-bis-(2-chloroethyl)-1- nitrosourea by class mu glutathione transferase and its role in cellular resistance in rat brain tumour cells Cancer Res, 50, pp. 2621-2625.