Differences in expression of specific biomarkers distinguish human beard from scalp dermal papilla cells

Journal of Investigative Dermatology

Volumn 126, Issue 12, 2006, Pages 2583-2595

  Rutberg, Susan E ^a   Kolpak, Meredith L ^a   Gourley, John A ^a   Tan, Gege ^a   Henry, James P ^a   Shander, Douglas ^a  

^a Gillette/P and G Technical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; FIBULIN; PROTEIN; PROTEIN ATP1B; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; HAIR FOLLICLE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MALE; MICRODISSECTION; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN CELL;

ADULT; ANDROGENS; BIOLOGICAL MARKERS; CALCIUM-BINDING PROTEINS; CELL ADHESION; CELL PROLIFERATION; CELLS, CULTURED; EPIDERMIS; FACE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HAIR FOLLICLE; HUMANS; KERATINOCYTES; MALE; MEMBRANE PROTEINS; NA(+)-K(+)-EXCHANGING ATPASE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; RECEPTORS, ANDROGEN; SCALP;

EID: 33751074668     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700454     Document Type: Article

References (77)

1. Almond-Roesler B, Schon M, Schon MP, Blume-Peytavi U, Sommer C, Loster K et al. (1997) Cultured dermal papilla cells of the rat vibrissa follicle. Proliferative activity, adhesion properties and reorganization of the extracellular matrix in vitro. Arch Dermatol Res 289:698-704
2. Ando Y, Yamaguchi Y, Hamada K, Yoshikawa K, Itami S (1999) Expression of mRNA for androgen receptor, 5alpha-reductase and 17beta-hydroxysteroid dehydrogenase in human dermal papilla cells. Br J Dermatol 141:840-5
3. Argraves WS, Tran H, Burgess WH, Dickerson K (1990) Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure. J Cell Biol 111:3155-64
4. Aspberg A, Adam S, Kostka G, Timpl R, Heinegard D (1999) Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican. J Biol Chem 274:20444-9
5. Bardin A, Moll F, Margueron R, Delfour C, Chu ML, Maudelonde T et al. (2005) Transcriptional and posttranscriptional regulation of fibulin-1 by estrogens leads to differential induction of messenger ribonucleic acid variants in ovarian and breast cancer cells. Endocrinology 146:760-8
6. Bergwitz C, Wendlandt T, Kispert A, Brabant G (2001) Wnts differentially regulate colony growth and differentiation of chondrogenic rat calvaria cells. Biochim Biophys Acta 1538:129-40
7. Botchkarev VA, Botchkareva NV, Nakamura M, Huber O, Funa K, Lauster R et al. (2001) Noggin is required for induction of the hair follicle growth phase in postnatal skin. FASEB J 15:2205-14
8. Bratka-Robia CB, Mitteregger G, Aichinger A, Egerbacher M, Helmreich M, Bamberg E (2002) Primary cell culture and morphological characterization of canine dermal papilla cells and dermal fibroblasts. Vet Dermatol 13:1-6
9. Buijs A, van Rompaey L, Molijn AC, Davis JN, Vertegaal AC, Potter MD et al. (2000) The MN1-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity. Mol Cell Biol 20:9281-93
10. Cha SY, Sung YK, Im S, Kwack MH, Kim MK, Kim JC (2005) URB expression in human dermal papilla cells. J Dermatol Sci 39:128-30
11. Chiu HC, Chang CH, Chen JS, Jee SH (1996) Human hair follicle dermal papilla cell, dermal sheath cell and interstitial dermal fibroblast characteristics. J Formos Med Assoc 95:667-74
12. Choudhry R, Hodgins MB, Van der Kwast TH, Brinkmann AO, Boersma WJ (1992) Localization of androgen receptors in human skin by immunohistochemistry: implications for the hormonal regulation of hair growth, sebaceous glands and sweat glands. J Endocrinol 133:467-75
13. Couchman JR (1993) Hair follicle proteoglycans. J Invest Dermatol 101(Suppl):60S-4S
14. Davies GC, Thornton MJ, Jenner TJ, Chen YJ, Hansen JB, Carr RD et al. (2005) Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles. J Invest Dermatol 124:686-94
15. de Almeida H Jr, Zigrino P, Muller F, Krieg T, Korge B, Mauch C (2005) Human scalp dermal papilla and fibrous sheath cells have a different expression profile of matrix metalloproteinases in vitro when compared to scalp dermal fibroblasts. Arch Dermatol Res 297:121-6
16. Elliott K, Stephenson TJ, Messenger AG (1999) Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: implications for the control of hair follicle size and androgen responses. J Invest Dermatol 113:873-7
17. Eicheler W, Happle R, Hoffmann R (1998) 5 alpha-reductase activity in the human hair follicle concentrates in the dermal papilla. Arch Dermatol Res 290:126-32
18. Ferraris C, Cooklis M, Polakowska RR, Haake AR (1997) Induction of apoptosis through the PKC pathway in cultured dermal papilla fibroblasts. Exp Cell Res 234:37-46
19. Francz PI, Bayreuther K, Limat A, Noser F (1993) Differentiation and polypeptide expression in human papilla and dermal fibroblasts in vitro. Eur J Cell Biol 60:337-45
20. Hamada K, Thornton MJ, Laing I, Messenger AG, Randall VA (1996) The metabolism of testosterone by dermal papilla cells cultured from human pubic and axillary hair follicles concurs with hair growth in 5 alpha-reductase deficiency. J Invest Dermatol 106:1017-22
21. Han JH, Kwon OS, Chung JH, Cho KH, Eun HC, Kim KH (2004) Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle. J Dermatol Sci 34:91-8
22. Hennings H, Michael D, Cheng C, Steinert P, Holbrook K, Yuspa SH (1980) Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19:245-54
23. Hibino T, Nishiyama T (2004) Role of TGF-beta2 in the human hair cycle. J Dermatol Sci 35:9-18
24. Hoffmann R (2002) Male androgenetic alopecia. Clin Exp Dermatol 27:373-82
25. Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W (2001) beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105:533-45
26. Inui S, Fukuzato Y, Nakajima T, Yoshikawa K, Itami S (2002) Androgen-inducible TGF-beta1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understand paradoxical effects of androgen on human hair growth. FASEB J 16:1967-9
27. Inui S, Fukuzato Y, Nakajima T, Yoshikawa K, Itami S (2003) Identification of androgen-inducible TGF-beta1 derived from dermal papilla cells as a key mediator in androgenetic alopecia. J Invest Dermatol Symp Proc 8:69-71
28. Itami S, Inui S (2005) Role of androgen in mesenchymal epithelial interactions in human hair follicle. J Invest Dermatol Symp Proc 10:209-11
29. Itami S, Kurata S, Sonoda T, Takayasu S (1995) Interaction between dermal papilla cells and follicular epithelial cells in vitro: effect of androgen. Br J Dermatol 132:527-32
30. Itami S, Kurata S, Sonoda T, Takayasu S (1991) Characterization of 5 alpha-reductase in cultured human dermal papilla cells from beard and occipital scalp hair. J Invest Dermatol 96:57-60
31. Itami S, Sonoda T, Kurata S, Takayasu S (1994) Mechanism of action of androgen in hair follicles. J Dermatol Sci 7:S98-103
32. Jahoda CA, Oliver RF (1984) Histological studies of the effects of wounding vibrissa follicles in the hooded rat. J Embryol Exp Morphol 83:95-108
33. Jahoda CA, Horne KA, Oliver RF (1984) Induction of hair growth by implantation of cultured dermal papilla cells. Nature 311:560-2
34. Jahoda CA, Reynolds AJ, Chaponnier C, Forester JC, Gabbiani G (1991) Smooth muscle alpha-actin is a marker for hair follicle dermis in vivo and in vitro. J Cell Sci 99:627-36
35. Jahoda CA, Reynolds AJ, Oliver RF (1993) Induction of hair growth in ear wounds by cultured dermal papilla cells. J Invest Dermatol 101:584-90
36. Kaszynski E (1983) The stimulation of hair growth in the flank organs of female hamsters by subcutaneous testosterone propionate and its inhibition by topical cyproterone acetate: dose-response studies. Br J Dermatol 109:565-9
37. Katsuoka K, Mauch C, Schell H, Hornstein OP, Krieg T (1988) Collagen-type synthesis in human-hair papilla cells in culture. Arch Dermatol Res 280:140-4
38. Kim CD, Lee MH, Roh SS (2003) Identification of androgen-regulated genes in SV40-transformed human hair dermal papilla cells. J Dermatol Sci 32:143-9
39. Kishimoto J, Burgeson RE, Morgan BA (2000) Wnt signaling maintains the hair-inducing activity of the dermal papilla. Genes Dev 14:1181-5
40. Kishimoto J, Ehama R, Wu L, Jiang S, Jiang N, Burgeson RE (1999) Selective activation of the versican promoter by epithelial- mesenchymal interactions during hair follicle development. Proc Natl Acad Sci USA 96:7336-41
41. Krugluger W, Rohrbacher W, Laciak K, Moser K, Moser C, Hugeneck J (2005) Reorganization of hair follicles in human skin organ culture induced by cultured human follicle-derived cells. Exp Dermatol 14:580-5
42. Lekanne Deprez RH, Riegman PH, Groen NA, Warringa UL, van Biezen NA, Molijn AC et al. (1995) Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma. Oncogene 10:1521-8
43. Li M, Marubayashi A, Nakaya Y, Fukui K, Arase S (2001) Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. J Invest Dermatol 117:1594-600
44. Lingrel JB, Orlowski J, Shull MM, Price EM (1990) Molecular genetics of Na,K-ATPase. Prog Nuc Acid Res Mol Biol 38:37-89
45. Matsuzaki T, Yoshizato K (1998) Role of hair papilla cells on induction and regeneration processes of hair follicles. Wound Repair Regen 6:524-30
46. McElwee KJ, Kissling S, Wenzel E, Huth A, Hoffmann R (2003) Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla. J Invest Dermatol 121:1267-75
47. Meester-Smoor MA, Vermeij M, van Helmond MJ, Molijn AC, van Wely KH, Hekman AC et al. (2005) Targeted disruption of the Mn1 oncogene results in severe defects in development of membranous bones of the cranial skeleton. Mol Cell Biol 25:4229-36
48. Messenger AG (1984) The culture of dermal papilla cells from human hair follicles. Br J Dermatol 110:685-9
49. Midorikawa T, Chikazawa T, Yoshino T, Takada K, Arase S (2004) Different gene expression profile observed in dermal papilla cells related to androgenic alopecia by DNA macroarray analysis. J Dermatol Sci 36:25-32
50. Okada H, Nakajima T, Yoshimura T, Yasuda K, Kanzaki H (2003) Microarray analysis of genes controlled by progesterone in human endometrial stromal cells in vitro. Gynecol Endocrinol 17:271-80
51. Olin AI, Morgelin M, Sasaki T, Timpl R, Heinegard D, Aspberg A (2001) The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding. J Biol Chem 276:1253-61
52. Pan HJ, Uno H, Inui S, Fulmer NO, Chang C (1999) Roles of testosterone in the growth of keratinocytes through bald frontal dermal papilla cells. Endocrine 11:321-7
53. Penas PF, Jones-Caballero M, Amigo A, Aragues M, Garcia-Diez A (1994) Cutaneous meningioma underlying congenital localized hypertrichosis. J Am Acad Dermatol 30:363-6
54. Philpott MP, Green MR, Kealey T (1990) Human hair growth in vitro. J Cell Sci 97:463-71
55. Randall VA, Hibberts NA, Thornton MJ, Hamada K, Merrick AE, Kato S et al. (2000) The hair follicle: a paradoxical androgen target organ. Horm Res 54:243-50
56. Randall VA, Hibberts NA, Thornton MJ, Merrick AE, Hamada K, Kato S et al. (2001) Do androgens influence hair growth by altering the paracrine factors secreted by dermal papilla cells? Eur J Dermatol 11:315-20
57. Randall VA, Thornton MJ, Hamada K, Messenger AG (1992) Mechanism of androgen action in cultured dermal papilla cells derived from human hair follicles with varying responses to androgens in vivo. J Invest Dermatol 98:86S-91S
58. Randall VA, Thornton MJ, Hamada K, Messenger AG (1994) Androgen action in cultured dermal papilla cells from human hair follicles. Skin Pharmacol 7:20-6
59. Rattner A, Hsieh JC, Smallwood PM, Gilbert DJ, Copeland NG, Jenkins NA et al. (1997) A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci USA 94:2859-63
60. Reddy S, Andl T, Bagasra A, Lu MM, Epstein DJ, Morrisey EE et al. (2001) Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech Dev 107:69-82
61. Rendl M, Lewis L, Fuchs E (2005) Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol 3:e331
62. Reynolds AJ, Jahoda CA (1992) Cultured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis. Development 115:587-93
63. Reynolds AJ, Chaponnier C, Jahoda CA, Gabbiani G (1993) A quantitative study of the differential expression of alpha-smooth muscle actin in cell populations of follicular and non-follicular origin. J Invest Dermatol 101:577-83
64. Roh C, Tao Q, Lyle S (2004) Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin. Physiol Genomics 19:207-17
65. Schreiber E, Matthias P, Muller MM, Schaffner W (1989) Rapid detection of octamer binding proteins with "mini-extracts", prepared from a small number of cells. Nucleic Acids Res 17:6419
66. Seo J, Kim J, Kim M (2001) Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells. Mol Cells 11:35-40
67. Sleeman MA, Murison JG, Strachan L, Kumble K, Glenn MP, McGrath A et al. (2000) Gene expression in rat dermal papilla cells: analysis of 2529 ESTs. Genomics 69:214-24
68. Soma T, Tajima M, Kishimoto J (2005) Hair cycle-specific expression of versican in human hair follicles. J Dermatol Sci 39:147-54
69. Soma T, Tsuji Y, Hibino T (2002) Involvement of transforming growth factor-beta2 in catagen induction during the human hair cycle. J Invest Dermatol 118:993-7
70. Sutton AL, Zhang X, Ellison TI, Macdonald PN (2005) The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation. Mol Endocrinol 19:2234-44
71. Thornton MJ, Laing I, Hamada K, Messenger AG, Randall VA (1993) Differences in testosterone metabolism by beard and scalp hair follicle dermal papilla cells. Clin Endocrinol (Oxf) 39:633-9
72. van Wely KH, Molijn AC, Buijs A, Meester-Smoor MA, Aarnoudse AJ, Hellemons A et al. (2003) The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription. Oncogene 22:699-709
73. Vereninov AA, Vassilieva IO, Yurinskaya VE, Matveev VV, Glushankova LN, Lang F et al. (2001) Differential transcription of ion transporters, NHE1, ATP1B1, NKCC1 in human peripheral blood lymphocytes activated to proliferation. Cell Physiol Biochem 11:19-26
74. Yang XC, Hao F, Song ZQ, Cheng B, Yang WB, Zhong BY et al. (2004) Identification of differentially expressed genes in anagen dermal papilla by suppression subtractive hybridization. Chin Med J (Engl) 117:371-5
75. Yu D, Cao Q, He Z, Sun TT (2004) Expression profiles of tyrosine kinases in cultured follicular papilla cells versus dermal fibroblasts. J Invest Dermatol 123:283-90
76. Yuspa SH, Wang Q, Weinberg WC, Goodman L, Ledbetter S, Dooley T et al. (1993) Regulation of hair follicle development: an in vitro model for hair follicle invasion of dermis and associated connective tissue remodeling. J Invest Dermatol 101:27S-32S
77. Zhang HY, Timpl R, Sasaki T, Chu ML, Ekblom P (1996) Fibulin-1 and fibulin-2 expression during organogenesis in the developing mouse embryo. Dev Dyn 205:348-64