Do androgens influence hair growth by altering the paracrine factors secreted by dermal papilla cells?

European Journal of Dermatology

Volumn 11, Issue 4, 2001, Pages 315-320

  Randall, V A ^a   Hibberts, N A ^a   Thornton, M J ^a   Merrick, A E ^a   Hamada, K ^a   Kato, S ^a   Jenner, T J ^a   De Oliveira, I ^a   Messenger, A G ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

Androgens; Dermal papilla cells; Hair; Human; Paracrine factors

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR;

ALOPECIA; CELL CULTURE; HAIR FOLLICLE; HAIR GROWTH; HORMONAL REGULATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PARACRINE SIGNALING; PROTEIN LOCALIZATION; REVIEW; SKIN CELL;

ANDROGENS; HAIR; HUMANS; PARACRINE COMMUNICATION; SKIN;

EID: 0034942019     PISSN: 11671122     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (61)

1. Androgens: The main regulator of human hair growth
2. Variations in pattern of pubertal change in girls
3. Variations in the pattern of pubertal changes in boys
4. Pituitary-gonadal relations in male children and adolescents
5. Pituitary-gonadal relations in female children and adolescents
6. Age, sex and genetic factors in the regulation of hair growth in man: A comparison of Caucasian and Japanese populations
7. A secondary sexual character that develops in men but not in women upon ageing of an organ present in both sexes
8. Patterned loss of hair in man; types and incidence
9. Male hormone stimulation is a prerequisite and an incitant in common baldness
10. Effect of castration in adolescent and young adult males upon further changes in the proportions of bare and hairy scalp
11. The biology of androgenetic alopecia
12. The androgen receptor: Physiology and pathophysiology
13. Androgens and human hair growth
14. The dermal papilla and maintenance of hair growth
15. Dermal-epidermal interactions; adult follicle - Derived cell populations and hair growth
16. The endocrinology and developmental biology of the prostate
17. Androgens and the hair follicle: Cultured human dermal papilla cells as a model system
18. Localisation of androgen receptors in human skin by immunohistochemistry: Implications for the hormonal regulation of hair growth, sebaceous glands and sweat glands
19. Different levels of 5α-reductase type I and II, aromatase and androgen receptor in hair follicles of women and men with androgenetic alopecia
20. Cultured dermal papilla cells from androgen-dependent human follicles (e.g. beard) contain more androgen receptors than those from non-balding areas
21. Dermal papilla cells from human balding scalp hair follicles contain higher levels of androgen receptors than those from non-balding scalp
22. 5α-reductase activity in cultured human dermal papilla cells from beard compared with reticular dermal fibroblasts
23. Differences in testosterone metabolism by beard and scalp hair follicle dermal papilla cells
24. The metabolism of testosterone by dermal papilla cells cultured from human pubic and axillary hair follicles ?? whith hair growth in 5α-reductase deficiency
25. Steroid 5α-reductase 2 deficiency
26. Beard, but not scalp, dermal papilla cells secrete autocrine growth factors in response to testosterone in vitro
27. Soluble factors from human hair papilla cells and dermal fibroblasts dramatically increase the clonal growth of outer root sheath cells
28. Androgen induction of follicular epthelial cell growth is mediated via insulin-like growth factor I from dermal papilla cells
29. Testosterone inhibits the capacity of cultured cells from human balding scalp dermal papilla cells to produce keratinocyte mitogenic factors
30. Dermal papilla cells from human hair follicles secrete factors (eg. VEGF) mitogenic for endothelial cells
31. Androgenetic alopecia dermal papilla cells have a reduced ability to stimulate growth of both human and rat dermal papilla cells in vitro and mouse hair growth in vivo
32. Geometric relationships between the matrix of the hair bulb and its dermal papilla in normal and alopecic scalp
33. Differences in hair follice dermal papilla volume are due to extracellular matrix volume and cell number: Implications for the control of hair follicle size and androgen responses
34. Only androgen-dependent cultured dermal papilla cells secrete additional proteinaceous factors mitogenic for keratinocytes in response to testosterone
35. Dermal papilla cells in macaque alopecia trigger a testosterone-dependent inhibition of follicular cell proliferation
36. Androgenetic alopecia in the stump-tailed macaque: An important model for investigating the pathology and antiandrogenic therapy of male pattern baldness
37. Hair follicle growth controls
38. Signallinq molecules in human hair follicle cell populations
39. The roles of growth factors in hair follicles: Investigations using cultured hair follicles
40. Expression of growth hormone receptor, insulin-like growth factor (IGF-1) and IGF-1 receptor mRNA and proteins in human skin
41. Effects of insulin and insulin-like growth factors on cultured human hair follicles; IGF-1 at physiologic concentrations is an important regulator of hair follicle growth in vitro
42. Mice carrying null mutations of the genes encoding insulin-like growth factor 1 (IGF-1) and type 1 IGF receptor (IGF 1r)
43. Scatter factor/hepatocyte growth factor and its receptor the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development
44. Dermal papilla cells express hepatocyte growth factor
45. Balding dermal papilla cells from human hair follicles express less hepatocyte growth factor (HGF) than normal scalp and beard cells
46. Hepatocyte growth factor/scatter factor stimulates hair growth of mouse vibrissa in organ culture
47. The effect of hepatocyte growth factor/scatter factor on human hair growth
48. Dermal papilla cells from human hair follicles secrete factors (e.g. VEGF) mitogenic for endothelial cells
49. Vascular endothelial growth factor is an autocrine growth factor for hair dermal papilla cells
50. Both beard and scalp cultured dermal papilla cells express mRNA for, and secrete, VEGF but the levels are unaltered by testosterone in vitro
51. Control of the hair follicle growth cycle
52. The steel factor
53. The SCF/KIT pathway plays a critical role in the control of normal human melanocyte homeostasis
54. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
55. Deletion of the c-kit proto-oncogene in the human developmental defect piebald trait
56. Dermal papilla cells derived from beard hair follicles secrete more stem cell factor (SCF) in culture than scalp cells or dermal fibroblasts
57. The human hair follicle contains several populations of melanocyte-lineage cells with differential expression of three melanocyte-lineage markers c-kit and Bcl-2
58. The mRNA for protease nexin-1 is expressed in human dermal papilla cells and its level is affected by androgen
59. Cells regulate their mitogenic response to thrombin through release of protease mexin
60. Regulation of protease nexin-1 target protease specificity by collagen type IV
61. Expression of basement membrane proteins and interstitial colleaagens in dermal papillae of human hair follicles