The hair follicle: A paradoxical androgen target organ

Hormone Research

Volumn 54, Issue 5-6, 2000, Pages 243-250

  Randall, Valerie A ^a   Hibberts, Nigel A ^a   Thornton, M Julie ^a   Hamada, Kazuto ^b   Merrick, Alison E ^a   Kato, Shoji ^c   Jenner, Tracey J ^a   De Oliveira, Isobel ^a   Messenger, Andrew G ^d  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b Odawara City   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

^d ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

Author keywords

Balding; Beard; Dermal papilla cells; Growth factors; Hair follicle; Human; Stem cell factor

Indexed keywords

ANDROGEN; ANDROSTANOLONE; STEROID 5ALPHA REDUCTASE;

ANDROGEN SYNTHESIS; AXILLA; CONFERENCE PAPER; DERMIS; EMBRYO DEVELOPMENT; ENZYME DEFICIENCY; EPITHELIUM; EYELASH; GENE EXPRESSION; HAIR FOLLICLE; HAIR GROWTH; HAIR ROOT; HORMONAL REGULATION; HORMONE ACTION; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; MALE TYPE ALOPECIA; MESENCHYME; MITOGENESIS; PARACRINE SIGNALING; PIGMENTATION; PRIORITY JOURNAL; PUBERTY; RECEPTOR AFFINITY; SCALP; SKIN RECEPTOR;

ANDROGENS; CHOLESTENONE 5 ALPHA-REDUCTASE; HAIR; HAIR FOLLICLE; HUMANS; OXIDOREDUCTASES;

EID: 0034583176     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053266     Document Type: Conference Paper

References (45)

1. Androgens and human hair growth
2. Variations in pattern of pubertal change in girls
3. Variations in the pattern of pubertal changes in boys
4. Pituitary-gonadal relations in male children and adolescents
5. Pituitary-gonadal relations in female children and adolescents
6. Age, sex and genetic factors in the regulation of hair growth in man: A comparison of Caucasian and Japanese populations
7. Androgens: The main regulator of human hair growth
8. A secondary sexual character that develops in men but not in women upon ageing of an organ present in both sexes
9. Patterned loss of hair in man; types and incidence
10. Male hormone stimulation is a prerequisite and an incitant in common baldness
11. Effect of castration in adolescent and young adult males upon further changes in the proportions of bare and hairy scalp
12. The biology of androgenetic alopecia
13. Androgenetic alopecia in the stump-tailed macaque: An important model for investigating the pathology and antiandrogenic therapy of male pattern baldness
14. Steroid 5α-reductase 2 deficiency
15. The role of 5α-reductase in health and disease
16. Androgens and the hair follicle: Cultured human dermal papilla cells as a model system
17. The culture of dermal papilla cells from human hair follicles
18. A comparison of the culture and growth of dermal papilla cells derived from normal and balding (androgentic alopecia) scalp
19. Dermal-epidermal interactions; adult follicle - Derived cell populations and hair growth
20. Androgen induction of follicular epithelial cell growth is mediated via insulin-like growth factor I from dermal papilla cells
21. Geometric relationships between the matrix of the hair bulb and its dermal papilla in normal and alopecic scalp
22. Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: Implications for the control of hair follicle size and androgen responses
23. Do androgens influence hair growth by altering the paracrine factors secreted by dermal papilla cells?
24. Cultured dermal papilla cells from androgen-dependent human follicles (e.g. beard) contain more androgen receptors than those from non-balding areas
25. Dermal papilla cells from human balding scalp hair follicles contain higher levels of androgen receptors than those from non-balding scalp
26. 5α-reductase activity in cultured human dermal papilla cells from beard compared with reticular dermal fibroblasts
27. Differences in testosterone metabolism by beard and scalp hair follicle dermal papilla cells
28. The metabolism of testosterone by dermal papilla cells cultured from human pubic and axillary hair follicles concurs with hair growth in 5α-reductase deficiency
29. The metabolism of testosterone by dermal papilla cells cultured from scalp follicles of men with androgenetic alopecia
30. Finasteride in the treatment of men with androgenetic alopecia
31. Clinical trials of oral finasteride
32. Hair follicle growth controls
33. Signalling molecules in human hair follicle cell populations
34. The roles of growth factors in hair follicles: Investigations using cultured hair follicles
35. Control of the hair follicle growth cycle
36. Beard, but not scalp, dermal papilla cells secrete autocrine growth factors in response to testosterone in vitro
37. Only androgen-dependent cultured dermal papilla cells secrete additional proteinaceous factors mitogenic for keratinocytes in response to testosterone
38. Dermal papilla cells from human hair follicles secrete factors (e.g. VEGF) mitrogenic for endothelial cells
39. Balding dermal papilla cells from human hair follicles express less hepatocyte growth factor (HGF) than normal scalp and beard cells
40. Dermal papilla cells derived from beard hair follicles secrete more stem cell factor (SCF) in culture than scalp cells or dermal fibroblasts
41. The steel factor
42. The SCF/KIT pathway plays a critical role in the control of normal human melanocyte homeostasis
43. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
44. Deletion of the c-kit proto-oncogene in the human developmental defect piebald trait