A metabolically stable tight-binding transition-state inhibitor of glyoxalase-I

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 23, 2006, Pages 6039-6042

  More, Swati S ^a   Vince, Robert ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Glutamyltranspeptidase; Glutathione; Glyoxalase; Hydroxamic acid; Methylglyoxal; Transition state inhibitor

Indexed keywords

HYDROLASE INHIBITOR;

ARTICLE; CHELATION; CHEMICAL BOND; DRUG METABOLISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME KINETICS; EVALUATION;

ENZYME INHIBITORS; GLUTATHIONE; LACTOYLGLUTATHIONE LYASE; MOLECULAR STRUCTURE; PROTEIN BINDING;

EID: 33751039268     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.121     Document Type: Article

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21. R = 17.52 min, purity = 98.07%.