Synthesis and activity of γ-(L-γ-azaglutamyl)-S-(p-bromobenzyl)-L- cysteinylglycine: A metabolically stable inhibitor of glyoxalase I

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 6, 1999, Pages 853-856

  Vince, Robert ^a   Brownell, Jay ^a   Akella, Lakshmi B ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; GAMMA GLUTAMYLTRANSFERASE; GAMMA(GAMMA AZAGLUTAMYL) S (4 BROMOBENZYL)CYSTEINYLGLYCINE; LACTOYLGLUTATHIONE LYASE; LACTOYLGLUTATHIONE LYASE INHIBITOR; METHYLGLYOXAL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME DEGRADATION; ENZYME INHIBITION; REACTION ANALYSIS;

ANIMALS; AZA COMPOUNDS; CHROMATOGRAPHY, THIN LAYER; GLUTATHIONE; KIDNEY; LACTOYLGLUTATHIONE LYASE; MICE; MODELS, CHEMICAL; TIME FACTORS;

EID: 0033594241     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00097-9     Document Type: Article

References (10)

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8. (b) for a review, see Thornalley, P. J. Advances in glyoxalase research. Glyoxalase expression in malignancy, anti-proliferative effects of methylglyoxal, glyoxalase I inhibitor diesters and S-D-lactoylglutathione, and methylglyoxal-modified protein binding and endocytosis by the advanced glycation endproduct receptor. Crit. Rev. Oncology & Hematol. 1995, 20, 99-128.
9. Lyon, P. A.; Vince, R. J. Med. Chem. 1977, 20, 77.
10. Calcagni, A.; Dupre, S.; Lucente, G.; Luisi, G.; Pinnen, F.; Rossi, D. Int. J. Peptide Protein Res. 1995, 46, 434.