Negative thymocyte selection to HERV-K18 superantigens in humans

Blood

Volumn 105, Issue 11, 2005, Pages 4377-4382

  Meylan, Françoise ^b   De Smedt, Magda ^b   Leclercq, Georges ^b   Plum, Jean ^b   Leupin, Olivier ^b   Marguerat, Samuel ^b   Conrad, Bernard ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS ANTIGEN;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; CELL SELECTION; CLONAL ANERGY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE;

EID: 19344372600     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-07-2596     Document Type: Article

References (40)

1. Herman A, Kappler JW, Marrack P, Pullen AM. Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu Rev Immunol. 1991;9:745-772.
2. Acha-Orbea H, MacDonald HR. Superantigens of mouse mammary tumor virus. Annu Rev Immunol. 1995;13:459-486.
3. Sundberg EJ, Li Y, Mariuzza RA. So many ways of getting in the way: diversity in the molecular architecture of superantigen-dependent T-cell signaling complexes. Curr Opin Immunol. 2002;14:36-44.
4. Acha-Orbea H, Held W, Waanders GA, et al. Exogenous and endogenous mouse mammary tumor virus superantigens. Immunol Rev. 1993;131:5-25.
5. Marrack P, Winslow GM, Choi Y, et al. The bacterial and mouse mammary tumor virus superantigens: two different families of proteins with the same functions. Immunol Rev. 1993;131:79-92.
6. Blackman MA, Gerhard-Burgert H, Woodland DL, et al. A role for clonal inactivation in T cell tolerance to Mls-1a. Nature 1990;345:540-542.
7. Sprent J, Kishimoto H. The thymus and negative selection. Immunol Rev. 2002;185:126-135.
8. Cho HJ, Edmondson SG, Miller AD, et al. Cutting edge: identification of the targets of clonal deletion in an unmanipulated thymus. J Immunol. 2003;170:10-13.
9. Waanders GA, Lees RK, Held W MacDonald HR. Quantitation of endogenous mouse mammary tumor virus superantigen expression by lymphocyte subsets. Eur J Immunol. 1995;25:2632-2637.
10. Barnett A, Mustafa F, Wrona TJ, Lozano M, Dudley JP. Expression of mouse mammary tumor virus superantigen mRNA in the thymus correlates with kinetics of self-reactive T-cell loss. J Virol. 1999;73:6634-6645.
11. Burkly LC, Degermann S, Longley J, et al. Clonal deletion of V beta 5+ T cells by transgenic I-E restricted to thymic medullary epithelium. J Immunol. 1993;151:3954-3960.
12. Moore NC, Anderson G, McLoughlin DE, Owen JJ, Jenkinson EJ. Differential expression of Mtv loci in MHC class II-positive thymic stromal cells. J Immunol. 1994;152:4826-4831.
13. Delcourt M, Thibodeau J, Denis F, Sekaly RP. Paracrine transfer of mouse mammary tumor virus superantigen. J Exp Med. 1997;135:471-480.
14. Reilly M, Mix D, Reilly AA, Yang Ye X, Winslow GM. Intercellular transfer of a soluble viral superantigen. J Virol. 2000;74:8262-8267.
15. Ohashi PS. Negative selection and autoimmunity. Curr Opin Immunol. 2003;15:668-676.
16. Conrad B, Weissmahr RN, Boni J, et al. A human endogenous retroviral superantigen as candidate autoimmune gene in type I diabetes. Cell. 1997;90:303-313.
17. Sutkowski N, Chen G, Calderon G, Huber BT. Epstein-Barr virus latent membrane protein LMP-2A is sufficient for transactivation of the human endogenous retrovirus HERV-K18 superantigen. J Virol. 2004;78:7852-7860.
18. Marguerat S, Wang WY, Todd JA, Conrad B. Association of human endogenous retrovirus K-18 polymorphisms with type 1 diabetes. Diabetes. 2004;53:852-854.
19. Conrad B, Weidmann E, Trucco G, et al. Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology. Nature. 1994;371:351-355.
20. Somoza N, Vargas F, Roura-Mir C, et al. Pancreas in recent onset insulin-dependent diabetes mellitus: changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor V beta usage, and cytokine profile. J Immunol. 1994;153:1360-1377.
21. Luppi P, Zanone MM, Hyoty H, et al. Restricted TCR V beta gene expression and enterovirus infection in type I diabetes: a pilot study. Diabetologia. 2000;43:1484-1497.
22. Sutkowski N, Conrad B, Thortey-Lawson DA, Huber BT. Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen. Immunity. 2001;15:579-589.
23. Stauffer Y, Marguerat S, Meylan F, et al. Interferon-alpha-induced endogenous superantigen: a model linking environment and autoimmunity. Immunity. 2001;15:591-601.
24. Tagnon T, De Smedt M, Stolz F, et al. Enforced expression of GATA-3 severely reduces human thymic cellularity. J Immunol. 2001;167:4468-4475.
25. Bonnaud B, Bouton O, Oriol G, et al. Evidence of selection on the domesticated ERVWE1 env retroviral element involved in placentation. Mol Biol Evol. 2004;21:1895-1901.
26. Fass D, Kim PS. Dissection of a retrovirus envelope protein reveals structural similarity to influenza hemagglutinin. Curr Biol. 1995;5:1377-1383.
27. Spits H. Development of αβ T cells in the human thymus. Nat Rev Immunol. 2002;2:760-772.
28. Swat W, Ignatowicz L, von Boehmer H, Kisielow P. Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells. Nature. 1991;351:150-153.
29. Kotb M, Norrby-Teglund A, McGeer A, et al. An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat Med. 2002;8:1398-1404.
30. Llewelyn M, Sriskandan S, Peakman M, et al. HLA class II polymorphisms determine responses to bacterial superantigens. J Immunol. 2004;172:1719-1726.
31. Brewer JA, Kanagawa O, Sleckman BP, Muglia LJ. Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J Immunol. 2002;169:1837-1843.
32. Tiso M, Gangemi R, Bargellesi SA, et al. Spontaneous apoptosis in human thymocytes. Am J Pathol. 1995;147:434-444.
33. Boussiotis VA, Freeman GJ, Taylor PA, et al. p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes. Nat Med. 2000;6:290-297.
34. Gilbert KM, Weigle WO. Th1 cell anergy and blockade in G1a phase of the cell cycle. J Immunol. 1993;151:1245-1254.
35. Attinger A, MacDonald HR, Acha-Orbea H. Lymphoid environment limits superantigen and antigen-induced T cell proliferation at high precursor frequency. Eur J Immunol. 2001;31:884-893.
36. Seboun E, Robinson MA, Kindt TJ, Hauser SL. Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex. J Exp Med. 1989;170:1263-1270.
37. Fleischer B, Gerardy-Schahn R, Metzroth B, et al. An evolutionary conserved mechanism of T cell activation by microbial toxins: evidence for different affinities of T cell receptor-toxin interaction. J Immunol. 1991;146:11-17.
38. Plum J, De Smedt M, Verhasselt B, et al. Human T lymphopoiesis: in vitro and in vivo study models. Ann N Y Acad Sci. 2000;917:724-731.
39. Muraro PA, Jacobsen M, Necker A, et al. Rapid identification of local T cell expansion in inflammatory organ diseases by flow cytometric T cell receptor Vβ analysis. J Immunol Methods. 2000;246:131-143.
40. van den Beemd R, Boor PP, van Lochern EG, et al. Flow cytometric analysis of the Vβ repertoire in healthy controls. Cytometry. 2000;40:336-345.