Analysis of the evolution of the thrombin-inhibiting DNA aptamers using a genetic algorithm

Biotechnology Letters

Volumn 28, Issue 23, 2006, Pages 1933-1937

  Ikebukuro, Kazunori ^a   Yoshida, Wataru ^a   Noma, Takahisa ^a   Sode, Koji ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Aptamer; G quartet structure; Genetic algorithm; Inhibitor; Systematic evolution of ligands by exponential enrichment

Indexed keywords

BIOASSAY; ENZYME INHIBITION; GENETIC ALGORITHMS; MUTAGENESIS;

APTAMER; DUPLEX REGION; G-QUARTET STRUCTURES; SYSTEMATIC EVOLUTION;

DNA;

APTAMER; DNA; FIBRINOGEN; LIGAND; RNA; THROMBIN;

ALGORITHM; ARTICLE; BIOLOGICAL MODEL; BIOTECHNOLOGY; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; HUMAN; METHODOLOGY; MUTATION; PHYSICAL CHEMISTRY;

ALGORITHMS; APTAMERS, NUCLEOTIDE; BIOTECHNOLOGY; CHEMISTRY, PHYSICAL; DNA; FIBRINOGEN; HUMANS; LIGANDS; MODELS, GENETIC; MOLECULAR CONFORMATION; MUTATION; NUCLEIC ACID CONFORMATION; RNA; THROMBIN;

EID: 33751014555     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-006-9174-8     Document Type: Article

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