Directed evolution of trypsin inhibiting peptides using a genetic algorithm

Journal of the Chemical Society - Perkin Transactions 1

Volumn , Issue 20, 1996, Pages 2435-2437

  Yokobayashi, Yohei ^a   Ikebukuro, Kazunori ^a   McNiven, Scott ^a   Karube, Isao ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33748976088     PISSN: 0300922X     EISSN: None     Source Type: Journal    
DOI: 10.1039/p19960002435     Document Type: Article

References (16)

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2. (b) K. D. Janda, Proc. Natl. Acad. Sci. USA, 1994, 91, 19 779;
3. (c) Acc. Chem. Res., 1996, 29, pp. 111-170. Special Issue on Combinatorial Chemistry.
4. (a) K. S. Lam, S. E. Salmon, E. M. Hersh, V. J. Hruby, W. M. Kazmierski and R. J. Knapp, Nature, 1991, 354, 82;
5. (b) R. A. Houghten, C. Pinilla, S. E. Blondelle, J. R. Appel, C. T. Dooley and J. H. Cuervo, Nature, 1991, 354, 84.
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14. (b) W. P. C. Stemmer, Proc. Natl. Acad. Sci. USA, 1994, 91, 10 747.
15. While this work was in progress, two reports of similar work were published. The first uses GAs to explore the chemistry of Ugi reaction products while the second investigates the substrate specificity of stromelysin. (a) L. Weber, S. Wallbaum, C. Broger and K. Gubernator, Angew. Chem., Int. Ed. Engl., 1995, 34, 2280;
16. (b) J. Singh, M. A. Ator, E. P. Jaeger, M. P. Allen, D. A. Whipple, J. E. Soloweij, S. Chowdhary and A. M. Treasurywala, J. Am. Chem. Soc. 1996, 118, 1669.