Discovery of highly potent small molecule kallikrein inhibitors

Medicinal Chemistry

Volumn 2, Issue 6, 2006, Pages 545-553

  Zhang, J ^a   Krishnan, R ^a   Arnold, C S ^a   Mattsson, E ^b   Kilpatrick, J M ^a   Bantia, S ^a   Dehghani, A ^a   Boudreaux, B ^a   Gupta, S N ^a   Kotian, P L ^a   Chand, P ^a   Babu, Y S ^a  

^a BIOCRYST PHARMACEUTICALS INC   (United States)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Bradykinin; Contact activation; Inhibitor; Kallikrein; Modeling

Indexed keywords

BCX 1; BCX 2; BCX 3; BCX 4; BCX 5; BLOOD CLOTTING FACTOR 7A; BRADYKININ; KALLIKREIN; KALLIKREIN INHIBITOR; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ANGIONEUROTIC EDEMA; ARTICLE; BACTERIAL STRAIN; BINDING AFFINITY; CARDIOPULMONARY BYPASS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME IMMUNOASSAY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; HUMAN; IC 50; IN VITRO STUDY; MICHAELIS CONSTANT; MOLECULAR MODEL; NONHUMAN; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SEPTIC SHOCK; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS;

EID: 33750991095     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/1573406410602060545     Document Type: Article

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