Bromelain

Plastic and Reconstructive Surgery

Volumn 118, Issue 7, 2006, Pages 1640-1644

  Orsini, Roger A ^a  

^a Shore Aesthetic and Reconstruction Associates   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMOXICILLIN; ANTIBIOTIC AGENT; BROMELAIN; DEBRIDASE; PHLOGENZYM; RUTOSIDE; TRYPSIN; WARFARIN;

ANTIINFLAMMATORY ACTIVITY; BLEEDING; BURN; CLINICAL TRIAL; DEBRIDEMENT; DISEASE EXACERBATION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG ERUPTION; DRUG HYPERSENSITIVITY; DRUG MEGADOSE; DRUG POTENTIATION; DRUG SAFETY; EDEMA; FATIGUE; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; INFLAMMATION; ISCHEMIA; NONHUMAN; OCCUPATIONAL ASTHMA; OSTEOARTHRITIS; PAIN; PLASTIC SURGERY; POSTOPERATIVE CARE; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW; THROMBOCYTE AGGREGATION; WOUND HEALING; XEROSTOMIA;

BROMELAINS; HUMANS; RECONSTRUCTIVE SURGICAL PROCEDURES;

EID: 33750978425     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.prs.0000242503.50548.ee     Document Type: Review

References (34)

1. Lotz-Winter, H. On the pharmacology of bromelain: An update with special regard to animal studies on dose-dependent effects. Planta Med. 56: 249, 1990.
2. Heinicke, R. M., and Gortner, W. A. Stem bromelain: A new protease preparation from pineapple plants. Econ. Bot. 11: 225, 1957.
3. Taussig, S. J., Yokoyama, M. M., Chinen, A., et al. Bromelain: A proteolytic enzyme and its clinical application. Hiroshima J. Med. Sci. 24: 185, 1975.
4. Maurer, H. R. Bromelain: Biochemistry, pharmacology and medical use. Cell Mol. Life Sci. 58: 1234, 2001.
5. Rowan, A. D., and Buttle, D. J. Pineapple cysteine endopeptidases. Methods Enzymol. 244: 555, 1994.
6. U.S. Food and Drug Administration. Partial list of enzyme preparations that are used in foods. Washington, D.C.: U.S. Food and Drug Administration, Center of Food Safety and Applied Nutrition, Office of Food Additive Safety. Available at http://www.cfsan.fda.gov/~dms/opa-enzy.html. Accessed May 24, 2006.
7. Hale, L. P., Greer, P. K., and Sempowski, G. D. Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation. Clin. Immunol. 104: 183, 2002.
8. Khan, R. H., Rasheedi, S., and Haq, S. K. Effect of pH, temperature and alcohols on the stability of glycosylated and deglycosylated stem bromelain. J. Biosci. 28: 709, 2003.
9. National Library of Medicine and National Institute of Health. Bromelain. Available at MedlinePlus, www.nlm.nih.gov/medlineplus/druginfo/natural/patient- bromelain.html. Accessed May 24, 2006.
10. Zatuchni, G. I., and Colombi, D. J. Bromelains therapy for the prevention of episiotomy pain. Obstet. Gynecol. 29: 275, 1967.
11. Bodi, T. The effects of oral bromelains on tissue permeability to antibiotics and pain response to bradykinin: Double blind studies on human subjects. Clin. Med. 73: 61, 1966.
12. Walker, A. F., Bundy, R., Hicks, S. M, et al. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine 9: 681, 2002.
13. Stone, M. B., Merrick, M. A., Ingersoll, C. D., et al. Preliminary comparison of bromelain and ibuprofen for delayed onset muscle soreness management. Clin. J. Sport Med. 12: 373, 2002.
14. Seltzer, A. P. A double-blind study of bromelains in the treatment of edema and ecchymoses following surgical and non-surgical trauma to the face. Eye Ear Nose Throat Mon. 43: 54, 1964.
15. Neumayer, C., Fügl, A., Nanobashvili, J., et al. Combined enzymatic and antioxidative treatment reduces ischemia-reperfusion injury in rabbit skeletal muscle. J. Surg. Res. 133: 150, 2006.
16. Gaspani, L., Limiroli, E., Ferrario, P., and Bianchi, M. In vivo and in vitro effects of bromelain on PGE2 and SP concentrations in the inflammatory exudate in rats. Pharmacology 65: 83, 2002.
17. Hale, L. P., Greer, P. K., Trinh, C. T, et al. Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease. Clin. Immunol. 116: 135, 2005.
18. Secor, E. R., Carson, W. F., IV, Cloutier M. M, et al. Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease. Cell. Immunol. 237: 68, 2005.
19. Kane, S., and Goldberg M. J. Use of bromelain for mild ulcerative colitis. Ann. Intern. Med. 132: 680, 2000.
20. Howat, R. C. L., and Lewis, G. D. The effect of bromelain therapy on episiotomy wounds: A double blind controlled clinical trial. J. Obstet. Gynaecol. Br. Commonw. 79: 951, 1972.
21. Brown, S. A., Coimbra, M., Coberly, D. M, et al. Oral nutritional supplementation accelerates skin wound healing: A randomized, placebo-controlled, double-arm, crossover study. Plast. Reconstr. Surg. 114: 237, 2004.
22. Heiniche, R. M., Van der Wal, L., and Yokoyama, M. M. Effect of bromelain (Ananase®) on human platelet aggregation. Experientia 28: 844, 1972.
23. Livio, M., Bertoni, M. P., DeGaetano, G., et al. Effect of bromelain on fibrinogen level, prothrombin complex factors and platelet aggregation in the rat: A preliminary report. Drugs Exp. Clin. Res. 4: 49, 1978.
24. Gläser, D., and Hilberg, T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 17: 37, 2006.
25. Tinozzi, S., and Venegoni, A. Effect of bromelain on serum and tissue levels of amoxicillin. Drugs Exp. Clin. Res. 4: 39, 1978.
26. Shahid, S. K., Turakhia, N. H., Kundra, M., et al. Efficacy and safety of Phlogenzym: A protease formulation, in sepsis in children. J. Assoc. Physicians India 50: 527, 2002.
27. Levine, N., Seifter, E., Connerton, C., et al. Debridement of experimental skin burns of pigs with bromelain, a pineapple-stem enzyme. Plast. Reconstr. Surg. 52: 413, 1973.
28. Rosenberg, L., Lapid, O., Bogdanov-Berezovsky, A., et al. Safety and efficacy of a proteolytic enzyme for enzymatic burn debridement: A preliminary report. Burns 30: 843, 2004.
29. Krieger, Y., Rosenberg, L., Lapid, O., et al. Escharotomy with an enzymatic debridement agent for treating experimental burn-induced compartment syndrome in an animal model. J. Trauma 58: 1259, 2005.
30. Brien, S., Lewith, G., Walker, A., et al. Bromelain as a treatment for osteoarthritis: A review of clinical studies. Evid. Based Complement Alternat. Med. 1: 251, 2004.
31. Galleguillos, F., and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin. Allergy 8: 21, 1978.
32. Baur, X., and Fruhmann, G. Allergic reactions, including asthma, to the pineapple protease bromelain following occupational exposure. Clin. Allergy 9: 443, 1979.
33. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., et al. Asthma caused by bromelain: An occupational allergy. 18: 445, 1988.
34. Abebe, W. An overview of herbal supplement utilization with particular emphasis on possible interactions with dental drugs and oral manifestations. J. Dent. Hyg. 77: 37, 2003.-