Preliminary comparison of bromelain and ibuprofen for delayed onset muscle soreness management

Clinical Journal of Sport Medicine

Volumn 12, Issue 6, 2002, Pages 373-378

  Stone, Marcus B ^a   Merrick, Mark A ^b   Ingersoll, Christopher D ^a   Edwards, Jeffrey E ^a  

^a INDIANA STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Exercise induced muscle injury; Nonsteroidal anti inflammatory drugs; Nutritional supplements; Proteolytic enzyme

Indexed keywords

BROMELAIN; IBUPROFEN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; ELBOW FLEXION; EXERCISE; FEMALE; HUMAN; MALE; MOTION; MUSCLE STRENGTH; MYOSITIS; PAIN ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TORQUE; TREATMENT OUTCOME; ADOLESCENT; ANALYSIS OF VARIANCE; ARM; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECT; FOLLOW UP; JOINT CHARACTERISTICS AND FUNCTIONS; MUSCLE FATIGUE; PAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; PROBABILITY; REFERENCE VALUE; SKELETAL MUSCLE; TIME;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; BROMELAINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; EXERCISE; FEMALE; FOLLOW-UP STUDIES; HUMANS; IBUPROFEN; MALE; MUSCLE FATIGUE; MUSCLE, SKELETAL; PAIN; PAIN MEASUREMENT; PROBABILITY; RANGE OF MOTION, ARTICULAR; REFERENCE VALUES; TIME FACTORS; TREATMENT OUTCOME; UPPER EXTREMITY;

EID: 1842845388     PISSN: 1050642X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042752-200211000-00009     Document Type: Article

References (66)

1. Taussig S, Batkin S. Bromelaim, the enzyme complex of pineapple (Ananas comosus) and its clinical application: An update. J Ethnopharmacol 1988;22:191-203.
2. Peckoldt T, Peckoldt G, de Sousa Q. Rev Soc Bras Quimica 1948; 14:67-80.
3. Chittenden R, Joslin E, Meara F. On the ferments contained in the juice of the pineapple (Ananas sativa), together with some observations on the composition and proteolytic action of the juice. Trans Conn Acad Sci 1891;8:231-308.
4. Heinecke R, Gortner W. Stem bromelain, a new protease preparation from pineapple plants. Econ Bot 1972;11:225-234.
5. Tassman G, Zafrma J, Zayon G. Bromelain treatment following oral surgery. J Dent Med 1965;20:51.
6. Miller J, Ginsberg M, McEljatrick G, et al. The administration of bromelain orally in the treatment of inflammation and edema. Erp Med Surg 1964;22:293-299.
7. Howat R, Lewis G. Bromelain therapy in the recovery of episiotomy. J Obstet Gynecol 1972;79:951.
8. Deitrick RE. Oral proteolytic enzymes in the treatment of athletic injuries: A double-blind study. Penn Med J 1965;68:35-37.
9. Rathgeber W. The use of proteolytic enzymes (Chymoral) in sporting injuries. S Afr Med J 1971;181-183.
10. Cohen G. Bromelain therapy in rheumatoid arthritis. Penn Med J 1964:127-131.
11. Seligman B. Oral bromelains as adjuncts in the treatment of acute thrombophlebitis. Angiology 1969;20:22-26.
12. Seligman B. Bromelain: An anti-inflammatory agent. Angiology 1962;13:408.
13. Piau R. A double-blind clinical evaluation of bromelains in the treatment of acute sinusitis. Headache 1967;7:13.
14. Hino S. The role of bromelain (Ananase) in the treatment of chronic rhino sinusitis. Otolaryngology (Tokyo) 1966;38:439.
15. Vital Produx. Enzymes for Athletic Injuries. Available at: http://www.vitalprodux.com/enzymes_for_athetic_injuries.html. Accessed December 20, 2001.
16. Pharmanex. Muscle Fix. Availabte at: http://www.pharmanex.com. Accessed January 8, 2002.
17. Armstrong R. Mechanisms of exercise induced delayed onset muscular soreness: A brief review. Med Sci Sports Exerc 1985;16:529-538.
18. Denegar C, Perrin D. Effect of transcutaneous electrical nerve stimulation, cold, and a combination treatment on pain, decreased range of motion, and strength loss associated with delayed onset muscle soreness, J Athl Train 1992;27:200-206.
19. Walker J, Cerny F, Cotter J, et al. Attenuation of contraction-induced skeletal muscle injury by bromelain. Med Sci Sports Exerc 1992;24:20-25.
20. Hasson S, Daniels J, Divine J, et al. Effect of ibuprofen use on muscle soreness, damage, and performance: A preliminary investigation. Med Sci Sports Exerc 1993;25:9-17.
21. Grossman J, Arnold B, Perrin D, et al. Effect of ibuprofen use on delayed onset muscle soreness of the elbow flexors. J Sport Rehabil 1995;4:253-263,
22. Donnelly A, Maughan R, Whiting P. Effects of ibuprofen on exercise-induced muscle soreness and indices of muscle damage. Br J Sports Med 1990;24:191-195.
23. Howell J, Conatser R, Chleboun G, et al. The effect of nonsteroidal anti-inflammatory drugs on recovery from exercise-induced muscle injury. J Musculoskeletal Pain 1998;6:69-83.
24. Pizza F, Cavender D, Stockard A, et al. Anti-inflammatory doses of ibuprofen: Effect on neutrophils and exercise-induced muscle injury. Int J Sports Med 1999;20:98-102.
25. Vane J. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 1971;231:232-235.
26. Zand J, Spreen A, LaValle J. Muscle sprain, strain, and pain, In: Smart Medicine for Healthier Living. Garden City Park. NY: Avery Publishing Group. 1999:431.
27. Murray M. The Healing Power of Herbs: The Enlightened Person's Guide to the Wonders of Medicinal Plants. Prima Publishing. 1995.
28. Ohnhaus E, Adler R. Methodological problems in the measurement of pain a comparison between the verbal rating scale and the visual analogue scale. Pain 1975;1:379-384.
29. Jensen M, Karoly P, O'Riordan E, et al. The subjective experience of acute pain: An assessment of the utility of 10 indices. Clin J Pain 1989;5:153-159.
30. Carroll D, Bowsher D. Pain: Management and Nursing Care. Jordan Hill, Oxford: Butterworth-Heinemann. 1993.
31. NORM Testing and Rehabilitation System User's Guide. Ronkonkoma NCI. 1996:6.
32. Taussig S. The mechanism of the physiological action of bromelain. Med Hypoth 1980;6:99-104.
33. Storms C, Felton G, DuPont J. Effects of oral bromelain on ex-vivo synthesis of prostaglandins in rats. Fed Proc 1982;4:403.
34. Livio M, Bertoni M, DeGaetano G, et al. Effect of bromelain on fibrinogen level prothrombin complex factors and platelet aggregation in the rat: A preliminary report. Drugs Under Exp Clin Res 1978;4:49-53.
35. Korlof B, Ponten B, Ugland O. Bromelain: A proteolytic enzyme. Scand J Plast Reconstr Surg 1969;3:27-29.
36. Rathgeber W. The use of proteolytic enzymes (Chymoral) in sporting injuries. S Afr Med J 1971;45:181-183.
37. Ryan R. A double-blind clinical evaluation of bromelains in the treatment of acute sinusitis. Headache 1967;7:13-17.
38. Kumakura S, Yamashita M, Tsurufuji S. Effect of bromelain on kaolin-induced inflammation in rats. Eur J Pharmacol 1988;150: 295-301.
39. Castell J, Friedrich G, Kuhn C, et al. Intestinal absorption of undegraded proteins in men: Presence of bromelain in plasma after oral intake. Am J Physiol 1997;273:G139-G146.
40. Kim Y, Erickson R. Role of peptidases of the human small intestine in protein digestion. Gastroenterology 1985;88:1071-1073.
41. Izaka K, Yamada M, Kawano T, et al. Gastrointestinal absorption and anti-inflammatory effect of bromelain. Jpn J Pharmacol 1972;22:519-534.
42. Ciccone C, Leggin B, Callamaro J. Effects of ultrasound and trolamine salicylate phonophoresis on delayed-onset muscle soreness. Phys Ther 1991;71:666-678.
43. Stay J, Ricard M, Draper D, et al. Pulsed ultrasound fails to diminish delayed-onset muscle soreness symptoms. J Athl Train 1998;33:341-346.
44. Denegar C, Huff C. High and low frequency TENS in the treatment of induced musculoskeletal pain: A comparison study. Athl Train 1988;23:235-237,258.
45. Denegar C, Perrin D, Rogol A, et al. Influence of transcutaneous nerve stimulation on pain, range of motion, and serum cortisol concentration in females experiencing delayed onset muscle soreness. J Orthop Sports Phys Ther 1989;11:100-103.
46. Gulick D, Kimura I, Sitler M, et al. Various treatment techniques on signs and symptoms of delayed onset muscle soreness. J Athl Train 1996;31:145-152.
47. Isabell W, Durrant E, Myrer W, et al. The effects of ice massage, ice massage with exercise, and exercise on the prevention and treatment of delayed onset muscle soreness. J Athl Train 1992;27: 208-217.
48. Kuligowski L, Lephart S, Giannantonio F, et al. Effect of whirlpool therapy on the signs and symptoms of delayed-onset muscle soreness. J Athl Train 1998;33:222-228.
49. Smith L, Brunetz M, Chenier T, et al. The effect of static and ballistic stretching on delayed onset muscle soreness and creatine kinase. Res Q Exerc Sport 1993;64:103-107.
50. Wessel J, Wan A. Effect of stretching on the intensity of delayed-onset muscle soreness. Clin J Sport Med 1994;4:83-87.
51. Schmits R, Martin D, Perrin D, et al. Effect of interterential current on perceived pain and serum cortisol associated with delayed onset muscle soreness. J Sport Rehab 1997;6:30-37.
52. Butterfield D, Draper D, Ricard M. et al. The effects of high-volt pulsed current electrical stimulation on delayed-onset muscle soreness. J Athl Train 1997;32:15-20.
53. Weber M, Servedio F, Woodall W. The effects of three modalities on delayed onset muscle soreness. J Orthop Sport Phys Ther 1994;20:236-242.
54. Smith L, Keating M, Holbert D, et al. The effects or athletic massage on delayed onset muscle soreness, creatine kinase, and neutrophil count: A preliminary report. J Orthop Sport Phys Ther 1994;19:93-99.
55. Allen J, Mattacola C, Perrin D. Effect of microcurrent stimulation on delayed-onset muscle soreness: A double-blind comparison. J Athl Train 1999;34:334-337.
56. Lecomte JM, Lacroix VJ, Montgomery DL. A randomized controlled trial of the effect of naproxen on delayed onset muscle soreness and muscle strength. Clin J Sport Med 1998;8:82-87.
57. Bourgeois J, MacDougall D, MacDonald J, et al. Naproxen does not alter indices of muscle damage in resistance-exercise trained men. Med Sci Sports Exerc 1998;31:4-9.
58. Francis KT, Hoobler T. Effects of aspirin on delayed muscle soreness. J Sports Med Phys Fitness 1987;27:333-337.
59. Smith L, George R, Chenier T, et al. Do over-the-counter analgesics reduce delayed onset muscle soreness and serum creatine kinase values. Sports Med Train Rehabil 1995;6:81-88.
60. Donnelly A, McCormick K, Maughan R, et al. Effects of a nonsteroidal anti-inflammatory drug on delayed onset muscle soreness and indices of damage. Br J Sports Med 1988;22:35-38.
61. O'Grady M, Hackney AC, Schneider K, et al. Diclofenac sodium (Voltaren) reduced exercise-induced injury in human skeletal muscle. Med Sci Sports Exerc 2000;32:1196.
62. Semark A, Noakes TD, St Clair Gibson A, et al. The effect of a prophylactic dose of flurbiprofen on muscle soreness and sprinting performance in trained subjects. J Sports Sci 1999;17:197-203.
63. Kuipers H, Keizer H, Verstappen F, et al. Influence of a prostaglandin-inhibiting drug on muscle soreness after eccentric work. Int J Sports Med 1985;6:336-339.
64. Abraham W. Factors in delayed onset muscle soreness. Med Sci Sports Exerc 1977;9:11-20.
65. Clarkson P, Nosaka K, Braun B. Muscle function after exercise-induced muscle damage and rapid adaptation. Med Sci Sports Exerc 1992;24:512-520.
66. Talag T. Residual muscle soreness as influenced by concentric, eccentric and static contractions. Res Q 1973;44:458-469.