Effect of phytosterols and phytostanols on the solubilization of cholesterol by dietary mixed micelles: An in vitro study

Chemistry and Physics of Lipids

Volumn 127, Issue 2, 2004, Pages 121-141

  Mel'nikov, Sergey M ^a   Seijen Ten Hoorn, Jack W M ^a   Eijkelenboom, Astrid P A M ^a  

^a UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

Author keywords

Amphiphilic self assembly; Cholesterol absorption; Dietary mixed micelle; L phosphatidylcholine; PC; Phytostanols; Phytosterols

Indexed keywords

CHOLESTEROL; PHYTOSTEROL; SITOSTANOL; SITOSTEROL;

ARTICLE; CALORIMETRY; CHEMICAL MODEL; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; DIETARY INTAKE; DIFFUSION; GAS CHROMATOGRAPHY; IN VITRO STUDY; INTESTINE ABSORPTION; ISOTHERM; MICELLE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUTRIENT DYNAMICS; PHOSPHOLIPID VESICLE; PRIORITY JOURNAL; SOLUBILIZATION; STEROL ANALYSIS; TITRIMETRY; TRANSMISSION ELECTRON MICROSCOPY;

EID: 0346023058     PISSN: 00093084     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chemphyslip.2003.09.015     Document Type: Article

References (58)

1. Almgren M. Mixed micelles and other structures in the solubilization of bilayer lipid membranes by surfactants. Biochim. Biophys. Acta. 1508:2000;146-163.
2. Amundsen A.L., Ose L., Nenseter M.S., Ntanios F.Y. Plant sterol ester-enriched spread lowers plasma total and LDL cholesterol in children with familial hypercholesterolemia. Am. J. Clin. Nutr. 76:2002;338-344.
3. Bangham A.D., Standish M.M., Watkins J.C. Diffusion of univalent ions across the lamellae of swollen phospholipids. J. Mol. Biol. 13:1965;238-252.
4. Carey M.C., Small D.M. The characteristics of mixed micellar solutions with particular reference to bile. Am. J. Med. 49:1970;590-608.
5. Cullis P.R., Mayer L.D., Bally M.B., Madden T.D., Hope M.J. Generating and loading of liposomal systems for drug delivery applications. Adv. Drug Deliv. Rev. 3:1989;267-282.
6. Datsenko Z.M., Kholodova Y.D., Kokunin V.A., Klimashevsky V.M., Perederey O.F., Timchenko A.P. Effect of beta-sitosterol incorporated into liposomes on some patterns of lipid-metabolism in experimental hypercholesterolemia of rats. Vopr. Med. Khim. 30:1984;33-38.
7. Ellsworth J.L., Starr J.R. Inhibition of acyl coenzyme A:cholesterol acyltransferase blocks esterification but not uptake of cholesterol in Caco-2 cells. Metabolism. 47:1998;325-332.
8. Ellul J.P.M., Murphy G.M., Parkes H.G., Slapa R.Z., Dowling R.H. Nuclear magnetic resonance spectroscopy to determine the micellar cholesterol in human bile. FEBS Lett. 23:1992;30-32.
9. Evans, D.F., Wennerström, H., 1999. The Colloidal Domain: Where Physics, Chemistry, Biology and Technology Meet, 2nd edition. Wiley VCH, New York.
10. 1H NMR to determine the distribution of lecithin between the micellar and vesicular phases in model bile J. Lipid Res. 31:1990;1315-1321.
11. Grundy S.M., Mok H.Y.I. Determination of cholesterol absorption in man by intestinal perfusion. J. Lipid Res. 18:1977;263-271.
12. Hendriks H.F.J., Weststrate J.A., van Vliet T., Meijer G.W. Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur. J. Clin. Nutr. 53:1999;319-327.
13. Hernell O., Staggers J.E., Carey M.C. Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings. Biochemistry. 29:1990;2041-2056.
14. Hildebrand A., Neubert R., Garidel P., Blume A. Bile salt induced solubilization of synthetic phosphatidylcholine vesicles studied by isothermal titration calorimetry. Langmuir. 18:2002;2836-2847.
15. Hjelm R.P., Schteingart C.D., Hofmann A.F., Thiyagarajan P. Structure of conjugated bile salt-fatty acid-monoglyceride mixed colloids: studies by small-angle neutron scattering. J. Phys. Chem. B. 104:2000;197-211.
16. Hofmann A.F. The entheropatic circulation of bile acid. Adv. Int. Med. 21:1976;501-534.
17. Hofmann A.F., Small D.M. Detergent properties of bile salts: correlation with physiological function. Annu. Rev. Med. 18:1967;333-376.
18. Homan R., Krause B.P. Established and emerging strategies for inhibition of cholesterol absorption. Curr. Pharm. Design. 3:1997;29-44.
19. Hope M.J., Bally M.B., Webb G., Cullis P.R. Production of large unilamellar vesicles by a rapid extrusion procedure - characterization of size distribution, trapped volume and ability to maintain a membrane potential. Biochim. Biophys. Acta. 812:1985;55-65.
20. Huang C.H. Studies on phosphatidylcholine vesicles. Formation and physical characteristics. Biochemistry. 8:1969;344-351.
21. Ikeda I., Sugano M. Some aspects of mechanism of inhibition of cholesterol absorption by β-sitosterol. Biochim. Biophys. Acta. 732:1983;651-658.
22. Ikeda I., Tanabe Y., Sugano M. Effects of sitosterol and sitostanol on micellar solubility of cholestero. J. Nutr. Sci. Vitaminol. (Tokyo). 35:1989;361-369.
23. Ikeda I., Tanaka K., Sugano M., Vahouny G.V., Gallo L.L. Discrimination between cholesterol and sitosterol for absorption in rats. J. Lipid Res. 29:1988b;1583-1591.
24. Ikeda I., Tanaka K., Sugano M., Vahouny G.V., Gallo L.L. Inhibition of cholesterol absorption in rats by plant sterols. J. Lipid Res. 29:1988a;1573-1582.
25. Jönsson, B., Lindman, B., Holmberg, K., Kronberg, B., 1998. Surfactants and Polymers in Aqueous Solution. John Wiley & Sons, New York.
26. Lichtenberg D., Opatowski E., Kozlov M.M. Phase boundaries in mixtures of membrane-forming amphiphiles and micelle-forming amphiphiles. Biochim. Biophys. Acta. 1508:2000;1-19.
27. Lutton C., Brotlaroche E. Biliary cholesterol absorption in normal and L-thyroxin-fed rats. Lipids. 14:1979;441-446.
28. MacDonald R.C., MacDonald R.I., Menco B.P.M., Takeshita K., Subbarao N.K., Hu L.R. Small-volume extrusion apparatus for preparation of large unilamellar vesicles. Biochim. Biophys. Acta. 1061:1991;297-303.
29. Mattson F.H., Grundy S.M., Crouse J.R. Optimizing the effect of plant sterols on cholesterol absorption in man. Am. J. Clin. Nutr. 35:1982;697-700.
30. Mattson F.H., Volpenhein R.A., Erickson B.A. Effect of plant sterol esters on the absorption of dietary cholesterol. J. Nutr. 107:1977;1139-1146.
31. Mel'nikov, S.M., Seijen ten Hoorn, J.W.M., Bertrand, B., in press. Can cholesterol absorption be reduced by phytosterols and phytostanols via a cocrystallization mechanism? Chem. Phys. Lipids, 2004 (in press).
32. Mironova V.N., Datsenko Z.M., Kokunin V.A., Kalashnikova L.A. Hypolipidemic action of beta-sitosterol contained by liposomes in rats. Farmakol. Toksikol. 47:1984;71-74.
33. National Cholesterol Education Program, 2001. High blood cholesterol: what you need to know. U.S. Department of Health and Human Services, NIH Publication No. 01-3290 ( http://www.nhlbi.nih.gov/health/public/heart/chol/ wyntk.pdf ).
34. Ollila F., Slotte J.P. A thermodynamic study of bile salt interactions with phosphatidylcholine and sphingomyelin unilamellar vesicles. Langmuir. 17:2001;2835-2840.
35. Ostlund R.E. Jr., Spilburg C.A., Stenson W.F. Sitostanol administered in lecithin micelles potently reduces cholesterol absorption in humans. Am. J. Clin. Nutr. 70:1999;826-831.
36. Patton, J.S., 1981. Gastrointestinal lipid digestion. In: Johnson, L.R. (Ed.), Physiology of Gastrointestinal Tract, 1st edition. Raven Press, New York, pp. 1123-1146.
37. Patton J.S., Carey M.C. Watching fat digestion. Science. 204:1979;145-148.
38. Peterson D.W. Effect of soybean sterols in the diet on plasma and liver cholesterol in chicks. Proc. Soc. Exp. Biol. Med. 78:1951;143-147.
39. Pollak O.J. Successful prevention of experimental hypercholesterolemia and cholesterol atherosclerosis in the rabbit. Circulation. 7:1953a;696-701.
40. Pollak O.J. Reduction of blood cholesterol in man. Circulation. 7:1953b;702-706.
41. Reymond J.P., Sucker H. In vitro model for ciclosporin intestinal absorption in lipid vehicles. Pharm. Res. 5:1988;673-676.
42. Rigler M.W., Honkanen R.E., Patton J.S. Visualization by freeze-fracture, in vitro and in vivo, of the products of fat digestion. J. Lipid Res. 27:1986;836-857.
43. Schuler I., Milon A., Nakatani Y., Ourisson G., Albrecht A.M., Benveniste P., Hartman M.A. Differential effects of plant sterols on water permeability and on acyl chain ordering of soybean phosphatidylcholine bilayers. Proc. Natl. Acad. Sci. USA. 88:1991;6926-6930.
44. 1H NMR studies that bile with shorter nuleation times contain cholesterol-enriched vesicles Biochim. Biophys. Acta. 1256:1995;360-366.
45. Shiau, Y.F., 1987. Lipid digestion and absorption. In: Johnson, L.R. (Ed.), Physiology of Gastrointestinal Tract, 2nd edition. Raven Press, New York, pp. 1527-1556.
46. Sierksma A., Weststrate J.A., Meijer G.W. Spreads enriched with plant sterols, either esterified 4,4-dimethylsterols or free 4-desmethylsterols, and plasma total- and LDL-cholesterol concentrations. Brit. J. Nutr. 82:1999;273-282.
47. Small D.M., Bourges M., Dervichian D.G. Ternary and quaternary aqueous systems containing bile salt, lecithin and cholesterol. Nature. 211:1966;816-818.
48. Söderman O., Stilbs P. NMR-studies of complex surfactant systems. Prog. Nucl. Mag. Res. Sp. 26:1994;445-482.
49. Staggers, J.E., Hernell, O., Stafford, R.J., Carey, M.C., 1990. Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings. Biochemistry 29, 2028-2040.
50. Stryer, L., 1988. Biochemistry, 3rd edition. W.H. Freeman & Co., New York.
51. Trautwein E.A., Duchateau G.S.M.J.E., Lin Y., Mel'nikov S.M., Molhuizen H.O.F., Ntanios F.Y. Proposed mechanisms of cholesterol-lowering action of plant sterols. Eur. J. Lipid Sci. Technol. 105:2003;171-185.
52. Wang D.Q.H., Carey M.C. Characterization of crystallization pathways during cholesterol precipitation from human gallbladder biles: identical pathways to corresponding model biles with three predominating sequences. J. Lipid Res. 37:1996;606-630.
53. Weststrate J.A., Meijer G.W. Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur. J. Clin. Nutr. 52:1998;334-343.
54. Wilson M.D., Rudel L.L. Review of cholesterol absorption with emphasis on dietary and biliary cholesterol. J. Lipid Res. 35:1994;943-955.
55. Wu D., Chen A., Johnson C.H. Jr. An improved diffusion-ordered spectroscopy experiment incorporating bipolar-gradient pulses. J. Magn. Res. A. 115:1995;260-264.
56. Yetley E.A., Park Y.K. Diet and heart disease - health claims. J. Nutr. 125:1995;S679-S685.
57. Zangenberg N.H., Müllertz A., Kristensen H.G., Hovgaard L. A dynamic in vitro lipolysis model. I. Controlling the rate of lipolysis by continuous addition of calcium. Eur. J. Pharm. Sci. 14:2001a;115-122.
58. Zangenberg N.H., Müllertz A., Kristensen H.G., Hovgaard L. A dynamic in vitro lipolysis model. II. Evaluation of the model. Eur. J. Pharm. Sci. 14:2001b;237-244.