Dietary sitostanol reciprocally influences cholesterol absorption and biosynthesis in hamsters and rabbits

Atherosclerosis

Volumn 143, Issue 2, 1999, Pages 341-351

  Ntanios, Fady Y ^a   Jones, Peter J H ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Cholesterol absorption; Cholesterol synthesis; Plasma cholesterol; Plasma phytosterols; Sitostanol; Tall oil

Indexed keywords

SITOSTANOL;

ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; DOSE RESPONSE; DRUG EFFECT; HAMSTER; INTESTINE ABSORPTION; LIPID TRANSPORT; MALE; NONHUMAN; PRIORITY JOURNAL;

ANALYSIS OF VARIANCE; ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; CHOLESTEROL, DIETARY; CRICETINAE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FECES; LIPIDS; MALE; PHYTOSTEROLS; RABBITS; REFERENCE VALUES; SITOSTEROLS; SPECIES SPECIFICITY;

EID: 0032920384     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(98)00321-9     Document Type: Article

References (46)

1. Weihrauch J.L., Gardner J.M. Sterol content of foods of plant origin. J Am Diet Assoc. 73:1978;39-47.
2. Salen G., Ahrens E.H. Jr, Grundy S.M. Metabolism of beta-sitosterol in man. J Clin Invest. 49:1970;952-967.
3. Miettinen T.A., Puska P., Gylling H., Vanhanen H.T., Vartiainen E. Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. New Engl J Med. 333:1995;1308-1312.
4. Heinemann T., Pietruck B., Kullak-Ublick G., von Bergmann K. Comparison of sitosterol and sitostanol on inhibition of intestinal cholesterol absorption. Agents Actions. 26:1988;S117-S122.
5. Jones P.J.H., MacDougall D.E., Ntanios F., Vanstone C.A. Dietary phytosterols as cholesterol-lowering agents in humans. Can J Physiol Pharmacol. 75:1997;217-227.
6. Pollak O.J., Kritchevsky D. Sitosterol. Monographs on Atherosclerosis. 1981;Karger, Basel.
7. Dutta P.C., Appelqvist L.A. Saturated sterols (stanols) in unhydrogenated and hydrogenated edible vegetable oils and in cereal lipids. J Sci Food Agric. 71:1996;383-391.
8. Ling W.H., Jones P.J.H. Enhanced efficacy of sitostanol-containing versus sitostanol- free phytosterol mixtures in altering lipoprotein cholesterol levels and synthesis in rats. Atherosclerosis. 118:1995;319-331.
9. Lees A.M., Mok H.Y., Lees R.S., McCluskey M.A., Grundy S.M. Plant sterols as cholesterol-lowering agents: clinical trials in patients with hypercholesterolemia and studies of sterol balance. Atherosclerosis. 28:1977;325-338.
10. Ikeda I., Morioka H., Sugano M. The effect of dietary β-sitosterol and β-sitostanol on the metabolism of cholesterol in rats. Agric Biol Chem. 43:1979;1927-1933.
11. Ikeda I., Tanabe Y., Sugano M. Effects of sitosterol and sitostanol on micellar solubility of cholesterol. J Nutr Sci Vitaminol. 35:1989;361-369.
12. Sugano M., Morioka H., Ikeda I. A comparison of hypocholesterolemic activity of beta-sitosterol and beta-sitostanol in rats. J Nutr. 107:1977;2011-2019.
13. Heinemann T., Leiss O., von Bergmann K. Effect of low-dose sitostanol on serum cholesterol in patients with hypercholesterolemia. Atherosclerosis. 61:1986;219-223.
14. Heinemann T., Axtmann G., von Bergmann K. Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur J Clin Invest. 23:1993;827-831.
15. Child P., Kuksis A. Investigation of the role of micellar phospholipid in the preferential uptake of cholesterol over sitosterol by dispersed rat jejunal villus cells. Biochem Cell Biol. 64:1986;847-853.
16. Child P., Kuksis A. Critical role of ring structure in the differential uptake of cholesterol and plant sterols by membrane preparations in vitro. J Lipid Res. 24:1983;1196-1209.
17. Ikeda I., Sugano M. Some aspects of mechanism of inhibition of cholesterol absorption by β-sitosterol. Biochim Biophys Acta. 732:1983;651-658.
18. Grundy S.M., Ahrens E.H. Jr, Davignon J. The interaction of cholesterol absorption and cholesterol synthesis in man. J Lipid Res. 10:1969;304-315.
19. Gerson T., Shorland F., Dunckley G.G. The effect of beta-sitosterol on the metabolism of cholesterol and lipids in rats on a diet low in fat. Biochem J. 92:1964;385-390.
20. Gerson T., Shorland F.B., Dunckley G.G. The effect of beta-sitosterol on the metabolism of cholesterol and lipids in rats on a diet containing coconut oil. Biochem J. 96:1965;399-403.
21. Konlande J.E., Fisher H. Evidence for a nonabsorptive antihypercholesterolemic action of phytosterols in the chicken. J Nutr. 98:1969;435-442.
22. Kakis G., Kuksis A. Effect of intravenous infusion of intralipid, cholesterol, and plant sterols on hepatic cholesterogenesis. Can J Biochem Cell Biol. 62:1984;1-10.
23. Subbiah M.T., Kuksis A. Differences in metabolism of cholesterol and sitosterol following intravenous injection in rats. Biochim Biophys Acta. 306:1973;95-105.
24. Turley S.D., Herndon M.W., Dietschy J.M. Reevaluation and application of the dual-isotope plasma ratio method for the measurement of intestinal cholesterol absorption in the hamster. J Lipid Res. 35:1994;328-339.
25. Ostlund R.E.J., Hsu F.F., Bosner M.S., Stenson W.F., Hachey D.L. Quantification of cholesterol tracers by gas chromatography-negative ion chemical ionization mass spectrometry. J Mass Spectrom. 31:1996;1291-1296.
26. Ntanios F., Jones P.J.H. Effects of variable dietary sitostanol concentrations on plasma lipid profile and phytosterol metabolism in hamsters. Biochim Biophys Acta. 1390:1998;237-244.
27. Ntanios F., Jones P.J.H., Frohlich J. Dietary sitostanol reduces plaque formation but not lecithin cholesterol acyl transferase activity in rabbits. Atherosclerosis. 138:1998;101-110.
28. Bosner M.S., Ostlund R.E.J., Osofisan O., Grosklos J., Fritschle C., Lange L.G. Assessment of percent cholesterol absorption in humans with stable isotopes. J Lipid Res. 34:1993;1047-1053.
29. 3H water. J Lipid Res. 21:1980;364-376.
30. Jones P.J.H., Dendy S.M., Frohlich J.J., Leitch C.A., Schoeller D.A. Cholesterol and triglyceride fatty acid synthesis in apolipoprotein E2-associated hyperlipidemia. Arterioscler Thromb Vasc Biol. 12:1992;106-113.
31. Jones P.J.H., Scanu A.M., Schoeller D.A. Plasma cholesterol synthesis using deuterated water in humans: effect of short-term food restriction. J Lab Clin Med. 111:1988;627-633.
32. 18O-cholesterol and hypocholesterolemic effect of soy protein. J Nutr. 125:1995;612-618.
33. Jones P.J.H., Ausman L.M., Croll D.H., Feng J.Y., Schaefer E.J., Lichtenstein A.H. Validation of deuterium incorporation against sterol balance for measurement of human cholesterol biosynthesis. J Lipid Res. 39:1998;1111-1117.
34. Ikeda I., Kawasaki A., Samezima K., Sugano M. Antihypercholesterolemic activity of beta-sitostanol in rabbits. J Nutr Sci Vitaminol. 27:1981;243-251.
35. Sugano M., Kamo F., Ikeda I., Morioka H. Lipid-lowering activity of phytostanols in rats. Atherosclerosis. 24:1976;301-309.
36. Gylling H., Siimes M.A., Miettinen T.A. Sitostanol ester margarine in dietary treatment of children with familial hypercholesterolemia. J Lipid Res. 36:1995;1807-1812.
37. Becker M., Staab D., von Bergmann K. Long-term treatment of severe familial hypercholesterolemia in children: effect of sitosterol and bezafibrate. Pediatrics. 89:1992;138-142.
38. Huff M.W., Carroll K.K. Effects of dietary proteins and amino acid mixtures on plasma cholesterol levels in rabbits. J Nutr. 110:1980;1676-1685.
39. Turley S.D., Spady D.K., Dietschy J.M. Regulation of fecal bile acid excretion in male golden Syrian hamsters fed a cereal-based diet with and without added cholesterol. Hepatology. 25:1997;797-803.
40. Bilhartz L.E., Dietschy J.M. Bile salt hydrophobicity influences cholesterol recruitment from rat liver in vivo when cholesterol synthesis and lipoprotein uptake are constant. Gastroenterology. 95:1988;771-779.
41. Zilversmit D.B., Hughes L.B. Validation of a dual-isotope plasma ratio method for measurement of cholesterol absorption in rats. J Lipid Res. 15:1974;465-473.
42. Zilversmit D.B. A single blood sample dual isotope method for the measurement of cholesterol absorption in rats. Proc Soc Exp Biol Med. 140:1972;862-865.
43. Heinemann T., Kullak-Ublick G.A., Pietruck B., von Bergmann K. Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol. Eur J Clin Pharmacol. 40:1991;S59-S63.
44. Mattson F.H., Volpenhein R.A., Erickson B.A. Effect of plant sterol esters on the absorption of dietary cholesterol. J Nutr. 107:1977;1139-1146.
45. Mills G.L., Taylaur C.E. The distribution and composition of serum lipoproteins in eighteen animals. Comp Biochem Physiol. 40:1971;489-496.
46. Roach P.D., Balasubramaniam S., Hirata F., Abbey M., Szanto A., Simons L.A., Nestel P.J. The low-density lipoprotein receptor and cholesterol synthesis are affected differently by dietary cholesterol in the rat. Biochim Biophys Acta. 1170:1993;165-172.