Inhibition of AMP-activated protein kinase suppresses IL-2 expression through down-regulation of NF-AT and AP-1 activation in Jurkat T cells

Biochemical and Biophysical Research Communications

Volumn 351, Issue 4, 2006, Pages 986-992

  Jhun, Bong Sook ^a   Lee, Jung Yeon ^a   Oh, Young Taek ^a   Lee, Ju Hie ^a   Choe, Wonchae ^a   Baik, Hyung Hwan ^a   Kim, Sung Soo ^a   Yoon, Kyung Sik ^a   Ha, Joohun ^a   Kang, Insug ^a  

^a Kyung Hee University Hospital   (South Korea)

Author keywords

AMPK; AP 1; CD3; GSK 3; IL 2; Ionomycin; Jurkat cells; MAPK; NF AT; PMA

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERLEUKIN 2; IONOMYCIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY CD28; MONOCLONAL ANTIBODY CD3; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME INHIBITION; ENZYME MECHANISM; HUMAN; HUMAN CELL; IMMUNOREGULATION; LEUKEMIA CELL LINE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

DOWN-REGULATION; HUMANS; INTERLEUKIN-2; JURKAT CELLS; MULTIENZYME COMPLEXES; NFATC TRANSCRIPTION FACTORS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; T-LYMPHOCYTES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1;

EID: 33750811161     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.10.138     Document Type: Article

References (29)

1. Hardie D.G., and Carling D. The AMP-activated protein kinase-fuel gauge of the mammalian cell?. Eur. J. Biochem. 246 (1997) 259-273
2. Kemp B.E., Mitchelhill K.I., Stapleton D., Michell B.J., Chen Z.P., and Witters L.A. Dealing with energy demand: the AMP-activated protein kinase. Trends Biochem. Sci. 24 (1999) 22-25
3. Minokoshi Y., Kim Y.B., Peroni O.D., Fryer L.G., Muller C., Carling D., and Kahn B.B. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415 (2002) 339-343
4. Witters L.A., Kemp B.E., and Means A.R. Chutes and Ladders: the search for protein kinases that act on AMPK. Trends Biochem. Sci. 31 (2006) 13-16
5. Long Y.C., and Zierath J.R. AMP-activated protein kinase signaling in metabolic regulation. J. Clin. Invest. 116 (2006) 1776-1783
6. Motoshima H., Goldstein B.J., Igata M., and Araki E. AMPK and cell proliferation-AMPK as a therapeutic target for atherosclerosis and cancer. J. Physiol. 574 (2006) 63-71
7. Kefas B.A., Cai Y., Kerckhofs K., Ling Z., Martens G., Heimberg H., Pipeleers D., and Van de C.M. Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis. Biochem. Pharmacol. 68 (2004) 409-416
8. McCullough L.D., Zeng Z., Li H., Landree L.E., McFadden J., and Ronnett G.V. Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke. J. Biol. Chem. 280 (2005) 20493-20502
9. Pilon G., Dallaire P., and Marette A. Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase: a new mechanism of action of insulin-sensitizing drugs. J. Biol. Chem. 279 (2004) 20767-20774
10. Giri S., Nath N., Smith B., Viollet B., Singh A.K., and Singh I. 5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J. Neurosci. 24 (2004) 479-487
11. Hattori Y., Suzuki K., Hattori S., and Kasai K. Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells. Hypertension 47 (2006) 1183-1188
12. Smith K.A. Interleukin-2. Curr. Opin. Immunol. 4 (1992) 271-276
13. Nel A.E. T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse. J. Allergy Clin. Immunol. 109 (2002) 758-770
14. Crabtree G.R. Contingent genetic regulatory events in T lymphocyte activation. Science 243 (1989) 355-361
15. Rao A., Luo C., and Hogan P.G. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15 (1997) 707-747
16. Beals C.R., Sheridan C.M., Turck C.W., Gardner P., and Crabtree G.R. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 275 (1997) 1930-1934
17. Chow C.W., Dong C., Flavell R.A., and Davis R.J. c-Jun NH(2)-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1. Mol. Cell. Biol. 20 (2000) 5227-5234
18. Gomez del A.P., Martinez-Martinez S., Maldonado J.L., Ortega-Perez I., and Redondo J.M. A role for the p38 MAP kinase pathway in the nuclear shuttling of NFATp. J. Biol. Chem. 275 (2000) 13872-13878
19. Wu C.C., Hsu S.C., Shih H.M., and Lai M.Z. Nuclear factor of activated T cells c is a target of p38 mitogen-activated protein kinase in T cells. Mol. Cell. Biol. 23 (2003) 6442-6454
20. Koike T., Yamagishi H., Hatanaka Y., Fukushima A., Chang J.W., Xia Y., Fields M., Chandler P., and Iwashima M. A novel ERK-dependent signaling process that regulates interleukin-2 expression in a late phase of T cell activation. J. Biol. Chem. 278 (2003) 15685-15692
21. Macian F., Lopez-Rodriguez C., and Rao A. Partners in transcription: NFAT and AP-1. Oncogene 20 (2001) 2476-2489
22. Tamas P., Hawley S.A., Clarke R.G., Mustard K.J., Green K., Hardie D.G., and Cantrell D.A. Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes. J. Exp. Med. 203 (2006) 1665-1670
23. Jhun B.S., Oh Y.T., Lee J.Y., Kong Y., Yoon K.S., Kim S.S., Baik H.H., Ha J., and Kang I. AICAR suppresses IL-2 expression through inhibition of GSK-3 phosphorylation and NF-AT activation in Jurkat T cells. Biochem. Biophys. Res. Commun. 332 (2005) 339-346
24. Hur Y.G., Yun Y., and Won J. Rosmarinic acid induces p56lck-dependent apoptosis in Jurkat and peripheral T cells via mitochondrial pathway independent from Fas/Fas ligand interaction. J. Immunol. 172 (2004) 79-87
25. Im S.S., Kim J.W., Kim T.H., Song X.L., Kim S.Y., Kim H.I., and Ahn Y.H. Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter. Exp. Mol. Med. 37 (2005) 101-110
26. Lee J.Y., Jhun B.S., Oh Y.T., Lee J.H., Choe W., Baik H.H., Ha J., Yoon K.S., Kim S.S., and Kang I. Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NF-kappaB activation in murine BV2 microglial cells. Neurosci. Lett. 396 (2006) 1-6
27. Zhou G., Myers R., Li Y., Chen Y., Shen X., Fenyk-Melody J., Wu M., Ventre J., Doebber T., Fujii N., Musi N., Hirshman M.F., Goodyear L.J., and Moller D.E. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108 (2001) 1167-1174
28. Truneh A., Albert F., Golstein P., and Schmitt-Verhulst A.M. Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester. Nature 313 (1985) 318-320
29. Bauer B., and Baier G. Protein kinase C and AKT/protein kinase B in CD4+ T-lymphocytes: new partners in TCR/CD28 signal integration. Mol. Immunol. 38 (2001) 1087-1099