Target brain sites of the anxiolytic effect of citalopram, a selective serotonin reuptake inhibitor

European Journal of Pharmacology

Volumn 534, Issue 1-3, 2006, Pages 129-132

  Izumi, Takeshi ^a   Inoue, Takeshi ^a   Kitaichi, Yuji ^a   Nakagawa, Shin ^a   Koyama, Tsukasa ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Anxiolytic; c Fos; Citalopram; Conditioned fear stress (CFS); Selective serotonin reuptake inhibitor (SSRI); Serotonin

Indexed keywords

CITALOPRAM; PROTEIN C FOS; SEROTONIN UPTAKE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; DRUG MECHANISM; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANQUILIZING ACTIVITY;

AMYGDALA; ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; CITALOPRAM; CONDITIONING (PSYCHOLOGY); DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; FEAR; MALE; MOTOR ACTIVITY; MOTOR CORTEX; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN UPTAKE INHIBITORS; SOMATOSENSORY CORTEX;

EID: 33644887125     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.12.073     Document Type: Article

References (19)

1. C.H.M. Beck, and H.C. Fibiger Conditioned fear-induced changes in behavior and in the expression of the immediate early gene c-fos: with and without diazepam pretreatment J. Neurosci. 15 1995 709 720
2. P. Carrive, P. Leung, J. Harris, and G. Paxinos Conditioned fear to context is associated with increased Fos expression in the caudal ventrolateral region of the midbrain periaqueductal gray Neuroscience 78 1997 165 177
3. E. Erikkson, and M. Humble Serotonin in psychiatric pathophysiology: a review of data from experimental and clinical research R. Pohl S. Gershon The Biological Basis of Psychiatric Treatment Prog. Basic Clin. Pharmacol. vol. 3 1990 Karger Basel 66 119
4. M.S. Fanselow Conditioned and unconditioned components of postshock freezing Pavlovian J. Biol. Sci. 15 1980 177 182
5. R.W. Fuller Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis Life Sci. 55 1994 163 167
6. D. Funk, and S. Amir Enhanced Fos expression within the primary olfactory and limbic pathways induced by an aversive conditioned odor stimulus Neuroscience 98 2000 403 406
7. R.N. Golden Making advances where it matters: improving outcomes in mood and anxiety disorders CNS Spectr. 9 2004 14 22
8. S. Hashimoto, T. Inoue, and T. Koyama Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats Psychopharmacology 123 1996 182 186
9. S. Hashimoto, T. Inoue, and T. Koyama Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats Eur. J. Pharmacol. 378 1999 23 30
10. M.R. Holahan, and N.M. White Amygdala c-Fos induction corresponds to unconditioned and conditioned aversive stimuli but not to freezing Behav. Brain Res. 152 2004 109 120
11. T. Inoue, X.B. Li, T. Abekawa, Y. Kitaichi, T. Izumi, S. Nakagawa, and T. Koyama Selective serotonin reuptake inhibitor reduces conditioned fear through its effect in the amygdala Eur. J. Pharmacol. 497 2004 311 316
12. D. Krupa, and M.A.L. Nicolelis Network level properties of short-term plasticity in the somatosensory system Prog. Brain Res. 128 2000 161 172
13. J.E. LeDoux The amygdala and emotion: a view through fear J.P. Agglton The Amygdala. A Functional Analysis 2nd ed 2000 Oxford University Press New York, NY 289 310
14. A. Lysakowski, B.H. Wainer, G. Bruce, and L.B. Hersh An atlas of the regional and laminar distribution of choline acetyltransferase immunoreactivity in rat cerebral cortex Neuroscience 28 1989 291 336
15. I. Muraki, T. Inoue, S. Hashimoto, T. Izumi, K. Ito, T. Ohmori, and T. Koyama Effects of subchronic lithium carbonate treatment on anxiolytic-like effect of citalopram and MKC-242 in conditioned fear stress in the rats Eur. J. Pharmacol. 383 1999 223 229
16. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates 3rd ed 1997 Academic Press New York
17. M.A. Pezzone, W.S. Lee, G.E. Hoffman, and B.S. Rabin Induction of c-Fos immunoreactivity in the rat forebrain by conditioned and unconditioned aversive stimuli Brain Res. 597 1992 41 50
18. L.F. Schettino, and T. Otto Patterns of c-Fos expression in the amygdala and ventral perirhinal cortex induced by training in an olfactory fear conditioning paradigm Behav. Neurosci. 115 2001 1257 1272
19. A. Umino, T. Nishikawa, and K. Takahashi Methamphetamine-induced nuclear c-Fos in rat brain region Neurochem. Int. 26 1995 85 90