AgRP-deficiency could lead to increased lifespan

Biochemical and Biophysical Research Communications

Volumn 351, Issue 4, 2006, Pages 860-864

  Redmann Jr , Stephen M ^a   Argyropoulos, George ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Body weight; Diet; Longevity; Metabolism; Neuropeptide

Indexed keywords

AGOUTI RELATED PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FAT INTAKE; HAZARD ASSESSMENT; LIFESPAN; LIPID DIET; LONGEVITY; LOW FAT DIET; METABOLIC PARAMETERS; MORTALITY; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SURVIVAL; WILD TYPE;

ANIMALS; DIET; DIETARY FATS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LONGEVITY; MALE; MICE; MICE, MUTANT STRAINS; OBESITY; THINNESS;

AGOUTI;

EID: 33750797795     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.10.129     Document Type: Article

References (24)

1. Stutz A.M., Morrison C.D., and Argyropoulos G. The Agouti-related protein and its role in energy homeostasis. Peptides 26 (2005) 1771-1781
2. Shutter J.R., Graham M., Kinsey A.C., Scully S., Luthy R., and Stark K.L. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev. 11 (1997) 593-602
3. Graham M., Shutter J.R., Sarmiento U., Sarosi I., and Stark K.L. Overexpression of Agrt leads to obesity in transgenic mice. Nat. Genet. 17 (1997) 273-274
4. Ollmann M.M., Wilson B.D., Yang Y.K., Kerns J.A., Chen Y., Gantz I., and Barsh G.S. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278 (1997) 135-138
5. Haskell-Luevano C., and Monck E.K. Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor. Regul. Pept. 99 (2001) 1-7
6. Bewick G.A., Gardiner J.V., Dhillo W.S., Kent A.S., White N.E., Webster Z., Ghatei M.A., and Bloom S.R. Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype. FASEB J. 19 (2005) 1680-1682
7. Gropp E., Shanabrough M., Borok E., Xu A.W., Janoschek R., Buch T., Plum L., Balthasar N., Hampel B., Waisman A., Barsh G.S., Horvath T.L., and Bruning J.C. Agouti-related peptide-expressing neurons are mandatory for feeding. Nat. Neurosci. 8 (2005) 1289-1291
8. Luquet S., Perez F.A., Hnasko T.S., and Palmiter R.D. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310 (2005) 683-685
9. Flier J.S. AgRP in energy balance: will the real AgRP please stand up?. Cell Metab. 3 (2006) 83-85
10. Qian S., Chen H., Weingarth D., Trumbauer M.E., Novi D.E., Guan X., Yu H., Shen Z., Feng Y., Frazier E., Chen A., Camacho R.E., Shearman L.P., Gopal-Truter S., MacNeil D.J., Van Der Ploeg L.H., and Marsh D.J. Neither Agouti-related protein nor neuropeptide Y Is critically required for the regulation of energy homeostasis in Mice. Mol. Cell. Biol. 22 (2002) 5027-5035
11. Wortley K.E., Anderson K.D., Yasenchak J., Murphy A., Valenzuela D., Diano S., Yancopoulos G.D., Wiegand S.J., and Sleeman M.W. Agouti-related protein-deficient mice display an age-related lean phenotype. Cell Metab. 2 (2005) 421-427
12. Argyropoulos G., Rankinen T., Bai F., Rice T., Province M., Leon A., Skinner J., Wilmore J., Rao D., and Bouchard B. The agouti related protein and body fatness in humans. Int. J. Obes. 27 (2003) 276-280
13. Argyropoulos G., Rankinen T., Neufeld D.R., Rice T., Province M.A., Leon A.S., Skinner J.S., Wilmore J.H., Rao D.C., and Bouchard C. A polymorphism in the human agouti-related protein is associated with late-onset obesity. J. Clin. Endocrinol. Metab. 87 (2002) 4198-4202
14. Bonilla C., Panguluri R.K., Taliaferro-Smith L., Argyropoulos G., Chen G., Adeyemo A.A., Amoah A., Owusu S., Acheampong J., Agyenim-Boateng K., Eghan B.A., Oli J., Okafor G., Abbiyesuku F., Johnson T., Rufus T., Fasanmade O., Chen Y., Collins F.S., Dunston G.M., Rotimi C., and Kittles R.A. Agouti-related protein promoter variant associated with leanness and decreased risk for diabetes in West Africans. Int. J. Obes. Relat. Metab. Disord. (2005)
15. Olshansky S.J., Passaro D.J., Hershow R.C., Layden J., Carnes B.A., Brody J., Hayflick L., Butler R.N., Allison D.B., and Ludwig D.S. A potential decline in life expectancy in the United States in the 21st century. N. Engl. J. Med. 352 (2005) 1138-1145
16. Wolf G. Calorie restriction increases life span: a molecular mechanism. Nutr. Rev. 64 (2006) 89-92
17. Goodrick C.L. Life-span and the inheritance of longevity of inbred mice. J. Gerontol. 30 (1975) 257-263
18. Goodrick C.L. Body weight change over the life span and longevity for C57BL/6J mice and mutations which differ in maximal body weight. Gerontology 23 (1977) 405-413
19. Klebanov S., Astle C.M., Roderick T.H., Flurkey K., Archer J.R., Chen J., and Harrison D.E. Maximum life spans in mice are extended by wild strain alleles. Exp. Biol. Med. (Maywood) 226 (2001) 854-859
20. Miller R.A., Harper J.M., Galecki A., and Burke D.T. Big mice die young: early life body weight predicts longevity in genetically heterogeneous mice. Aging Cell 1 (2002) 22-29
21. Kunstyr I., and Leuenberger H.G. Gerontological data of C57BL/6J mice. I. Sex differences in survival curves. J. Gerontol. 30 (1975) 157-162
22. Bartke A. Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology 146 (2005) 3718-3723
23. Bonkowski M.S., Rocha J.S., Masternak M.M., Al Regaiey K.A., and Bartke A. From the cover: targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc. Natl. Acad. Sci. USA 103 (2006) 7901-7905
24. Loos R.J., Rankinen T., Rice T., Rao D.C., Leon A.S., Skinner J.S., Bouchard C., and Argyropoulos G. Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake. Am. J. Clin. Nutr. 82 (2005) 1097-1101