Molecular mechanisms of GD3-induced apoptosis in U-1242 MG glioma cells

Neurochemical Research

Volumn 31, Issue 10, 2006, Pages 1171-1180

  Omran, O M ^a   Saqr, H E ^a   Yates, Allan J ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; Caspase 8; DR5; Ganglioside; GD3; Glioma; TNF R1

Indexed keywords

CASPASE 8; DEATH RECEPTOR 5; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; GANGLIOSIDE GD3; TUMOR NECROSIS FACTOR RECEPTOR 1;

APOPTOSIS; ARTICLE; CARBOHYDRATE SYNTHESIS; CAVEOLA; CONTROLLED STUDY; GLIOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION;

APOPTOSIS; BLOTTING, WESTERN; BRAIN NEOPLASMS; CASPASE 8; CELL LINE, TUMOR; GANGLIOSIDES; GLIOMA; HUMANS;

EID: 33750743426     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-006-9147-2     Document Type: Article

References (38)

1. Hakomori S, Yamamura S, Handa AK (1998) Signal transduction through glyco(sphingo)lipids. Introduction and recent studies on glyco(sphingo)lipid- enriched microdomains. Ann N Y Acad Sci 845:1-10
2. Dolo V, Li R, Dillinger M et al (2000) Enrichment and localization of ganglioside G(D3) and caveolin-1 in shed tumor cell membrane vesicles. Biochim Biophys Acta 1486(2-3):265-274
3. Vyas KA, Patel HV, Vyas AA et al (2001) Segregation of gangliosides GM1 and GD3 on cell membranes, isolated membrane rafts, and defined supported lipid monolayers. Biol Chem 382(2):241-250
4. Degli Esposti M (2004) Mitochondria in apoptosis: past, present and future. Biochem Soc Trans 32(Pt 3):493-495
5. Sartorius U, Schmitz I, Krammer PH (2001) Molecular mechanisms of death-receptor-mediated apoptosis. Chembiochem 2(1):20-29
6. Bhunia AK, Schwarzmann G, Chatterjee S (2002) GD3 recruits reactive oxygen species to induce cell proliferation and apoptosis in human aortic smooth muscle cells. J Biol Chem 277(19):16396-16402
7. Melchiorri D, Martini F, Lococo E et al (2002) An early increase in the disialoganglioside GD3 contributes to the development of neuronal apoptosis in culture. Cell Death Differ 9(6):609-615
8. Wang XQ, Sun P, Paller AS (2001) Inhibition of integrin-linked kinase/protein kinase B/Akt signaling: mechanism for ganglioside-induced apoptosis. J Biol Chem 276(48):44504-44511
9. Simon BM, Malisan F, Testi R et al (2002) Disialoganglioside GD3 is released by microglia and induces oligodendrocyte apoptosis. Cell Death Differ 9(7):758-767
10. Saqr HE, Omran O, Dasgupta S et al (2006) Endogenous GD3 ganglioside induces apoptosis in U-1242 MG glioma cells. J Neurochem 25:25
11. Yates AJ, Agudelo JD, Sung C-C (1992) Glycolipids of a human glioma cell line bearing receptors for platelet-derived growth factor (PDGF). Lipids 27:308-310
12. Saqr HE, Omran OM, Oblinger JL et al (2006) TRAIL-induced apoptosis in U-1242 MG glioma cells. J Neuropathol Exp Neurol 65(2):152-161
13. Song KS, Li S, Okamoto T et al (1996) Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains Detergent-free purification of caveolae microdomains. J Biol Chem 271(16):9690-9697
14. Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Med Sci 37(8):911-917
15. Harris G, MacWilliam IC (1954) Dipping technique for revealing sugars on paper chromatograms. Chem Ind 249
16. Higuchi H, Yoon JH, Grambihler A et al (2003) Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis. J Biol Chem 278(1):454-461
17. Sottocornola E, Berra B, Colombo I (2003) GM3 content modulates the EGF-activated p185c-neu levels, but not those of the constitutively activated oncoprotein p185neu. Biochim Biophys Acta 1635(2-3):55-66
18. Oblinger JL, Boardman CL, Yates AJ et al (2003) Domain-dependent modulation of PDGFRbeta by ganglioside GM1. J Mol Neurosci 20(2):103-114
19. Hynds DL, Summers M, Van Brocklyn J et al (1995) Gangliosides inhibit platelet-derived growth factor-stimulated growth, receptor phosphorylation, and dimerization in neuroblastoma SH-SY5Y cells. J Neurochem 65:2251-2258
20. Van Brocklyn J, Bremer EG, Yates AJ (1993) Gangliosides inhibit platelet-derived growth factor-stimulated receptor dimerization in human glioma U-1242MG and Swiss 3T3 Cells. J Neurochem 61:371-374
21. Bremer EG, Hakomori S, Bowen-Pope DF et al (1984) Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation. J Biol Chem 259(11):6818-6825
22. Yates AJ, Saqr HE, Van Brocklyn J (1995) Ganglioside modulation of the PDGF receptor. A model for ganglioside function. J Neuro-Oncol 24:65-73
23. Husain N, Chiocca EA, Rainov N et al (1998) Co-expression of Fas and Fas ligand in malignant glial tumors and cell lines. Acta Neuropathol (Berl) 95(3):287-290
24. Daniotti JL, Landa CA, Gravotta D et al (1990) GD3 ganglioside is prevalent in fully differentiated neurons from rat retina. J Neurosci Res 26(4):436-46
25. Seyfried TN, Bernard DJ, Yu RK (1984) Cellular distribution of gangliosides in the developing mouse cerebellum: analysis using the staggerer mutant. J Neurochem 43(4):1152-1162
26. Kawai K, Kuroda S, Watarai S et al (1994) Occurrence of GD3 ganglioside in reactive astrocytes-an immunocytochemical study in the rat brain. Neurosci Lett 174(2):225-227
27. Sung CC, Pearl DK, Coons SW et al (1995) Correlation of ganglioside patterns of primary brain tumors with survival. Cancer 75(3):851-859
28. Oblinger JL, Pearl DK, Boardman CL et al (2006) Diagnostic and prognostic value of glycosyltransferase mRNA in glioblastoma multiforme patients. Neuropathol Appl Neurol (32):410-418
29. Malisan F, Franchi L, Tomassini B et al (2002) Acetylation supresses the propaoptotic activity of GD3 ganglioside. J Exp Med 196(12):1535-41
30. Mitsuda T, Furukawa K, Fukumoto S et al (2002) Overexpression of ganglioside GM1 results in the dispersion of platelet-derived growth factor receptor from glycolipid-enriched microdomains and in the suppression of cell growth signals. J. Biol. Chem 277(13):11239-11246
31. Micheau O, Solary E, Hammann A et al (1999) Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs. J Biol Chem 274(12):7987-7992
32. Chen Y, Lai MZ (2001) c-Jun NH2-terminal kinase activation leads to a FADD-dependent but Fas ligand-independent cell death in Jurkat T cells. J Biol Chem 276(11):8350-8357
33. Kulms D, Dussmann H, Poppelmann B et al (2002) Apoptosis induced by disruption of the actin cytoskeleton is mediated via activation of CD95 (Fas/APO-1). Cell Death Differ 9(6):598-608
34. MacFarlane M, Ahmad M, Srinivasula SM et al (1997) Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J Biol Chem 272(41):25417-25420
35. Yang X, Thiele CJ (2003) Targeting the tumor necrosis factor-related apoptosis-inducing ligand path in neuroblastoma. Cancer Lett 197(1-2):137-143
36. Wang XQ, Sun P, Paller AS (2002) Ganglioside induces caveolin-1 redistribution and interaction with the epidermal growth factor receptor. J Biol Chem 277(49):47028-47034
37. Cremesti A, Paris F, Grassme H et al (2001) Ceramide enables fas to cap and kill. J Biol Chem 276(26):23954-23961
38. Paris R, Morales A, Coll O et al (2002) Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy. J Biol Chem 277(51):49870-49876